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  3. Harmless Plus Suspension

Harmless Plus Suspension, Pack of 1 Suspension
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Harmless Plus Suspension is used to treat bacterial infections. It contains Colistin Sulphate which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as dizziness, upset stomach, rash, diarrhoea, vertigo (spinning sensation), paresthesia (tingling or pricking sensation) and slurred speech. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Synonym :

COLISTIN

Composition :

COLISTIN SULPHATE-25MG/5ML

Consume Type :

ORAL

Return Policy :

Not Returnable

About Harmless Plus Suspension

Harmless Plus Suspension belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections caused by susceptible Gram-negative bacteria. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Harmless Plus Suspension contains Colistin Sulphate. Colistin effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Harmless Plus Suspension destroys the bacteria and successfully treats the infection.

Take Harmless Plus Suspension as prescribed by your doctor. Depending on your medical condition, you are advised to take Harmless Plus Suspension for as long as your doctor prescribes it. Sometimes, you may experience common side effects like dizziness, upset stomach, rash, diarrhoea, vertigo (spinning sensation), paresthesia (tingling or pricking sensation) and slurred speech. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Harmless Plus Suspension, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Harmless Plus Suspension can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Harmless Plus Suspension

Treatment of Severe bacterial infections

Directions for Use

Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Harmless Plus Suspension contains Colistin Sulphate, which is used for treating acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa. Colistin sulphate effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Harmless Plus Suspension destroys the bacteria and successfully treats the infection.

How Harmless Plus Suspension Works

Harmless Plus Suspension contains Colistin Sulphate. Colistin effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Harmless Plus Suspension destroys the bacteria and successfully treats the infection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Harmless Plus Suspension
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Harmless Plus Suspension

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Before taking the Harmless Plus Suspension, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Harmless Plus Suspension. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
ColistinAmikacin
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Harmless Plus Suspension:
Coadministration of Harmless Plus Suspension along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Harmless Plus Suspension with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinAmikacin
Severe
How does the drug interact with Harmless Plus Suspension:
Coadministration of Harmless Plus Suspension with Amikacin can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Amikacin, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ColistinAdefovir dipivoxil
Severe
How does the drug interact with Harmless Plus Suspension:
Combining Harmless Plus Suspension with Adefovir dipivoxil may decrease Harmless Plus Suspension's excretion rate, which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Adefovir dipivoxil, you can take these medicines together if prescribed by your doctor. However, if you experience any irregular urination, swelling, shortness of breath, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinHuman immunoglobulin
Severe
How does the drug interact with Harmless Plus Suspension:
Taking Human immunoglobulin with Harmless Plus Suspension, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Human immunoglobulin and Harmless Plus Suspension, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinVecuronium
Severe
How does the drug interact with Harmless Plus Suspension:
Using Vecuronium with Harmless Plus Suspension can make Vecuronium more effective in therapy.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Vecuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinSuxamethonium
Severe
How does the drug interact with Harmless Plus Suspension:
Using Suxamethonium together with Harmless Plus Suspension may increase the effects of Suxamethonium.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Suxamethonium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash Paresthesia (tingling or pricking sensation) Dizziness Slurred speech Vertigo, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinTobramycin
Severe
How does the drug interact with Harmless Plus Suspension:
Coadministration of Tobramycin with Harmless Plus Suspension can increase the blood levels and risk of Harmless Plus Suspension side effects.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Tobramycin, you can take these medicines together if prescribed by your doctor. However, if you experience, shortness of breath, muscle pain, dizziness, or palpitations, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
ColistinNeomycin
Severe
How does the drug interact with Harmless Plus Suspension:
Combining Harmless Plus Suspension with Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Neomycin, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinPancuronium
Severe
How does the drug interact with Harmless Plus Suspension:
Using Pancuronium with Harmless Plus Suspension can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Pancuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinGentamicin
Severe
How does the drug interact with Harmless Plus Suspension:
Co-administration of Harmless Plus Suspension with Gentamicin can increase the levels and risk of Harmless Plus Suspension side effects.

How to manage the interaction:
Although there is a possible interaction between Harmless Plus Suspension and Gentamicin, you can take these medicines together if prescribed by your doctor. However, if you experience weight gain or loss suddenly, muscle pain, dizziness, or palpitations, call your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After taking the full course of Harmless Plus Suspension, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Harmless Plus Suspension.
  • Avoid intake of alcoholic beverages with Harmless Plus Suspension as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Harmless Plus Suspension in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Harmless Plus Suspension Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Harmless Plus Suspension is known to cause drowsiness. Taking alcohol along with it may increase drowsiness and cause excessive sleepiness.

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Pregnancy

Caution

Harmless Plus Suspension should not be used in pregnancy unless necessary. Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Harmless Plus Suspension.

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Breast Feeding

Caution

Harmless Plus Suspension should not be used in breastfeeding unless necessary. Inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Harmless Plus Suspension.

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Driving

Caution

Harmless Plus Suspension may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Harmless Plus Suspension should be used with caution if you have liver disease. Your doctor may adjust the dose based on your condition.

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Kidney

Consult your doctor

Harmless Plus Suspension should be used with caution if you have kidney disease. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Harmless Plus Suspension is probably safe when used in children who are above 40 kgs in weight. However, your child's doctor will adjust the dose based on the age, body weight and health condition of your child.

Have a query?

FAQs

Harmless Plus Suspension is used to treat bacterial infections.

Harmless Plus Suspension contains Colistin Sulphate, an anti-bacterial medicine used to treat severe bacterial infections. It works by stopping the growth of bacterial cell walls, which is required for bacteria's growth and multiplication.

Before taking Harmless Plus Suspension, let your doctor know if you have or ever had any problems related to your kidneys/liver or lungs (such as asthma). Also, mention all the other medicines you are taking to avoid any drug interaction.

No, Harmless Plus Suspension does not treat cold and flu infections. It is used to treat severe bacterial infections and should be taken only if prescribed by a doctor.

After taking Harmless Plus Suspension, you may have diarrhoea. Harmless Plus Suspension is an antibiotic that kills or prevents bacterial growth. Some good intestinal bacteria that aid digestion might also be killed. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration). Consult the doctor if diarrhoea worsens, and never take anti-diarrhoea medication without consulting a doctor.

Harmless Plus Suspension is safe for the elderly population, but if you have any kidney problem, then Harmless Plus Suspension should be used with caution as it might lead to kidney complications and slow overall body processes. In such cases, inform your doctor before starting Harmless Plus Suspension so that dose adjustment can be made.

Harmless Plus Suspension may cause live bacterial vaccines (such as typhoid vaccine) not to work either. Do not have immunizations/vaccinations while using this medication unless your doctor tells you to.

Yes, Harmless Plus Suspension is effective in the treatment of bacterial infections of the stomach, bowel, intestines, and diarrhoea.

If you forget to take a dose of Harmless Plus Suspension, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular schedule.

Harmless Plus Suspension should not be used in people who are allergic to any of its components. Consult the doctor if you have any concerns.

Harmless Plus Suspension should be used during pregnancy only if advised by the doctor. You are recommended to consult your doctor before taking Harmless Plus Suspension if you are pregnant.

Yes, Harmless Plus Suspension is safe when used as prescribed by your doctor. However, it may cause some side effects like nausea, vomiting, loss of appetite, and stomach upset while using it.

The common side effects of Harmless Plus Suspension may include nausea, vomiting, loss of appetite and stomach upset. Most of these side effects of Harmless Plus Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Other Info - HARM513

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a682860.htmlmedicines.org.uk/emc/files/pil.5648.pdf
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