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  1. Home
  2. Medicine

  3. Flulast PR 20mg/10mg Tablet

Prescription drug
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Flulast PR 20mg/10mg Tablet, Pack of 1
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Extra 15% Off with Bank Offers

Composition :

FLUNARIZINE-10MG + PROPRANOLOL-20MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Flulast PR 20mg/10mg Tablet

Flulast PR 20mg/10mg Tablet is used to treat migraine. Migraine is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Its symptoms include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Flulast PR 20mg/10mg Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits the cortical spreading of depression and electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused by migraine. It is also used to treat vertigo (spinning sensation).

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Flulast PR 20mg/10mg Tablet include dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Flulast PR 20mg/10mg Tablet. Flulast PR 20mg/10mg Tablet may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking Flulast PR 20mg/10mg Tablet if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol along with Flulast PR 20mg/10mg Tablet as it could lead to increased drowsiness.

Uses of Flulast PR 20mg/10mg Tablet

Flulast PR 20mg/10mg Tablet is used in the treatment of migraine. The detailed uses of Flulast PR 20mg/10mg Tablet are as follows:

  • Prevents migraine headaches: Flulast PR 20mg/10mg Tablet helps to reduce the frequency, severity, and duration of migraine attacks by calming overactive nerves and improving blood flow to the brain.
  • Controls physical symptoms of anxiety: Flulast PR 20mg/10mg Tablet helps to relieve symptoms such as a fast heartbeat, shaking, and sweating that often occur with anxiety or stress.
  • Manages vertigo and dizziness: Flulast PR 20mg/10mg Tablet can also be used to treat balance problems like vertigo by stabilizing inner ear and brain signals.

Have a query?

Directions for Use

  • Take Flulast PR 20mg/10mg Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Flulast PR 20mg/10mg Tablet is used to treat migraine. It consists of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and has anxiolytic (anxiety-reducing), anti-arrhythmic, and antihypertensive properties. It works by lowering cerebral (brain) blood flow and inhibits cortical spreading depression, as well as electrical activity in the brain that causes pain and inflammation. It reduces the severity and frequency of migraine headaches. Flunarizine is a channel blocker that improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused by migraine. 

How Flulast PR 20mg/10mg Tablet Works

Flulast PR 20mg/10mg Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits the cortical spreading of depression and electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused by migraine.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Flulast PR 20mg/10mg Tablet
Managing Medication-Triggered Productive cough (wet cough): A Step-by-Step Guide:
  • If you experience a persistent cough after taking medication, consult your doctor to determine the best course of action.
  • Your doctor will assess and adjust your medication regimen if necessary to minimize the cough.
  • Your doctor may recommend cough medications, such as expectorants, to help loosen and clear mucus.
  • Stay hydrated by drinking plenty of fluids, and consider a soothing lifestyle, such as a warm, humid environment, avoiding irritants like smoke and dust, and getting plenty of rest.
  • If your cough persists or worsens, follow up with your doctor for further evaluation and treatment.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
  • Keep regular sleeping hours.
  • Don’t consume nicotine, caffeine, or alcohol in the hours leading up to bed.
  • Practice relaxation exercises before bedtime.
  • Regular physical activity can promote deeper and better sleep. However, avoid intense exercise within 2-3 hours of bedtime, as it can disrupt your sleep.
  • If nightmares continue, cognitive behavioral therapy (CBT) may be a helpful treatment option. Your doctor may recommend CBT to address underlying issues and provide coping strategies to manage nightmares.

What if I have taken an overdose of Flulast PR 20mg/10mg Tablet

Do not take more than the prescribed dose of Flulast PR 20mg/10mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Inform your doctor if you have any history of liver or kidney diseases, breathing problems (asthma, bronchitis, emphysema), diabetes, heart failure, heart rhythm problems (sinus bradycardia, Wolff-Parkinson-White syndrome, atrioventricular block), overactive thyroid, blood circulation problems (Raynaud's disease), adrenal gland tumour (pheochromocytoma), depression, metabolic acidosis (excess acid in the blood), and myasthenia gravis (muscle weakness) before starting Flulast PR 20mg/10mg Tablet. Please consult your doctor if you are pregnant and planning to conceive if the doctor advised you Flulast PR 20mg/10mg Tablet. Avoid consuming alcohol along with Flulast PR 20mg/10mg Tablet as it could lead to increased dizziness and drowsiness.

Drug-Drug Interactions

verifiedApollotooltip
PropranololThioridazine
Critical
PropranololClonidine
Severe

Drug-Drug Interactions

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PropranololThioridazine
Critical
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of thioridazine with Flulast PR 20mg/10mg Tablet may increase the blood levels of thioridazine and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Flulast PR 20mg/10mg Tablet and thioridazine, they can be taken together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, and shortness of breath contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololClonidine
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Co-administration of Clonidine and Flulast PR 20mg/10mg Tablet may lower blood pressure and slower heart rate.

How to manage the interaction:
Although there is a possible interaction between Clonidine and Flulast PR 20mg/10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience headaches, slow heartbeat, dizziness, or feeling like you might pass out, contact your doctor.
PropranololIsoetarine
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Using Flulast PR 20mg/10mg Tablet together with isoetharine may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Flulast PR 20mg/10mg Tablet can sometimes cause breathing problems.

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Isoetarine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololEpinephrine
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Co-administration of Epinephrine with Flulast PR 20mg/10mg Tablet may cause severe high blood pressure and reduced heart rate.

How to manage the interaction:
Taking Epinephrine with Flulast PR 20mg/10mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololCeritinib
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Combining ceritinib with Flulast PR 20mg/10mg Tablet can decrease heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Posaconazole together with Ceritinib can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience lightheadedness, generalized weakness, dizziness, or shortness of breath, consult a doctor immediately. Do not stop using any medications consulting a doctor.
PropranololIobenguane (131i)
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of iobenguane (131i) and Flulast PR 20mg/10mg Tablet may interfere with the effects of iobenguane I-131 in treating your condition.

How to manage the interaction:
Although there is a possible interaction between Flulast PR 20mg/10mg Tablet and Iobenguane (131i), you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololAtazanavir
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Taking Flulast PR 20mg/10mg Tablet together with atazanavir can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Atazanavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, or an irregular heartbeat. Do not stop taking any medication without consulting your doctor.
PropranololAminophylline
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Coadministration of Aminophylline with Flulast PR 20mg/10mg Tablet together can make Flulast PR 20mg/10mg Tablet less effective and increase the effects of aminophylline.

How to manage the interaction:
Taking Aminophylline with Flulast PR 20mg/10mg Tablet can cause an interaction. However, it can be taken only if a doctor has advised it. If you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PropranololDiltiazem
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Taking Flulast PR 20mg/10mg Tablet and Diltiazem together increases the risk of side effects.

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Diltiazem can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. Do not stop using any medications without consulting your doctor.
PropranololTheophylline
Severe
How does the drug interact with Flulast PR 20mg/10mg Tablet:
Using Flulast PR 20mg/10mg Tablet together with Theophylline makes the Flulast PR 20mg/10mg Tablet less effective in controlling blood pressure, and it also increases the effects of theophylline

How to manage the interaction:
Although taking Flulast PR 20mg/10mg Tablet together with Theophylline can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor if you experience nausea, vomiting, sleeplessness, tremors, restlessness, irregular heartbeats, or difficulty breathing. Do not stop using any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. Instead, eat a healthy diet and do regular exercise to avoid weight gain caused due to Flulast PR 20mg/10mg Tablet.
  • Avoid loud music, extreme temperatures, bright lights, and noisy places as it can increase headache.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine to relieve headaches.
  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Flulast PR 20mg/10mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Flulast PR 20mg/10mg Tablet. Alcohol intake, along with Flulast PR 20mg/10mg Tablet, may cause increased dizziness and drowsiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning to conceive before using Flulast PR 20mg/10mg Tablet.

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Breast Feeding

Caution

Please consult your doctor before taking Flulast PR 20mg/10mg Tablet if you are a lactating mother.

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Driving

Caution

Flulast PR 20mg/10mg Tablet may make you feel drowsy. Do not drive or operate machinery if you experience drowsiness.

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Liver

Caution

Therapy with propranolol should be administered cautiously in patients with liver disease. Please consult your doctor if you have a history of liver impairment/liver disease.

bannner image

Kidney

Caution

Plasma clearance of Propranolol in Flulast PR 20mg/10mg Tablet is reduced in patients with renal failure. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Safe if prescribed

Flulast PR 20mg/10mg Tablet is safe to use for children below 12 years of age when prescribed by the doctor.

FAQs

Flulast PR 20mg/10mg Tablet belongs to the class of anti-migraine drugs used to treat migraine.

Flulast PR 20mg/10mg Tablet is a combination of two drugs: Propranolol and Flunarizine. Flulast PR 20mg/10mg Tablet treats migraine by reducing the blood flow to the brain, and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation.

Flulast PR 20mg/10mg Tablet may sometimes cause weight gain during its prolonged use. It is always advised to maintain a well-balanced, healthy diet and exercise regularly.

Flulast PR 20mg/10mg Tablet does not work for a sudden migraine attack. It is helpful in only preventing new episodes of migraine headaches. Please let your doctor know if you have sudden attacks to be prescribed other suitable medications.

Flulast PR 20mg/10mg Tablet is contraindicated in asthma, slow heart rate, abnormal heart rhythms, heart conditions like AV (Atrioventricular) block or sick sinus syndrome, depression, and Parkinson's disease. Please consult your doctor before starting Flulast PR 20mg/10mg Tablet if you have a medical history.

Your doctor will prescribe Flulast PR 20mg/10mg Tablet to prevent any new episodes of migraine. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of migraine. Flulast PR 20mg/10mg Tablet also contains Propranolol, and its sudden withdrawal may cause sweating, shaking, irregular heartbeat, and worsening of underlying angina or heart attack. Hence, do not stop using Flulast PR 20mg/10mg Tablet unless advised by your doctor.

Flulast PR 20mg/10mg Tablet may cause sleepiness in some individuals as a potential side effect. If this occurs, exercise caution and avoid activities that require mental alertness, such as driving or operating heavy machinery.

Store Flulast PR 20mg/10mg Tablet at room temperature in a cool and dry place, away from sunlight and moisture. Keep out of reach of children.

The common side effects of Flulast PR 20mg/10mg Tablet are weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). Please consult your doctor if any of these side effects persist or worsen.

Manufacturer/Marketer address

304,Uttam Chamber,Pune 411011
Other Info - FL65762

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Sep 10, 2025 | 3:16 PM IST

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Reference

  1. https://www.drugs.com/dosage/propranolol.htmlhttp://ahckids.org/wp-content/uploads/2015/02/SibeliumInsert.pdf
  2. https://ijpsr.com/bft-article/formulation-evaluation-and-estimation-of-propranolol-hydrochloride-and-flunarizine-dihydrochloride-conventional-tablets-in-combined-dosage-form-and-its-comparison-with-marketed-formulations/?view=fulltext
  3. https://pubchem.ncbi.nlm.nih.gov/compound/Propranolol#section=Drug-and-Medication-Information
  4. https://www.gosh.nhs.uk/medical-information-0/search-medical-conditions/medicines-information/flunarizine-prevent-migraine
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