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  3. Ethyfos 500mg Injection

Ethyfos 500mg Injection, Pack of 1 Injection
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Ethyfos 500mg Injection is used to treat Ovarian Cancer. It contains Amifostine, which belongs to the class of protective agents. It works by protecting the kidneys in patients undergoing chemotherapy and radiation therapy. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this medication. Ethyfos 500mg Injection may cause certain side effects such as nausea, vomiting, pain at the site of injection, and injection site reactions.

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Composition :

AMIFOSTINE-500MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Ethyfos 500mg Injection

Ethyfos 500mg Injection belongs to the class of cytoprotective agents. It is used in reducing cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. It is also used for the reduction of the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Ethyfos 500mg Injection contains Amifostine, which belongs to the class of protective agents. It works by protecting the kidneys in patients undergoing chemotherapy and radiation therapy.

Ethyfos 500mg Injection may cause certain side effects such as nausea, vomiting, pain at the site of injection, and injection site reactions. Inform your doctor if any of these side effects persist for longer. Ethyfos 500mg Injection will be administered by your physician in the hospital. Do not self-administer.

Avoid receiving Ethyfos 500mg Injection and inform your doctor if you are allergic to it or any other components of it. Before taking Ethyfos 500mg Injection, tell your doctor if you have/had liver or kidney disease, cardiac problems, skin disorders, and low calcium levels. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this Ethyfos 500mg Injection.

Uses of Ethyfos 500mg Injection

Ethyfos 500mg Injection is used to protect healthy tissues, especially the kidneys and salivary glands, from damage caused by chemotherapy and radiation therapy. The detailed uses of Ethyfos 500mg Injection are as follows:<br/>• Kidney protection during chemotherapy: Ethyfos 500mg Injection is used to protect the kidneys from damage caused by cisplatin, a chemotherapy drug commonly used in ovarian cancer treatment. It helps reduce the risk of nephrotoxicity without interfering with the cancer-fighting effects of the chemotherapy.<br/>• Dry mouth prevention during radiation therapy: Ethyfos 500mg Injection is used to prevent severe dry mouth (xerostomia) in patients undergoing radiation therapy for head and neck cancers. It protects the salivary glands from radiation-induced damage, improving comfort and quality of life.<br/>• Cytoprotective support: Ethyfos 500mg Injection is used as a cytoprotective agent to shield healthy tissues from the harmful effects of chemotherapy and radiation. It works by scavenging free radicals and detoxifying harmful compounds generated during cancer treatment.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Ethyfos 500mg Injection will be administered by a doctor or nurse in a healthcare facility.• Do not self-administer.

Medicinal Benefits

Ethyfos 500mg Injection contains Amifostine, which is used in protecting kidneys from renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. It is a cytotoxic medicine that detoxifies the reactive metabolites of platinum and alkylating agents.

How Ethyfos 500mg Injection Works

Ethyfos 500mg Injection contains Amifostine, which belongs to the class of protective agents. It works by protecting the kidneys in patients undergoing chemotherapy and radiation therapy.

Storage

Store in a cool and dry place away from sunlight
Side effects of Ethyfos 500mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
  • Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
  • Your doctor may order blood tests to check your calcium levels and monitor for any changes.
  • To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
  • If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.

What if I have taken an overdose of Ethyfos 500mg Injection

As Ethyfos 500mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Ethyfos 500mg Injection may cause dizziness, lightheadedness and fainting.

Drug Warnings

To treat your condition effectually, continue receiving Ethyfos 500mg Injection for the period that your doctor has prescribed. Ethyfos 500mg Injection may cause severe cutaneous reactions, hypotension, cardiovascular problems, nausea, vomiting, and hypocalcemia. Therefore, caution should be exercised if you have/had liver or kidney disease, heart problems, and skin disorders while receiving Ethyfos 500mg Injection. This medicine may also cause severe hypersensitivity reactions. Hence, careful monitoring is recommended and discontinue the treatment if any severe allergic reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children as the safety and efficacy are not established. 

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Ethyfos 500mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

It is unknown whether Ethyfos 500mg Injection interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Ethyfos 500mg Injection is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Ethyfos 500mg Injection. You should not become pregnant while you are receiving Ethyfos 500mg Injection. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Ethyfos 500mg Injection should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine.

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Driving

Not applicable

Ethyfos 500mg Injection will be administered to hospitalized patients.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Ethyfos 500mg Injection. Tell your doctor if you have little or no urination, swelling in your feet or ankles, or blood in your urine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Ethyfos 500mg Injection is not recommended for use in children as the safety and efficacy is not established.

Have a query?

FAQs

Ethyfos 500mg Injection is used to treat ovarian cancer.

Ethyfos 500mg Injection contains Amifostine, which works by protecting the kidneys in patients undergoing chemotherapy and radiation therapy.

The common side effects of Ethyfos 500mg Injection may include nausea, vomiting, pain at the site of injection, and injection site reactions. Inform your doctor if any of these side effects persist for longer.

Country of origin

India

Manufacturer/Marketer address

Sco-290 Manimajra Chandigarh, Chandigarh, 160101 India
Other Info - ET48775

Disclaimer

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020221s036lbl.pdf
  2. https://go.drugbank.com/drugs/DB01143
  3. https://medlineplus.gov/druginfo/meds/a696014.html
  4. https://reference.medscape.com/drug/ethyol-amifostine-342249
  5. https://www.mayoclinic.org/drugs-supplements/amifostine-intravenous-route/description/drg-20061637
  6. https://www.drugs.com/mtm/amifostine.html
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