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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Itrasys 200mg Capsule is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. It contains Itraconazole, which works by killing fungi. Some people may experience side effects such as nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ITRACONAZOLE-200MG

Manufacturer/Marketer :

Systopic Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Itrasys 200mg Capsule

Itrasys 200mg Capsule is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. Fungal infection is a disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).

Itrasys 200mg Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.Thus, it causes the main components of fungal cells to leak out, killing fungi and clearing the fungal infection.

Take Itrasys 200mg Capsule as prescribed. Your doctor will advise you on how often you take Itrasys 200mg Capsule based on your medical condition. Some people may experience nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Most of these side effects of Itrasys 200mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Itrasys 200mg Capsule or any other medicines, please tell your doctor. Itrasys 200mg Capsule is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy or a nursing mother, it is advised to consult a doctor before using Itrasys 200mg Capsule. Do not take Itrasys 200mg Capsule if you have or have heart failure, as it may cause severe life-threatening adverse effects. If you have kidney, liver, heart or lung problems, inform your doctor before taking Itrasys 200mg Capsule. Avoid taking fentanyl (a strong opioid narcotic medicine) with Itrasys 200mg Capsule as it may cause severe breathing problems and can even lead to death. If you experience numbness or tingling in your hands or feet, stop taking Itrasys 200mg Capsule and consult your doctor immediately as they might be symptoms of nerve damage.

Uses of Itrasys 200mg Capsule

Itrasys 200mg Capsule is used in the treatment of fungal infections. The detailed uses of Itrasys 200mg Capsule are as follows:
• Yeast Infection Treatment: Itrasys 200mg Capsule is commonly used to combat vaginal yeast infections caused by the Candida fungus.
• Fungal Infection Management: Itrasys 200mg Capsule effectively treats various systemic fungal infections, especially in individuals with weakened immune systems.
• Preventive Care: Doctors may prescribe Itrasys 200mg Capsule to prevent fungal infections in patients undergoing chemotherapy or those prone to such infections due to immune deficiencies.
• Oral Thrush Treatment: Itrasys 200mg Capsule is also useful in managing oral candidiasis (thrush), a fungal overgrowth in the mouth caused by Candida.

Directions for Use

Tablet: Take it with food to avoid stomach upset or as advised by the doctor. Swallow the whole tablet with a glass of water. Do not break, crush or chew it. If you are taking any stomach acid suppressor or have achlorhydria (stomach does not produce hydrochloric acid), take Itrasys 200mg Capsule with cola.

Medicinal Benefits

Itrasys 200mg Capsule is an antifungal used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Itrasys 200mg Capsule inhibits the production of ergosterol (a main component of the cell membranes of fungi). This weakens and damages the fungal cell membranes, causing the main components of fungal cells to leak out. Thus, it kills fungi and clears the fungal infection.

How Itrasys 200mg Capsule Works

Itrasys 200mg Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of the cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.Thus, it causes the main components of fungal cells to leak out, killing fungi and clearing the fungal infection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Itrasys 200mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Itrasys 200mg Capsule

Do not take more than the prescribed dose of Itrasys 200mg Capsule as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

If you are known to be allergic to Itrasys 200mg Capsule or any other medicines, please tell your doctor. Itrasys 200mg Capsule is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy, or are a nursing mother, it is advised to consult a doctor before using Itrasys 200mg Capsule. Avoid taking fentanyl (a strong opioid pain killer narcotic medicine) with Itrasys 200mg Capsule, as it may cause severe breathing problems and can even lead to death. Do not take Itrasys 200mg Capsule if you have had heart failure, as it may cause severe, life-threatening adverse effects. If you experience a yellow colour change of your eyes or skin, dark coloured urine, stomach pain, pale stools, loss of appetite, unusual tiredness, vomiting or nausea, stop taking Itrasys 200mg Capsule and consult a doctor immediately, as they might be symptoms of liver failure. If you have kidney, liver, heart, or lung problems, inform your doctor before taking Itrasys 200mg Capsule.

Drug-Drug Interactions

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ItraconazoleSimvastatin
Critical
ItraconazoleTriazolam
Critical

Drug-Drug Interactions

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ItraconazoleSimvastatin
Critical
How does the drug interact with Itrasys 200mg Capsule:
Simvastatin's blood levels and effects may be greatly increased when combined with Itrasys 200mg Capsule.

How to manage the interaction:
Simvastatin and Itrasys 200mg Capsule may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you have side effects such unexplained pain in the muscles or tenderness, muscle weakness, fever or flu-like symptoms, or dark urine. Without consulting a doctor, never stop taking any medication.
ItraconazoleTriazolam
Critical
How does the drug interact with Itrasys 200mg Capsule:
Co-administration of Triazolam and Itrasys 200mg Capsule may significantly increase the levels of Triazolam.

How to manage the interaction:
Although combining Triazolam and Itrasys 200mg Capsule may possibly lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.
ItraconazoleTolvaptan
Critical
How does the drug interact with Itrasys 200mg Capsule:
Co-administration of Tolvaptan and Itrasys 200mg Capsule may significantly raise Tolvaptan blood levels and effects.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Itrasys 200mg Capsule, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
ItraconazoleIsavuconazole
Critical
How does the drug interact with Itrasys 200mg Capsule:
The blood levels and effects of Isavuconazole may be significantly enhanced by taking Itrasys 200mg Capsule along with it.

How to manage the interaction:
Co-administration of Isavuconazole and Itrasys 200mg Capsule can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ItraconazoleSolifenacin
Critical
How does the drug interact with Itrasys 200mg Capsule:
The blood levels and effects of solifenacin may be greatly increased when combined with Itrasys 200mg Capsule.

How to manage the interaction:
Solifenacin and Itrasys 200mg Capsule may interact, however, if recommended by a physician, they are safe to consume. Consult a doctor if you feel sleepy, or uneasy, have an irregular heartbeat, have blurry vision, have trouble urinating, have a dry mouth, a headache, have digestive problems, or have constipation. Without consulting a doctor, never stop taking any medication.
ItraconazoleColchicine
Critical
How does the drug interact with Itrasys 200mg Capsule:
Coadministration of colchicine with Itrasys 200mg Capsule may increase the blood levels of colchicine, increasing the risk of serious side effects.

How to manage the interaction:
Colchicine with Itrasys 200mg Capsule can be taken if prescribed by a doctor, despite the possibility of an interaction. However, contact a doctor if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet. Do not stop using any medications without first talking to your doctor.
ItraconazoleEplerenone
Critical
How does the drug interact with Itrasys 200mg Capsule:
The blood levels and effects of eplerenone may be greatly increased when combined with Itrasys 200mg Capsule.

How to manage the interaction:
Although there is a possible interaction between Eplerenone and Itrasys 200mg Capsule, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
ItraconazoleSilodosin
Critical
How does the drug interact with Itrasys 200mg Capsule:
Coadministration of Itrasys 200mg Capsule with Silodosin can increase the blood levels and effects of Silodosin, which may lead to side effects including extremely low blood pressure and increased heart rate.

How to manage the interaction:
Taking Itrasys 200mg Capsule with Silodosin together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
ItraconazoleTicagrelor
Critical
How does the drug interact with Itrasys 200mg Capsule:
The blood levels and effects of ticagrelor may be greatly increased when combined with Itrasys 200mg Capsule.

How to manage the interaction:
Itrasys 200mg Capsule and ticagrelor may interact, however if prescribed by a physician, they can be used together. While receiving therapy, you should consult a doctor if you develop any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Without consulting a doctor, never stop taking any medication.
ItraconazoleDisopyramide
Critical
How does the drug interact with Itrasys 200mg Capsule:
Coadministration of Itrasys 200mg Capsule with Disopyramide can reduce the metabolism and increase the levels of Disopyramide in the body. This may increase the risk or severity of side effects like irregular heart rhythms.

How to manage the interaction:
Taking Itrasys 200mg Capsule with Disopyramide together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, dizziness, irritation, confusion, chest pain or tightness, swelling, fatigue, palpitations, shortness of breath, or constipation, you should contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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ITRACONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ITRACONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming Grapefruit, Grapefruit juice with Itrasys 200mg Capsule may impair the absorption of Itrasys 200mg Capsule, resulting in decreased antifungal effects. Avoid consuming Grapefruit and grapefruit juice with Itrasys 200mg Capsule.

Diet & Lifestyle Advise

  • Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.
  • Don't walk barefoot in wet places such as changing rooms and gym showers to prevent fungal infections.
  • Do not scratch the affected area of skin, as it can spread the infection to other body parts.
  • Avoid sharing towels, combs, bedsheets, shoes or socks with others.
  • Wash your bed sheets and towels regularly.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Itrasys 200mg Capsule Substitute

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Alcohol

Unsafe

Avoid consumption of alcohol with Itrasys 200mg Capsule as it may increase the risk of liver problems and other adverse effects.

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Pregnancy

Unsafe

Itrasys 200mg Capsule is category C pregnancy drug and is unsafe for pregnant women as it may cause harm to the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Itrasys 200mg Capsule.

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Breast Feeding

Caution

Itrasys 200mg Capsule is excreted in human milk and may harm the baby. Therefore, Itrasys 200mg Capsule is given to breastfeeding mothers only if doctor thinks benefits are greater than risks.

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Driving

Caution

Itrasys 200mg Capsule may cause dizziness, hearing loss, double or blurred vision in some people. Therefore, drive only if you alert after taking Itrasys 200mg Capsule.

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Liver

Caution

Take Itrasys 200mg Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Itrasys 200mg Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Itrasys 200mg Capsule is not recommended for children below 12 years as the safety and effectiveness were not established.

FAQs

Itrasys 200mg Capsule is used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. It works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby killing fungi and clearing the fungal infection.

You are not recommended to take Itrasys 200mg Capsule with simvastatin as co-administration of these two medicines may cause muscle weakness, unexplained muscle pain or tenderness, dark coloured urine, fever or flu symptoms. However, please consult a doctor before using Itrasys 200mg Capsule with other medicines.

No, Itrasys 200mg Capsule is not recommended for use during pregnancy as it may cause harm to the fetus. Also, it is advised to use effective contraceptive measures while taking Itrasys 200mg Capsule and after 2 months of stopping treatment with Itrasys 200mg Capsule. However, please inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before taking Itrasys 200mg Capsule.

Itrasys 200mg Capsule may cause temporary or permanent hearing loss in some people. It is not necessary for everyone taking Itrasys 200mg Capsule to experience this adverse effect. However, if you notice any changes in hearing, stop taking Itrasys 200mg Capsule and consult a doctor immediately.

You are advised to take antacids (drugs used to reduce acid in the stomach) such as omeprazole, pantoprazole and esomeprazole at least 1 hour before or 2 hours after taking Itrasys 200mg Capsule as co-administration of these medicines at the same time may reduce the effectiveness of Itrasys 200mg Capsule because antacids decrease the absorption and blood levels of Itrasys 200mg Capsule. However, please consult a doctor before taking other medicines with Itrasys 200mg Capsule.

Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin to skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.

You are not recommended to stop taking Itrasys 200mg Capsule without consulting your doctor as it may cause recurring infection. Therefore, take Itrasys 200mg Capsule for as long as your doctor has prescribed it, and if you experience any difficulty while taking Itrasys 200mg Capsule, please consult your doctor.

Inform your doctor if you are sexually active and discuss effective contraception methods. Itrasys 200mg Capsule may reduce the effectiveness of oral contraceptive pills. Thus, you are advised to use barrier methods of contraception like condoms, if you are taking Itrasys 200mg Capsule.

Inform the doctor about your detailed medical and surgical history, if you have liver, kidney or heart disease or fits and if you are pregnant, breastfeeding or planning pregnancy. Inform your doctor if you are taking any other medicines including supplements or herbal products as Itrasys 200mg Capsule may interact with other medicines. Also, let your doctor know if you are stopping any medicine.

Itrasys 200mg Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.

Yes, you should swallow the capsule whole with a glass of water. Do not crush, chew or break it.

The side effects of Itrasys 200mg Capsule include nausea, headache, diarrhoea, stomach pain, fatigue (overtiredness), back pain, cough, and sore throat. If these side effects persist or worsen, please consult your doctor.

If you have taken overdose of Itrasys 200mg Capsule, please consult your doctor immediately.

Store Itrasys 200mg Capsule at room temperature. Protect from light and moisture. Keep out of reach and sight of children.

Country of origin

INDIA

Manufacturer/Marketer address

Office No. 11A ? 15, 1st Floor, Free Press House, 215, Nariman Point, Mumbai ? 400 021.
Other Info - ITR0029

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