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  3. Lenafast-25 mg Capsule 21's

Lenafast-25 mg Capsule 21's, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Lenafast-25 mg Capsule 21's is used to treat cancers such as multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, and follicular lymphoma. It contains lenalidomide, which works by stimulating the immune system to attack the cancer cells. It also kills the abnormal cells in the bone marrow and helps the bone marrow to produce normal blood cells. In some cases, this medicine may cause side effects, such as fatigue, constipation, diarrhoea, and weakness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

LENALIDOMIDE-25MG

Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lenafast-25 mg Capsule 21's

Lenafast-25 mg Capsule 21's is used to treat multiple myeloma, myelodysplastic syndromes, deletion 5q MDS, mantle cell lymphoma, and follicular lymphoma. Multiple myeloma is a cancer of plasma cells that causes abnormal antibody production and bone damage.

Lenafast-25 mg Capsule 21's contains ‘lenalidomide’, which works by helping the body’s immune system and directly attacks cancer.

In some cases, you may experience certain common side effects, such as fatigue, constipation, diarrhoea, muscle cramps, nausea, headache, upper respiratory tract infection, dizziness, shortness of breath, and weakness. Talk with your doctor if you experience any of these side effects persistently.

Inform your doctor if you are allergic to Lenafast-25 mg Capsule 21's or any of its components. Avoid taking Lenafast-25 mg Capsule 21's if you are pregnant or breastfeeding. Lenafast-25 mg Capsule 21's may cause dizziness, sleepiness, tiredness, and blurred vision, so drive only if you are alert. Men and women taking Lenafast-25 mg Capsule 21's must use effective contraception.

Uses of Lenafast-25 mg Capsule 21's

Lenafast-25 mg Capsule 21's is used in the treatment of certain types of blood cancers and related disorders. The detailed uses of Lenafast-25 mg Capsule 21's include:

  • Treatment of multiple myeloma: Lenafast-25 mg Capsule 21's is used in combination with other medicines to treat patients with multiple myeloma, a cancer of plasma cells.
  • Management of myelodysplastic syndromes (MDS): Lenafast-25 mg Capsule 21's is effective in treating certain types of MDS, a group of disorders caused by poorly formed or dysfunctional blood cells.
  • Treatment of mantle cell lymphoma: Lenafast-25 mg Capsule 21's is used to manage mantle cell lymphoma, a rare and aggressive type of non-Hodgkin’s lymphoma.
  • Treatment of follicular lymphoma: Lenafast-25 mg Capsule 21's may be used in adults with follicular lymphoma, a slow-growing type of non-Hodgkin’s lymphoma, especially after prior treatment failure.

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Directions for Use

  • Lenafast-25 mg Capsule 21's can be taken with or without food.
  • It is usually taken once daily or as prescribed by your doctor.
  • Swallow Lenafast-25 mg Capsule 21's as a whole with a glass of water.
  • Do not crush, chew, or open it.

Medicinal Benefits

  • Lenafast-25 mg Capsule 21's is used to treat multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, and follicular lymphoma.
  • Lenafast-25 mg Capsule 21's works by helping the body’s immune system and directly attacks cancer. 
  • This medicine stops the development of cancer cells, prevents the growth of blood vessels in cancer, and stimulates the part of the immune system that attacks cancer cells.
  • Lenafast-25 mg Capsule 21's kills the abnormal cells in the bone marrow and helps the bone marrow to produce normal blood cells.
  • Lenafast-25 mg Capsule 21's is used to treat a type of myelodysplastic syndrome (MDS) known as deletion 5q MDS, where part of chromosome 5 is missing.

How Lenafast-25 mg Capsule 21's Works

Lenafast-25 mg Capsule 21's contains lenalidomide, which works by helping the body's immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels from growing in cancer, and stimulates the part of the immune system to attack the cancer cells. Lenafast-25 mg Capsule 21's kills the abnormal cells in the bone marrow and helps the bone marrow to produce normal blood cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Lenafast-25 mg Capsule 21's out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Lenafast-25 Capsule
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Lenafast-25 mg Capsule 21's

Take Lenafast-25 mg Capsule 21's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause serious side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Lenafast-25 mg Capsule 21's if you are allergic to any of its components.
  • Inform your doctor if you have/had blood clots, a heart attack, neuropathy, a slow heart rate, high blood pressure, low blood pressure, high cholesterol levels, infections/signs of infections, a viral infection, HIV, hepatitis B, epilepsy, liver or kidney problems.
  • Do not take Lenafast-25 mg Capsule 21's if you are pregnant, as it might cause severe birth defects or the death of the unborn baby.
  • Avoid taking Lenafast-25 mg Capsule 21's if you are breastfeeding, as it is unknown if it passes into breastmilk.
  • Lenafast-25 mg Capsule 21's may cause dizziness, sleepiness and blurred vision, so drive only if you are alert. Lenafast-25 mg Capsule 21's is not recommended for use in children.
  • Avoid consuming alcohol along with Lenafast-25 mg Capsule 21's as it could lead to increased dizziness and sleepiness.
  • Let your doctor know regarding your health condition and medications you are taking, including over the counter and herbal products.

Drug-Drug Interactions

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LenalidomideAnakinra
Critical
LenalidomideBCG vaccine
Critical

Drug-Drug Interactions

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LenalidomideAnakinra
Critical
How does the drug interact with Lenafast-25 Capsule:
Taking anakinra with Lenafast-25 Capsule can increase the risk of negative side effects.

How to manage the interaction:
Taking Lenafast-25 Capsule with Anakinra is not recommended, but it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
LenalidomideBCG vaccine
Critical
How does the drug interact with Lenafast-25 Capsule:
Combining the BCG vaccine with Lenafast-25 Capsule increases the risk of vaccine-related infections or a diminished vaccine response.

How to manage the interaction:
Taking Lenafast-25 Capsule with BCG vaccine is not recommended, but it can be taken if prescribed by a doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
LenalidomideRotavirus vaccine
Critical
How does the drug interact with Lenafast-25 Capsule:
Administering the Rotavirus vaccine together with Lenafast-25 Capsule may increase the risk of infections.

How to manage the interaction:
Taking Lenafast-25 Capsule with the Rotavirus vaccine is not recommended, but it can be taken if prescribed by a doctor. It is recommended to take the rotavirus vaccine a few weeks after the treatment with Lenafast-25 Capsule. Do not stop using any medications without consulting a doctor.
LenalidomideYellow fever vaccine
Critical
How does the drug interact with Lenafast-25 Capsule:
When combining the Yellow fever vaccine with Lenafast-25 Capsule, there's an increased risk of vaccine-related infections or a diminished vaccine response.

How to manage the interaction:
Taking Lenafast-25 Capsule with Yellow fever vaccine is not recommended, but it can be taken if prescribed by a doctor. However, contact a doctor if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
LenalidomideFingolimod
Severe
How does the drug interact with Lenafast-25 Capsule:
Taking Lenafast-25 Capsule with Fingolimod can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Lenafast-25 Capsule and Fingolimod, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LenalidomideVedolizumab
Severe
How does the drug interact with Lenafast-25 Capsule:
Combining Lenafast-25 Capsule with Vedolizumab can increase the chances of experiencing harmful side effects.

How to manage the interaction:
Taking Lenafast-25 Capsule with Vedolizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor if you experience any symptoms of infection, such as chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort, or burning during urination. Do not stop using any medications without first talking to your doctor.
LenalidomideNivolumab
Severe
How does the drug interact with Lenafast-25 Capsule:
These drugs together may raise the likelihood of adverse effects.

How to manage the interaction:
There may be a possibility of interaction between Lenafast-25 Capsule and Nivolumab, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
LenalidomideCertolizumab
Severe
How does the drug interact with Lenafast-25 Capsule:
Coadministration of Lenafast-25 Capsule with certolizumab can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Lenafast-25 Capsule and certolizumab, it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing, immediately contact your doctor. Do not discontinue any medications without consulting a doctor.
LenalidomideBaricitinib
Severe
How does the drug interact with Lenafast-25 Capsule:
Coadministration of baricitinib and Lenafast-25 Capsule can raise your risk of developing serious infections.

How to manage the interaction:
Although there is an interaction between baricitinib and Lenafast-25 Capsule, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood while coughing, weight loss, red or irritated skin, body sores, and discomfort, consult a doctor. Do not discontinue any medications without consulting a doctor.
LenalidomideRosuvastatin
Severe
How does the drug interact with Lenafast-25 Capsule:
Co-administration of rosuvastatin with Lenafast-25 Capsule may increase the risk of a rare condition called rhabdomyolysis (breakdown of skeletal muscle tissue).

How to manage the interaction:
Although there is an interaction between Lenafast-25 Capsule and rosuvastatin, it can be taken if prescribed by a doctor. However, if you experience muscle pain, tenderness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include food rich in iron, such as lean red meat, raisins, bell peppers, Brussel sprouts, and broccoli.
  • To prevent constipation, consume fibre-rich foods such as whole grains, broccoli, dried fruits, nuts, beans, apples, oranges, and pears.

Habit Forming

No

Therapeutic Class

IMMUNOMODULATORS

Lenafast-25 mg Capsule 21's Substitute

Substitutes safety advice
bannner image

Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lenafast-25 mg Capsule 21's as it might cause increased dizziness.

bannner image

Pregnancy

Unsafe

Lenafast-25 mg Capsule 21's should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of childbearing age. Inform your doctor if you are pregnant, think you are pregnant or are planning a pregnancy.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Lenafast-25 mg Capsule 21's as it is unknown if Lenafast-25 mg Capsule 21's passes into breastmilk.

bannner image

Driving

Unsafe

Lenafast-25 mg Capsule 21's may cause dizziness, sleepiness, and blurred vision. Do not drive or operate heavy machinery unless you are alert.

bannner image

Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Lenafast-25 mg Capsule 21's is not recommended for children below 18 years as the safety and effectiveness have not been established.

FAQs

Lenafast-25 mg Capsule 21's is used to treat multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, and follicular lymphoma. It is also used to treat a type of myelodysplastic syndrome (MDS) known as deletion 5q MDS, where part of chromosome 5 is missing.

Lenafast-25 mg Capsule 21's works by helping the body immune system and directly attacks cancer. It stops the development of cancer cells, stops the blood vessels growing in cancer, and stimulates the part of the immune system to attack the cancer cells.

Do not stop taking Lenafast-25 mg Capsule 21's on your own. You are advised to take Lenafast-25 mg Capsule 21's for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Lenafast-25 mg Capsule 21's.

No, it is not safe to father a child while taking Lenafast-25 mg Capsule 21's. Lenafast-25 mg Capsule 21's can pass into human semen. During sexual activity with females of reproductive potential, always use effective contraception such as latex or synthetic condom while taking Lenafast-25 mg Capsule 21's and for at least 4weeks after discontinuing Lenafast-25 mg Capsule 21's, even if you have undergone a successful vasectomy. Male patients taking Lenafast-25 mg Capsule 21's must not donate semen whilst taking Lenafast-25 mg Capsule 21's and for 4weeks after discontinuing Lenafast-25 mg Capsule 21's.

Patients taking Lenafast-25 mg Capsule 21's must not donate blood during the treatment with Lenafast-25 mg Capsule 21's and for 1month after discontinuation of Lenafast-25 mg Capsule 21's as the donated blood might be given to pregnant women whose foetus should not be exposed to Lenafast-25 mg Capsule 21's since it causes severe birth defects.

People with multiple myeloma taking Lenafast-25 mg Capsule 21's may have an increased risk for blood clots in veins, arteries, and lungs. The risk is even higher if you are taking dexamethasone with Lenafast-25 mg Capsule 21's for treating multiple myeloma. Consult your doctor immediately if you notice symptoms such as shortness of breath, chest pain, and swelling in the legs or arm.

Lenafast-25 mg Capsule 21's might cause neutropenia (low white blood cells) or thrombocytopenia (low platelets). Blood count should be checked regularly during treatment with Lenafast-25 mg Capsule 21's.

You should take Lenafast-25 mg Capsule 21's at the same time every day. You can take the capsules with or without food.

Dose adjustment may be necessary. Please consult your doctor if you have kidney impairment or any concerns regarding this.

Some people treated with Lenafast-25 mg Capsule 21's may rarely get other cancers. Consult your doctor for more details.

Yes, you will need to get regular blood tests while taking Lenafast-25 mg Capsule 21's. Your doctor may suggest taking tests before and during treatment.

Yes, even women with fertility difficulties must take birth control while taking this medication. You must also take a negative pregnancy test 10 to 14 days before treatment and again 24 hours before. You will be tested for pregnancy every 2 to 4 weeks while on Lenafast-25 mg Capsule 21's.

Lenafast-25 mg Capsule 21's contains Lenalidomide as an active ingredient.

Common side effects of Lenafast-25 mg Capsule 21's may include fatigue, constipation, diarrhoea, muscle cramps, nausea, headache, upper respiratory tract infection, dizziness, shortness of breath, and weakness. Talk with your doctor if you persistently experience any of these side effects.

Lenafast-25 mg Capsule 21's should not be taken during pregnancy as it causes severe birth defects or death to an unborn baby. Use highly effective contraception if you are a woman of childbearing age. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.

Avoid breastfeeding while taking Lenafast-25 mg Capsule 21's as it is unknown if Lenafast-25 mg Capsule 21's passes into breastmilk.

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - LEN0187

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 22, 2025 | 8:54 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.347.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021880s034lbl.pdf
  3. https://www.drugs.com/mtm/lenalidomide.html
  4. https://medlineplus.gov/druginfo/meds/a608001.html
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