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  3. Istamet XR CP Tablet 10's

Istamet XR CP Tablet 10's, Pack of 10
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Istamet XR CP Tablet 10's is used to treat Type 2 diabetes. It contains Sitagliptin and Metformin, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high. Additionally, it reduces glucose production in the liver, slows glucose absorption from the intestines, and enhances the body's sensitivity to insulin. Thus, it controls blood glucose levels from rising to very high after meals. The most common side effect is hypoglycemia (low blood glucose levels), characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth, and skin, among others. To avoid hypoglycemia, it is essential to eat regularly and carry a source of sugar with you. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

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Composition :

METFORMIN-1000MG + SITAGLIPTIN-100MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Istamet XR CP Tablet 10's

Istamet XR CP Tablet 10's is a combination drug used in the treatment of type 2 diabetes mellitus. Type 2 diabetes develops when the body does not produce enough insulin or when the body's insulin does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance which helps to lower the level of sugar in your blood, especially after meals.

Istamet XR CP Tablet 10's contains metformin and vildagliptin, which help control blood sugar levels. It works by causing the pancreas to produce more insulin and less glucagon (the effect of vildagliptin) and also by helping the body utilise insulin more effectively (the effect of metformin).

Not everyone who is taking Istamet XR CP Tablet 10's will get these side effects. The most common side effect of Istamet XR CP Tablet 10's is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, hunger pangs, dry mouth and skin, etc. Other side effects include changes in taste, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Istamet XR CP Tablet 10's should be taken with food to avoid an upset stomach. It is advised to take it at the same time each day for best results. For better advice, your doctor will determine the appropriate dose, which can change quickly depending on your condition. Do not skip your meals, and also carry a form of sugar with you to prevent low blood sugar levels.

Avoid taking Istamet XR CP Tablet 10's if you are allergic to it. Istamet XR CP Tablet 10's should not be stopped even if you feel better without consulting your doctor, as sugar levels may change. If you stop taking Istamet XR CP Tablet 10's abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney damage and nerve damage. Istamet XR CP Tablet 10's should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or are planning to get pregnant or breastfeed. You must continue following the diet and exercise recommended for you while on treatment with Istamet XR CP Tablet 10's.

Uses of Istamet XR CP Tablet 10's

Istamet XR CP Tablet 10's is used in the treatment of Type 2 Diabetes Mellitus. The detailed uses of Istamet XR CP Tablet 10's are as follows:
• Management of Diabetes: Istamet XR CP Tablet 10's is commonly prescribed to help regulate blood sugar levels in patients with type 2 diabetes, particularly those who may require additional medication alongside lifestyle changes.
• Improvement of Glycemic Control: Istamet XR CP Tablet 10's aids in improving overall glycemic control by enhancing insulin sensitivity and decreasing hepatic glucose production.
• Weight Management: In some cases, Istamet XR CP Tablet 10's can assist in weight management for diabetic patients, as it may help reduce appetite or modify fat metabolism.
• Prevention of Diabetes Complications: Regular use of Istamet XR CP Tablet 10's can contribute to the prevention of long-term complications associated with diabetes, such as neuropathy, nephropathy, and retinopathy.

Directions for Use

• Istamet XR CP Tablet 10's should be taken with meals to avoid stomach upset. • It is usually taken twice daily; however, your doctor may adjust the dosage based on your blood sugar levels. • Swallow Istamet XR CP Tablet 10's as a whole with a glass of water. • Do not crush, chew, or break it.

Medicinal Benefits

  • Istamet XR CP Tablet 10's helps your pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar that your liver makes.
  • It helps control the rise of blood sugar levels in your body after a meal. 
  • Istamet XR CP Tablet 10's plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

How Istamet XR CP Tablet 10's Works

Istamet XR CP Tablet 10's is a combination of Sitagliptin and Metformin. Metformin slows the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that stimulate the pancreas to release more insulin, thereby helping to regulate blood sugar levels. Thus, Istamet XR CP Tablet 10's controls blood glucose levels from rising to very high after meals.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Istamet XR CP Tablet 10's

Do not take more than the prescribed dose of Istamet XR CP Tablet 10's as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Inform your doctor if you are allergic to Istamet XR CP Tablet 10's.
  • This medicine should not be used in patients with type 1 diabetes or with diabetic ketoacidosis.
  • Some diabetic patients, while taking Istamet XR CP Tablet 10's, might develop a rare but serious condition called lactic acidosis (too much lactic acid accumulated in the blood) that can damage the working of your liver and kidneys, which are required for the elimination of excess lactic acid from the blood.
  • Before you start taking Istamet XR CP Tablet 10's, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, or a low vitamin B12 level.
  • Istamet XR CP Tablet 10's, when used with insulin, may significantly lower the blood sugar level, leading to a hypoglycemic condition, which can be fatal.
  • Inform your doctor if you are pregnant, planning for a pregnancy or breastfeeding before starting the treatment.
  • Prolonged intake of Istamet XR CP Tablet 10's may lower your thyroid-stimulating hormone (TSH); hence, an annual checkup of TSH is recommended.
  • In rare cases, you may also develop a severe skin reaction known as bullous pemphigoid that requires immediate medical attention.
  • Inform your doctor if you are scheduled to undergo a diagnostic test that involves an injection of dye or an X-ray contrast agent. The use of Istamet XR CP Tablet 10's should be stopped for a short time before having an X-ray procedure.
  • It is always important to check for the expiry of the medicine. Discard the medicine if it reaches the expiry date.

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
MetforminMetrizamide
Critical

Drug-Drug Interactions

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SitagliptinGatifloxacin
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Istamet XR CP Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Taking Istamet XR CP Tablet with Gatifloxacin is not recommended as it can lead to a possible interaction, However, it can be taken if advised by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not stop using any medications without a doctor's advice.
MetforminMetrizamide
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Istamet XR CP Tablet with Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Istamet XR CP Tablet with Metrizamide is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, muscle cramps or pain, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetforminIodamide
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Istamet XR CP Tablet and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Istamet XR CP Tablet with Iodamide is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopamidol
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Iopamidol with Istamet XR CP Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet XR CP Tablet with Iopamidol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIopromide
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Iopromide with Istamet XR CP Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Istamet XR CP Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIomeprol
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Iomeprol with Istamet XR CP Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet XR CP Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoversol
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Ioversol with Istamet XR CP Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet XR CP Tablet with Ioversol is not recommended, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Iopentol with Istamet XR CP Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet XR CP Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIohexol
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Iohexol with Istamet XR CP Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet XR CP Tablet with Iohexol is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopanoic acid
Critical
How does the drug interact with Istamet XR CP Tablet:
Co-administration of Iopanoic acid with Istamet XR CP Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Istamet XR CP Tablet with Iopanoic acid is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include starchy veggies, proteins, and whole grains in your diet.
  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly.
  • If you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
  • Invest in at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrate-containing foods with whole grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Istamet XR CP Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while on treatment with Istamet XR CP Tablet 10's.

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Pregnancy

Consult your doctor

Istamet XR CP Tablet 10's is only recommended during pregnancy when the benefit outweighs the risk. Please consult your doctor before starting Istamet XR CP Tablet 10's if you are pregnant or planning to conceive.

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Breast Feeding

Consult your doctor

Consult your doctor; Istamet XR CP Tablet 10's should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

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Liver

Consult your doctor

If you have or have a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

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Kidney

Consult your doctor

If you have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

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Children

Consult your doctor

It is advisable to consult a doctor before using it.

Have a query?

FAQs

Istamet XR CP Tablet 10's is used to treat Type 2 Diabetes Mellitus.

Sitagliptin and Metformin are combined to form $ name. Metformin slows down the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that stimulate the pancreas to release more insulin, thereby helping to regulate blood sugar levels. Thus, Istamet XR CP Tablet 10's controls blood glucose levels from rising to very high after meals.

Increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sore healing, and frequent infections are the signs of type 2 diabetes. Please consult your doctor if you notice such symptoms.

No. Istamet XR CP Tablet 10's is only prescribed for the treatment of type 2 diabetes, also called non-insulin-dependent diabetes.

Istamet XR CP Tablet 10's needs to be taken with food to avoid stomach upset. Take it as prescribed by your doctor.

Do not crush or chew Istamet XR CP Tablet 10's as it may release all of the medicine at once and cause side effects. It should be taken as a whole, with food, or as advised by your doctor.

Generally, Istamet XR CP Tablet 10's does not cause hypoglycemia. It can cause low blood sugar if taken along with other antidiabetic medications, especially when engaging in strenuous exercise or consuming low-calorie foods. Symptoms of low blood sugar include sudden sweating, blurred vision, shaking, hunger, increased heart rate, dizziness, or tingling sensations in the hands or feet. If you experience low blood sugar while taking Istamet XR CP Tablet 10's, consult your doctor.

To quickly increase your blood sugar, eat sugar, candy, honey, or drink fruit juice or non-diet soda if you have sudden sweating, blurry vision, shaking, dizziness, increased heartbeat, or hunger.

Long-term use of Istamet XR CP Tablet 10's can lead to Vitamin B12 deficiency. It interferes with the absorption of Vitamin B12 in the stomach. If left untreated, it may lead to anaemia and nerve problems, which can cause the patient to experience tingling sensations and numbness in the hands and feet, urinary problems, weakness, changes in mental status, and difficulty maintaining balance (ataxia). Some researchers recommend the intake of vitamin B12 from external sources at least once a year to avoid such problems.

Istamet XR CP Tablet 10's may cause side effects such as headache, nausea, vomiting, diarrhoea, low blood sugar, or upper respiratory tract infection. If these side effects persist or worsen, please consult your doctor.

Istamet XR CP Tablet 10's should be avoided in patients with known allergy to any of the components or excipients in it and in patients with severe liver impairment, kidney impairment, congestive heart failure, diabetic ketoacidosis or lactic acidosis.

No, it is not safe to take alcohol while using Istamet XR CP Tablet 10's as it may increase the chance of a life-threatening condition known as lactic acidosis.

Store Istamet XR CP Tablet 10's at room temperature. Protect from light and moisture. Keep it out of reach of children.

Yes, the use of Istamet XR CP Tablet 10's can lead to lactic acidosis. It is a life threatening condition caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect of metformin and thus, it is avoided in patients with underlying kidney disease, elderly patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, tiredness, dizziness, difficulty in breathing, feeling of cold in arms and legs, stomach pain, nausea, vomiting, or slow heart rate. If you have these symptoms, stop taking Istamet XR CP Tablet 10's and consult your doctor immediately.

Istamet XR CP Tablet 10's can lower the chance of severe complications such as nerve problems, kidney damage, blindness, limb amputations, and heart diseases by controlling high blood sugar.

You are recommended to consult your doctor before taking other medications with Istamet XR CP Tablet 10's to avoid drug interactions.

Avoid alcohol consumption while taking Istamet XR CP Tablet 10's and ensure regular monitoring of kidney function. Always take Istamet XR CP Tablet 10's as prescribed by your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - IST0046

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 15, 2025 | 12:16 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/medicine/23111
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022044s022lbl.pdf
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