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compositionComposition:TRASTUZUMAB-440MG
prescription
Prescription Medicine
info
Haltrust 440 Injection 1's

Haltrust 440 Injection is used to treat Breast Cancer and Stomach Cancer. Haltrust 440 Injection contains Trastuzumab, which works by attaching itself to the HER2 proteins so that the cancer cells are no longer stimulated to grow. It also helps the body's immune system to destroy breast cancer cells. It should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy. Advise women not to breastfeed while taking Haltrust 440 Injection.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TRASTUZUMAB-440MG

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Haltrust 440 Injection

Haltrust 440 Injection is an anti-cancer medicine used in the treatment of HER2-positive Breast cancer and HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Haltrust 440 Injection contains Trastuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Haltrust 440 Injection may cause certain side effects such as abdominal pain, chills, diarrhoea, fatigue, nausea, back pain, bone pain, edema, insomnia, fever, dizziness, headache, vomiting, cough, rash, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Haltrust 440 Injection will be administered by a trained doctor. Hence, do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Haltrust 440 Injection or its components. Inform your doctor if you have any cardiovascular conditions, lung problems, or liver/kidney disease, as it can cause adverse effects. Haltrust 440 Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Haltrust 440 Injection

Haltrust 440 Injection is used in the treatment of Breast Cancer and Stomach Cancer. The detailed uses of Haltrust 440 Injection are as follows:

  • HER2-Positive Breast Cancer: Haltrust 440 Injection is used in the treatment of breast cancer and used alone or with other agents to slow disease progression.
  • HER2-Positive Gastric and Gastroesophageal Junction Cancer: Haltrust 440 Injection is used in treatment of HER2-Positive Gastric and Gastroesophageal Junction Cancer or in combination with chemotherapy for advanced or metastatic cases.

Key Benefits

Haltrust 440 Injection contains Trastuzumab, which is used for treating patients with HER2-positive breast cancer and HER2-positive metastatic gastroesophageal adenocarcinoma. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

Side effects of Haltrust 440 Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Haltrust 440 Injection will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
  • Do not self-administer.

How Haltrust 440 Injection Works

Haltrust 440 Injection contains Trastuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.
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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Unsafe

Haltrust 440 Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Haltrust 440 Injection. Use reliable methods of birth control while on treatment with Haltrust 440 Injection.

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Haltrust 440 Injection as it can cause serious side effects to the baby.

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Driving

Not applicable

-

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Haltrust 440 Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Limited data are available on the effect of Haltrust 440 Injection in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Haltrust 440 Injection is not recommended for use in children as the safety and efficacy are not established.

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Heart

Caution

Haltrust 440 Injection may increase the risk of heart problems. Therefore, please inform your doctor if you have any heart-related problems before using Haltrust 440 Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Haltrust 440 Injection to geriatric patients. Your doctor will prescribe Haltrust 440 Injection if the benefits outweigh the risks.

What if I have taken an overdose of Haltrust 440 Injection

As Haltrust 440 Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Have a query?

How Soon It Starts Working

The time required for Haltrust 440 Injection to start to work: The time required for Haltrust 440 Injection to show its action is not clinically established. The time for which the effects of Haltrust 440 Injection last: The duration of action for Haltrust 440 Injection is not clinically established.

What if you forget to take Haltrust 440 Injection

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Haltrust 440 Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

Drug Warnings

Haltrust 440 Injection should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any lung problems, cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Haltrust 440 Injection may cause left ventricular ejection fraction, cardiomyopathy, pulmonary toxicity, exacerbations of chemotherapy-induced neutropenia, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. Haltrust 440 Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Haltrust 440 Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Haltrust 440 Injection may interact with monoclonal antibodies (etanercept, golimumab, infliximab, natalizumab), antiviral drugs (indinavir, efavirenz, atazanavir), live vaccines, etc.

Drug-Food Interactions: No interaction found.

Drug-Disease Interactions: Inform your doctor if you have cardiac problems, lung disease, liver/kidney disease or allergic reactions.

TrastuzumabClozapine
Severe
TrastuzumabEtanercept
Severe

Drug-Drug Interactions

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TrastuzumabClozapine
Severe
How does the drug interact with Haltrust 440 Injection:
Co-administration of Haltrust 440 Injection and clozapine can increase the risk of toxicity.

How to manage the interaction:
Although taking Haltrust 440 Injection and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not stop using any medications without first talking to your doctor.
TrastuzumabEtanercept
Severe
How does the drug interact with Haltrust 440 Injection:
When Etanercept is used with Haltrust 440 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Haltrust 440 Injection and Etanercept, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TrastuzumabInfliximab
Severe
How does the drug interact with Haltrust 440 Injection:
Combining Haltrust 440 Injection with Infliximab can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Haltrust 440 Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrastuzumabCladribine
Severe
How does the drug interact with Haltrust 440 Injection:
Combining Haltrust 440 Injection with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Haltrust 440 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TrastuzumabTofacitinib
Severe
How does the drug interact with Haltrust 440 Injection:
Combining Haltrust 440 Injection with Tofacitinib can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Haltrust 440 Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TrastuzumabIdarubicin
Severe
How does the drug interact with Haltrust 440 Injection:
Taking Haltrust 440 Injection with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
Co-administration of Haltrust 440 Injection with Idarubicin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience difficulty breathing, fluid retention, or chest pain, consult a doctor. Do not discontinue any medications without a doctor's advice.
TrastuzumabThalidomide
Severe
How does the drug interact with Haltrust 440 Injection:
Taking thalidomide together with Haltrust 440 Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Haltrust 440 Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
TrastuzumabBaricitinib
Severe
How does the drug interact with Haltrust 440 Injection:
Coadministration of Haltrust 440 Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Haltrust 440 Injection and Baricitinib, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Haltrust 440 Injection is used to treat Breast Cancer and Stomach Cancer.
Haltrust 440 Injection contains Trastuzumab, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.
Inform your doctor whether you have received any other cancer treatment. Haltrust 440 Injection may cause a decrease in left ventricular ejection fraction, cardiomyopathy, hypersensitivity reactions, pulmonary toxicity, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Haltrust 440 Injection.
Consult the doctor immediately, if you experience symptoms of an infection, such as a high temperature, chills, or feeling unwell despite a normal temperature. It could be due to a reduced white blood cell count caused by Haltrust 440 Injection, increasing your risk of severe infections. Additionally, swollen feet or ankles, stomach pain, or lower back pain may indicate heart problems.
It is recommended to wait at least 6 months after completing Haltrust 440 Injection therapy before trying to get pregnant. This is because the medication can remain in the body for some time and may potentially affect pregnancy. However, it is essential to consult the doctor for personalized advice and to ensure that it is safe for you to become pregnant after this treatment.
The duration of treatment with Haltrust 440 Injection will depend on an individual treatment plan, which your doctor will determine based on your specific condition. It may vary based on personal medical conditions and how you respond to the therapy. In some cases, the treatment duration may be shorter or longer. Always attend follow-up appointments as instructed by the doctor for effective treatment.
Fasting is not typically required before administering Haltrust 440 Injection. However, it is always best to follow the doctor's specific instructions regarding preparations before treatment. If fasting is necessary, your doctor will provide detailed guidance.
Haltrust 440 Injection should be administered through subcutaneous (SC) or intravenous (IV) routes by the doctor or nurse. Do not self-administer.
Haltrust 440 Injection should not be administered to patients with HER2-negative cancer cells as it is a monoclonal antibody that specifically targets a protein called human epidermal growth factor receptor 2 (HER2), which is present in high amounts on the surface of specific cancer cells.
The doctor may recommend heart investigations while you are taking Haltrust 440 Injection as it may potentially affect heart function. It has been associated with heart-related side effects, including a decrease in left ventricular ejection fraction, which could lead to heart failure in some patients. Monitoring heart health helps detect any issues early, ensuring prompt action to manage the risk. Always follow the doctor's recommendations for regular check-ups during treatment.
During treatment with Haltrust 440 Injection for advanced-stage disease, cardiac monitoring was conducted every 3 to 8 months for up to 2 years. However, the doctor will adjust the frequency of heart investigations based on your specific condition and response to treatment. It's essential to follow their advice for optimal monitoring and early detection of any heart-related issues.
The side effects of Haltrust 440 Injection include abdominal pain, chills, headache, diarrhoea, fatigue, nausea, back pain, bone pain, oedema, insomnia, fever, dizziness, vomiting, cough, rash, and injection site reactions. Consult the doctor if any of these side effects persist or worsen.

Disclaimer

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Reference

  1. U.S. Food and Drug Administration (FDA). 103792S5250Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Trastuzumab Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. MedlinePlus. A699019 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026] Check here
  4. Trastuzumab Trastuzumab. 1998. [Accessed on 27 Mar. 2019] Check here
  5. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 19 Feb. 2020] Check here
  6. Herceptin 150mg Powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 6 January 2025] Check here
  7. Herceptin 150mg Powder for concentrate for solution for infusion - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 6 January 2025]Check here

Country of origin

India
Other Info - HAL0413

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