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compositionComposition:TEMSIROLIMUS-25MG/ML
prescription
Prescription Medicine
info
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Genxtor Injection is used to treat advanced renal cell carcinoma (a type of cancer that begins in the kidney). It contains Temsirolimus, which works by blocking the action of abnormal proteins needed for cancer cells to multiply. This helps slow the growth of tumours, thus helping treat kidney cancer. Sometimes, Genxtor Injection may cause side effects such as diarrhoea, nausea, vomiting, constipation, headache, fever, and decreased appetite.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TEMSIROLIMUS-25MG/ML

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Genxtor Injection

Genxtor Injection is a prescription injection primarily used to treat advanced stage kidney cancer. It works by targeting specific proteins in the body to help slow down the growth and spread of cancer cells.

This medicine is typically given as a weekly intravenous infusion by a healthcare provider in a clinic or hospital setting. Consistency in attending your scheduled infusion appointments is vital to ensure the medication works effectively. Maintaining a balanced diet and staying well-hydrated can also help your body cope better during the treatment period.

While receiving this treatment, you may experience some common side effects such as weakness, skin rash, or loss of appetite. However, it is crucial to consult your doctor immediately if you notice serious signs like severe breathing difficulties, sudden swelling, or signs of an infection.

Talk to your doctor before starting this medicine if you have a history of diabetes, liver damage, high cholesterol, or recent major surgery. Do not receive this injection if you have had a severe allergic reaction to this medication or any of its ingredients in the past.

Genxtor Injection can interact with other medicines, such as certain antibiotics or seizure medications, which may change how the drug works in your body. It is also important to avoid alcohol during treatment as it may worsen certain side effects. If you are pregnant, planning to breastfeed, or are an elderly patient, consult your healthcare provider to discuss the risks and benefits.

Uses of Genxtor Injection

Your doctor may prescribe Genxtor Injection to treat the following condition to help slow disease progression and improve treatment outcomes:

  • Advanced Kidney Cancer: Genxtor Injection helps by slowing down the growth of cancer cells and delaying the progression of advanced stage kidney cancer in adults.

Key Benefits

Using Genxtor Injection as prescribed helps slow the growth of advanced kidney cancer, delay disease progression, and support long-term treatment outcomes. Here are the key benefits you can expect:

  • Slows tumour growth: Helps block the pathways that cancer cells use to grow and spread, delaying the progression of advanced kidney cancer.
  • Relieves cancer-related discomfort: By helping control tumour growth, it may reduce pressure on surrounding organs, easing pain and improving overall comfort.
  • Provides ongoing medical support: As the medicine is administered by healthcare professionals, you receive regular monitoring during treatment, allowing any immediate concerns or side effects to be managed promptly.
Side effects of Genxtor Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Genxtor Injection will be administered by the doctor or nurse.
  • Do not self-administer.

How Genxtor Injection Works

Genxtor Injection contains temsirolimus, an mTOR inhibitor that works by blocking a protein called the mammalian target of rapamycin (mTOR). This protein plays a key role in regulating the growth, survival, and division of cancer cells, as well as the formation of new blood vessels that supply tumours. Genxtor Injection blocks the activity of the mTOR protein, preventing cancer cells from receiving the signals they need to grow and multiply. It also reduces the formation of new blood vessels that provide oxygen and nutrients to the tumour. By slowing tumour growth and limiting its blood supply, Genxtor Injection helps delay the progression of advanced kidney cancer.
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Genxtor Injection. Please consult the doctor.

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Pregnancy

Caution

Genxtor Injection may cause fetal harm when administered to pregnant women. Genxtor Injection should not be used during pregnancy unless clearly necessary. Consult the doctor if you are pregnant, planning for pregnancy, or thinking you may be pregnant.

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Breast Feeding

Unsafe

Avoid breastfeeding while using Genxtor Injection and for three weeks after the last dose.

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Driving

Safe

Genxtor Injection is unlikely to affect your ability to drive.

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Liver

Caution

Genxtor Injection is not recommended in patients with liver problems. Consult the doctor if you have/had liver problems.

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Kidney

Caution

Please consult the doctor if you have kidney impairment or any concerns regarding this. Your doctor may monitor kidney function while on treatment with this medicine.

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Children

Unsafe

Genxtor Injection is not recommended for children below 18 years as effectiveness has not been established.

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Heart

Caution

Take Genxtor Injection with caution, especially if you have a history of heart diseases/conditions. The dose may be adjusted by your doctor as required.

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Geriatrics

Caution

Genxtor Injection can be used in the elderly when prescribed by a doctor. If you have any concerns about using Genxtor Injection, please consult a doctor.

What if I have taken an overdose of Genxtor Injection

Because this medicine is given by healthcare professionals in a controlled clinic environment, an overdose is highly unlikely. However, if you suspect you have received too much or experience severe symptoms after an infusion, seek immediate medical attention.

Diet & Lifestyle Advise

  • Manage mouth sores: Rinse your mouth regularly with a gentle, alcohol-free mouthwash or a salt-and-baking-soda mixture to soothe and prevent irritation.
  • Monitor blood sugar levels: Since this medication can affect how your body processes sugar, try to limit sugary foods and drinks, and monitor your glucose levels closely if you have diabetes.
  • Eat small, frequent meals: If you experience a loss of appetite or nausea, consuming smaller portions throughout the day can help you maintain your strength and nutritional intake.
  • Avoid raw or undercooked foods: Because your immune system may be weakened during treatment, eat fully cooked meals and wash fresh produce thoroughly to reduce the risk of infections.
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Have a query?

How Soon It Starts Working

The time required for Genxtor Injection to start to work: The time required for Genxtor Injection to show its action is unknown. The time for which the effects of Genxtor Injection last: The duration of action for Genxtor Injection is unknown.

What if you forget to take Genxtor Injection

If you miss an appointment for your scheduled injection, contact your clinic or healthcare provider immediately to reschedule. Do not try to double the dose or catch up without professional medical guidance.

Storage

•Genxtor Injection is usually stored and handled by healthcare professionals at the clinic or hospital pharmacy. If temporary storage is required, keep the vials refrigerated between 2°C and 8°C (36°F and 46°F).

Drug Warnings

  • Inspect the solution before use: Ensure a trained healthcare professional checks the solution before administration. It should be clear to slightly cloudy and free from unusual particles.
  • Report infusion site reactions: Tell your healthcare provider immediately if you experience pain, burning, or swelling at the injection site during the infusion.
  • Avoid live vaccines: Do not receive live vaccines while being treated with Genxtor Injection, as your immune system may not be strong enough to respond safely.
  • Inform your healthcare providers: Tell your surgeon or dentist that you are receiving Genxtor Injection before any planned surgery or dental procedure, as this medicine may affect wound healing.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines: Medicines such as carbamazepine or phenytoin may reduce the effectiveness of Genxtor Injection.
  • Tuberculosis medicines: Medicines such as rifampicin may lower the level of Genxtor Injection in your body, making it less effective.
  • Antifungal medicines: Medicines such as ketoconazole may increase the level of Genxtor Injection in your body, raising the risk of side effects.
  • Macrolide antibiotics: Medicines such as clarithromycin may increase the level of Genxtor Injection in your body, which may increase the risk of side effects.
TemsirolimusAmphotericin b
Severe
TemsirolimusEtodolac
Severe

Drug-Drug Interactions

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TemsirolimusAmphotericin b
Severe
How does the drug interact with Genxtor Injection:
Coadministration of Amphotericin b and Genxtor Injection may increase the risk of kidney problem.

How to manage the interaction:
Although taking Amphotericin b and Genxtor Injection together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting the doctor.
TemsirolimusEtodolac
Severe
How does the drug interact with Genxtor Injection:
Taking Etodolac and Genxtor Injection can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Etodolac and Genxtor Injection, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
TemsirolimusVancomycin
Severe
How does the drug interact with Genxtor Injection:
Coadministration of Vancomycin with Genxtor Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Vancomycin with Genxtor Injection may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
TemsirolimusInfliximab
Severe
How does the drug interact with Genxtor Injection:
When Genxtor Injection is taken with Infliximab, it can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Infliximab and Genxtor Injection, you can take these medicines together if prescribed by your doctor. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TemsirolimusFondaparinux
Severe
How does the drug interact with Genxtor Injection:
Taking fondaparinux with Genxtor Injection can increase the risk of bleeding.

How to manage the interaction:
Taking Fondaparinux with Genxtor Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
TemsirolimusApixaban
Severe
How does the drug interact with Genxtor Injection:
Coadministration of Genxtor Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Genxtor Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
TemsirolimusGentamicin
Severe
How does the drug interact with Genxtor Injection:
Co-administration of Gentamicin and Genxtor Injection may increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Gentamicin with Genxtor Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like peeing more or less than usual, it's a good idea to let your doctor know right away. Some signs to watch out for include gaining weight quickly, feeling bloated, having trouble breathing, or feeling sick to your stomach. Other symptoms to be aware of are not feeling hungry, losing weight, swelling, muscle cramps, feeling weak or dizzy, feeling confused, or having an irregular heartbeat. Do not stop using any medications without a doctor's advice.
TemsirolimusPiroxicam
Severe
How does the drug interact with Genxtor Injection:
Taking Piroxicam with Genxtor Injection may increase the risk of kidney damage.

How to manage the interaction:
Taking Piroxicam with Genxtor Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without consulting a doctor.
TemsirolimusTofacitinib
Severe
How does the drug interact with Genxtor Injection:
Taking Tofacitinib with Genxtor Injection may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofacitinib and Genxtor Injection, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TemsirolimusFosphenytoin
Severe
How does the drug interact with Genxtor Injection:
When Genxtor Injection is taken with Fosphenytoin, it can cause Genxtor Injection to be broken down faster in the body. This can lead to low treatment outcomes

How to manage the interaction:
Although taking Fosphenytoin and Genxtor Injection together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any unusual symptoms or if your condition worsens, make sure to contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: Avoid consuming grapefruit or grapefruit juice during treatment, as they can interfere with how your body breaks down Genxtor Injection and increase the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Genxtor Injection is used to treat Renal cell cancer (Kidney cancer).
Genxtor Injection works by blocking tumour cell growth and division. Thereby, it helps treat kidney cancer.
Genxtor Injection may result in immunosuppression, leading to an increased risk of infections. Wash your hands frequently and avoid contact with sick people.
Fertility may be compromised during treatment with Genxtor Injection. Consult the doctor if you have any concerns.
Genxtor Injection is given as an intravenous infusion (an injection into a vein) by a healthcare professional in a clinic or hospital setting. Talk to your doctor if you have questions about your treatment plan.
You should avoid receiving live vaccines while undergoing this treatment, as it can weaken your immune system and increase the risk of infection. Always discuss any planned vaccinations with your doctor first.
While not the most common side effect, some patients may experience mild hair thinning or loss during treatment. If this concerns you, talk to your doctor or pharmacist for supportive care options.
Keep your mouth clean by rinsing with a mild salt-water solution and using a soft-bristled toothbrush. Avoid spicy, acidic, or extremely hot foods, and talk to your doctor if the sores become painful or prevent you from eating.
It is highly recommended to avoid or severely limit alcohol, as it can interact with the medication and increase the risk of liver damage or drowsiness. Talk to your doctor about what is safe for you.
This medicine can slow down your body's natural wound-healing process. If you have an upcoming surgery or dental procedure, talk to your doctor, as you may need to temporarily pause treatment.
Some patients may feel dizzy, tired, or receive pre-medications (like antihistamines) that cause drowsiness. It is best to have someone else drive you home after your appointment. Talk to your doctor about whether it is safe for you to drive.
No, this medication can cause harm to an unborn baby. You should use effective birth control during treatment and for a period after your last dose. If you suspect you are pregnant, talk to your doctor immediately.

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Country of origin

India
Other Info - GE97060
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