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compositionComposition:AMBROXOL-15MG+GUAIFENESIN-50MG+TERBUTALINE-1.25MG
prescriptionPrescription Medicine
Kofbrox Syrup

Kofbrox Syrup is used to treat cough associated with mucus. It works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Also, it increases the volume of fluid in the airways, reduces the stickiness of mucus, and removes it from the airways. It relaxes muscles and widens the airways. Thus, it makes breathing easier. Some people may experience side effects such as nausea, vomiting, drowsiness, headache, dizziness, skin rash, nervousness, tremors, stomach upset, and fast heartbeats. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMBROXOL-15MG+GUAIFENESIN-50MG+TERBUTALINE-1.25MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Kofbrox Syrup

Kofbrox Syrup is used to treat cough associated with mucus. Coughing (dry or productive) is the body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways.

Kofbrox Syrup is a combination of three drugs: Ambroxol (mucolytic agent), Guaifenesin (expectorant), and Terbutaline (bronchodilator). Ambroxol belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Terbutaline belongs to the class of bronchodilators that relax muscles and widen the airways. Thus, it makes breathing easier.

Take Kofbrox Syrup as prescribed. Your doctor will recommend how often you take Kofbrox Syrup based on your medical condition. Some people may experience nausea, vomiting, drowsiness, headache, dizziness, skin rash, nervousness, tremors, stomach upset, and fast heartbeats. Most of these side effects of Kofbrox Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Kofbrox Syrup or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Kofbrox Syrup. Use Kofbrox Syrup with caution in children if prescribed by a doctor. If you are suffering from fits or have a history of fits, please inform your doctor before taking Kofbrox Syrup as it may increase the risk of recurrent fits. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Kofbrox Syrup. If you have diabetes, fits, high blood pressure, overactive thyroid, stomach ulcers, phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body), kidney, liver, or heart problems, inform your doctor before taking Kofbrox Syrup.

Uses of Kofbrox Syrup

Kofbrox Syrup is used to treat a chesty cough. The detailed uses of Kofbrox Syrup are as follows:

  • Cough Relief: Kofbrox Syrup treats productive coughs and provides relief from respiratory congestion.
  • Mucolytic Action: Kofbrox Syrup breaks down and thins mucus, making it easier to cough up, which helps relieve respiratory congestion.
  • Bronchial Distress: Kofbrox Syrup can relieve bronchial distress by reducing inflammation and clearing mucus, benefiting conditions like bronchitis.
  • Support for Respiratory Conditions: Kofbrox Syrup supports treatment for chronic respiratory conditions like asthma and COPD by improving airflow and reducing airway obstruction.

Key Benefits

Kofbrox Syrup is a combination of three drugs, namely: Ambroxol, Guaifenesin, and Terbutaline. Ambroxol belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose for coughing out easily. Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Terbutaline is a bronchodilator that relaxes muscles and widens the airways. Thus, it makes breathing easier.

Side effects of Kofbrox Syrup
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Gently massage the affected area using your hands or a massager.
  • Light exercises such as walking or climbing stairs may help the muscles return to normal.
  • Apply heat/ice to the affected area.
  • Drink electrolyte-rich fluids.
  • Exercise regularly and maintain a healthy weight.
  • Manage cholesterol and blood pressure.
  • Limit intake of caffeine and alcohol.
  • Avoid vaping and tobacco smoke.
  • Get enough sleep.
  • Talk to your doctor about antiarrhythmic drugs or other medications to treat your condition.

Directions for Use

  • Kofbrox Syrup can be taken with or without food, or as advised by a doctor.
  • Follow your doctor's specific instructions regarding dosage and timing for better effectiveness.
  • Swallow Kofbrox Syrup as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Kofbrox Syrup Works

Kofbrox Syrup is a combination of three drugs: Ambroxol (mucolytic agent), Guaifenesin (expectorant), and Terbutaline (bronchodilator). Ambroxol belongs to the class of mucolytic agents (cough/sputum thinner) that work by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Guaifenesin belongs to the class of expectorants that increase the volume of fluid in the airways, reduce the stickiness of mucus, and remove it from the airways. Terbutaline belongs to the class of bronchodilators that relax muscles and widen the airways. Thus, it makes breathing easier.
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Alcohol

Caution

The interaction of alcohol with Kofbrox Syrup is unknown. Please consult a doctor before consuming alcohol with Kofbrox Syrup.

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Pregnancy

Caution

The safety of Kofbrox Syrup in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Kofbrox Syrup is excreted in human milk. Kofbrox Syrup is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Kofbrox Syrup may cause dizziness or drowsiness in some people. Therefore, drive only if you are alerted after taking the Kofbrox Syrup.

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Liver

Caution

Take Kofbrox Syrup with caution, especially if you have a history of liver diseases. Your doctor may adjust the dose as required.

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Kidney

Caution

Take Kofbrox Syrup with caution, especially if you have a history of Kidney diseases. Your doctor may adjust the dose as required.

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Children

Caution

Kofbrox Syrup should be used with caution in children if prescribed by a doctor.

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Heart

Unsafe

Kofbrox Syrup is not recommended for use in heart patients as it can lead to cardiovascular effects.

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Geriatrics

Unsafe

Kofbrox Syrup is not recommended for use in elderly patients as it can lead to side effects.

What if I have taken an overdose of Kofbrox Syrup

Do not take more than the prescribed dose of Kofbrox Syrup as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as they may increase mucus production. Also, avoid processed or refined foods to relieve cough. Instead, replace baked foods, fried foods, white bread, white pasta, French fries, sugary desserts, and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid dry throat while you have a cough and loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Have a query?

How Soon It Starts Working

The time required for Kofbrox Syrup to start to work: The time required for Kofbrox Syrup to start to work is 30 minutes after administration. The time for which the effects of Kofbrox Syrup last: The duration of action for Kofbrox Syrup is unknown.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

If you are allergic to Kofbrox Syrup or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Kofbrox Syrup. If you are suffering from fits or have a history of fits, please inform your doctor before taking Kofbrox Syrup as it may increase the risk of recurrent fits. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Kofbrox Syrup. Drink plenty of fluids while taking Kofbrox Syrup to loosen mucus. Drive only if you are alert after taking Kofbrox Syrup as it may cause dizziness or drowsiness in some people. If you have diabetes, fits, high blood pressure, overactive thyroid, stomach ulcers, phenylketonuria (a congenital disability that causes accumulation of amino acid, phenylalanine in the body), kidney, liver or heart problems, inform your doctor before taking Kofbrox Syrup.

Drug-Drug Interactions

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Drug-Drug Interaction: Kofbrox Syrup may have interaction with medicines used to lower high blood pressure (propranolol), antibiotics (erythromycin, doxycycline, cefuroxime, amoxicillin), water pills (furosemide), chemical messengers (epinephrine), bronchodilators (formoterol, dyphylline), anti-allergic drugs (promethazine), anti-sickness drug (ondansetron), uterine stimulant (oxytocin).

Drug-Food Interaction: Kofbrox Syrup may interact with caffeine. Therefore, avoid or limit the intake of caffeinated beverages, foods, or dietary supplements with Kofbrox Syrup as it may increase the risk of adverse effects.

Drug-Disease Interaction: If you have diabetes, fits, high blood pressure, an overactive thyroid, stomach ulcers, phenylketonuria (a birth defect that causes the accumulation of the amino acid phenylalanine in the body), kidney, liver, or heart problems, inform your doctor before taking Kofbrox Syrup.

Ambroxol + Guaifenesin + TerbutalineCarvedilol
Severe
Ambroxol + Guaifenesin + TerbutalinePropranolol
Severe

Drug-Drug Interactions

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Ambroxol + Guaifenesin + TerbutalineCarvedilol
Severe
How does the drug interact with Kofbrox Syrup:
Taking Carvedilol and Terbutaline may reduce the beneficial effects of both medications.

How to manage the interaction:
There may be a possibility of interaction between Terbutaline and Carvedilol, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Ambroxol + Guaifenesin + TerbutalinePropranolol
Severe
How does the drug interact with Kofbrox Syrup:
Using propranolol together with Kofbrox Syrup may reduce the benefits of both medications since they have opposing effects on the body. In addition, propranolol can sometimes cause breathing problems.

How to manage the interaction:
Although taking Propranolol together with Kofbrox Syrup can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience shortness of breath, chest pain, or any other breathing issues contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Ambroxol + Guaifenesin + TerbutalineAmisulpride
Severe
How does the drug interact with Kofbrox Syrup:
Using Kofbrox Syrup together with amisulpride can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Amisulpride and Kofbrox Syrup can cause an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
Ambroxol + Guaifenesin + TerbutalineEfavirenz
Severe
How does the drug interact with Kofbrox Syrup:
Taking Efavirenz and Kofbrox Syrup can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Terbutaline together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ambroxol + Guaifenesin + TerbutalinePhenelzine
Severe
How does the drug interact with Kofbrox Syrup:
Using Kofbrox Syrup together with Phenelzine can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking Phenelzine and Kofbrox Syrup together can cause an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
Ambroxol + Guaifenesin + TerbutalineGatifloxacin
Severe
How does the drug interact with Kofbrox Syrup:
Taking Gatifloxacin and Kofbrox Syrup together can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Kofbrox Syrup together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Ambroxol + Guaifenesin + TerbutalinePimozide
Severe
How does the drug interact with Kofbrox Syrup:
Using Kofbrox Syrup together with Pimozide can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Taking pimozide and Kofbrox Syrup together can cause an interaction, but it can be taken if prescribed by a doctor. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
Ambroxol + Guaifenesin + TerbutalineNilotinib
Severe
How does the drug interact with Kofbrox Syrup:
Combining Kofbrox Syrup and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Kofbrox Syrup and Nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Ambroxol + Guaifenesin + TerbutalineZiprasidone
Severe
How does the drug interact with Kofbrox Syrup:
Taking Kofbrox Syrup with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Co-administration of Ziprasidone with Kofbrox Syrup can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
Ambroxol + Guaifenesin + TerbutalineCeritinib
Severe
How does the drug interact with Kofbrox Syrup:
Taking terbutaline with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Ceritinib and Terbutaline, you can take these medicines together if prescribed by your doctor. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[EXPECTORANT AND COUGH PRODUCTS]

FAQs

Kofbrox Syrup belongs to the class of medicines called expectorants used to treat cough associated with mucus.

Kofbrox Syrup contains Ambroxol, Guaifenesin and Terbutaline. Ambroxol is a mucolytic agent (cough/sputum thinner) that thins and loosens phlegm (mucus) in the lungs, helping to cough out easily. Guaifenesin is an expectorant that increases the volume of fluid in the airways, reduces the stickiness of mucus, and helps to remove it from the airways. Terbutaline is a bronchodilator that relaxes muscles and widens the airways, making breathing easier.

Kofbrox Syrup should be used with caution in hyperthyroid (overactive thyroid) patients as it may worsen the condition. Inform your doctor if you have hyperthyroidism before taking Kofbrox Syrup so that the dose may be adjusted appropriately. However, regular monitoring of thyroid hormone levels is recommended while taking Kofbrox Syrup.

Yes, Kofbrox Syrup may cause drowsiness or dizziness. It is not necessary for everyone taking Kofbrox Syrup to experience this side effect. Therefore, avoid driving if you feel drowsy or dizzy after taking Kofbrox Syrup.

Kofbrox Syrup should be used with caution in diabetic patients if prescribed by a doctor. However, regular monitoring of blood sugar levels is recommended while taking Kofbrox Syrup as it may increase blood sugar levels.

You are recommended to take Kofbrox Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen, such as rash, fever, or persistent headache, after one week of using Kofbrox Syrup, please consult your doctor.

No, you are not recommended to stop taking Kofbrox Syrup without consulting your doctor, as it may worsen your cough or cause recurring symptoms. Therefore, take Kofbrox Syrup for as long as your doctor has prescribed it, and if you experience any difficulty while taking Kofbrox Syrup, please consult your doctor.

No, Kofbrox Syrup is not an antibiotic. It is a combination medication that belongs to the class of medications called expectorants primarily used to treat cough associated with mucus.

The side effects of Kofbrox Syrup include skin rash, nausea, vomiting, headache, dizziness, drowsiness, nervousness, tremors, stomach upset, and fast heartbeats. Most of these side effects of Kofbrox Syrup do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.

Yes, Kofbrox Syrup is considered safe for children when prescribed by a doctor. However, caution is advised, as it may not be suitable for all children. Therefore, always follow the doctor's recommended dosage and avoid self-medication to ensure safety and effectiveness for your children.

Kofbrox Syrup is specifically used to treat coughs associated with mucus production. Therefore, it is not usually recommended for dry coughs, which do not involve mucus. Other medications may be more appropriate for dry coughs. Therefore, you must consult a doctor to determine the most suitable treatment for your symptoms.

Kofbrox Syrup should not be used if you have certain medical conditions, take specific medications, or are allergic to any of its components. This is because Kofbrox Syrup may interact with other medications, worsen certain conditions, or cause allergic reactions. Consulting a doctor before using Kofbrox Syrup helps ensure safe usage and minimizes potential risks.

Taking Kofbrox Syrup higher than the recommended dose will not be more effective. Instead, it may cause an overdose and increase the risk of serious side effects. Therefore, always take Kofbrox Syrup in prescribed doses to treat your condition effectively.

Kofbrox Syrup should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.

No, Kofbrox Syrup is not an antibiotic. It is a combination medication that belongs to the expectorant class, and it is primarily used to treat coughs associated with mucus.

The common side effects of Kofbrox Syrup include skin rash, nausea, vomiting, headache, dizziness, drowsiness, nervousness, tremors, stomach upset, and fast heartbeats. Most of these side effects of Kofbrox Syrup do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.

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Country of origin

India
Other Info - KO66309
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