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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Levo-Anawin 0.5% 4ml Injection is used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It contains Bupivacaine, which works by blocking the transmission of pain signals and numbing the area. In some cases, this medicine may cause side effects such as weakness, numbness or tingling, restlessness, drowsiness, headache, nausea and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Synonym :

BUPIVACAINE HYDROCHLORIDE

Composition :

BUPIVACAINE-0.5%

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Levo-Anawin 0.5% 4ml Injection

Levo-Anawin 0.5% 4ml Injection belongs to the class of 'local anaesthetics', primarily used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It produces local numbness and relieves pain. Levo-Anawin 0.5% 4ml Injection is given in the form of an epidural injection at the spinal cord to prevent pain during labour and Caesarean section. Pain is a symptom triggered by the nervous system, which causes uncomfortable sensations in the body. Pain may be dull or sharp, and it might be constant or intermittent. The tolerance level of pain might vary from person to person.

Levo-Anawin 0.5% 4ml Injection contains 'Bupivacaine' that belongs to the group of medicines called 'amide-type anaesthetics'. Bupivacaine is a numbing medication that blocks the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus, Levo-Anawin 0.5% 4ml Injection helps in numbing the area and provides relief from pain.

Your doctor will decide the dose and duration based on the severity of your pain and response to treatment. Common side effects of Levo-Anawin 0.5% 4ml Injection include weakness, numbness or tingling, restlessness, drowsiness, tremors or shakiness, headache, blurred vision, irregular heartbeat, chills or shivering, back pain, nausea and vomiting. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor if you have liver, kidney or heart diseases, high or low blood pressure, excess fat in the body and breathing problems before starting Levo-Anawin 0.5% 4ml Injection. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother before using Levo-Anawin 0.5% 4ml Injection. Levo-Anawin 0.5% 4ml Injection causes drowsiness, so do not drive until you are mentally alert. Avoid alcohol to further prevent the worsening of side effects like drowsiness. Levo-Anawin 0.5% 4ml Injection is not recommended for children less than one year of age.

Uses of Levo-Anawin 0.5% 4ml Injection

Levo-Anawin 0.5% 4ml Injection is used to relieve pain. The detailed uses of Levo-Anawin 0.5% 4ml Injection are as follows:

  • Surgical anaesthesia: Effectively numbs the surgical area, helping prevent pain during major or minor operations.
  • Labour pain relief: Administered as an epidural injection to ease pain during childbirth without affecting consciousness.
  • Dental procedures: Used to numb the mouth, gums, or jaw to ensure a pain-free dental treatment.
  • Minor surgeries: Provides localised numbness aiding minor surgeries.

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Directions for Use

  • Levo-Anawin 0.5% 4ml Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer it.

Medicinal Benefits

Levo-Anawin 0.5% 4ml Injection contains 'Bupivacaine,' a local anaesthetic used to relieve pain and discomfort during labour, surgery, dental treatment and other medical procedures. It works by blocking the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus, Levo-Anawin 0.5% 4ml Injection helps in numbing the localised area and provides relief from pain. Levo-Anawin 0.5% 4ml Injection, when injected as an epidural injection at the spinal cord, it prevents pain during labour and Caesarean section.

How Levo-Anawin 0.5% 4ml Injection Works

Levo-Anawin 0.5% 4ml Injection contains 'Bupivacaine' that belongs to the group of medicines called 'amide-type anaesthetics'. Bupivacaine is a numbing medication that blocks the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus, Levo-Anawin 0.5% 4ml Injection helps in numbing the area and provides relief from pain.

Storage

• Store in a cool and dry place away from sunlight.• Keep Levo-Anawin 0.5% 4ml Injection out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Levo-Anawin 0.5% 4ml Injection

Since Levo-Anawin 0.5% 4ml Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Brief your medical history to the doctor if you have any liver, kidney or heart diseases, high or low blood pressure, excess fat in the body, breathing problems, excess fluid in womb during pregnancy (a condition called hydramnios), a tumour of the ovary, blood poisoning (septicaemia) and fluid around lungs before starting Levo-Anawin 0.5% 4ml Injection. Let your doctor know if you use any prescription and non-prescription medications, including vitamins and herbal supplements, before starting Levo-Anawin 0.5% 4ml Injection. Levo-Anawin 0.5% 4ml Injection may affect the foetus when used by a pregnant mother. It is also released into breast milk during breastfeeding. Please consult your doctor if you are pregnant, planning to conceive or a breastfeeding mother. Levo-Anawin 0.5% 4ml Injection causes dizziness and drowsiness, so do not drive until you are mentally alert. Avoid alcohol to prevent the worsening of side effects further. Levo-Anawin 0.5% 4ml Injection is not recommended in children younger than one year of age.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Coadministration of Phenytoin and Levo-Anawin 0.5% 4ml Injection can induce methemoglobinemia (a condition in which the iron in the hemoglobin molecule - the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levo-Anawin 0.5% 4ml Injection and phenytoin together may cause an interaction, it is safe to do so if a doctor has prescribed it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Taking Levo-Anawin 0.5% 4ml Injection and Hydroxycarbamide may cause methemoglobinemia (a rare disorder in which the iron in the hemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately).

How to manage the interaction:
Although taking hydroxycarbamide and Levo-Anawin 0.5% 4ml Injection together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineEtidocaine
Severe
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Combining Levo-Anawin 0.5% 4ml Injection with etidocaine can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
Although there is a possible interaction between Etidocaine and Levo-Anawin 0.5% 4ml Injection, you can take these medicines together if prescribed by your doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Taking Levo-Anawin 0.5% 4ml Injection and Flutamide may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levo-Anawin 0.5% 4ml Injection and Flutamide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Taking Lidocaine with Levo-Anawin 0.5% 4ml Injection may cause serious side effects including methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells), brain related problems and heart problems.

How to manage the interaction:
There may be a possibility of interaction between Lidocaine and Levo-Anawin 0.5% 4ml Injection, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop pale, gray, or blue colored skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without talking to a doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Taking Levo-Anawin 0.5% 4ml Injection and Trimethoprim may cause methemoglobinemia, (blood disorder that affects how red blood cells deliver oxygen throughout the body).

How to manage the interaction:
Although there is an interaction between Levo-Anawin 0.5% 4ml Injection and trimethoprim, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, headache, dizziness, lightheadedness, fatigue, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Coadministration of Primaquine and Levo-Anawin 0.5% 4ml Injection can induce methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levo-Anawin 0.5% 4ml Injection and primaquine together may cause an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, breathing difficulty, rapid or shallow breathing, a rapid heartbeat, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineMepivacaine
Severe
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Combining Levo-Anawin 0.5% 4ml Injection with Mepivacaine can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
Although taking Mepivacaine and Levo-Anawin 0.5% 4ml Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Coadministration of Levo-Anawin 0.5% 4ml Injection and sulfasalazine may result in methemoglobinemia, an uncommon disorder that lowers the blood's ability to carry oxygen, which can induce oxygen deprivation in tissues and essential organs.

How to manage the interaction:
Although taking Levo-Anawin 0.5% 4ml Injection and sulfasalazine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Levo-Anawin 0.5% 4ml Injection:
Taking Levo-Anawin 0.5% 4ml Injection and Nitrofurantoin may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Taking Levo-Anawin 0.5% 4ml Injection and nitrofurantoin together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

LOCAL ANESTHETICS
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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking Levo-Anawin 0.5% 4ml Injection. Alcohol intake, along with Levo-Anawin 0.5% 4ml Injection, may cause increased drowsiness.

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Pregnancy

Caution

Levo-Anawin 0.5% 4ml Injection is a pregnancy category C drug. Please consult your doctor before taking Levo-Anawin 0.5% 4ml Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Levo-Anawin 0.5% 4ml Injection is excreted into the breast milk. Please consult your doctor before taking Levo-Anawin 0.5% 4ml Injection if you are a nursing mother.

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Driving

Unsafe

Levo-Anawin 0.5% 4ml Injection may make you feel dizzy and drowsy that can affect your ability to drive. Do not drive or operate machinery if you experience these side effects.

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Liver

Caution

Please consult your doctor since Levo-Anawin 0.5% 4ml Injection should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor since Levo-Anawin 0.5% 4ml Injection should be used with caution in patients with kidney impairment/kidney disease.

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Children

Caution

Levo-Anawin 0.5% 4ml Injection is not recommended in children, unless prescribed by a doctor.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Levo-Anawin 0.5% 4ml Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Levo-Anawin 0.5% 4ml Injection in elderly patients. Please consult your doctor.

FAQs

Country of origin

India

Manufacturer/Marketer address

140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - LEV0526

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