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compositionComposition:ACETYLCYSTEINE-150MG+TAURINE-500MG
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Prescription Medicine
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Lupinac Tablet is used in the treatment of diabetic nephropathy (diabetic kidney disease). It contains Taurine and Acetylcysteine, which functions by shielding the kidneys from damage caused by dangerous substances (free radicals), hence assisting in the reduction of free radical generation that damages tissue. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, drowsiness, fever, abdominal pain, and rash.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ACETYLCYSTEINE-150MG+TAURINE-500MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lupinac Tablet

Lupinac Tablet is an oral prescription medicine used as supportive therapy to help protect kidney health and manage chronic kidney disease. It contains taurine and acetylcysteine, which work together to reduce oxidative stress and support healthy kidney cells. Evidence for this combination in chronic kidney disease is still evolving and is based on limited clinical studies. It is used as supportive therapy alongside standard treatment, not as a replacement for it.

For the best results, you must take Lupinac Tablet regularly and consistently at the same times every day. You can take this tablet either with or without food, but keeping your routine consistent is highly recommended. Incorporating a low-sodium diet and managing your daily fluid intake under your doctor's guidance will further help improve your treatment outcomes.

While taking this medication, some people may experience mild stomach irritation, nausea, or a metallic taste in the mouth. If you experience severe side effects, such as breathing difficulties or a severe skin rash, you should stop taking the medicine and consult your doctor immediately.

Talk to your doctor before starting Lupinac Tablet if you have a history of asthma, stomach ulcers, or severe liver issues. Do not take this if you have a known allergy to taurine, acetylcysteine, or any other inactive ingredients in the formulation.

Some medications, like certain blood pressure drugs or charcoal tablets, can interact with this medicine, while smoking and alcohol may reduce its protective effects on the kidneys. Pregnant, breastfeeding, or elderly individuals must consult their doctor or pharmacist before starting this treatment to ensure it is safe for their specific health status.
 

Uses of Lupinac Tablet

Lupinac Tablet is prescribed to support kidney health and help manage chronic kidney disease. Common uses include:

  • Chronic kidney disease: Lupinac Tablet helps delay the decline of kidney function by protecting renal cells from oxidative stress and harmful toxins.
  • Diabetic kidney disease (diabetic nephropathy): It may help protect the kidneys from cellular damage caused by chronically high blood sugar levels when used as supportive therapy. Evidence for this use is still limited, and your doctor will determine whether it is appropriate for you.
     

Key Benefits

Lupinac Tablet is used as supportive therapy to help protect kidney function by reducing oxidative stress and supporting healthy kidney cells. Regular use may help slow the progression of kidney damage in people with chronic kidney disease.

  • Supports Kidney Health: May help protect kidney cells from oxidative damage and support normal kidney function.
  • Slows Progression of Kidney Disease: May help reduce the rate of kidney function decline in some people with chronic kidney disease when used as prescribed.
  • Provides Antioxidant Protection: Helps reduce oxidative stress, which may contribute to kidney damage.
  • Supports Overall Kidney Function: May help support the kidneys' ability to filter waste products and maintain the body's fluid and electrolyte balance.
  • Promotes Long-Term Well-Being: By supporting kidney health, it may help reduce the risk of kidney disease-related complications as part of an overall treatment plan. 
     
Side effects of Lupinac Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • To help reduce symptoms, eat foods high in vitamin C, such as oranges, bell peppers and strawberries.
  • Lightly blow your nose to remove mucus; steer clear of blowing hard.
  • Infections can be prevented from spreading by washing hands frequently and staying away from other people.
  • If you have allergies, do your best to avoid triggering allergens that could contribute to a runny nose.
  • Don't smoke, as irritating the nasal passages can make a runny nose worse.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Take Lupinac Tablet with or without food or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Lupinac Tablet Works

Lupinac Tablet contains taurine and acetylcysteine, which work together to help protect your kidneys from oxidative damage. Acetylcysteine is a precursor to glutathione, one of the body's natural antioxidants. By increasing glutathione levels, it helps protect kidney cells from damage caused by harmful free radicals. Taurine is a naturally occurring amino sulfonic acid that helps regulate fluid and mineral balance in kidney cells. It may also help reduce inflammation and protect the kidneys from ongoing damage, although its role in chronic kidney disease is still being studied. Together, these ingredients help support kidney function and may slow the progression of kidney damage when used alongside standard medical care.
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Alcohol

Caution

Consumption of alcohol may worsen your health condition. Therefore, avoid alcohol consumption.

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Pregnancy

Caution

Lupinac Tablet is a category B medicine. It should be used with caution in pregnant women. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Caution

The safe use of Lupinac Tablet in breastfeeding mothers has not yet been established. So, it should be used in breastfeeding women only when prescribed by a doctor.

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Driving

Safe if prescribed

Lupinac Tablet may not affect your ability to drive.

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Liver

Caution

Lupinac Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Lupinac Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Lupinac Tablet is not recommended for use in children.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Lupinac Tablet in elderly patients. Please consult your doctor.

What if I have taken an overdose of Lupinac Tablet

If you suspect an overdose or experience severe symptoms after taking too much of this medication, seek immediate emergency medical attention or contact a poison control centre.

Diet & Lifestyle Advise

  • Limit salt intake: Reduce your sodium consumption to help manage your blood pressure and decrease the workload on your kidneys.
  • Monitor fluid intake: Drink an appropriate amount of water as recommended by your doctor; do not overhydrate or underhydrate if you have kidney impairment.
  • Manage blood sugar and blood pressure: Keep your glucose and blood pressure levels within your target range, as uncontrolled levels can accelerate kidney damage.
  • Eat a kidney-friendly diet: Talk to a dietitian about managing your protein, potassium, and phosphorus intake based on your specific kidney function stage.
health query

Have a query?

How Soon It Starts Working

The time required for Lupinac Tablet to start to work: The time required for Lupinac Tablet to show its action is unknown. The time for which the effects of Lupinac Tablet last: The effect of Lupinac Tablet lasts for 33 hours.

What if you forget to take Lupinac Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Lupinac Tablet at room temperature, below 30°C, in a cool and dry place.

Drug Warnings

  • Inspect the tablets before use: Do not take the medication if you notice any discolouration, cracks, or damage to the blister packaging.
  • Inform your doctor if you have asthma: If you have asthma or chronic obstructive pulmonary disease (COPD), tell your doctor before starting treatment. Although the risk is much lower with oral acetylcysteine than with inhaled forms, caution may still be needed in some patients.
  • Avoid taking with activated charcoal: Activated charcoal can bind to the ingredients in this medicine and reduce its absorption, making it less effective.
  • Schedule regular kidney tests: Attend all scheduled appointments for blood and urine tests so your doctor can monitor how well your kidneys are functioning.
  • Report unusual breath odor: Acetylcysteine naturally has a slight sulfur-like (rotten egg) smell when the package is opened; this is normal and not a sign of spoilage, but if the tablet tastes highly abnormal, consult your pharmacist.
     

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Lupinac Tablet :

  • Nitroglycerin: Acetylcysteine may significantly enhance the blood pressure-lowering effects of nitroglycerin, increasing the risk of dizziness, headache, or fainting. Tell your doctor if you are taking nitroglycerin, as closer monitoring or dose adjustments may be needed.
  • Activated Charcoal: Activated charcoal may reduce the absorption and effectiveness of Lupinac Tablet if taken at the same time.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

Food: No significant food interactions are known. However, take Lupinac Tablet consistently either with food or on an empty stomach, as advised by your doctor, to maintain predictable absorption.
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Lupinac Tablet is used to treat diabetic nephropathy (diabetic kidney disease).
Lupinac Tablet is a combination of two medicines: Taurine and Acetylcysteine. They both act as antioxidants that can reduce cell death and delay the progression of kidney damage in patients with diabetic nephropathy.
It is not recommended to take Lupinac Tablet with antibiotics such as tetracycline, amoxicillin, amikacin, streptomycin, and gentamicin simultaneously, as it may reduce the effectiveness of antibiotics. Please consult a doctor before using Lupinac Tablet with antibiotics or any other medicines.
Diabetic kidney disease can be prevented by controlling blood glucose levels. So, follow your doctor's advice regarding diet and medicines to achieve optimal glucose levels.
Lupinac Tablet may cause severe skin reactions rarely, though not everybody taking this medicine may experience skin reactions. However, if you notice a skin rash, including lesions on the nose, throat, mouth, genitals, or eyes, stop taking Lupinac Tablet and consult a doctor immediately.
There is limited safety data on using this medication during pregnancy. You should only take it if your doctor determines the benefits outweigh the potential risks. Talk to your doctor to discuss safer alternatives.
This is typically a long-term treatment used to slow the progression of chronic kidney disease. Your doctor will monitor your kidney health to decide how long you need to continue taking it. Talk to your doctor if you have concerns about long-term use.
Yes, the acetylcysteine component in the medicine can sometimes have a mild, sulfur-like smell when you open the package. This is completely normal for this active ingredient and does not mean the medicine has expired. Talk to your doctor or pharmacist if you find the smell intolerable.
If you have asthma, you must use this medication with caution, as it can occasionally trigger airway spasms. Your doctor will evaluate your lung health before prescribing it. Talk to your doctor immediately if you experience wheezing or chest tightness.
It is highly advisable to limit or avoid alcohol while taking this medicine, as alcohol can strain your kidneys and worsen underlying medical conditions. Talk to your doctor about what limit is safe for you.
Take the missed dose as soon as you remember, unless your next dose is due shortly. Never take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently miss doses.
This medicine can sometimes irritate the gastrointestinal tract and may not be suitable if you have active stomach ulcers. Your doctor will determine if this medication is safe for you to use. Talk to your doctor before starting this treatment.
Before taking cough syrups or any new medicine with Lupinac Tablet , tell your doctor or pharmacist about all the medicines you are using. They can check for possible interactions and advise you on the safest option for your condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.11586 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. WebMD Medical Reference Review Board. Taurine Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  3. NACSYS 600mg Effervescent Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 29 Jul 2025]Check here
  4. Viswanathan V, Nair MB, Tilak P. Effect of taurine and acetylcysteine in attenuating microalbuminuria in type 2 diabetes. Indian J Nephrol. 2008 Apr;18(2):85. [Accessed on 29 Jul 2025]Check here
  5. Abdel-Wahab WM, Moussa FI, Saad NA. Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats. Drug Des Devel Ther. [Accessed on 29 Jul 2025]Check here
  6. Kidney Disease Nephropathy. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - LUP0231
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