Gexofen 400 mg/325 mg Tablet
MRP ₹11.56
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Composition :
IBUPROFEN-400MG + PARACETAMOL-325MG
Manufacturer/Marketer :
Zydus Cadila
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Gexofen 400 mg/325 mg Tablet
Gexofen 400 mg/325 mg Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. Pain can be temporary (acute) or long-lasting (chronic).
Gexofen 400 mg/325 mg Tablet contains Ibuprofen and Paracetamol. This medicine works by blocking the effect of prostaglandin, which is responsible for inducing pain and inflammation in the body.
Like all medicines, Gexofen 400 mg/325 mg Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate, or any signs of hypersensitivity.
Inform your doctor if you are allergic to any of the components present in it. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug.
Uses of Gexofen 400 mg/325 mg Tablet
Gexofen 400 mg/325 mg Tablet is used for the treatment of Pain and Fever. The detailed uses of Gexofen 400 mg/325 mg Tablet are as follows:
- Pain Relief: Gexofen 400 mg/325 mg Tablet is widely used to alleviate mild to moderate pain, such as headaches, toothaches, menstrual cramps, and muscle aches.
- Fever Reduction: Combining Ibuprofen and Paracetamol, Gexofen 400 mg/325 mg Tablet effectively reduces fever caused by infections or other health conditions.
- Anti-inflammatory Benefits: Its anti-inflammatory properties make Gexofen 400 mg/325 mg Tablet valuable for managing inflammation and swelling in conditions like arthritis and other inflammatory diseases.
- Post-Surgical Pain Management: Gexofen 400 mg/325 mg Tablet is often prescribed to manage pain and discomfort following surgical procedures, aiding recovery.
- Managing Chronic Pain: Gexofen 400 mg/325 mg Tablet is sometimes included in chronic pain management plans, particularly for conditions like osteoarthritis or persistent back pain, under a healthcare professional's supervision.
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Directions for Use
- Gexofen 400 mg/325 mg Tablet should be taken with food.
- Follow your doctor's instructions on the dosage and timing of this medication.
- Swallow Gexofen 400 mg/325 mg Tablet as a whole with a glass of water.
- Do not crush, break, or chew it.
Medicinal Benefits
- Gexofen 400 mg/325 mg Tablet is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains.
- Gexofen 400 mg/325 mg Tablet comprises Ibuprofen and Paracetamol, primarily used to treat mild to moderate pain.
- Ibuprofen works by blocking the effect of a chemical known as prostaglandin, which is responsible for inducing pain and inflammation in the body.
- Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat.
- Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.
How Gexofen 400 mg/325 mg Tablet Works
Gexofen 400 mg/325 mg Tablet is composed of two medicines, namely Ibuprofen and Paracetamol. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together, these two medicines help reduce mild to moderate pain in a shorter duration.
Storage
• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Gexofen 400 mg/325 mg Tablet
- Drink water or other clear fluids.
- To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
- Include bland foods like rice, toast, crackers, and rice in your diet.
- Avoid lying down immediately after eating as it may cause indigestion or heartburn.
- Avoid acidic and spicy food as it may cause indigestion.
- Drink fluids: Water, clear broth, or electrolyte-rich beverages.
- Follow a balanced diet, which would be rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
- Mindfulness: Manage stress with meditation, deep breathing or yoga.
- Stay away from smoke, dust and other irritants.
- Get adequate rest to facilitate recovery.
- Wash hands and avoid close contact, do not share personal items.
Here are the precise steps to cope with diarrhoea caused by medication usage:
- Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
- Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
- Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
- Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
- Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
- Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
- Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
- High levels of liver enzymes need immediate medical attention.
- Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
- Regularly do strengthening exercises to control your cholesterol levels.
- Avoid drinking alcohol as it can affect your liver.
- Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
- Practice yoga and meditation to improve liver functioning and overall health.
What if I have taken an overdose of Gexofen 400 mg/325 mg Tablet
Do not take more than the prescribed dose of Gexofen 400 mg/325 mg Tablet as it may cause severe side effects. If you suspect you have taken overdose, please consult a doctor immediately.
Drug Warnings
- Caution is advised in people with underlying sensitivity to aspirin and other painkillers.
- Gexofen 400 mg/325 mg Tablet is contraindicated in children below 12 years of age, weighing under 40 kg.
- If treatment is required for more than three days, consult your doctor.
- Gexofen 400 mg/325 mg Tablet should be taken with caution if you have an allergy to paracetamol, ibuprofen, aspirin, or other pain killers, highly sensitive reactions (asthma, lip/face/throat swelling), existing stomach ulcer or bleeding associated pain killers, blood clotting disorder, heart diseases (like congestive heart failure), kidney disease, peptic ulcer, another active bleeding (like brain stroke bleeding), and severe dehydration (due to vomiting, diarrhea).
- Liver damage might occur if taken for a longer duration, as it contains paracetamol.
- The skin should be closely monitored as skin allergic reactions like Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported with Gexofen 400 mg/325 mg Tablet.
- Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Gexofen 400 mg/325 mg Tablet, especially in people affected with high blood pressure and who have a history of heart failure.
- Consult your doctor if your pain, inflammation, and fever symptoms do not disappear even after ten days.
Drug-Drug Interactions
Drug-Drug Interactions
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How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Taking Ketorolac and Gexofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.
How to manage the interaction:
Taking Ketorolac and Gexofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Taking Ketorolac and Gexofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.
How to manage the interaction:
Taking Ketorolac and Gexofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Combining Meloxicam and Gexofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
How to manage the interaction:
Taking Meloxicam and Gexofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Combining Meloxicam and Gexofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
How to manage the interaction:
Taking Meloxicam and Gexofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Coadministration of Tenofovir disoproxil and Gexofen 400 mg/325 mg Tablet can increase the risk of developing kidney problems.
How to manage the interaction:
Co-administration of Tenofovir disoproxil and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, irregular urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, weakness, and irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Coadministration of Tenofovir disoproxil and Gexofen 400 mg/325 mg Tablet can increase the risk of developing kidney problems.
How to manage the interaction:
Co-administration of Tenofovir disoproxil and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, irregular urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, weakness, and irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Coadministration of methotrexate with Gexofen 400 mg/325 mg Tablet can increase the effect and side effects of methotrexate.
How to manage the interaction:
Although there is a possible interaction between methotrexate and Gexofen 400 mg/325 mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
Coadministration of methotrexate with Gexofen 400 mg/325 mg Tablet can increase the effect and side effects of methotrexate.
How to manage the interaction:
Although there is a possible interaction between methotrexate and Gexofen 400 mg/325 mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Co-administration of Sirolimus and Gexofen 400 mg/325 mg Tablet together increases the risk or severity of kidney problems.
How to manage the interaction:
Co-administration of Sirolimus and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Co-administration of Sirolimus and Gexofen 400 mg/325 mg Tablet together increases the risk or severity of kidney problems.
How to manage the interaction:
Co-administration of Sirolimus and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
The combined use of Teriflunomide and Gexofen 400 mg/325 mg Tablet can increase the risk of liver problems.
How to manage the interaction:
Co-administration of Teriflunomide and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light- colored stools, and/or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Teriflunomide and Gexofen 400 mg/325 mg Tablet can increase the risk of liver problems.
How to manage the interaction:
Co-administration of Teriflunomide and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light- colored stools, and/or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenOmacetaxine mepesuccinate
Severe
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
The combined use of Omacetaxine mepesuccinate and Gexofen 400 mg/325 mg Tablet can increase the risk of bleeding.
How to manage the interaction:
Co-administration of Omacetaxine mepesuccinate and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Omacetaxine mepesuccinate and Gexofen 400 mg/325 mg Tablet can increase the risk of bleeding.
How to manage the interaction:
Co-administration of Omacetaxine mepesuccinate and Gexofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Taking Human immunoglobulin with Gexofen 400 mg/325 mg Tablet may raise the risk of kidney problems.
How to manage the interaction:
Co-administration of Human immunoglobulin with Gexofen 400 mg/325 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Taking Human immunoglobulin with Gexofen 400 mg/325 mg Tablet may raise the risk of kidney problems.
How to manage the interaction:
Co-administration of Human immunoglobulin with Gexofen 400 mg/325 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
Coadministration of Gexofen 400 mg/325 mg Tablet and Apixaban co-administration may raise the risk of bleeding.
How to manage the interaction:
Even though combining Gexofen 400 mg/325 mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
Coadministration of Gexofen 400 mg/325 mg Tablet and Apixaban co-administration may raise the risk of bleeding.
How to manage the interaction:
Even though combining Gexofen 400 mg/325 mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
IbuprofenAminolevulinic acid
Severe
How does the drug interact with Gexofen 400 mg/325 mg Tablet:
The combined use of Aminolevulinic acid and Gexofen 400 mg/325 mg Tablet can increase the risk of severe sunburn.
How to manage the interaction:
Using Aminolevulinic acid and Gexofen 400 mg/325 mg Tablet together can lead to an interaction, they can be taken together if advised by your doctor. After treatment, avoid exposing your eyes and skin to sunlight or bright interior lights for 48 hours. Do not stop using any medications without a doctor's advice.
The combined use of Aminolevulinic acid and Gexofen 400 mg/325 mg Tablet can increase the risk of severe sunburn.
How to manage the interaction:
Using Aminolevulinic acid and Gexofen 400 mg/325 mg Tablet together can lead to an interaction, they can be taken together if advised by your doctor. After treatment, avoid exposing your eyes and skin to sunlight or bright interior lights for 48 hours. Do not stop using any medications without a doctor's advice.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do low-impact aerobic exercises like walking on the treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
- In the chronic condition of arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Habit Forming
No
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Alcohol
Unsafe
Taking Gexofen 400 mg/325 mg Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Gexofen 400 mg/325 mg Tablet.
Pregnancy
Unsafe
Use of Gexofen 400 mg/325 mg Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.
Breast Feeding
Consult your doctor
Take Gexofen 400 mg/325 mg Tablet only if prescribed by your doctor.
Driving
Unsafe
After taking Gexofen 400 mg/325 mg Tablet you may notice dizziness, sleepiness, drowsiness or fatigue.
Liver
Caution
Gexofen 400 mg/325 mg Tablet to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.
Kidney
Caution
Gexofen 400 mg/325 mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.
Children
Caution
Gexofen 400 mg/325 mg Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.
Heart
Gexofen 400 mg/325 mg Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks
Geriatrics
Caution
Gexofen 400 mg/325 mg Tablet should be used under caution in geriatric patients as it can lead to serious side effects.
FAQs
Country of origin
India
Manufacturer/Marketer address
Zydus Tower, Satellite Cross Roads,Ahmedabad 380015 Gujarat, India.
Other Info - GE29665
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Reference
- https://www.medicines.org.uk/emc/files/pil.7020.pdf
- https://www.medicines.org.uk/emc/files/pil.1958.pdf
- https://www.ciplamed.com/content/ibugesic-plus-oral-suspension
- https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjdjZ6y3fXsAhVD6XMBHfAoDaYQFjAAegQIAxAC&url=https%3A%2F%2Fwww.sanofi.in%2F-%2Fmedia%2FProject%2FOne-Sanofi-Web%2FWebsites%2FAsia-Pacific%2FSanofi-IN%2FHome%2Fscience-and-innovation%2Ffor-healthcare-professionals%2Fproduct-information%2FCombiflam-tablets-PI_08072019.pdf&usg=AOvVaw0eY32ELNXM94knsmS25x-D
