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compositionComposition:GLIPIZIDE-5MG
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Glynase XL-5 Tablet is used to treat type-2 diabetes mellitus when diet and exercise alone cannot control their blood sugar levels. It contains Glipizide, which works by increasing insulin production by stimulating insulin secretion from the beta cells of the pancreas, thereby reducing high blood glucose (sugar) levels. In some cases, you may experience certain common side effects such as hypoglycemia (low blood glucose levels), nausea, diarrhoea, and stomach pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIPIZIDE-5MG

Manufacturer/Marketer :

USV Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Glynase XL-5 Tablet

Glynase XL-5 Tablet is a prescription medication used to control high blood sugar in adults with type 2 diabetes. Its primary medical purpose is to help your body manage glucose levels, reducing the risk of serious health complications associated with diabetes. This medication is prescribed when diet and exercise alone are not enough to control your blood sugar.

For this medicine to work effectively, you must take it consistently and exactly as prescribed, typically once or twice a day. You should always take it 30 minutes before your first main meal of the day to ensure it is properly absorbed and to prevent sudden drops in blood sugar. Incorporating balanced meals, regular physical activity, and weight management will significantly improve your clinical results.

While taking Glynase XL-5 Tablet , some people may experience mild side effects like minor stomach upset, headaches, or temporary dizziness. However, if you experience severe symptoms such as extreme weakness, persistent sweating, confusion, or signs of liver damage like yellow skin or eyes, you must consult your doctor immediately.

Do not take this if you have type 1 diabetes or diabetic ketoacidosis. Before starting Glynase XL-5 Tablet , talk to your doctor if you have a history of liver damage, kidney issues, or a specific enzyme deficiency known as G6PD deficiency. Discussing these pre-existing conditions helps your healthcare provider ensure the medicine is safe for you.

Certain substances can affect how this medicine works in your body. Drinking alcohol while taking Glynase XL-5 Tablet can cause highly unpredictable blood sugar drops, and smoking may reduce the drug's overall effectiveness. Smoking can worsen insulin resistance and make blood sugar management more difficult. Quitting smoking may help improve overall diabetes control and reduce the risk of diabetes-related complications. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss safer alternatives or personalised precautions.

Uses of Glynase XL-5 Tablet

Glynase XL-5 Tablet is an oral antidiabetic medication used to help control blood sugar levels in people with type 2 diabetes. It works by stimulating the pancreas to release more insulin, particularly after meals.

  • Type 2 Diabetes Mellitus: Glynase XL-5 Tablet is used to improve blood sugar control in adults with type 2 diabetes by assisting the pancreas in releasing insulin when glucose levels rise.
  • Combination Therapy: Glynase XL-5 Tablet is sometimes prescribed together with other diabetes medications, such as metformin, when a single medicine does not provide adequate blood sugar control. Your doctor may adjust your treatment regimen over time based on your blood sugar readings, HbA1c results, and overall health needs. 
     

Key Benefits

By helping to maintain healthy blood sugar levels, Glynase XL-5 Tablet plays an important role in both the short-term management and long-term control of type 2 diabetes.

  • Improved blood sugar control: Glynase XL-5 Tablet helps lower elevated blood glucose levels, making it easier to manage diabetes effectively.
  • Relief from diabetes symptoms: It helps reduce common symptoms of high blood sugar, such as excessive thirst, frequent urination, fatigue, and increased hunger.
  • Supports long-term health: Maintaining stable blood sugar levels can help lower the risk of diabetes-related complications affecting the nerves, kidneys, eyes, and cardiovascular system.
  • Convenient oral treatment: As a tablet taken by mouth, Glynase XL-5 Tablet offers a simple and effective option for managing type 2 diabetes as part of a comprehensive treatment plan.
  • Supports Long-Term Diabetes Monitoring: Glynase XL-5 Tablet helps improve long-term blood sugar control, which can be assessed through periodic HbA1c testing. HbA1c reflects your average blood sugar levels over the previous two to three months and helps your healthcare provider evaluate the effectiveness of your treatment plan. 
     

Directions for Use

To get the maximum benefit from Glynase XL-5 Tablet , it is important to take it correctly and consistently as directed by your healthcare provider. 

  • Take this medicine by mouth, usually 30 minutes before your breakfast or your first main meal of the day.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can release the medication too quickly into your system.
  • Always take Glynase XL-5 Tablet exactly as prescribed by your doctor. Do not change your dose or stop taking it without consulting your healthcare provider first.

Important Formulation Note: Glynase XL-5 Tablet is available in immediate-release and extended-release formulations. Immediate-release tablets are typically taken about 30 minutes before a meal. Extended-release tablets are generally taken with breakfast or the first main meal of the day. Always follow the specific instructions provided for your prescribed formulation.

Tablet Handling: Extended-release tablets should be swallowed whole and should not be crushed, chewed, or broken. Some immediate-release formulations may have different administration instructions. If you are unsure which formulation you have, consult your pharmacist or healthcare provider.
 

How Glynase XL-5 Tablet Works

Glynase XL-5 Tablet works by stimulating the beta cells in your pancreas to release more insulin, which is the hormone responsible for moving sugar from your bloodstream into your cells. The active mechanism relies on Glynase XL-5 Tablet , which belongs to a class of medicines known as sulfonylureas. By increasing insulin production in response to meals, it effectively prevents post-meal blood sugar spikes and maintains overall glucose balance throughout the day.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Glynase XL-5 Tablet to prevent unpleasant side-effects.

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Pregnancy

Unsafe

Do not take Glynase XL-5 Tablet if you are pregnant. Your doctor may switch you to insulin injections during your pregnancy. It is not recommended to take Glynase XL-5 Tablet during the last month of pregnancy.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding. Your doctor will decide if Glynase XL-5 Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Glynase XL-5 Tablet may cause dizziness and drowsiness, drive, and operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Glynase XL-5 Tablet should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Glynase XL-5 Tablet should be used with caution in patients with kidney impairment/kidney disease.Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Glynase XL-5 Tablet is not recommended for children as safety and efficacy have not been established.

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Heart

Consult your doctor

Please consult your doctor before using Glynase XL-5 Tablet if you have pre-existing heart problems. Your doctor will prescribe Glynase XL-5 Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Glynase XL-5 Tablet to geriatric patients. Your doctor will prescribe Glynase XL-5 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Glynase XL-5 Tablet

Do not take more than the prescribed dose of Glynase XL-5 Tablet as it may cause overdose and lead to life-threatening hypoglycemia (low blood sugar). The symptoms of severe low blood sugar include blurred vision, sweating, tremors, extreme weakness, stomach pain, trouble speaking, seizures (fits), or confusion. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Eat consistent meals: Do not skip meals while taking Glynase XL-5 Tablet , as skipping meals significantly increases your risk of developing low blood sugar.
  • Carry fast-acting sugar: Always keep a source of fast-acting glucose with you, such as fruit juice, hard candy, or glucose tablets, to treat sudden mild drops in blood sugar.
  • Monitor blood glucose regularly: Keep track of your daily blood sugar levels as directed by your doctor to ensure your medication is working correctly.
  • Stay active safely: Engage in regular physical activity, but monitor your blood sugar before and after exercise, as physical exertion can lower your glucose levels.
     

Have a query?

How Soon It Starts Working

The time required for Glynase XL-5 Tablet to start to work: Glynase XL-5 Tablet ideally shows its action within 30 minutes after administration. The time for which the effects of Glynase XL-5 Tablet last: The effect of Glynase XL-5 Tablet lasts for 12 to 24 hours.

What if you forget to take Glynase XL-5 Tablet

If you miss a dose of Glynase XL-5 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

Store Glynase XL-5 Tablet tablets at room temperature, ideally between 20°C and 25°C. •Keep the medication in a dry place away from direct light and moisture.

Drug Warnings

  • Always check your tablet before taking it; do not use it if the packaging is damaged or if the tablets appear discolored.
  • Wear a medical alert bracelet or carry an identification card stating that you have diabetes and are taking Glynase XL-5 Tablet .
  • Limit or avoid alcohol intake completely, as alcohol alters blood sugar levels and can trigger severe, dangerous reactions when combined with this medication.
  • Be prepared for changes in blood sugar control during periods of physical stress, such as a high fever, severe infection, injury, or surgery; contact your doctor immediately in these situations.
  • Inform your healthcare provider if you have a history of allergy to sulfonamide ('sulfa') medicines or have experienced allergic reactions to similar medications. Although cross-reactivity is uncommon, additional caution may be appropriate.
  • Contact your doctor if your blood sugar levels remain consistently elevated despite taking Glynase XL-5 Tablet as prescribed. Your treatment plan, dosage, diet, exercise routine, or medication combination may need adjustment.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Glynase XL-5 Tablet may interact with other medications, which can affect blood sugar control or increase the risk of side effects. Inform your doctor about all prescription medicines, over-the-counter products, and supplements you are taking.

  • Beta-blockers: May mask the warning signs of low blood sugar, such as a rapid heart rate or palpitations.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) and certain antibiotics (like sulfonamides): May increase the risk of low blood sugar when combined with Glynase XL-5 Tablet .
  • Corticosteroids and diuretics (water pills): May decrease the effectiveness of Glynase XL-5 Tablet , causing your blood sugar levels to rise.

Drug-Food Interactions

Certain foods and beverages can affect how Glynase XL-5 Tablet works or increase the likelihood of side effects during treatment.

  • Alcohol: Can significantly increase the risk of severe low blood sugar and cause a flushing reaction, headache, or nausea.

Drug-Disease Interactions

Some medical conditions may influence the safety and effectiveness of Glynase XL-5 Tablet and may require closer monitoring by your healthcare provider.

  • Kidney or liver damage: May slow down how your body processes and clears Glynase XL-5 Tablet , greatly increasing the risk of prolonged, severe low blood sugar.
  • G6PD deficiency: May increase the risk of red blood cell destruction (hemolytic anaemia).
  • Persistent Hyperglycaemia: If your blood sugar remains consistently above your target range despite proper use of Glynase XL-5 Tablet , your healthcare provider may need to reassess your treatment plan, evaluate medication adherence, or consider additional therapies.
     

Drug-Drug Interactions

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How does the drug interact with Glynase XL-5 Tablet:
Co-administration of Glynase XL-5 Tablet with Gatifloxacin may affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Glynase XL-5 Tablet can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glynase XL-5 Tablet:
Taking Moxifloxacin with Glynase XL-5 Tablet may affect blood glucose levels. Both high blood sugar levels or and low blood glucose.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Moxifloxacin if prescribed by the doctor. Consult the doctor if you experience dizziness, headache, rapid heartbeat, increased urination, increased thirst. Do not discontinue the medications without consulting a doctor.
GlipizideGrepafloxacin
Severe
How does the drug interact with Glynase XL-5 Tablet:
Taking Grepafloxacin with Glynase XL-5 Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Grepafloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlipizideEnoxacin
Severe
How does the drug interact with Glynase XL-5 Tablet:
Taking Enoxacin with Glynase XL-5 Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Enoxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glynase XL-5 Tablet:
Taking Ciprofloxacin with Glynase XL-5 Tablet may affect both high blood sugar levels or/and, less frequently, low blood glucose.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Ciprofloxacin if prescribed by the doctor. However, consult the doctor if you experience symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, excessive sweating, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not discontinue the medications without consulting a doctor.
GlipizideCinoxacin
Severe
How does the drug interact with Glynase XL-5 Tablet:
Taking Cinoxacin with Glynase XL-5 Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Cinoxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glynase XL-5 Tablet:
Co-administration of Norfloxacin with Glynase XL-5 Tablet may occasionally affect blood glucose levels. Both Hyperglycemia (high blood sugar levels) and Hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Norfloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Glynase XL-5 Tablet:
Taking Voriconazole may increase the blood levels and effects of Glynase XL-5 Tablet leading to hypoglycemia (low blood sugar levels).

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Voriconazole if prescribed by the doctor. Consult a prescriber if you experience dizziness, headache, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glynase XL-5 Tablet:
Taking Levofloxacin with Glynase XL-5 Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glynase XL-5 Tablet can be taken with Levofloxacin if prescribed by the doctor. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glynase XL-5 Tablet:
Co-administration of Ofloxacin and Glynase XL-5 Tablet can sometimes have an effect on blood glucose levels.

How to manage the interaction:
Although combining Ofloxacin and Glynase XL-5 Tablet can lead to an interaction, they can be taken on a doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), consult a doctor. Keep an eye on your blood glucose levels. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Glynase XL-5 Tablet is used to treat type-2 diabetes mellitus when diet and exercise alone cannot control the blood sugar levels.

Glynase XL-5 Tablet works by increasing insulin production by stimulating insulin secretion from the beta cells of the pancreas, thereby reduces high blood glucose (sugar) levels.

Glynase XL-5 Tablet may sometimes lower the blood glucose levels more than normal, leading to hypoglycemia. Regularly monitor your blood sugar levels while taking Glynase XL-5 Tablet . Hypoglycemia symptoms include headache, dizziness, drowsiness, shakiness, faintness, confusion, and visual disturbances.

Hypoglycaemia may occur following prolonged or severe exercise, during illness, alcohol consumption, low food intake, or when Glynase XL-5 Tablet is taken along with other antidiabetic medicines.

Maintain a healthy diet by regular intake of carbohydrates such as bread and products containing starch and sugar. Eat your meals regularly, and do not exercise heavily for a longer duration with an empty stomach. Try to keep sugar candies and when you feel symptoms of low blood sugar like excessive hunger, sweating, feeling tired, dizziness, feeling hungry, feeling shaky, and fast heartbeat, immediately take it. This will increase the level of glucose (sugar) in your blood and you will feel normal.

Please do not stop taking Glynase XL-5 Tablet without consulting your doctor as it may cause an increase in blood glucose levels. Continue taking Glynase XL-5 Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Glynase XL-5 Tablet .

If you are going to have a major operation or have recently had a serious infection or illness; in such cases, diabetic control may be lost. Consult your doctor if you have any concerns regarding this; your doctor may ask you to temporarily take insulin instead of Glynase XL-5 Tablet to control blood glucose levels.

Glynase XL-5 Tablet might sometimes affect laboratory test results. Inform the person performing the tests that you are taking Glynase XL-5 Tablet .

Do not use Glynase XL-5 Tablet if you have a condition called diabetic ketoacidosis (too much acids in the blood) and ever have had an allergic reaction to glipizide.

No, Glynase XL-5 Tablet is not the same as metformin. Glynase XL-5 Tablet contains glipizide, a sulfonylurea, whereas metformin is a biguanide.

Glynase XL-5 Tablet may not be bad for the kidneys. However, it should be used with caution in patients with kidney impairment/kidney disease and only if advised by the doctor.

No, Glynase XL-5 Tablet is not known to cause sleepiness. However, it may cause dizziness and drowsiness. Do not drive or operate machinery if you experience these symptoms.

Glynase XL-5 Tablet can be taken with insulin if prescribed by the doctor. The doctor will adjust the dose of Glynase XL-5 Tablet or insulin based on your condition.

No, Glynase XL-5 Tablet is not a thiazolidinedione. It contains glipizide, a sulfonylurea.

Taking more than the recommended dose of Glynase XL-5 Tablet may cause hypoglycemia (low blood sugar). The symptoms of severe low blood sugar include blurred vision, sweating, tremors, extreme weakness, stomach pain, trouble speaking, seizures (fits), or confusion. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Glynase XL-5 Tablet may cause side effects such as hypoglycemia (low blood glucose levels), nausea, diarrhoea, and stomach pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are recommended to consult your doctor if you experience these side effects persistently.

No, you should not take Glynase XL-5 Tablet on an empty stomach. It must be taken 30 minutes before your first main meal of the day to ensure it works correctly and to prevent your blood sugar from dropping too low. Talk to your doctor if you struggle with meal timing.

If you experience shakiness, sweating, or dizziness, eat or drink a fast-acting sugar source immediately, such as a half-cup of fruit juice or 3 to 4 hard candies. If your symptoms do not improve or if they worsen, seek emergency medical care. Talk to your doctor to adjust your therapy.

You should avoid drinking alcohol while taking Glynase XL-5 Tablet . Alcohol can interfere with blood sugar control, increase the risk of severe hypoglycemia, and cause unpleasant reactions like flushing, nausea, and headaches. Talk to your doctor about your alcohol consumption habits.

Immediate-release Glynase XL-5 Tablet typically begins lowering blood sugar within 30 minutes to 1 hour after administration, with peak effects occurring within a few hours. Extended-release formulations release the medication gradually throughout the day and are designed to provide more sustained blood sugar control. Consistent daily use is important for achieving optimal results. Talk to your doctor if your blood sugar remains uncontrolled despite treatment.

Yes, some patients may experience mild weight gain when starting Glynase XL-5 Tablet because the body begins processing blood sugar more efficiently. This can be managed through a balanced diet and regular physical exercise. Talk to your doctor or a dietitian for personalised guidance.

It is generally not recommended to take Glynase XL-5 Tablet during pregnancy or breastfeeding, as alternative treatments are typically preferred to manage blood sugar safely during these times. Talk to your doctor to find the safest treatment option for you and your baby.

The best time to take Glynase XL-5 Tablet is 30 minutes before your breakfast or your first large meal of the day. Consistent daily timing helps maintain optimal blood sugar levels throughout the day. Talk to your doctor or pharmacist if you need help scheduling your doses.

Taking pain relievers like ibuprofen (NSAIDs) with Glynase XL-5 Tablet can occasionally increase the risk of low blood sugar. Always check with your healthcare provider before combining over-the-counter pain relievers with your diabetes medication. Talk to your doctor for safe alternatives.

Your doctor will usually monitor your treatment using periodic HbA1c tests, which measure your average blood sugar levels over the previous two to three months. Regular HbA1c testing, along with home blood glucose monitoring, helps determine whether your diabetes treatment plan is working effectively.

If your blood sugar levels remain consistently above your target range despite taking Glynase XL-5 Tablet as prescribed, contact your doctor. Do not increase your dose on your own. Your healthcare provider may review your diet, exercise habits, medication schedule, HbA1c results, and overall treatment plan, and may recommend dose adjustments or additional diabetes medications.

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Country of origin

India

Manufacturer/Marketer address

Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai - 400 088. , India.
Other Info - GLY0039
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