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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

GP-0.5 Tablet is used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM). It contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. It may cause side effects such as allergic reaction (skin rash, hives, sensitivity to sun rays), liver dysfunction (jaundice, bile duct blockage, and hepatitis), seizures, or low glucose levels. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

GLIMEPIRIDE-0.5MG

Manufacturer/Marketer :

USV Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About GP-0.5 Tablet

GP-0.5 Tablet is used to lower raised blood sugar levels in Type 2 diabetes mellitus. Type 2 diabetes develops if the body does not produce enough insulin or when the body's insulin does not work as well as it should.

GP-0.5 Tablet contains glimepiride, which helps the pancreas release more insulin, thereby lowering blood sugar levels. Therefore, it prevents symptoms of type 2 diabetes.

Some people may experience an allergic reaction (skin rash, hives & sensitivity to sun rays), low glucose levels, nausea, headache, and shock. Most of these side effects of GP-0.5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to GP-0.5 Tablet . GP-0.5 Tablet should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. GP-0.5 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or plan to get pregnant or breastfeed.

Uses of GP-0.5 Tablet

GP-0.5 Tablet is used in the treatment of type 2 diabetes mellitus. The detailed uses of GP-0.5 Tablet are as follows:

  • Management of Type 2 Diabetes: GP-0.5 Tablet helps lower blood sugar levels in individuals diagnosed with type 2 diabetes.
  • Improvement of Insulin Sensitivity: GP-0.5 Tablet enhances the action of insulin, making the body's tissues more responsive to it.
  • Reduction of Cardiovascular Risks: Regular use of GP-0.5 Tablet can help reduce the risk of cardiovascular diseases in diabetic patients.
  • Control of Blood Sugar Levels Post Meals: GP-0.5 Tablet assists in lowering postprandial blood sugar spikes, which is beneficial for overall diabetes management.

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Directions for Use

  • GP-0.5 Tablet should be taken with food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow GP-0.5 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • GP-0.5 Tablet is indicated as an adjunct to diet and exercise to improve glycaemic control in patients with type 2 diabetes.
  • It helps manage blood glucose levels in patients with diabetes and prevents diabetes-related complications like kidney damage, eye problems, and nerve issues.
  • Glimepiride stimulates cells in the pancreas that produce insulin, which helps remove sugar from the blood.

How GP-0.5 Tablet Works

The GP-0.5 Tablet contains Glimepiride, which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells, allowing insulin to exit the cell. This insulin then makes each cell in the body take up glucose and utilise it, thus lowering the blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of GP-0.5 Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of GP-0.5 Tablet

Do not take more than the prescribed dose of GP-0.5 Tablet as it may cause an overdose, leading to low blood sugar. Early signs of low blood sugar include sweating, feeling hungry, trembling or shaking, feeling confused, or having problems concentrating. If you suspect you have low blood sugar, eat or drink something that quickly increases blood sugar levels, such as fruit juice or sugar cubes. However, if your condition does not improve, please consult a doctor immediately.

Drug Warnings

  • Do not take GP-0.5 Tablet if you are allergic to any of its components, if you have type 1 diabetes mellitus, diabetic ketoacidosis or diabetic coma.
  • Inform the doctor if you have liver or kidney problems, low blood sugar, or circulation problems.
  • GP-0.5 Tablet is not recommended for pregnant women as it may harm the unborn baby. Please consult a doctor if you are pregnant or planning to become pregnant. This medicine may pass into breast milk; therefore, it should be avoided in nursing mothers.
  • GP-0.5 Tablet may decrease alertness in some people. Therefore, drive only if you are alert after taking GP-0.5 Tablet .
  • Avoid alcohol consumption with GP-0.5 Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
  • Beware of symptoms of hypoglycemia (low blood sugar), which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume candies, glucose biscuits, or honey/sugar. Make sure to carry these with you at all times, especially during long travels

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with GP-0.5 Tablet:
Concomitant use of bisoprolol with GP-0.5 Tablet may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar). It may also mask some of the symptoms of hypoglycemia such as palpitation, tremor, and rapid heartbeat, making it more difficult to recognize an oncoming episode.

How to manage the interaction:
Although there may be an interaction, bisoprolol can be taken with GP-0.5 Tablet if prescribed by the doctor. Consult the prescriber if you develop symptoms of low blood sugar like shakiness, dizziness, sweating, nausea, hunger, weakness, or lightheadedness.
How does the drug interact with GP-0.5 Tablet:
Co-administration of Furosemide may interfere with blood glucose control and lower the effectiveness of GP-0.5 Tablet.

How to manage the interaction:
Although there is a possible interaction, GP-0.5 Tablet can be taken with furosemide if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP-0.5 Tablet:
Taking GP-0.5 Tablet with Vilazodone may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, GP-0.5 Tablet can be taken with Vilazodone if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP-0.5 Tablet:
Co-administration of GP-0.5 Tablet with Levofloxacin can affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Co-administration of Levofloxacin with GP-0.5 Tablet can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP-0.5 Tablet:
Taking Clarithromycin with GP-0.5 Tablet may increase the effects of GP-0.5 Tablet on lowering blood sugar.

How to manage the interaction:
Although there is a possible interaction, Clarithromycin can be taken with GP-0.5 Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, hunger, weakness, dizziness, drowsiness, nervousness, sweating, confusion, and tremor. Do not discontinue the medications without consulting a doctor.
How does the drug interact with GP-0.5 Tablet:
Co-administration of GP-0.5 Tablet with Isoniazid may interfere with blood glucose control and reduce the effectiveness of GP-0.5 Tablet.

How to manage the interaction:
Although there is a possible interaction, GP-0.5 Tablet can be taken with Isoniazid if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideDiethylstilbestrol
Severe
How does the drug interact with GP-0.5 Tablet:
Co-administration of Diethylstilbestrol may interfere with blood glucose control and reduce the effectiveness of GP-0.5 Tablet.

How to manage the interaction:
Although there is a possible interaction between GP-0.5 Tablet and Diethylstilbestrol, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much urine you're producing. If you notice any of these signs - very high or very low blood sugar levels - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with GP-0.5 Tablet:
Taking Ketoprofen with GP-0.5 Tablet may increase the risk of hypoglycemia (low blood sugar).

How to manage the interaction:
Although there is a possible interaction, GP-0.5 Tablet can be taken with Ketoprofen if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not taking the medications without consulting a doctor.
GlimepirideAminolevulinic acid
Severe
How does the drug interact with GP-0.5 Tablet:
Aminolevulinic acid sensitizes your skin to bright lights and combining it with other medications that can also have this effect (i.e., photosensitivity) such as GP-0.5 Tablet may increase the risk of a severe sunburn.

How to manage the interaction:
Taking GP-0.5 Tablet with Aminolevulinic acid together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a really bad sunburn, it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with GP-0.5 Tablet:
Taking GP-0.5 Tablet with sunitinib may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, GP-0.5 Tablet can be taken with sunitinib if prescribed by the doctor. Consult the prescriber if you experience symptoms if low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain healthy body weight as obesity is also related to the onset of diabetes.
  • Maintain a low fat and a low sugar diet. Replace carbohydrates-containing foods with whole grains, fruits and vegetables, as carbohydrates turn to sugars, leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

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Alcohol

Caution

Not recommended to take GP-0.5 Tablet with alcohol. Alcohol intake may increase or decrease the blood sugar lowering action of GP-0.5 Tablet in an unpredictable way resulting in a harmful event.

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Pregnancy

Caution

GP-0.5 Tablet is a pregnancy Category C medicine which means that there are no well-controlled studies that have been done in pregnant women. However, if you are taking GP-0.5 Tablet during pregnancy, stop taking it at least 2 weeks before your due date or as prescribed by your doctor.

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Breast Feeding

Caution

Not recommended to be taken by breastfeeding mothers. GP-0.5 Tablet may pass into breast milk and may cause the risk of low blood sugar in the infant. Consult your doctor for further advice.

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Driving

Caution

Not recommended in patients with fluctuating glucose levels. GP-0.5 Tablet can reduce the ability to concentrate or react, if your blood sugar is lowered (hypoglycemia) or raised (hyperglycemia) or if you develop visual problems as a result of such conditions. Thus not recommended as the patient can endanger himself or others (e.g. when driving a car or using machines).

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Liver

Consult your doctor

Take GP-0.5 Tablet with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required.

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Kidney

Consult your doctor

Take GP-0.5 Tablet with caution, especially if you have a history of kidney disease. The dose may be adjusted by your doctor as required.

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Children

Unsafe

GP-0.5 Tablet is not approved for use by a person less than 18 years old.

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Heart

Please consult your doctor before using GP-0.5 Tablet if you have pre-existing heart problems. Your doctor will prescribe GP-0.5 Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering GP-0.5 Tablet to geriatric patients. Your doctor will prescribe GP-0.5 Tablet if the benefits outweigh the risks.

FAQs

GP-0.5 Tablet is used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM).

The GP-0.5 Tablet contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

A patient is advised to take the missed dose as soon as possible or skip to the next dose if it's been too late. A patient should never attempt to take a double dose to compensate for the missed dose as it may prove harmful.

GP-0.5 Tablet is not recommended with warfarin as these two drugs are contraindicated with each other and hence may result in any harmful symptom when taken together in heart patients.

Avoid intake of GP-0.5 Tablet and consult a doctor if you have an allergy to sulfa drugs, diabetic ketoacidosis, heart disease, liver or kidney disease, an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Country of origin

India

Manufacturer/Marketer address

Arvind Vithal Gandhi Chowk, BSD Marg, Station Road, Govandi East, Mumbai - 400 088. , India.
Other Info - GP00001

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