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compositionComposition:LORLATINIB-25MG
prescriptionPrescription Medicine
Lorbriqua 25 mg Tablet 10's is used to treat non-small cell lung cancer. It contains Lorlatinib which works by triggering the death of cancer cells. In some cases, this medicine may cause side effects such as diarrhoea, constipation, joint pain, weight gain, headache, rash, and muscle pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions. Women of childbearing potential are advised to avoid becoming pregnant while on treatment with this medicine as it may cause foetal harm.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LORLATINIB-25MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Lorbriqua 25 mg Tablet 10's

Lorbriqua 25 mg Tablet 10's belongs to the group of medicines that inhibit an enzyme called anaplastic lymphoma kinase (ALK). It is used to treat adults with advanced stages of lung cancer called non-small cell lung cancer (NSCLC). Non-small cell lung cancer is a disease in which malignant (cancer) cells form in the lung tissues. There are several types of non-small cell lung cancer. Smoking is the major risk factor for non-small cell lung cancer.

Lorbriqua 25 mg Tablet 10's contains the active substance Lorlatinib, a medicine used to treat adults with advanced stages of a form of lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for ALK. Lorbriqua 25 mg Tablet 10's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine as your doctor has told you or per the package leaflet. You must keep to your doctor's instructions to get the maximum benefit. In some cases, you may experience common side effects such as diarrhoea, constipation, joint pain, weight gain, headache, rash, and muscle pain. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Lorbriqua 25 mg Tablet 10's if you are pregnant or breastfeeding. Lorbriqua 25 mg Tablet 10's may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Lorbriqua 25 mg Tablet 10's as it could lead to increased dizziness. Lorbriqua 25 mg Tablet 10's is not recommended for children below 18 years as safety and effectiveness have not been established. Lorbriqua 25 mg Tablet 10's is listed as pregnancy category D. Because Lorbriqua 25 mg Tablet 10's can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Lorbriqua 25 mg Tablet 10's. Consult your doctor if you are breastfeeding; your doctor will decide whether Lorbriqua 25 mg Tablet 10's can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Lorbriqua 25 mg Tablet 10's may affect male fertility. Talk to your doctor about fertility preservation before taking Lorbriqua 25 mg Tablet 10's.

Uses of Lorbriqua 25 mg Tablet 10's

Lorbriqua 25 mg Tablet 10's is used in the treatment of advanced stages of non-small cell lung cancer (NSCLC). The detailed uses of Lorbriqua 25 mg Tablet 10's include:

  • Treatment of non-small cell lung cancer (NSCLC): Lorbriqua 25 mg Tablet 10's is indicated for patients with advanced or metastatic NSCLC that is positive for specific genetic mutations (such as ALK-positive), helping to slow the growth and spread of cancer cells.
  • Targeted therapy: Lorbriqua 25 mg Tablet 10's works as a targeted therapy that inhibits abnormal proteins driving cancer progression, offering improved outcomes in patients who have progressed on prior ALK inhibitor treatments.

Key Benefits

Lorbriqua 25 mg Tablet 10's contains the active substance Lorlatinib, a medicine used to treat adults with advanced stages of a form of lung cancer called non-small cell lung cancer (NSCLC). Lorbriqua 25 mg Tablet 10's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for ALK.

Directions for Use

  • Lorbriqua 25 mg Tablet 10's can be taken with or without food. However, avoid taking it with grapefruit or grapefruit juice, as they may affect the amount of Lorlatinib in your body.
  • It is usually taken once daily at the same time each day or as prescribed by your doctor.
  • Swallow Lorbriqua 25 mg Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Lorbriqua 25 mg Tablet 10's Works

Lorbriqua 25 mg Tablet 10's contains the active substance Lorlatinib, a medicine used to treat adults with advanced stages of a form of lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for ALK. Lorbriqua 25 mg Tablet 10's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.
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Alcohol

Caution

It is not known if alcohol interacts with Lorbriqua 25 mg Tablet 10's. However, as a precautionary measure, you are recommended not to consume alcohol with the Lorbriqua 25 mg Tablet 10's to avoid unpleasant side effects.

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Pregnancy

Unsafe

Lorbriqua 25 mg Tablet 10's is listed as pregnancy category D. Because Lorbriqua 25 mg Tablet 10's can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Lorbriqua 25 mg Tablet 10's.

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Breast Feeding

Unsafe

Do not breastfeed for seven days after the last dose while taking this medicine. This is because it is unknown if the Lorbriqua 25 mg Tablet 10's can pass into breast milk and could harm your baby.

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Driving

Caution

Lorbriqua 25 mg Tablet 10's moderately influences the ability to drive and use machines. Caution should be exercised when driving or operating machines, as patients may experience CNS effects.

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Liver

Caution

Inform your doctor before receiving the Lorbriqua 25 mg Tablet 10's if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Inform your doctor before receiving the Lorbriqua 25 mg Tablet 10's if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your current kidney conditions.

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Children

Unsafe

Lorbriqua 25 mg Tablet 10's is only indicated in adults, and it is not to be given to children and adolescents.

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Heart

Caution

Please consult your doctor if you have a history of heart disease before taking Lorbriqua 25 mg Tablet 10's. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Caution

Limited data is available regarding the use of Lorbriqua 25 mg Tablet 10's in elderly patients. If you have any concerns about the usage of Lorbriqua 25 mg Tablet 10's in geriatrics, please consult your doctor.

What if I have taken an overdose of Lorbriqua 25 mg Tablet 10's

Take Lorbriqua 25 mg Tablet 10's only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Have a query?

How Soon It Starts Working

The time required for Lorbriqua 25 mg Tablet 10's to start to work: Lorbriqua 25 mg Tablet 10's starts to show its action within 1 to 2 hours of administration. The time for which the effects of Lorbriqua 25 mg Tablet 10's last: Lorbriqua 25 mg Tablet 10's effect lasts for 24 hours.

What if you forget to take Lorbriqua 25 mg Tablet 10's

If you miss a dose of Lorbriqua 25 mg Tablet 10's, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep Lorbriqua 25 mg Tablet 10's out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Consult your doctor before taking Lorbriqua 25 mg Tablet 10's if you are pregnant or breastfeeding. Lorbriqua 25 mg Tablet 10's may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Lorbriqua 25 mg Tablet 10's as it could lead to increased dizziness. Lorbriqua 25 mg Tablet 10's is not recommended for children below 18 years as safety and effectiveness have not been established. Lorbriqua 25 mg Tablet 10's is listed as pregnancy category D. Because Lorbriqua 25 mg Tablet 10's can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Lorbriqua 25 mg Tablet 10's. Consult your doctor if you are breastfeeding; your doctor will decide whether the Lorbriqua 25 mg Tablet 10's can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Lorbriqua 25 mg Tablet 10's may affect male fertility. Talk to your doctor about fertility preservation before taking Lorbriqua 25 mg Tablet 10's.

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Drug-Drug Interactions: Lorbriqua 25 mg Tablet 10's may interact with various medications, including medicines used to treat fungal infections (e.g. Ketoconazole, Itraconazole), medications used to treat bacterial infections/CYP3A4 inhibitors (e.g. Erythromycin), a drug used to treat irregular heartbeat and other heart problems. (e.g. Quinidine), medications used to treat severe pain (e.g. Alfentanil and Fentanyl), medicines used in organ transplantation to prevent organ rejection (e.g. Ciclosporin, Sirolimus, and Tacrolimus), medicines used to treat AIDS/HIV (e.g. Efavirenz, Cobicistat), medications used to treat migraine headaches (e.g. Dihydroergotamine, Ergotamine ), a drug used to treat depression or to help people quit smoking (e.g. Buproprion), and medication used to treat hepatitis C (e.g. Boceprevir).

Drug-Food Interactions: You must not drink grapefruit juice or eat grapefruit while on treatment with Lorbriqua 25 mg Tablet 10's as they may change the amount of Lorbriqua 25 mg Tablet 10's in your body.

Drug-Disease Interactions: Lorbriqua 25 mg Tablet 10's should be used with caution in patients with liver disorders, kidney disorders, central nervous system (CNS) and heart disorders.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Lorbriqua 25 mg Tablet 10's is used to treat advanced stages of lung cancer called non-small cell lung cancer (NSCLC).

Lorbriqua 25 mg Tablet 10's contains the active substance Lorlatinib, which inhibits a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for ALK. Lorbriqua 25 mg Tablet 10's is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Lorlatinib belongs to the kinase inhibitor class of drugs. Lorlatinib is a drug used to treat a kind of non-small cell lung cancer (NSCLC) that has spread to other places of the body in adults. It works by preventing the malfunctioning protein from causing cancer cells to multiply.

Lorbriqua 25 mg Tablet 10's should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Lorbriqua 25 mg Tablet 10's until your doctor asks you to stop it.

Avoid smoking before starting the treatment while taking Lorbriqua 25 mg Tablet 10's as smoking might alter the effectiveness of Lorbriqua 25 mg Tablet 10's.

In elderly patients, the risk of side effects is greater. For the elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

You should complete the full course of Lorbriqua 25 mg Tablet 10's as your doctor prescribes. After completing the full course of Lorbriqua 25 mg Tablet 10's will work. It would help if you took Lorbriqua 25 mg Tablet 10's at the right dose, right times and for the right number of days.

Detecting lung cancer in its early stages, when it is most treatable, is critical to survival. Early tumours have a cure rate of 85-90 per cent, but this depends on other factors.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18Th Floor , Plot No. C-70, ˜G♠Block , Bandra Kurla Complex, Bandra East , Mumbai 400051
Other Info - LOR0973
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