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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Flagyl 400 Tablet is used to treat and prevent bacterial and parasitic infections including blood, brain, bone, lung, stomach lining, pelvic area and genital infections, amoebiasis, gum and teeth infections, infected leg ulcers or pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by Trichomonas parasite. Furthermore, it can also be used to treat infections following childbirth or in a wound following an operation. It contains Metronidazole, which stops the growth of infection-causing bacteria or parasites. It may cause common side effects such as nausea, vomiting, upset stomach, loss of appetite, dry mouth, and metallic taste. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

METRONIDAZOLE-400MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Flagyl 400 Tablet

Flagyl 400 Tablet belongs to a group of medicines known as anti-microbial agents used to treat bacterial infections of the blood, brain, lung, bone, pelvic area, stomach lining, intestines, gum, teeth, following childbirth or wound infection following an operation. It is also used to treat infected leg ulcers, pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by Trichomonas parasite, amoebiasis (parasitic infection of the colon), and to prevent infections after surgery.

Flagyl 400 Tablet contains metronidazole that works by preventing the production of proteins required by the harmful microorganisms for their survival. Thereby Flagyl 400 Tablet treats bacterial and parasitic infections.

Your doctor will decide the duration depending on the type of infection. Some common side effects of Flagyl 400 Tablet are nausea, vomiting, upset stomach, loss of appetite, dry mouth, and metallic taste. Most of these side effects do not require medical attention and resolve over time. However, if the side effects persist or worsen, consult a doctor.

Flagyl 400 Tablet should not be used during pregnancy, especially during the first trimester and while breastfeeding. Do not drive or operate heavy machinery after taking Flagyl 400 Tablet as it may cause dizziness and drowsiness. Avoid consumption of alcohol while on treatment with Flagyl 400 Tablet and for 48 hours after completing the course as it may cause unpleasant side effects. Keep your doctor informed about your health condition and medications to rule out any side effects.

Uses of Flagyl 400 Tablet

Flagyl 400 Tablet is used to treat bacterial and protozoal infections. The detailed uses of Flagyl 400 Tablet are as follows:
•Bacterial infections: Flagyl 400 Tablet is widely used to treat infections caused by anaerobic bacteria, including conditions like bacterial vaginosis and pelvic inflammatory disease.
•Protozoal infections: Flagyl 400 Tablet is effective against protozoa such as Entamoeba histolytica (linked to amoebic dysentery); it inhibits protozoal reproduction.
•Dental infections: Flagyl 400 Tablet is often prescribed in dentistry to address gum and oral cavity infections, particularly those caused by anaerobic bacteria. It may be paired with other antibiotics for enhanced results.
•Helicobacter Pylori Eradication: Flagyl 400 Tablet helps eradicate helicobacter pylori, the bacterium associated with peptic ulcers, as part of a combination therapy, working alongside antibiotics and proton pump inhibitors.

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush, break or chew it. Syrup/suspension/drops: Shake the pack well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Flagyl 400 Tablet contains metronidazole used to treat and prevent bacterial and parasitic infections including blood, brain, bone, lung, stomach lining, pelvic area and genital infections, amoebiasis, gum and teeth infections, infected leg ulcers or pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by Trichomonas parasite. Furthermore, it can also be used to treat infections following childbirth or in a wound following an operation. It works by preventing the infection-causing bacteria or parasites from growing.

How Flagyl 400 Tablet Works

Flagyl 400 Tablet contains metronidazole that works by preventing the production of proteins required by the harmful microorganisms for their survival. Thereby Flagyl 400 Tablet treats bacterial and parasitic infections.

Storage

Store in a cool and dry place away from sunlight
Side effects of Flagyl 400 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Inflammation of Vagina needs immediate attention and cannot be ignored.
  • Get a physical examination and prevent wearing clothes that can hold heat and moisture.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Follow your doctor's instructions, and rest well with proper medication.
  • Take a balanced diet and get regular screenings to reduce inflammation.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Flagyl 400 Tablet

Do not take more than the prescribed dose of Flagyl 400 Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, seizures (fits), loss of muscle coordination and numbness, burning, pain, or tingling in hands/feet. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Flagyl 400 Tablet if you are allergic to any of its components. Flagyl 400 Tablet should not be used during pregnancy, especially during the first trimester. So, let your doctor know if you are pregnant or planning to get pregnant. Avoid breastfeeding while taking Flagyl 400 Tablet and for 12-24 hours after completing the course. Do not drive or operate heavy machinery after taking Flagyl 400 Tablet as it may cause dizziness and drowsiness. Inform your doctor if you have Clostridium difficile-associated diarrhoea, bone marrow depression/low blood count, CNS disorder, epilepsy, porphyria (blood disorder), peripheral neuropathy, heart, kidney or liver problems.

Drug-Drug Interactions

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MetronidazoleDisulfiram
Critical
MetronidazoleEthanol
Critical

Drug-Drug Interactions

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MetronidazoleDisulfiram
Critical
How does the drug interact with Flagyl 400 Tablet:
Coadministration of Disulfiram with Flagyl 400 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Flagyl 400 Tablet and Disulfiram together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
MetronidazoleEthanol
Critical
How does the drug interact with Flagyl 400 Tablet:
Drinking alcohol while taking Flagyl 400 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Flagyl 400 Tablet with Ethanol is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetronidazoleAmprenavir
Critical
How does the drug interact with Flagyl 400 Tablet:
Co-administration of Amprenavir with Flagyl 400 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Flagyl 400 Tablet with Amprenavir is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience throbbing in the head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetronidazoleBusulfan
Severe
How does the drug interact with Flagyl 400 Tablet:
Coadministration of Busulfan and Flagyl 400 Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Flagyl 400 Tablet and Busulfan together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
MetronidazoleMebendazole
Severe
How does the drug interact with Flagyl 400 Tablet:
Coadministration of Flagyl 400 Tablet with mebendazole may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Flagyl 400 Tablet and mebendazole, they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms like fever, body ache, painful red rash, cough, peeling of the skin, or Drooling, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MetronidazoleWarfarin
Severe
How does the drug interact with Flagyl 400 Tablet:
Coadministration of Flagyl 400 Tablet with warfarin can increase the risk of bleeding.

How to manage the interaction:
There is a possible interaction between Flagyl 400 Tablet and warfarin, but they can be taken together if a doctor has prescribed them. Consult a doctor if experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without talking to a doctor.
MetronidazoleFluconazole
Moderate
How does the drug interact with Flagyl 400 Tablet:
Co-administration of Fluconazole together with Flagyl 400 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
-Taking Flagyl 400 Tablet with Fluconazole together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Flagyl 400 Tablet to restore healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.

  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole grains like whole-grain bread, and brown rice, should be included in the diet.

  • Avoid intake of alcoholic beverages with Flagyl 400 Tablet as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Flagyl 400 Tablet in fighting off infections.

  • If you have diarrhoea, drink appropriate amounts of fluids to avoid dehydration. 

Habit Forming

No

Therapeutic Class

ANTIMICROBIALS

Flagyl 400 Tablet Substitute

Substitutes safety advice
  • Metrogyl 400 Tablet 20's

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  • Metrogyl 400 Tablet 15's

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  • METRONIDAZOLE 400MG TABLET

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    1.35per tablet
  • Metron 400 Tablet 15's

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    1.35per tablet
  • Aristogyl 400 mg Tablet 10's

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    1.53per tablet
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Alcohol

Unsafe

You are recommended not to consume alcohol while on treatment with Flagyl 400 Tablet and for 48 hours after completing the course to avoid unpleasant side effects such as nausea, vomiting, stomach pain, palpitations, headache, and hot flushes.

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Pregnancy

Unsafe

Flagyl 400 Tablet should not be used during pregnancy, especially during the first trimester. Inform your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Flagyl 400 Tablet and for 12-24 hours after completing the course.

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Driving

Caution

Flagyl 400 Tablet may cause dizziness and drowsiness; thus, avoid using machinery or driving unless you are alert.

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Liver

Caution

Flagyl 400 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your liver conditions.

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Kidney

Caution

Flagyl 400 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your kidney conditions.

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Children

Safe if prescribed

Flagyl 400 Tablet should be given to children only if prescribed by a doctor. Your doctor may adjust the dose as per the age.

FAQs

Flagyl 400 Tablet is used to treat bacterial and parasitic infections.

Flagyl 400 Tablet works by preventing the production of proteins required by harmful microorganisms for their survival. Thereby Flagyl 400 Tablet helps treat and prevent bacterial and parasitic infections.

No. You should complete the full course of Flagyl 400 Tablet as prescribed by your doctor. Consult your doctor if you experience any difficulty while taking Flagyl 400 Tablet .

No. Flagyl 400 Tablet is an antimicrobial medicine that acts only against bacterial infections and not viral infections like common cold and flu.

If you miss a dose of Flagyl 400 Tablet , take the missed dose as soon as you remember it. However, if it is almost time for the next dose, do not take a double dose to make up for a missed one.

Flagyl 400 Tablet may cause jaundice in a rare case. Please consult your doctor immediately if you notice yellowing of skin and eyes.

No. Do not stop taking Flagyl 400 Tablet until course completion, as the doctor prescribes. If you stop taking it, your problem may reoccur. If you face any difficulty or experience any adverse events that persist while taking it, report it to your doctor and seek appropriate treatment.

Flagyl 400 Tablet may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori). Even so, it can be used only if advised by the doctor.

Do not give more than the prescribed dose of Flagyl 400 Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, seizures (fits), loss of muscle coordination and numbness, burning, pain, or tingling in hands/feet. If you suspect you have given overdose or notice signs of overdose, please consult a doctor immediately.

If the symptoms do not improve within a few days after you start this medicine or if they become worse, consult with your doctor. They will reassess the condition and guide appropriate treatment.

Flagyl 400 Tablet may interact with certain medications. So, do not use any other medications with Flagyl 400 Tablet unless recommended by the doctor. Your doctor will check their potential interactions and prescribe you if necessary.

Antibiotics like Flagyl 400 Tablet may reduce the vaccine's activity. To ensure adequate vaccine response, vaccination should be given at least 14 days after you complete your treatment with Flagyl 400 Tablet or 10 days before starting therapy with Flagyl 400 Tablet . Talk to your doctor if you have any questions or concerns.

Let your doctor know about your child’s medical history and ongoing medications before prescribing Flagyl 400 Tablet .

Yes, it is normal. Flagyl 400 Tablet can cause urine discolouration. This is harmless and should resolve on its own once your child stops taking the medication.

Flagyl 400 Tablet may interfere with some drugs. Always check with a doctor before giving any medication, especially if your child is feverish. The doctor advises the best course of treatment!

To ensure the medication's effectiveness and progress of the medical condition, the doctor may perform certain lab tests, such as a complete blood count (CBC), liver function test (LFC), and kidney function test (KFT) if necessary.

Common side effects of Flagyl 400 Tablet may include nausea, vomiting, upset stomach, loss of appetite, dry mouth, and metallic taste. Most of these side effects do not require medical attention and resolve over time. However, if the side effects persist or worsen, consult a doctor.

Country of origin

India

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - FLA0005

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