Keytruda 100 mg Injection 4 ml

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Keytruda 100 mg Injection 4 ml

Keytruda 100 mg Injection 4 ml, Pack of 1 INJECTION

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Keytruda 100 mg Injection 4 ml is an anti-cancer medicine used in the treatment of various types of cancers in both adult and paediatric populations. It contains Pembrolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death receptor-1 (PD-1), thereby stopping the abnormal growth of cancer cells. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

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Composition :

PEMBROLIZUMAB-100MG

Manufacturer/Marketer :

Msd Pharmaceutical Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Keytruda 100 mg Injection 4 ml

Keytruda 100 mg Injection 4 ml is an anti-cancer medicine used in the treatment of various types of cancers in both adult and paediatric populations. Cancer is a disease caused due to the abnormal growth of cells that divide uncontrollably. This medicine is used in treating advanced renal cell carcinoma, hepatocellular carcinoma, colorectal cancer, non-small cell lung cancer, metastatic melanoma, small cell lung cancer, gastric cancer, classical Hodgkin’s disease, urothelial carcinoma, cervical cancer, primary mediastinal large B-cell lymphoma, endometrial cancer, microsatellite instability-high cancer, and head and neck cancer.

Keytruda 100 mg Injection 4 ml contains Pembrolizumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death receptor-1 (PD-1) and thereby stops the abnormal growth of cancer cells.

Keytruda 100 mg Injection 4 ml may cause certain side effects such as diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, cough, shortness of breath, muscle/joint pain, loss of appetite and injection site reactions. Inform your doctor if any of these side effects persist for a longer duration. Keytruda 100 mg Injection 4 ml will be administered by an oncologist. Avoid self-administration.

Avoid taking Keytruda 100 mg Injection 4 ml if you are allergic to it or any other components of it. Before taking Keytruda 100 mg Injection 4 ml, inform your doctor if you have/had liver or kidney disease, autoimmune disorders such as ulcerative colitis, Crohn’s disease, any history of organ transplants, received a stem cell transplant that uses donor stem cells (allogeneic), undergone radiation treatment to the chest or any other medical conditions. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Keytruda 100 mg Injection 4 ml

Treatment of Renal Cell Carcinoma, Hepatocellular carcinoma, Metastatic Melanoma, non-small cell lung cancer, Malignant pleural mesothelioma, Stomach Cancer, Squamous cell carcinoma of the head and neck, Cervical cancer, and Urothelial carcinoma

Directions for Use

Keytruda 100 mg Injection 4 ml will be administered by a trained oncologist in the hospital setting. Hence, do not self-administer. Your doctor will decide the dose and duration of the medicine based on the severity and type of cancer.

Medicinal Benefits

Keytruda 100 mg Injection 4 ml contains Pembrolizumab, which is used in the treatment different types of cancers. It works by inhibiting the action of a programmed death receptor-1 (PD-1) that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

How Keytruda 100 mg Injection 4 ml Works

Storage

Store in a cool and dry place away from sunlight

Side effects of Keytruda 100 mg Injection 4 ml

Inflammation Of The Colon (Large Intestine)

Manage the symptoms with medications as prescribed, and consult your doctor if symptoms persist.
Stay away from painkillers like NSAIDs (nonsteroidal anti-inflammatory drugs) and some antibiotics, as they can worsen the symptoms.
Make sure to have regular check-ups with your doctor, especially during flare-ups, and get immediate help if you have serious symptoms like dehydration or blood in your stool.
Avoid eating fried foods and foods high in fibre, as they can make your symptoms worse.
Practice stress-reduction techniques, like meditation or exercise.

Loose/ Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Itching

Here are the few steps for dealing with itching caused by drug use:

Report the itching to your doctor immediately; they may need to change your medication or dosage.
Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
Try not to scratch, as this can worsen the itching and irritate your skin.
If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Rash

Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
Protect your skin from extreme heat and try to apply wet compresses.
Soak in the cool bath, which gives a soothing impact to the affected area.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Keytruda 100 mg Injection 4 ml

As Keytruda 100 mg Injection 4 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

To treat your condition effectually, continue taking Keytruda 100 mg Injection 4 ml for the period that your doctor has prescribed. Keytruda 100 mg Injection 4 ml may cause severe immune-mediated adverse reactions (IMAR) such as immune-mediated colitis, hepatitis (hepatotoxicity), nephritis, endocrinopathies (such as adrenal insufficiency, diabetes, thyroid disorders), pneumonitis, and dermatologic reactions (such as Stevens-Johnson syndrome, epidermal necrolysis). It may also cause infusion-related reactions in some patients. Therefore, caution should be exercised if you have/had liver or kidney disease, any history of organ transplant, received a stem cell transplant that uses donor stem cells (allogeneic), undergone radiation treatment to the chest and autoimmune disorders such as ulcerative colitis, or Crohn’s disease while receiving Keytruda 100 mg Injection 4 ml. Discontinue the treatment if any severe infusion reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 2 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

PembrolizumabBetamethasone

Severe

PembrolizumabPomalidomide

Severe

Drug-Drug Interactions

PembrolizumabBetamethasone

Severe

How does the drug interact with Keytruda 100 mg Injection 4 ml:
Taking Keytruda 100 mg Injection 4 ml with betamethasone may decrease the effects of Keytruda 100 mg Injection 4 ml, which may make the medication less effective.

How to manage the interaction:
Although there is a possibility of interaction, it can be taken if prescribed by doctor. Do not stop using any medications without consulting a doctor.

PembrolizumabPomalidomide

Severe

How does the drug interact with Keytruda 100 mg Injection 4 ml:
Taking Keytruda 100 mg Injection 4 ml with Pomalidomide together may increase the risk of serious side effects.

How to manage the interaction:
Taking Keytruda 100 mg Injection 4 ml with Pomalidomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.

PembrolizumabThalidomide

Severe

How does the drug interact with Keytruda 100 mg Injection 4 ml:
Taking Keytruda 100 mg Injection 4 ml with thalidomide may increase the risk of serious side effects.

How to manage the interaction:
Although taking thalidomide and Keytruda 100 mg Injection 4 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.

PembrolizumabLenalidomide

Severe

How does the drug interact with Keytruda 100 mg Injection 4 ml:
Using lenalidomide and Keytruda 100 mg Injection 4 ml together can increase the risk of adverse effects.

How to manage the interaction:
Taking Lenalidomide with Keytruda 100 mg Injection 4 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
Eat food rich in antioxidants such as berries, spinach, etc.
Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
Avoid smoking and alcohol consumption.
Maintain a healthy weight.

Habit Forming

Therapeutic Class

ANTINEOPLASTIC

Alcohol

Consult your doctor

It is unknown whether Keytruda 100 mg Injection 4 ml interacts with alcohol. Consult your doctor.

Pregnancy

Unsafe

Keytruda 100 mg Injection 4 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Keytruda 100 mg Injection 4 ml. You should not become pregnant while you are taking Keytruda 100 mg Injection 4 ml for at least 4 months from the last dose of Keytruda 100 mg Injection 4 ml. Using effective birth control methods while on treatment is suggested.

Breast Feeding

Unsafe

Keytruda 100 mg Injection 4 ml should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and at least for 4 months from the last dose of medicine.

Driving

Caution

Keytruda 100 mg Injection 4 ml will be administered in the hospital setting. Driving is not recommended.

Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Keytruda 100 mg Injection 4 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

Children

Safe if prescribed

Keytruda 100 mg Injection 4 ml is safe for use in children above two years of age when recommended by the physician. It will be administered only if the benefits outweigh risks.

FAQs

What is the use of Keytruda 100 mg Injection 4 ml?

Keytruda 100 mg Injection 4 ml is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Metastatic Melanoma, non-small cell lung cancer, Malignant pleural mesothelioma, Stomach Cancer, Squamous cell carcinoma of the head and neck, Cervical cancer, and Urothelial carcinoma.

How does Keytruda 100 mg Injection 4 ml work?

Keytruda 100 mg Injection 4 ml contains Pembrolizumab, which works by inhibiting the action of a PD-1 that causes the multiplication of cancerous cells.

Country of origin

India

Manufacturer/Marketer address

Platina, 8Th Floor, C.59, G Block, Bandra Kurla Complex, Bandra (East) , Mumbai - 400098,

Other Info - KEY0037

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Author Details

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Composition :

Manufacturer/Marketer :

Consume Type :

Return Policy :

Expires on or after :

Drug-Drug Interactions

Drug-Food Interactions

FAQs

What is the use of Keytruda 100 mg Injection 4 ml?

How does Keytruda 100 mg Injection 4 ml work?

Disclaimer

Author Details

Reference