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compositionComposition:GLIMEPIRIDE-1MG+METFORMIN-500MG
prescriptionPrescription Medicine
Glucoryl-M1 Tablet 15's
Glucoryl-M1 Tablet 15's

Glucoryl-M1 Tablet is used to treat type 2 diabetes. It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIMEPIRIDE-1MG+METFORMIN-500MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Glucoryl-M1 Tablet

Glucoryl-M1 Tablet belongs to a class of medicines called anti-diabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone.

Glucoryl-M1 Tablet contains Glimepiride and Metformin. Glimepiride helps the pancreas release more insulin, thereby lowering blood sugar levels. Metformin reduces the amount of sugar produced by the liver, slows down sugar absorption from food, and helps the body use insulin more effectively.

In some cases, Glucoryl-M1 Tablet may cause side effects like stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects of Glucoryl-M1 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Glucoryl-M1 Tablet if you are allergic to any of its components. Glucoryl-M1 Tablet is not recommended during pregnancy, breastfeeding and in children. Avoid alcohol consumption with Glucoryl-M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Uses of Glucoryl-M1 Tablet

Glucoryl-M1 Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of Glucoryl-M1 Tablet are as follows:

  • Management of Type 2 Diabetes: Glucoryl-M1 Tablet helps lower blood sugar levels in individuals diagnosed with type 2 diabetes.
  • Control of Blood Sugar Levels Post Meals: Glucoryl-M1 Tablet assists in lowering postprandial blood sugar spikes, which is beneficial for overall diabetes management.

Key Benefits

  • Glucoryl-M1 Tablet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients with type 2 diabetes.
  • It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.
  • Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood.
  • Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Additionally, it enhances the sensitivity of muscle cells to insulin, allowing these cells to remove sugar more effectively from the bloodstream.

Directions for Use

  • Glucoryl-M1 Tablet can be taken with meals or as prescribed by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Glucoryl-M1 Tablet as a whole with a glass of water.
  • Do not chew, crush or break it.

How Glucoryl-M1 Tablet Works

Glucoryl-M1 Tablet is a combination of two antidiabetic drugs, namely: Glimepiride and Metformin. Glimepiride works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin, which enables these cells to remove sugar more effectively from the blood.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Glucoryl-M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Unsafe

Glucoryl-M1 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Glucoryl-M1 Tablet as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Glucoryl-M1 Tablet if you are breastfeeding.

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Driving

Caution

Glucoryl-M1 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Glucoryl-M1 Tablet .

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Liver

Caution

Take Glucoryl-M1 Tablet with caution, especially if you have a history of liver diseases. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Glucoryl-M1 Tablet with caution, especially if you have a history of kidney diseases. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Glucoryl-M1 Tablet is not recommended for children as the safety and effectiveness were not established.

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Heart

Caution

Glucoryl-M1 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Glucoryl-M1 Tablet .

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Geriatrics

Caution

Glucoryl-M1 Tablet should be given with caution in elderly patients due to an increased risk of side effects. If you have any concerns about the usage of Glucoryl-M1 Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Glucoryl-M1 Tablet

Take Glucoryl-M1 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include hypoglycaemia (low blood sugar) and lactic acidosis (buildup of lactic acid in the blood). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain a healthy body weight, as obesity is also related to the onset of diabetes.
  • Maintain a low-fat and low-sugar diet. Replace carbohydrate-containing foods with whole grains, fruits, and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid the consumption of alcohol and quit smoking.

Health Queries

As a type 2 diabetic on Lipisulin M-30-70 and Glucoryl M1, how can I stop insulin if my sugar level is between 130 to 170?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

You should not stop insulin on your own, even if your sugars are between 130 and 170, as sudden withdrawal can cause poor control. Consult your doctor to review readings, optimise diet and activity, and gradually reduce or adjust insulin safely if appropriate.

Have a query?

How Soon It Starts Working

The time required for Glucoryl-M1 Tablet to start to work: Glucoryl-M1 Tablet ideally shows its action within few hours after administration. 

The time for which the effects of Glucoryl-M1 Tablet last: The duration of action for Glucoryl-M1 Tablet is clinically unknown.

What if you forget to take Glucoryl-M1 Tablet

If you miss a dose of Glucoryl-M1 Tablet , take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Glucoryl-M1 Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not take Glucoryl-M1 Tablet if you are allergic to any of its components, if you have type 1 diabetes mellitus, diabetic ketoacidosis or diabetic coma.
  • Inform the doctor if you have liver or kidney problems, low blood sugar, or circulation problems.
  • Glucoryl-M1 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning to become pregnant. This medicine may pass into breast milk; therefore, it should be avoided in nursing mothers.
  • Glucoryl-M1 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking Glucoryl-M1 Tablet .
  • Avoid alcohol consumption with Glucoryl-M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Glucoryl-M1 Tablet may interact with certain medicines, potentially increasing side effects. Inform your doctor if you are taking any of the following:

  • Antibiotics (rifampicin, trimethoprim)
  • Calcium channel blockers (verapamil)
  • Antacids (cimetidine)
  • HIV/AIDS drugs (dolutegravir)
  • Heart-related medicine (ranolazine)
  • Anticancer drugs (vandetanib, crizotinib, olaparib)
  • Antifungals (fluconazole, miconazole)
  • Water pill (acetazolamide)
  • Antidiabetic drug (insulin)
  • Anticonvulsants (phenytoin)

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have severe infections, uncontrolled diabetes, lactic acidosis or ketoacidosis (accumulation of ketone bodies in the blood), dehydration, or liver or kidney problems, inform your doctor before taking Glucoryl-M1 Tablet .

Glimepiride + MetforminIopromide
Critical
Glimepiride + MetforminGatifloxacin
Critical

Drug-Drug Interactions

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Glimepiride + MetforminIopromide
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminGatifloxacin
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Taking Glimepiride with Gatifloxacin may cause both low blood glucose and high blood glucose have been reported.

How to manage the interaction:
Gatifloxacin is not recommended for patients with diabetes, however, it can be taken if advised by a doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Glimepiride + MetforminIodamide
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminIopamidol
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminMetrizamide
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Glimepiride + MetforminIomeprol
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminIodixanol
Critical
How does the drug interact with Glucoryl-M1 Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glimepiride + MetforminNalidixic acid
Severe
How does the drug interact with Glucoryl-M1 Tablet:
When Glimepiride is taken with Nalidixic acid, can cause both hyperglycemia (high blood glucose) and hypoglycemia (low blood glucose).

How to manage the interaction:
There may be a possibility of interaction between Glimepiride and Nalidixic acid, but it can be taken if prescribed by a doctor. Contact a doctor headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not discontinue any medications without consulting a doctor.
Glimepiride + MetforminTrovafloxacin
Severe
How does the drug interact with Glucoryl-M1 Tablet:
When Glimepiride is taken with Trovafloxacin, it can affect blood glucose levels either hypoglycemia or hyperglycemia.

How to manage the interaction:
Taking Glimepiride with Trovafloxacin together can result in an interaction, but it can be taken if a doctor has advised it. Contact a doctor if you experience headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not stop using any medications without a doctor's advice.
Glimepiride + MetforminTopiramate
Severe
How does the drug interact with Glucoryl-M1 Tablet:
The combined use of Metformin and Topiramate may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Coadministration Metformin and Topiramate can lead to an interaction, it can be taken if prescribed by a doctor. However, if you experience symptoms such as weakness, muscle pain, respiratory distress, fatigue, loss of appetite, slow or irregular heartbeat, breathing difficulty, or chills consult the doctor immediately. Do not stop using any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Therapeutic Class

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FAQs

Glucoryl-M1 Tablet is indicated in the treatment of type 2 diabetes mellitus.

Glucoryl-M1 Tablet works by decreasing the amount of glucose absorbed from the food and the amount of glucose made by the liver. It helps the pancreas to produce insulin and helps the body use insulin efficiently.

Glucoryl-M1 Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or miss snacks or meals. However, if you experience any signs of low blood pressure, such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completely. In type 2 diabetes, though islet cells are working, the body doesn't respond to insulin as the body becomes resistant to it.

You are not recommended to stop taking Glucoryl-M1 Tablet on your own as discontinuing Glucoryl-M1 Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Glucoryl-M1 Tablet , please consult your doctor so that alternative medicine may be prescribed.

You are not recommended to take Glucoryl-M1 Tablet with phenytoin as it may reduce the effect of Glucoryl-M1 Tablet and increase blood sugar levels. However, please consult a doctor before using Glucoryl-M1 Tablet with other medicines.

Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.

Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.

You are advised to take Glucoryl-M1 Tablet for the duration recommended by the doctor.

Store Glucoryl-M1 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.

Glucoryl-M1 Tablet may cause lactic acidosis (builds up of lactic acid in the blood). Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.

Glucoryl-M1 Tablet is an anti-diabetic medicine used to treat type 2 diabetes mellitus, also known as noninsulin-dependent diabetes mellitus.

Side effects of Glucoryl-M1 Tablet are stomach pain, nausea, diarrhoea, vomiting, headache or metallic taste. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Long-term use of Glucoryl-M1 Tablet may lead to vitamin B12 deficiency. Regular monitoring of vitamin B12 levels is recommended.

You are recommended to avoid consumption of alcohol with Glucoryl-M1 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

Glucoryl-M1 Tablet should be swallowed as a whole with water; do not crush, break or chew it.

Regularly monitor blood glucose levels. Have your meals regularly and never miss a meal. Always carry a source of sugar and consume it if you experience low blood sugar. If you are due to undergo any tests or surgery, inform the doctor that you are taking Glucoryl-M1 Tablet . Avoid drinking alcohol.

Other medicines should be taken with Glucoryl-M1 Tablet only if prescribed by the doctor. To prevent any interactions it is advised to consult the doctor before taking other medicines during treatment with Glucoryl-M1 Tablet .

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Author Details

Veda MaddalaDoctor badge

Written By

  • Veda Maddala

    M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

Doctor imageWe provide you with authentic, trustworthy and relevant information

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - GLU0078
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