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  3. Lofu 40mg Tablet

Lofu 40mg Tablet, Pack of 1 Tablet
Lofu 40mg Tablet, Pack of 1 Tablet
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Lofu 40mg Tablet is used to prevent severe gout attacks or flares. It contains Febuxostat, which reduces the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation. It may cause common side effects such as nausea, rash, dizziness, diarrhoea, pain, inaccurate liver function test results, gout flare-ups (intense joint pain that comes on suddenly, often in the middle of the night), and localised swelling due to retention of fluids in tissues (oedema). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

FEBUXOSTAT-40MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lofu 40mg Tablet

Lofu 40mg Tablet belongs to a class of anti-gout medications, also known as xanthine oxidase inhibitors, widely used to prevent severe gout attacks or flares. Gout is a chronic condition caused by the deposition of uric acid crystals in the joints. It is characterised by intense pain and swelling at the affected joints. Lofu 40mg Tablet prevents the sudden attacks of pain caused by severe gout and decreases pain, swelling, and inflammation.

Lofu 40mg Tablet contains febuxostat. It works by inhibiting the enzyme xanthine oxidase (an enzyme that helps your body make uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation. Lofu 40mg Tablet is used to prevent gout attacks or flares.

Your doctor will advise you on how often you should take off the Lofu 40mg Tablet based on your medical condition. The common side effects of Lofu 40mg Tablet nausea, rash, dizziness, diarrhoea, pain, rash, inaccurate liver function test results, gout flare-ups (intense joint pain that comes on suddenly, often in the middle of the night), localized swelling due to retention of fluids in tissues (oedema). Most of these side effects of Lofu 40mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Do not stop taking a Lofu 40mg Tablet of your own. Stopping it may worsen your condition and increase the risk of increased uric acid levels and future gout attacks. Inform your doctor if you are allergic to Lofu 40mg Tablet or any other medicines, have a heart problem (Lofu 40mg Tablet may cause heart problems that can lead to a heart attack), or have kidney/liver disease. Some people experience more gout flare-ups when they start taking Lofu 40mg Tablet. You should continue taking this drug even if gout flare-ups occur. Your doctor may prescribe a combination therapy to prevent flare-ups when you start Lofu 40mg Tablet. The safety and effectiveness of children under 18 years of age have not been established, so Lofu 40mg Tablet should not be given to them. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Lofu 40mg Tablet.

Uses of Lofu 40mg Tablet

Lofu 40mg Tablet is used to treat severe gout and prevent gout attacks. The detailed uses of Lofu 40mg Tablet are as follows:
• Gout Management: Lofu 40mg Tablet helps to manage gout by lowering uric acid levels, reducing pain, redness, and swelling in the joints.
• Chronic Kidney Disease Support: Lofu 40mg Tablet also supports patients with chronic kidney disease by managing uric acid levels, which can help in protecting kidney function.
• Prevention of Gout Attacks: Lofu 40mg Tablet is also involved in preventing gout attacks by keeping uric acid levels normal, reducing the frequency of painful episodes.
• Uric Acid Nephrolithiasis Prevention: Lofu 40mg Tablet can prevent uric acid kidney stones by reducing uric acid levels, lowering the risk of related complications.
• Treatment of Tumor Lysis Syndrome: Lofu 40mg Tablet manages tumor lysis syndrome in chemotherapy patients by preventing high uric acid levels caused by rapid cell breakdown.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Lofu 40mg Tablet is a class of medications called xanthine oxidase inhibitors (enzymes that help your body make uric acid). It works by inhibiting the enzyme xanthine oxidase, thereby reducing the level of uric acid that is made in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation. Lofu 40mg Tablet is used to prevent gout attacks or flares.

How Lofu 40mg Tablet Works

Lofu 40mg Tablet contains febuxostat. It works by inhibiting the enzyme xanthine oxidase (an enzyme that helps your body make uric acid), thereby reducing the level of uric acid in your body. Thus, it reduces the inflammation caused by uric acid crystals in affected joints, thereby reducing pain, swelling and inflammation. Lofu 40mg Tablet is used to prevent gout attacks or flares.

Storage

Store in a cool and dry place away from sunlight
Side effects of Lofu 40mg Tablet
  • Drink plenty of water to eliminate uric acid.
  • Avoid purine-rich foods such as red meat, organ meats, certain seafood (sardines, anchovies) and too much alcohol.
  • Regularly do low impact exercises like swimming or walking.
  • To reduce pain and swelling, apply ice packs to the affected area.
  • Take rest and avoid activities that strain the affected joint.
  • Elevate the affected joint to encourage fluid drainage.
  • Aim for weight loss and maintain a healthy body weight to reduce the risk of gout.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Lofu 40mg Tablet

Do not take more than the prescribed dose of Lofu 40mg Tablet as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

You should avoid taking Lofu 40mg Tablet if you are allergic to Lofu 40mg Tablet, or have heart-related problems, as it increases the risk of a heart attack. It should be used cautiously in patients with kidney problems and blood disorders. Caution is required before taking Lofu 40mg Tablet if you are pregnant, planning to become pregnant, or are already breastfeeding. The safety and effectiveness of children under 18 years of age have not been established, so Lofu 40mg Tablet should not be given to them.

Drug-Drug Interactions

verifiedApollotooltip
FebuxostatAzathioprine
Critical
FebuxostatMercaptopurine
Critical

Drug-Drug Interactions

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FebuxostatAzathioprine
Critical
How does the drug interact with Lofu 40mg Tablet:
Taking azathioprine and Lofu 40mg Tablet together can increase the blood levels of azathioprine

How to manage the interaction:
Taking Azathioprine with Lofu 40mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
FebuxostatMercaptopurine
Critical
How does the drug interact with Lofu 40mg Tablet:
Coadministration of Mercaptopurine with Lofu 40mg Tablet can increase the blood levels of mercaptopurine.

How to manage the interaction:
Taking Mercaptopurine with Lofu 40mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.
FebuxostatKetoconazole
Severe
How does the drug interact with Lofu 40mg Tablet:
Coadministration of Lofu 40mg Tablet with ketoconazole can increase the risk of liver problems.

How to manage the interaction:
Although taking Lofu 40mg Tablet with Ketoconazole can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
FebuxostatLeflunomide
Severe
How does the drug interact with Lofu 40mg Tablet:
Coadministration of Lofu 40mg Tablet with leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although taking Lofu 40mg Tablet with Leflunomide can result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.
FebuxostatTeriflunomide
Severe
How does the drug interact with Lofu 40mg Tablet:
Coadministration of Teriflunomide with Lofu 40mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Lofu 40mg Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.
FebuxostatMipomersen
Severe
How does the drug interact with Lofu 40mg Tablet:
Coadministration of Lofu 40mg Tablet with Mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lofu 40mg Tablet with Mipomersen can result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.
FebuxostatLomitapide
Severe
How does the drug interact with Lofu 40mg Tablet:
Coadministration of Lofu 40mg Tablet with lomitapide can increase the risk of liver problems.

How to manage the interaction:
Although taking Lofu 40mg Tablet with Lomitapide can result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulfate, vitamin D, and calcium-enriched supplements. Turmeric and fish can also help reduce inflammation in the tissue.

  • Please do not go for heavy exercise as it may increase your joint pain and arthritis. Instead, you can do low-impact aerobic movements like walking on a treadmill and swimming. You can also strengthen your muscles by lifting light weights.
  • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use a back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. You can also use a footrest if required.
  • Avoid a high purine-rich diet, including organ meats (kidneys, liver, and sweetbreads) and oily fish (sardines, anchovies, and herring).
  • Limit meat in favour of plant-based proteins like beans and legumes.
  • Eat complex carbohydrates, such as whole-grain bread, fruits, and vegetables, rather than sugary sweets and refined carbohydrates like white bread.
  • Avoid drinking beer and alcoholic beverages, and drink plenty of water or other nonalcoholic beverages.

Habit Forming

No

Therapeutic Class

ANTI- GOUT MEDICATIONS

Lofu 40mg Tablet Substitute

Substitutes safety advice

  • Febustat 40 Tablet 15's

    by AYUR

    ₹19.62per tablet

  • Feburic 40 Tablet 15's

    by AYUR

    ₹14.49per tablet

  • Febutaz 40 Tablet 15's

    by AYUR

    ₹14.73per tablet

  • Febuget 40 Tablet 15's

    by AYUR

    ₹13.50per tablet

  • Furic 40 mg Tablet 15's

    by AYUR

    ₹15.39per tablet

Product Substitutes

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Alcohol

Caution

You should avoid taking alcohol while taking Lofu 40mg Tablet because alcohol may affect Lofu 40mg Tablet effectiveness.

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Pregnancy

Caution

Lofu 40mg Tablet should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Caution

There is limited data on how Lofu 40mg Tablet affects breastfeeding. Please consult your doctor before starting Lofu 40mg Tablet.

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Driving

Caution

Do not drive or operate machinery if you experience sleepiness, blurred vision and numbness or tingling sensation while using Lofu 40mg Tablet. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Let your doctor know if you have any history of liver disease or hepatic impairment. Your doctor will weigh the benefits and any potential risks before prescribing Lofu 40mg Tablet.

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Kidney

Caution

Lofu 40mg Tablet should be used with caution in patients with renal impairment. The doctor may adjust the dose depending on your condition.

bannner image

Children

Caution

Lofu 40mg Tablet is not recommended for children below the age of 18 years. The safety and efficacy of Lofu 40mg Tablet have not been established in children due to limited testing of this drug on children.

Have a query?

FAQs

Lofu 40mg Tablet is used to prevent severe gout attacks or flares. It prevents the sudden attacks of pain caused by severe gout and decreases pain, swelling, and inflammation.

Lofu 40mg Tablet is a class of antigout drugs called xanthine oxidase inhibitors. It works by decreasing a high amount of uric acid to the normal level that is made in the body. Lofu 40mg Tablet is used to prevent gout attacks but not to treat them once they occur.

No, Do not discontinue Lofu 40mg Tablet without consulting your doctor. To treat your condition effectively, continue taking Lofu 40mg Tablet for as long as prescribed. If you stop taking Lofu 40mg Tablet, your uric acid levels will likely remain high and continue to cause gout symptoms.

Lofu 40mg Tablet is not recommended if you have heart disease; taking Lofu 40mg Tablet may cause serious heart problems, which can be life-threatening in some cases. So, please consult your doctor before taking the Lofu 40mg Tablet.

Do not drive or operate machinery if you experience dizziness or drowsiness while using Lofu 40mg Tablet.

The dose and duration of Lofu 40mg Tablet depend upon your medical condition. It may take several months before Lofu 40mg Tablet begins to prevent gout attacks. Do not stop taking Lofu 40mg Tablet without the advice of your doctor even if you feel better.

It is best taken in the morning. You can take Lofu 40mg Tablet with or without food. Keep taking Lofu 40mg Tablet every day, to prevent gout attacks.

Chronic hyperuricemia is a condition in which serum uric acid levels are higher than normal.

Hyperuricemia occurs when the body produces too much uric acid or when the kidneys are unable to excrete it properly.

Side effects of Lofu 40mg Tablet include nausea, rash, dizziness, diarrhoea, pain, rash, inaccurate liver function test results, gout flare-ups (intense joint pain that comes on suddenly, often in the middle of the night), localised swelling due to retention of fluids in tissues (oedema). Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Lofu 40mg Tablet may cause frequent urination, kidney stones, blood in urine, reduced ability to function properly, and abnormal urine tests. Talk to the doctor if you have any concerns.

You should know that Lofu 40mg Tablet may cause gout flares, cardiovascular events, and liver problems. Inform the doctor if you have kidney or liver problems, a history of heart disease or stroke, or if you are pregnant/breastfeeding.

Lofu 40mg Tablet may cause liver failure and liver function abnormalities. Consult the doctor if you notice signs of liver injury such as fatigue, right upper abdominal discomfort, jaundice, dark urine, or anorexia.

Country of origin

India
Other Info - LO70312

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

May 5, 2025 | 9:29 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/1925/smpc
  2. https://medlineplus.gov/druginfo/meds/a609020.html
  3. https://www.drugs.com/mtm/febuxostat.html
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