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  3. Gemibine 1.4Gm Inj

Gemibine 1.4Gm Inj, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Gemibine 1.4Gm Inj is an anti-cancer medicine used in the treatment of breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. This medicine works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include nausea, hair loss, skin rash, vomiting, and oedema.
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Composition :

GEMCITABINE-1.40GM

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Gemibine 1.4Gm Inj

Gemibine 1.4Gm Inj belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body.

Gemibine 1.4Gm Inj contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Gemibine 1.4Gm Inj is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers. 

A healthcare professional will administer Gemibine 1.4Gm Inj. Do not self-administer. Gemibine 1.4Gm Inj may cause certain common side effects such as nausea, hair loss, skin rash, vomiting, and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of the components. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Talk to your doctor if you are planning to father a child before taking Gemibine 1.4Gm Inj; your doctor may advise you regarding sperm storage. Avoid taking alcohol with Gemibine 1.4Gm Inj.

Uses of Gemibine 1.4Gm Inj

Treatment of Breast Cancer, Pancreatic Cancer, Non-small-cell Lung Cancer, Bladder Cancer, and Ovarian Cancer

Directions for Use

A healthcare professional will administer Gemibine 1.4Gm Inj. Do not self-administer.

Medicinal Benefits

Gemibine 1.4Gm Inj is an anti-cancer drug used in the treatment of various types of cancers. Gemibine 1.4Gm Inj is used either independently or in conjunction with other chemotherapy medications to treat breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Gemibine 1.4Gm Inj works by interfering with DNA synthesis. It blocks the production of new DNA, by locking itself into the DNA strands and inhibiting any further proliferation or growth of the cell. Hence, Gemibine 1.4Gm Inj has widespread application in the field of oncology (cancer-related medicine) and chemotherapy.

How Gemibine 1.4Gm Inj Works

Gemibine 1.4Gm Inj contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Gemibine 1.4Gm Inj is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers.

Storage

Store in a cool and dry place away from sunlight
Side effects of Gemibine 1.4Gm Inj
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Tell your doctor if you notice any unusual symptoms after taking the medication, such as flat purple, or red spots on your skin.
  • Your doctor may change your medication, lower the dose, or stop the treatment to help manage the symptoms.
  • Avoid heavy physical activity and get plenty of rest to prevent further worsening of the symptoms.
  • Apply cold packs to the affected areas for relief.
  • Drink plenty of fluids to stay hydrated, and eat fruits and vegetables or take supplements to get enough vitamins.
  • Over-the-counter pain relievers can help with discomfort.
  • Regularly wash your hands with alcohol-based sanitizer or soap and water.
  • Also, avoid sharing personal items like glasses or utensils with other individuals.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Gemibine 1.4Gm Inj

Since Gemibine 1.4Gm Inj is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe rash, pain, burning, or tingling in the hands or feet, unusual bleeding or bruising, red/black/tarry stools, pink/red/dark brown urine, coughing up or vomiting blood or material that looks like coffee grounds, signs of infection (fever, sore throat, ongoing cough and congestion), and extreme tiredness.

Drug Warnings

Gemibine 1.4Gm Inj should not be used in case of any known allergy to any of the components. Gemibine 1.4Gm Inj should be used with caution in case of high risk or previous history of heart disease, vascular disease, liver problems, kidney disease or alcoholism. Keep your doctor informed if you suffer from any shortness of breath, kidney problems, hypertension diabetes or epilepsy. Avoid Gemibine 1.4Gm Inj during pregnancy and breastfeeding. Offer a detailed medical history, vaccination history, and inform the doctor especially if you are on any radiotherapy.

Drug-Drug Interactions

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GemcitabineEtanercept
Severe
GemcitabineKetoconazole
Severe

Drug-Drug Interactions

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GemcitabineEtanercept
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Taking Etanercept with Gemibine 1.4Gm Inj can increase the risk of infections.

How to manage the interaction:
Taking Etanercept with Gemibine 1.4Gm Inj together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
GemcitabineKetoconazole
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Coadministration of Ketoconazole and Gemibine 1.4Gm Inj may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Gemibine 1.4Gm Inj together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medication without consulting a doctor.
GemcitabineVoclosporin
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
When Gemibine 1.4Gm Inj is taken with Voclosporin, the amount of Gemibine 1.4Gm Inj in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Gemibine 1.4Gm Inj and Voclosporin, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineThalidomide
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Taking thalidomide together with Gemibine 1.4Gm Inj may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Gemibine 1.4Gm Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
GemcitabineTeriflunomide
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Combining Gemibine 1.4Gm Inj with Teriflunomide can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Gemibine 1.4Gm Inj and Teriflunomide, but it can be taken if prescribed by a doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain or burning when urinating, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineInfliximab
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Combining Infliximab with Gemibine 1.4Gm Inj can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Gemibine 1.4Gm Inj and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineCertolizumab
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Combining Gemibine 1.4Gm Inj with Certolizumab can increase the risk of infections.

How to manage the interaction:
Co-administration of Gemibine 1.4Gm Inj with Certolizumab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineBaricitinib
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Using baricitinib together with Gemibine 1.4Gm Inj may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Gemibine 1.4Gm Inj if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
GemcitabineTofacitinib
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Coadministration of Tofacitinib and Gemibine 1.4Gm Inj can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Gemibine 1.4Gm Inj, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
GemcitabineDeferiprone
Severe
How does the drug interact with Gemibine 1.4Gm Inj:
Gemibine 1.4Gm Inj can cause higher levels of Deferiprone in the blood by reducing its excretion rate. This can increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Gemibine 1.4Gm Inj and Deferiprone, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain while urinating contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.
  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Avoid taking Gemibine 1.4Gm Inj with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Unsafe

It is not recommended to use alcohol with Gemibine 1.4Gm Inj as it might lead to increased drowsiness.

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Pregnancy

Unsafe

Gemibine 1.4Gm Inj should be avoided during pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Gemibine 1.4Gm Inj is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Gemibine 1.4Gm Inj may cause drowsiness and sleepiness, which may affect your ability to drive. Do not drive if you experience any side effects after using Gemibine 1.4Gm Inj.

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Liver

Caution

Exercise caution before using Gemibine 1.4Gm Inj in case of established liver disease. Please consult your doctor to address any concerns.

bannner image

Kidney

Caution

Exercise caution before using Gemibine 1.4Gm Inj in case of established kidney disease. Please consult your doctor to address any concerns.

bannner image

Children

Unsafe

Gemibine 1.4Gm Inj is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

FAQs

Gemibine 1.4Gm Inj belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer.

Gemibine 1.4Gm Inj works blocking DNA synthesis and causing cell death, thereby preventing the cells from proliferating beyond normal.

Men taking Gemibine 1.4Gm Inj are advised not to father a child during the treatment with Gemibine 1.4Gm Inj and for 6months after the treatment. Consult your doctor before starting Gemibine 1.4Gm Inj if you are planning to father a child. Your doctor may advise you regarding sperm storage.

If you suffer from CKD, please consult with your doctor before using Gemibine 1.4Gm Inj and discuss any concerns with them. Gemibine 1.4Gm Inj is to be used with caution in those suffering from kidney and liver problems.

Gemibine 1.4Gm Inj might cause low white blood cell count leading to increased risk of infections. Consult your doctor if you have a fever, sweating, and any signs of infections.

Gemibine 1.4Gm Inj may cause bleeding and bruising due to less platelet count. Consult a doctor if you notice unexpected bruising, pinkish or reddish urine, bleeding from gums, mouth, or nose.

Gemibine 1.4Gm Inj contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. It is very effective in controlling cancer cells from multiplying and is used for the treatment of various types of cancers.

The side effects of Gemibine 1.4Gm Inj include hair loss, vomiting, nausea, skin rash and oedema. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - GEM0246

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Author Details

Doctor imageDoctor badge

Written By

Veda Maddala

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:46 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2839.pdf
  2. https://chemocare.com/chemotherapy/drug-info/gemcitabine.aspx
  3. https://pubmed.ncbi.nlm.nih.gov/7481842/
  4. https://www.cancer.gov/about-cancer/understanding/what-is-cancer
  5. https://www.webmd.com/drugs/2/drug-13451/gemcitabine-intravenous/details
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649805/
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