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  3. Halsbev 400 Injection 16 ml

Halsbev 400 Injection 16 ml, Pack of 1 Injection
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Halsbev 400 Injection is an anti-cancer medicine used in the treatment of metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. This medicine works on vascular endothelial growth factor and causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Common side effects include loss of appetite, constipation, fever, nosebleeds, change in speech, and taste.
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Composition :

BEVACIZUMAB-400MG

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Halsbev 400 Injection

Halsbev 400 Injection is a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably. Cancer can start in one region of the body and spread to other parts. This is referred to as metastasis.

Halsbev 400 Injection contains 'Bevacizumab' that works against vascular endothelial growth factor (VEGF) which is found on the lining of lymph and blood vessels. VEGF causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Inhibition of vascular endothelial growth factor limits the flow of oxygen and nutrients to the tumour, causing it to shrink or cease developing. Thus, it helps treat cancers.

Halsbev 400 Injection will be administered by a healthcare professional; do not self-administer. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Halsbev 400 Injection may cause loss of appetite, constipation, fever, nosebleeds, change in speech, and taste. The majority of these side effects do not require medical treatment and fade away with time. However, consult your doctor if the side effects persist or worsen

Avoid taking Halsbev 400 Injection if you are pregnant. Use effective contraception during the treatment and for 6months after the last dose. Halsbev 400 Injection may cause sleepiness and fainting, so avoid driving while on treatment with Halsbev 400 Injection. Do not breastfeed during the treatment and for 6months after the last dose of Halsbev 400 Injection. Keep your doctor informed about your health condition and all the medicines you take to rule out any side effects.

Uses of Halsbev 400 Injection

Halsbev 400 Injection is used in the treatment of Metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. The detailed uses of Halsbev 400 Injection are as follows:<br/>• Colorectal Cancer: Halsbev 400 Injection is used in combination with chemotherapy for metastatic cases.<br/>• Non-Small Cell Lung Cancer (NSCLC): Halsbev 400 Injection helps slow tumor growth and spread when combined with carboplatin and paclitaxel.<br/>• Ovarian, Cervical, and Peritoneal Cancer: Halsbev 400 Injection is often used post-surgery or with chemotherapy to improve outcomes.<br/>• Renal Cell Carcinoma (Kidney Cancer): Halsbev 400 Injection enhances treatment efficacy when paired with other agents.<br/>• Glioblastoma (Brain Tumor): Halsbev 400 Injection is approved for recurrent cases to reduce tumor vascularization.<br/>• Hepatocellular Carcinoma (Liver Cancer): Halsbev 400 Injection is used in combination with other drugs for advanced stages.<br/>

Directions for Use

• Follow your doctor's instructions regarding doses and timing of Halsbev 400 Injection for optimal results.• Halsbev 400 Injection will be administered by a healthcare professional in a medical setting.• Kindly do not self-administer.

Medicinal Benefits

Halsbev 400 Injection contains Bevacizumab, a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. Halsbev 400 Injection works against a protein called vascular endothelial growth factor (VEGF). Vascular endothelial growth factor (VEGF) inhibition limits the flow of oxygen and nutrients to the tumour cells, causing them to shrink or cease developing. Thus, it helps treat cancer.

How Halsbev 400 Injection Works

Halsbev 400 Injection contains 'Bevacizumab' that works against vascular endothelial growth factor (VEGF) which is found on the lining of lymph and blood vessels. VEGF causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Inhibition of vascular endothelial growth factor limits the flow of oxygen and nutrients to the tumour, causing it to shrink or cease developing. Thus, it helps treat cancers.

Storage

Keep Halsbev 400 Injection out of the sight and reach of children.
Side effects of Halsbev 400 Injection 16 ml
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
  • Apply warm compresses to the affected eye to help loosen blockages.
  • Gently massage the eyelids to promote tear drainage.
  • Avoid rubbing the eyes, as this can exacerbate the condition.
  • Use artificial tears to help lubricate the eyes.
  • Keep the eyes clean and free of irritants.
  • Avoid exposure to wind, dust, and other environmental irritants.
  • Consider using humidifiers to add moisture to the air and reduce tear evaporation.

What if I have taken an overdose of Halsbev 400 Injection

An overdose of Halsbev 400 Injection does not have a recommended course of action or counteragent. Because infusion reactions can be quite severe, treatment for hypersensitivity reactions must be started as soon as possible. Your doctor may take necessary action if an overdose is suspected.

Drug Warnings

Halsbev 400 Injection should only be taken under medical supervision. While taking Halsbev 400 Injection, the doctor will monitor your condition on a regular basis. If you have a history of allergic reactions to Halsbev 400 Injection or other medications, inform your doctor before taking it. Avoid taking Halsbev 400 Injection if you are pregnant. Use effective contraception during the treatment and for 6months after the last dose. Halsbev 400 Injection may cause sleepiness and fainting, so avoid driving while on treatment with Halsbev 400 Injection. Inform your doctor if you have/had high blood pressure, heart attack, stroke, bleeding problems, stomach/intestinal bleeding, perforation; if you had surgery in the past 28days/are due to have surgery. Do not breastfeed during the treatment and for 6months after the last dose of Halsbev 400 Injection. While taking Halsbev 400 Injection, please do not get any immunizations or vaccinations unless your doctor has approved it. Halsbev 400 Injection may increase the risk of bleeding, so be cautious and consult your doctor if you notice any bleeding or bruising.

Drug-Drug Interactions

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BevacizumabClozapine
Severe
BevacizumabThalidomide
Severe

Drug-Drug Interactions

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BevacizumabClozapine
Severe
How does the drug interact with Halsbev 400 Injection 16 ml:
Taking Halsbev 400 Injection 16 ml and clozapine may increase the risk of infection.

How to manage the interaction:
Although taking Halsbev 400 Injection 16 ml and Clozapine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, losing weight, or feeling pain, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
BevacizumabThalidomide
Severe
How does the drug interact with Halsbev 400 Injection 16 ml:
Taking thalidomide together with Halsbev 400 Injection 16 ml may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Halsbev 400 Injection 16 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
BevacizumabIdarubicin
Severe
How does the drug interact with Halsbev 400 Injection 16 ml:
Taking Halsbev 400 Injection 16 ml with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
There may be a possibility of interaction between Halsbev 400 Injection 16 ml and Idarubicin, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditating, reading novels, taking a nice bubble bath, or listening to calming music can all help you relax.
  • Yoga can also aid in the improvement of both physical and mental health.
  • Maintain a healthy weight by engaging in low-strain workouts on a regular basis and consuming nutritious foods.
  • To maintain a healthy weight, eat a portion of nutritious food and exercise on a regular basis.
  • Leafy greens, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs should all be part of your daily diet.
  • Rest well and get a good night's sleep.
  • Avoid smoking and consuming alcoholic beverages.
  • Fast food, fried foods, processed meats, refined carbohydrates, and added sugars should be avoided.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

Halsbev 400 Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Halsbev 400 Injection. It could lead to unpleasant side effects.

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Pregnancy

Unsafe

Halsbev 400 Injection should not be used during pregnancy because it causes harm to the fetus. Women of childbearing potential must use an effective contraception method while taking Halsbev 400 Injection and at least six months after the last dose. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment and for 6months after the last dose. This is due to the possibility of the medication being passed on to the infant through breast milk.

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Driving

Caution

Caution should be exercised when driving or operating machinery because in some cases, Halsbev 400 Injection may cause sleepiness and fainting.

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Liver

Caution

If you have/had a history of any liver-related diseases, please inform the doctor before taking Halsbev 400 Injection. Your doctor will weigh the benefits and potential risks before prescribing Halsbev 400 Injection.

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Kidney

Caution

If you have/had a history of any kidney-related diseases, please inform the doctor before taking Halsbev 400 Injection. Your doctor will weigh the benefits and potential risks before prescribing Halsbev 400 Injection.

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Children

Unsafe

Halsbev 400 Injection is not recommended for children below 18years as the safety and effectiveness have not been established.

Have a query?

FAQs

Halsbev 400 Injection is a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum.

Halsbev 400 Injection works against a protein called vascular endothelial growth factor (VEGF). Inhibition of vascular endothelial growth factor (VEGF) limits the flow of oxygen and nutrients to the tumour cells, causing them to shrink or cease developing. Thereby, Halsbev 400 Injection helps treat cancer.

Halsbev 400 Injection may reduce the number of red blood cells leading to anaemia. Its symptoms include pale skin, lack of energy, feeling breathless, feeling dizzy and lightheadedness.

Chemotherapy remains necessary. Halsbev 400 Injection is given along with chemotherapy for treating cancer.

Halsbev 400 Injection may increase the risk of bleeding and problems with wound healing. If you have had major surgery in the past 28days or if the wound hasn&amp;#039;t healed, you should not take Halsbev 400 Injection. Talk to your doctor for more information.

Cancer can affect anyone, though the risk increases with age. Individual risk is determined by factors such as smoking and drinking habits, lifestyle choices such as what you eat and exercise; a family history of cancer, and factors in your workplace and environment.

Halsbev 400 Injection may increase the incidence of hypertension. Therefore, consult your doctor before taking Halsbev 400 Injection if you have high blood pressure.

Halsbev 400 Injection is given intravenously (into a vein) infusion by a healthcare professional. Halsbev 400 Injection should never be given as an intravenous push or bolus. Do not self-administer.

The duration of treatment with Halsbev 400 Injection depends on your condition and response to the treatment. Your doctor will decide the length of time, based on its effectiveness and your tolerance. Regular monitoring will guide ongoing treatment.

Chemotherapy targets and destroys rapidly dividing cells, including cancer cells, to stop their growth and spread. While, Halsbev 400 Injection works by inhibiting the formation of new blood vessels that supply oxygen and nutrients to tumors. Cutting off this blood supply helps shrink the tumor or prevent it from growing further.

A person taking Halsbev 400 Injection may still require chemotherapy. Halsbev 400 Injection is often used in combination with chemotherapy to treat certain cancers, as it helps prevent tumor growth by blocking blood vessel formation and improves the effectiveness of chemotherapy.

Halsbev 400 Injection causes side effects such as constipation, loss of appetite, fever, nose bleeds, change in speech, voice changes/hoarseness, and loss of body weight. Most of these side effects do not require any medical requirements as they will gradually reduce over time. Contact a doctor if these side effects persist for longer durations.

Country of origin

India
Other Info - HAL0409

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:55 AM IST

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Reference

  1. https://www.ema.europa.eu/en/documents/product-information/avastin-epar-product-information_en.pdf
  2. https://www.avastin.com/hcp.html
  3. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/bevacizumab
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125085s332lbl.pdf
  5. https://www.drugs.com/drug-interactions/bevacizumab.html
  6. https://www.medicines.org.uk/emc/files/pil.3885.pdf
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