What is the use of Lupride Depot 45 mg Injection?

Lupride Depot 45 mg Injection belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. It is also used to treat precocious puberty (early puberty) in children and in combination with other medicines to treat anaemia caused by uterine fibroids.

How does Lupride Depot 45 mg Injection work?

Lupride Depot 45 mg Injection contains Leuprolide acetate, a synthetic hormone that helps reduce the testosterone and oestrogen hormones in men and women, respectively. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer in men and shrinks endometriosis in women.

Can Lupride Depot 45 mg Injection cause hairloss?

Lupride Depot 45 mg Injection affects the hair, making it thin which further causes loss of hair. Hair reduction possibly happens due to the estrogen lowering effect of Lupride Depot 45 mg Injection. These effects are not long-lasting and may return after some time. If you have any concerns, contact your doctor for further advice.

Does Lupride Depot 45 mg Injection affect fertility in men?

Lupride Depot 45 mg Injection may cause impotence and affect fertility in men. It is advised to speak to your doctor if you plan to have a family in the future before starting Lupride Depot 45 mg Injection.

Can a diabetic patient take Lupride Depot 45 mg Injection?

Lupride Depot 45 mg Injection should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, regular monitoring of blood sugar levels is recommended while taking Lupride Depot 45 mg Injection and inform your doctor if you have diabetes before taking Lupride Depot 45 mg Injection.

I am being treated for depression, can I use Lupride Depot 45 mg Injection?

Lupride Depot 45 mg Injection may worsen your mood disorders like depression. Hence it is advised to use Lupride Depot 45 mg Injection only when you are free from any kind of mental problems. Please consult your doctor for more information.

Does Lupride Depot 45 mg Injection cause osteoporosis (brittle bones)?

Lupride Depot 45 mg Injection may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Lupride Depot 45 mg Injection.

Is Lupride Depot 45 mg Injection safe for patients suffering from heart rhythm problems?

Lupride Depot 45 mg Injection is not recommended for patients suffering from heart rhythm problems such as arrhythmia (irregular heartbeat) as it may increase the risk of cardiac disease. Therefore, inform your doctor if you have any heart problems before taking Lupride Depot 45 mg Injection.

Does Lupride Depot 45 mg Injection stop periods?

Lupride Depot 45 mg Injection may stop periods because it alters reproductive hormones in females. Additionally, people treated with Lupride Depot 45 mg Injection may experience menstruation or spotting in the first 2 months. If bleeding persists beyond 2 months, consult your doctor.

Is Lupride Depot 45 mg Injection a hormonal medicine and can it be given in pregnancy?

Yes, Lupride Depot 45 mg Injection is a hormonal medicine. Leuprolide acetate is a pregnancy category X drug. It should not be used during pregnancy because it may cause harm to the foetus.

Can Lupride Depot 45 mg Injection cause diabetes or increased blood sugar?

Lupride Depot 45 mg Injection may increase the risk of high blood sugar levels. Therefore, it should be used with caution in diabetic patients. Consult your doctor if you notice any changes in blood sugar levels.

Lupride Depot 45 mg Injection 1's

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Written By Lakshmithulasi Yarragunta ,

Reviewed By Santoshini Reddy G , M Pharmacy

Lupride Depot 45 mg Injection is a gonadotropin-releasing hormone medicine used in the treatment of prostate cancer, endometriosis and precocious puberty. This medicine works by inhibiting the synthesis of the testosterone in men and oestrogen in women, thereby lowers the hormone levels. Common side effects include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction.

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About Lupride Depot 45 mg Injection

Lupride Depot 45 mg Injection belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. Additionally, it is also used to treat precocious puberty (early puberty) in children. Lupride Depot 45 mg Injection is used in combination with other medicines to treat anaemia caused by uterine fibroids.

Lupride Depot 45 mg Injection contains Leuprolide acetate, which is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer and helps treat endometriosis.

Lupride Depot 45 mg Injection will be administered by a healthcare professional. The common side effects of Lupride Depot 45 mg Injection include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Avoid taking Lupride Depot 45 mg Injection if you are pregnant or breastfeeding. Both women and men using Lupride Depot 45 mg Injection should use effective contraception. Lupride Depot 45 mg Injection may affect fertility, hence discuss with your doctor if you have any plans to start a family in the future. Lupride Depot 45 mg Injection is not recommended for children below two years of age. Lupride Depot 45 mg Injection may cause dizziness, hence drive only if you are alert.

Uses of Lupride Depot 45 mg Injection

Treatment of Prostate cancer, Endometriosis and Precocious puberty

Directions for Use

• Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.• Lupride Depot 45 mg Injection will be administered by a healthcare professional.• Do not self-administer.

Medicinal Benefits

Lupride Depot 45 mg Injection contains Leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist. It treats prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. Lupride Depot 45 mg Injection is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. Lupride Depot 45 mg Injection works by lowering testosterone levels in men that help stop the growth of cancer cells in prostate cancer. Lupride Depot 45 mg Injection reduces oestrogen (a hormone required for the development and regulation of the female reproductive system and secondary sexual characteristics) levels in women, thus helping in endometriosis.

How Lupride Depot 45 mg Injection Works

Lupride Depot 45 mg Injection contains Leuprolide acetate, which is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer and helps treat endometriosis.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Lupride Depot 45 mg Injection out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ÂºC to 25ÂºC or below 30ÂºC.

What if I have taken an overdose of Lupride Depot 45 mg Injection

The overdose of Lupride Depot 45 mg Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Lupride Depot 45 mg Injection, please inform your doctor immediately.

Drug Warnings

If you are allergic to Lupride Depot 45 mg Injection or any other medicines, please tell your doctor. Lupride Depot 45 mg Injection is not indicated for use in pregnancy and breastfeeding women. If you are using Lupride Depot 45 mg Injection, make sure to use reliable forms of contraception. Lupride Depot 45 mg Injection may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. Lupride Depot 45 mg Injection is not recommended for children younger than two years of age. If you have a seizure or unusual changes in mood or behaviour, inform your doctor immediately. Before starting Lupride Depot 45 mg Injection, let your doctor know if you have liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Lupride Depot 45 mg Injection may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) and may affect heart rhythm, hence heart patients should be cautious while taking Lupride Depot 45 mg Injection. Lupride Depot 45 mg Injection can make you feel dizzy and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused.

Drug-Drug Interactions

LeuprorelinEliglustat

Critical

LeuprorelinPimozide

Critical

Drug-Drug Interactions

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LeuprorelinEliglustat

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.

LeuprorelinPimozide

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Taking Lupride Depot 45 mg Injection with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

LeuprorelinVandetanib

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Taking Lupride Depot 45 mg Injection with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

LeuprorelinCisapride

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Lupride Depot 45 mg Injection with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.

LeuprorelinDofetilide

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

LeuprorelinIbutilide

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

LeuprorelinNilotinib

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

LeuprorelinCitalopram

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Coadministration of Lupride Depot 45 mg Injection and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.

LeuprorelinSaquinavir

Critical

How does the drug interact with Lupride Depot 45 mg Injection:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lupride Depot 45 mg Injection with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

LeuprorelinPapaverine

Severe

How does the drug interact with Lupride Depot 45 mg Injection:
Taking leuprolide with papaverine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Lupride Depot 45 mg Injection and papaverine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience dizziness, lightheadedness, fainting, or shortness of breath, contact your doctor right away. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a fibre-rich diet and include fruits, vegetables and whole grains.
Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
Avoid grilled meat, red meat, saturated fat found in animal products, milk and dairy products.
Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
Eat at regular intervals.
Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.

Habit Forming

No

Therapeutic Class

HORMONES

Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lupride Depot 45 mg Injection to avoid unpleasant side-effects. Alcohol intake, along with Lupride Depot 45 mg Injection, may cause increased dizziness.

Pregnancy

Unsafe

Lupride Depot 45 mg Injection is a pregnancy category X drug. Lupride Depot 45 mg Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Women of childbearing potential must use an effective method of contraception while taking Lupride Depot 45 mg Injection. Please consult your doctor if you have any concerns regarding this.

Breast Feeding

Unsafe

Lupride Depot 45 mg Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

Driving

Caution

Lupride Depot 45 mg Injection causes dizziness and affects your ability to drive. Do not drive or operate machinery if you experience any unmanageable side effects with Lupride Depot 45 mg Injection.

Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Lupride Depot 45 mg Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Lupride Depot 45 mg Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

Children

Caution

Lupride Depot 45 mg Injection is not recommended in children younger than two years of age and should be used with caution and only if absolutely warranted in children under 12.

Have a query?

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Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., Sun House, Cts No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063

Other Info - LUP0406

Author Details

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 9:25 AM IST

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FAQs

What is the use of Lupride Depot 45 mg Injection?

How does Lupride Depot 45 mg Injection work?

Can Lupride Depot 45 mg Injection cause hairloss?

Does Lupride Depot 45 mg Injection affect fertility in men?

Can a diabetic patient take Lupride Depot 45 mg Injection?

I am being treated for depression, can I use Lupride Depot 45 mg Injection?

Does Lupride Depot 45 mg Injection cause osteoporosis (brittle bones)?

Is Lupride Depot 45 mg Injection safe for patients suffering from heart rhythm problems?

Is Lupride Depot 45 mg Injection a chemotherapy medicine?

Does Lupride Depot 45 mg Injection stop periods?

Is Lupride Depot 45 mg Injection a hormonal medicine and can it be given in pregnancy?

Can Lupride Depot 45 mg Injection cause diabetes or increased blood sugar?

What are the common side effects of Lupride Depot 45 mg Injection?

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