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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Graftide-S 360 mg Tablet 10's is used to prevent organ transplant rejection. It contains Mycophenolate sodium, which works by weakening the immune system and preventing it from rejecting the transplanted organ. In some cases, this medicine may cause side effects such as diarrhoea, cough, muscle pain, low blood pressure, fever and respiratory infections. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Graftide-S 360 mg Tablet 10's

Graftide-S 360 mg Tablet 10's is used to prevent the body from rejecting a transplanted organ such as a kidney, heart or liver. Transplant rejection occurs when the recipient’s immune system identifies the transplanted organ as a ‘foreign object’ and attacks it.

Graftide-S 360 mg Tablet 10's contains mycophenolate sodium, which works by suppressing the immune system, allowing the transplanted graft to avoid rejection.

In some cases, you may experience certain common side effects, such as diarrhoea, cough, muscle pain, low blood pressure, fever and respiratory infections. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Do not take Graftide-S 360 mg Tablet 10's if you are allergic to any of its ingredients. To avoid recurring symptoms, do not stop it midway. Do not take Graftide-S 360 mg Tablet 10's if you are pregnant or planning to become pregnant. Graftide-S 360 mg Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk. Graftide-S 360 mg Tablet 10's should not be given to children as safety and efficacy have not been established.

Uses of Graftide-S 360 mg Tablet 10's

Graftide-S 360 mg Tablet 10's is used to prevent organ rejection in patients who have undergone a kidney, heart, or liver transplant. The detailed uses of Graftide-S 360 mg Tablet 10's are as follows:

  • Prevents organ rejection: Graftide-S 360 mg Tablet 10's helps avoid rejection episodes in patients following organ transplantation.
  • Used with other medications: Graftide-S 360 mg Tablet 10's is commonly administered alongside other immunosuppressants to enhance effectiveness.
  • Maintains graft function: Graftide-S 360 mg Tablet 10's supports the long-term survival of the transplanted organ by reducing immune activity.

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Directions for Use

  • Graftide-S 360 mg Tablet 10's should be taken on an empty stomach, at least 1 hour before or 2 hours after eating or drinking.
  • Follow your doctor's instructions regarding the dosage and duration for effective results.
  • Swallow Graftide-S 360 mg Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Graftide-S 360 mg Tablet 10's contains Mycophenolate mofetil, an immunosuppressant used primarily in organ transplant recipients.
  • It helps the body accept transplanted organs (like the kidney, heart, or liver) by suppressing immune responses.
  • Graftide-S 360 mg Tablet 10's inhibits the function of white blood cells (T and B lymphocytes), which are responsible for attacking transplanted organs.
  • It enhances the long-term success of organ transplantation.
  • Graftide-S 360 mg Tablet 10's is often used along with other immunosuppressants like tacrolimus or cyclosporine for optimal effect.
  • Preferred over long-term use of corticosteroids due to fewer chronic side effects.

How Graftide-S 360 mg Tablet 10's Works

Graftide-S 360 mg Tablet 10's contains Mycophenolate sodium used in the treatment of organ transplant rejection, along with another immunosuppressant and anti-inflammatory agent. It inhibits T and B lymphocytes (white blood cells that attack foreign cells) and suppresses antibody production (identifies and kills foreign cells). These effects suppress the immune system so that the transplanted graft is not rejected.

Storage

• Store in a cool and dry place away from sunlight.• Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Graftide-S 360 mg Tablet
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Managing Medication-Triggered Hypocalcemia (Calcium deficiency or Low Calcium Levels In Blood): A Step-by-Step Guide:
  • Consult Your Doctor: If you experience symptoms such as muscle cramps, tingling, numbness, weakness, or spasms, which may indicate low calcium levels (hypocalcemia), consult your doctor to determine if your medication is the cause.
  • Your doctor will assess your medication regimen and adjust it if necessary to minimize the risk of hypocalcemia.
  • Your doctor may order blood tests to check your calcium levels and monitor for any changes.
  • To manage hypocalcemia, your doctor recommends dietary and lifestyle modifications. This may include increasing your intake of calcium-rich foods to support bone health and calcium levels. If necessary, your doctor may also prescribe calcium and vitamin D supplements to help stabilize your calcium levels.
  • If your condition does not improve or worsens, consult your doctor immediately for further evaluation and treatment.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.

What if I have taken an overdose of Graftide-S 360 mg Tablet 10's

Take Graftide-S 360 mg Tablet 10's only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include nausea, vomiting, stomach pain, diarrhoea, heartburn, and signs of infection (fever, chills, cough, sore throat). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Graftide-S 360 mg Tablet 10's if you are allergic to any immunosuppressant medicines or mycophenolate sodium.
  • Let your doctor know before using Graftide-S 360 mg Tablet 10's if you have liver or kidney problems, severe digestive issues, cancer, liver disease (such as hepatitis B, hepatitis C), current/past infections, or rare genetic disorders (such as Lesch-Nyhan or Kelley-Seegmiller syndromes).
  • Do not take Graftide-S 360 mg Tablet 10's if you are pregnant or planning for pregnancy, as Graftide-S 360 mg Tablet 10's is a pregnancy category risk D medicine, which can cause serious congenital disabilities to the unborn baby.
  • Graftide-S 360 mg Tablet 10's should not be taken by breastfeeding mothers, as it passes into breast milk.
  • Pregnant women should use reliable forms of birth control while on treatment and for six weeks after stopping treatment with Graftide-S 360 mg Tablet 10's.
  • While taking Graftide-S 360 mg Tablet 10's, do not contact anyone who has shingles, chickenpox, or measles.
  • Graftide-S 360 mg Tablet 10's causes dizziness and drowsiness, so drive with caution.
  • Graftide-S 360 mg Tablet 10's should not be given to children as safety and efficacy have not been established.
  • Avoid consuming alcohol along with Graftide-S 360 mg Tablet 10's as it could lead to increased dizziness.
  • Your doctor may advise you to undergo regular blood tests and kidney and liver tests to monitor your condition.
  • Avoid excessive exposure to sunlight, wear protective clothing, and use protective sunscreen with a high protection factor while using Graftide-S 360 mg Tablet 10's.

Drug-Drug Interactions

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Critical

Drug-Drug Interactions

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Critical
How does the drug interact with Graftide-S 360 mg Tablet:
Coadministration of Colestipol with Graftide-S 360 mg Tablet can reduce its absorption and action in the body. This can lead to low treatment results.

How to manage the interaction:
Taking Graftide-S 360 mg Tablet with Colestipol is not recommended as it can result in an interaction, it can be taken if your doctor has advised it.
How does the drug interact with Graftide-S 360 mg Tablet:
Coadministration of medroxyprogesterone with Graftide-S 360 mg Tablet may decrease the levels and effects of medroxyprogesterone.

How to manage the interaction:
There could be a possible interaction between Graftide-S 360 mg Tablet and Medroxyprogesterone, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Graftide-S 360 mg Tablet:
When Graftide-S 360 mg Tablet is taken with Rifampicin, the amount of Graftide-S 360 mg Tablet in the blood may decrease, resulting in reduced effectiveness.

How to manage the interaction:
Taking Graftide-S 360 mg Tablet with Rifampicin together can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Graftide-S 360 mg Tablet:
Combine use of Graftide-S 360 mg Tablet and Etanercept can increase the effect of Etanercept.

How to manage the interaction:
There could be a possible interaction between Graftide-S 360 mg Tablet and Etanercept, but they can be taken together if your doctor has prescribed them. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Graftide-S 360 mg Tablet:
Combined use of Graftide-S 360 mg Tablet and Infliximab can increase the risk or severity of developing serious infections.

How to manage the interaction:
There could be a possible interaction between Graftide-S 360 mg Tablet and Infliximab, but they can be taken together if your doctor has prescribed them. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Graftide-S 360 mg Tablet:
Coadministration of Graftide-S 360 mg Tablet and Colestyramine can decrease the effect of Graftide-S 360 mg Tablet.

How to manage the interaction:
There could be a possible interaction between Graftide-S 360 mg Tablet and Cholestyramine, it can be taken together if your doctor has prescribed them. However, if you experience fever, diarrhea, sore throat, muscle aches, shortness of breath, inflamed skin, body pain, or burning during urination consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Graftide-S 360 mg Tablet:
Taking Graftide-S 360 mg Tablet and Clozapine can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
There could be a possible interaction between Graftide-S 360 mg Tablet and Clozapine, but they can be taken together if a doctor has prescribed them. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination consult a doctor. Do not discontinue any medications without a doctor's advice.
Mycophenolic acidCertolizumab
Severe
How does the drug interact with Graftide-S 360 mg Tablet:
Taking Graftide-S 360 mg Tablet and Certolizumab can lead to or increase the risk of developing serious infections.

How to manage the interaction:
Taking Graftide-S 360 mg Tablet and Certolizumab together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, body pain, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Graftide-S 360 mg Tablet:
Co-administration of Ferrous sulfate with Graftide-S 360 mg Tablet decreases levels of Mycophenolate by reducing its absorption.

How to manage the interaction:
There could be a possible interaction between Graftide-S 360 mg Tablet and Ferrous sulfate, but they can be taken together if a doctor has prescribed them. However, if you experience upset stomach, nausea, vomiting, diarrhea, constipation sleep problems, fatigue, headache, painful urination, high blood pressure, or swelling of the lower legs, ankles, or feet, joint pain, cough, or shortness of breath consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Graftide-S 360 mg Tablet:
Coadministration of Baricitinib and Abatacept can increase the risk of developing serious infections.

How to manage the interaction:
Taking Baricitinib and Abatacept together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help improve joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Graftide-S 360 mg Tablet 10's. It could lead to increased dizziness and drowsiness.

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Pregnancy

Unsafe

Graftide-S 360 mg Tablet 10's may cause birth defects and miscarriage if taken during pregnancy. Follow the contraception advice given by your doctor if you are a woman who could become pregnant. Also, undergo a pregnancy test before starting treatment with Graftide-S 360 mg Tablet 10's.

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Breast Feeding

Unsafe

It is not recommended to take Graftide-S 360 mg Tablet 10's while you are breastfeeding. Graftide-S 360 mg Tablet 10's passes into breast milk.

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Driving

Unsafe

Graftide-S 360 mg Tablet 10's may cause dizziness, tiredness. Do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Consult the doctor if you have liver diseases/conditions, as your doctor may adjust the dose as required.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Graftide-S 360 mg Tablet 10's as your doctor may adjust the dose as required.

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Children

Unsafe

Graftide-S 360 mg Tablet 10's should not be used by children below 18 years of age, as the efficacy and safety have not been established.

FAQs

Graftide-S 360 mg Tablet 10's is used to prevent the body from rejecting a transplanted organ such as a kidney, heart‚ or liver.

Graftide-S 360 mg Tablet 10's belongs to the group of medications called immunosuppressants. It works by weakening the immune system by inhibiting the production of cells or antibodies that attack foreign cells. This effect helps in stopping the immune system from targeting and rejecting the transplanted organ.

Graftide-S 360 mg Tablet 10's causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infection, such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Diarrhoea might be a side-effect of Graftide-S 360 mg Tablet 10's. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Graftide-S 360 mg Tablet 10's can suppress the immune system and can increase the risk of skin cancer. So, it would be best if you avoid prolonged exposure to sunlight. Also, wear protective clothing covering your head, neck, arms and legs, and use a sunscreen lotion with a high SPF (sun protection factor).

Country of origin

India

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7Th To 12Th Floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103.
Other Info - GRA0258

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