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  3. Lefumax-20 Tablet 10's

Lefumax-20 Tablet 10's, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lefumax-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. In some cases, Lefumax-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Triumph Remedies Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lefumax-20 Tablet

Lefumax-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefumax-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefumax-20 Tablet at the same time every day as prescribed by your doctor. In some cases, Lefumax-20 Tablet may cause common side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefumax-20 Tablet if you are pregnant or planning for pregnancy, as Lefumax-20 Tablet may cause serious congenital disabilities. Lefumax-20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefumax-20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefumax-20 Tablet as it could lead to increased dizziness and liver damage. Lefumax-20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefumax-20 Tablet

Treatment of Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

• Take Lefumax-20 Tablet with or without food as advised by your doctor. • It is usually taken once daily; however, follow your doctor’s recommendation regarding the dosage and duration. • Swallow Lefumax-20 Tablet as a whole with a glass of water. • Do not crush, chew or break it.

Medicinal Benefits

Lefumax-20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefumax-20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

How Lefumax-20 Tablet Works

Lefumax-20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Keep Lefumax-20 Tablet out of reach and sight of children.
Side effects of Lefumax-20 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

What if I have taken an overdose of Lefumax-20 Tablet

Do not take more than the prescribed dose of Lefumax-20 Tablet as it may cause overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Lefumax-20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefumax-20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefumax-20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefumax-20 Tablet may cause dizziness, so drive with caution. Lefumax-20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomidePenicillamine
Severe
LeflunomideSulfasalazine
Severe

Drug-Drug Interactions

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LeflunomidePenicillamine
Severe
How does the drug interact with Lefumax-20 Tablet:
Using penicillamine with Lefumax-20 Tablet can increase the risk of low blood levels.

How to manage the interaction:
There may be a possibility of interaction between Lefumax-20 Tablet and Penicillamine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideSulfasalazine
Severe
How does the drug interact with Lefumax-20 Tablet:
Taking sulfasalazine with Lefumax-20 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between sulfasalazine and Lefumax-20 Tablet, it can be taken if prescribed by a doctor. Contact a doctor immediately if you develop paleness, fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
LeflunomideOrlistat
Severe
How does the drug interact with Lefumax-20 Tablet:
Co-administration of Lefumax-20 Tablet and orlistat can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lefumax-20 Tablet and Orlistat can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideCorticorelin
Severe
How does the drug interact with Lefumax-20 Tablet:
Using Lefumax-20 Tablet together with Corticorelin may raise the risk of severe infections.

How to manage the interaction:
Taking Lefumax-20 Tablet with Corticorelin together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideLamivudine
Severe
How does the drug interact with Lefumax-20 Tablet:
Combining Lamivudine with Lefumax-20 Tablet can increase the risk and severity of muscle problems.

How to manage the interaction:
Although there is a possible interaction between Lamivudine and Lefumax-20 Tablet, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms it's important to contact your doctor right away: fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, stomach ache, dark urine or bleeding. Do not stop using any medications without talking to your doctor.
LeflunomideAspirin
Severe
How does the drug interact with Lefumax-20 Tablet:
Coadministration of aspirin and Lefumax-20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between aspirin and Lefumax-20 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideBrigatinib
Severe
How does the drug interact with Lefumax-20 Tablet:
Brigatinib can cause higher levels of Lefumax-20 Tablet in the blood by reducing its excretion.

How to manage the interaction:
There may be a possibility of interaction between Lefumax-20 Tablet and Brigatinib, but it can be taken if prescribed by a doctor. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideSodium Valproate
Severe
How does the drug interact with Lefumax-20 Tablet:
Co-administration of Lefumax-20 Tablet and sodium valproate can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Lefumax-20 Tablet and sodium valproate can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideEtanercept
Severe
How does the drug interact with Lefumax-20 Tablet:
Taking Lefumax-20 Tablet with etanercept may affect bone marrow functioning, resulting in a low quantity of different types of blood cells. This increases your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Co-administration of Etanercept with Lefumax-20 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
LeflunomideMeloxicam
Severe
How does the drug interact with Lefumax-20 Tablet:
When Meloxicam and Lefumax-20 Tablet are taken together, can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Lefumax-20 Tablet and Meloxicam, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefumax-20 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefumax-20 Tablet . Alcohol intake, along with Lefumax-20 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefumax-20 Tablet while you are pregnant. Lefumax-20 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefumax-20 Tablet while you are breastfeeding. Lefumax-20 Tablet passes into breast milk.

bannner image

Driving

Caution

Lefumax-20 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefumax-20 Tablet .

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefumax-20 Tablet .

bannner image

Children

Unsafe

Lefumax-20 Tablet is not approved for children under the age of 18 years.

Have a query?

FAQs

Lefumax-20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Lefumax-20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Lefumax-20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefumax-20 Tablet . Take Lefumax-20 Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

The best time to take leflunomide is usually in the morning, with food, to help minimize stomach upset. However, following your doctor's specific instructions for taking leflunomide is essential, as the optimal timing may vary depending on your needs and health status.

Lefumax-20 Tablet is not a steroid. It contains leflunomide, which is an immunomodulatory medication used to treat rheumatoid arthritis and psoriatic arthritis. Leflunomide works by reducing inflammation and slowing the progression of the disease.

Lefumax-20 Tablet may cause weight loss as a side effect. This weight loss is usually insignificant and may be due to a loss of appetite. If you experience significant weight loss, it is essential to consult your doctor.

Patients taking leflunomide should notify their doctor if they experience any unusual symptoms, side effects, or concerns. They should also keep their doctor informed about any changes in their health or medications.

Lefumax-20 Tablet takes a long time to be eliminated from your body. It is generally recommended to wait at least 2 years after stopping Lefumax-20 Tablet before planning a pregnancy. It is essential to consult your healthcare provider for personalized advice and to discuss the best plan for pregnancy after stopping Lefumax-20 Tablet .

While taking leflunomide, it's reassuring to know that the risk of cancer is extremely low. Although there's a slight increase in the risk of certain types of cancer, such as lymphoma, this is very rare. Your healthcare provider will closely monitor you and address any concerns. Regular check-ups make you feel confident and safe while managing your condition with leflunomide.

Country of origin

India

Manufacturer/Marketer address

Room No.777, S.S-Iii Type, Sector -7, Koparkhairane Navi Mumbai Thane Mh 400709 India
Other Info - LEF0070

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:35 AM IST

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Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_4276_003_FinalPL.pdf
  2. https://www.drugs.com/uk/leflunomide-10-mg-tablets-leaflet.html
  3. https://www.drugs.com/cdi/leflunomide.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
  5. https://www.gwh.nhs.uk/media/190756/leflunomide2.pdf

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