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  3. I-Nem 250Mg Inj

I-Nem 250Mg Inj, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
I-Nem 250Mg Inj is used to treat severe bacterial infections. It contains Cilastatin and Imipenem which work by preventing the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, swelling, and redness at the site of injection. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

CILASTATIN-250MG + IMIPENEM-250MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About I-Nem 250Mg Inj

I-Nem 250Mg Inj is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach and female reproductive organs. I-Nem 250Mg Inj may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. I-Nem 250Mg Inj does not work against infections caused by the virus, including cold and flu. 
 
I-Nem 250Mg Inj is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, I-Nem 250Mg Inj helps to treat bacterial infections.
 
I-Nem 250Mg Inj will be administered by a healthcare professional; do not self-administer. In some cases, I-Nem 250Mg Inj may cause common side effects such as nausea, vomiting, diarrhoea, swelling, and redness at the site of injection. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. I-Nem 250Mg Inj may cause dizziness, so drive with caution. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. I-Nem 250Mg Inj should not be given to children below one year or those who weigh below 30kg with kidney problems. I-Nem 250Mg Inj is not recommended in paediatric patients with CNS infections due to the risk of seizures. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects.

Uses of I-Nem 250Mg Inj

Treatment of Severe bacterial infections.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• I-Nem 250Mg Inj will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

I-Nem 250Mg Inj is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). I-Nem 250Mg Inj is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach, and female reproductive organs. I-Nem 250Mg Inj may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, I-Nem 250Mg Inj helps to treat bacterial infections. Imipenem is a broad-spectrum antibiotic that is effective against a wide range of aerobic and anaerobic bacteria.

How I-Nem 250Mg Inj Works

I-Nem 250Mg Inj is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, I-Nem 250Mg Inj helps to treat bacterial infections.

Storage

Keep I-Nem 250Mg Inj out of reach and sight of children.

What if I have taken an overdose of I-Nem 250Mg Inj

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience symptoms of overdose such as confusion, drooping eyelids, and seizures.

Drug Warnings

Do not take I-Nem 250Mg Inj if you are allergic to any of its components. Inform your doctor if you have an allergy to antibiotics, colitis, gastrointestinal disease, urinary/kidney problems, CNS disorders, seizures/fits, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. I-Nem 250Mg Inj should not be given to children below one year or those who weigh below 30kg with kidney problems. I-Nem 250Mg Inj is not recommended in paediatric patients with CNS infections due to the risk of seizures. I-Nem 250Mg Inj may cause dizziness and sleepiness, so drive with caution.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid/limit the consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

I-Nem 250Mg Inj Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid alcohol consumption as it might cause increased dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe I-Nem 250Mg Inj only if the benefits outweigh the risks.

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Breast Feeding

Caution

I-Nem 250Mg Inj may pass into breast milk. Please consult your doctor if you are breastfeeding; your doctor will decide if I-Nem 250Mg Inj can be given to breastfeeding mothers or not.

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Driving

Caution

I-Nem 250Mg Inj may cause dizziness and sleepiness. Avoid driving or operating machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Caution

I-Nem 250Mg Inj should not be given to children below one year or those who weigh below 30kg with kidney problems. I-Nem 250Mg Inj is not recommended in paediatric patients with CNS infections due to the risk of seizures.

Have a query?

FAQs

I-Nem 250Mg Inj is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach and female reproductive organs.

I-Nem 250Mg Inj is a combination of two drugs, namely: Cilastatin and Imipenem. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, I-Nem 250Mg Inj helps to treat bacterial infections.

Diarrhoea might be a side-effect of I-Nem 250Mg Inj. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, consult your doctor. Do not take anti-diarrheal medicine on your own.

Concomitant administration of Probenecid (used to treat gout and hyperuricemia) along with I-Nem 250Mg Inj is not recommended as it might result in an increase of plasma levels and half-life of Imipenem.

Ganciclovir (anti-viral) should not be co-administered along with I-Nem 250Mg Inj unless benefits outweigh the risks as generalised seizures have been reported when taken together.

I-Nem 250Mg Inj may cause changes in urine colour and amount of urine. Do not worry and consult your doctor if you have any concerns regarding this.

I-Nem 250Mg Inj may rarely cause thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Other Info - INE0005

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:51 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.1515.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050587s074lbl.pdf
  3. https://www.drugs.com/mtm/imipenem-and-cilastatin.html

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