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  3. Macirol Tablet 10's

Macirol Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Macirol Tablet is an anti-hypertensive medicine used in the treatment of pulmonary arterial hypertension (PAH). This medicine contains macitentan which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure, thus increasing blood supply and lowering blood pressure. Common side effects include headache, inflammation of the airways, and oedema.
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Composition :

MACITENTAN-10MG

Manufacturer/Marketer :

Consern Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Macirol Tablet

Macirol Tablet belongs to the class of 'anti-hypertensive drugs', primarily used to treat high blood pressure in the lungs' arteries (pulmonary arterial hypertension). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of blood vessels. This condition makes the heart work harder in pumping blood to the whole body. Pulmonary hypertension affects arteries in the lungs and the right side of the heart.

Macirol Tablet contains 'macitentan', which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Macirol Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply, thus lowering blood pressure.

Take Macirol Tablet as prescribed by your doctor. Your dose and duration of Macirol Tablet will be advised by your doctor, depending upon your medical condition. In some cases, you may experience headaches, inflammation of the airways, and oedema. Most of these side effects of Macirol Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Please inform your doctor if you are using any prescription, or non-prescription drugs, including vitamins and herbal products. Before starting Macirol Tablet , let your doctor know if you have allergic reactions to Macirol Tablet or other medicines. Inform your doctor if you have low blood pressure, lung, heart, kidney, liver problems, and anaemia (lack of blood cells). It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking Macirol Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Do not consume alcohol with Macirol Tablet as it may increase the risk of low blood pressure.

Uses of Macirol Tablet

Treatment of Pulmonary arterial hypertension (PAH) in adults.

Directions for Use

• Macirol Tablet can be taken with or without food.• It is recommended to take Macirol Tablet once daily or as advised by your doctor.• Swallow Macirol Tablet as a whole with a glass of water.• Do not crush, chew, or break it.

Medicinal Benefits

Macirol Tablet is an anti-hypertensive medicine that treats high blood pressure in the lungs' arteries (pulmonary arterial hypertension (PAH)). It contains 'Macitentan,' which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. In people with PAH, the pulmonary arteries get narrower making the heart work harder to pump blood through them. Macirol Tablet widens these constricted arteries and makes it easier for the heart to pump blood, thus lowering the blood pressure.

How Macirol Tablet Works

Macirol Tablet contains 'macitentan', which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Macirol Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply, thus lowering blood pressure.

Storage

Keep out of sight and reach of children.
Side effects of Macirol Tablet
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Increase fibre intake to alleviate constipation.
  • Track your food intake to identify trigger foods.
  • Limit caffeine, fatty foods, and gas-producing foods.
  • Explore probiotics or a low fermented sugar diet for relief.
  • Regular exercise and stress management through therapy can help.
  • Stay hydrated by drinking plenty of water.
  • Your doctor may recommend medications to dissolve the small gallstones (like ursodiol) or use shock waves to break up the stones.
  • Try to eat regular meals because skipping meals can increase the risk of gallstones by making your gallbladder work less efficiently.
  • Eat breakfast soon after you wake up, as cholesterol in bile is highest in the morning.
  • If you are overweight, losing weight gradually can help lower the chance of developing gallstones.
  • Include plenty of fresh vegetables and fruits in your diet.
  • Base your meals around starchy foods like bread, pasta, rice, and potatoes, especially whole grain or high-fibre varieties.
  • If you experience symptoms like difficulty breathing, stridor (high-pitched whistling sound when breathing), high fever or chest pain, consult a doctor immediately.
  • Use a nebulizer or a cool-mist humidifier to help loosen mucus and soothe inflamed airway.
  • Drink lots of water to thin mucus and help with coughing.
  • Get enough sleep to allow the body to heal.
  • Suck on lozenges to soothe sore throat.
  • Quit smoking and alcohol consumption.
  • Drink more fluids as dehydration can decrease blood flow to kidneys and increase BUN levels.
  • Eat less protein and stop protein supplements as high protein diet may increase BUN levels.
  • Severe cases may require kidney transplant or dialysis.

What if I have taken an overdose of Macirol Tablet

Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include headache, nausea, and vomiting. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Please inform your doctor beforehand if you are allergic to Macirol Tablet or other medicines. Brief your medical history if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure) before starting Macirol Tablet . Macirol Tablet is contraindicated during pregnancy since it harms the foetus. Please get a pregnancy test done before starting Macirol Tablet . You should get a negative pregnancy test for sure before using Macirol Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Macirol Tablet to avoid pregnancy. Consult your doctor before using Macirol Tablet if you are a breastfeeding mother. Complete the course strictly as the doctor advises, even if you feel better, to avoid the recurrence of the disease. Do not drive or operate machinery since Macirol Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with Macirol Tablet as it may increase the risk of low blood pressure. Macirol Tablet is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions

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MacitentanMipomersen
Severe
MacitentanCarbamazepine
Severe

Drug-Drug Interactions

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MacitentanMipomersen
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Mipomersen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Macirol Tablet and Mipomersen together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
MacitentanCarbamazepine
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with carbamazepine may significantly reduce the blood levels of Macirol Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is a possible interaction between Macirol Tablet and Carbamazepine, but can be taken together if prescribed by your doctor. However, if you notice any unusual symptoms, you should consult a doctor immediately. Do not stop using any medications without consulting your doctor.
MacitentanSaquinavir
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Saquinavir may increase the blood levels of Macirol Tablet, which increases severe side effects.

How to manage the interaction:
Co-administration of Macirol Tablet with Saquinavir can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanVoriconazole
Severe
How does the drug interact with Macirol Tablet:
Using Macirol Tablet together with Voriconazole can significantly increase the risk of liver problems.

How to manage the interaction:
Although taking Voriconazole and Macirol Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience fever, joint pain or swelling, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
MacitentanItraconazole
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with itraconazole may increase the blood levels of Macirol Tablet that increases risk of side effects.

How to manage the interaction:
Itraconazole and Macirol Tablet may interact, but if a doctor prescribes them, you can still take them. If you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, seek medical attention. Never discontinue taking a medication without consulting a doctor.
MacitentanLomitapide
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Lomitapide affects the liver and may increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Macirol Tablet and Lomitapide, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
MacitentanAmprenavir
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Amprenavir may increase the blood levels of Macirol Tablet, which increases severe side effects.

How to manage the interaction:
There is a interaction between Macirol Tablet and Amprenavir, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanLeflunomide
Severe
How does the drug interact with Macirol Tablet:
Taking leflunomide with Macirol Tablet affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Leflunomide and Macirol Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
MacitentanNelfinavir
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Nelfinavir may increase the blood levels of Macirol Tablet, which increases severe side effects.

How to manage the interaction:
Although taking Macirol Tablet and Nelfinavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MacitentanRitonavir
Severe
How does the drug interact with Macirol Tablet:
Taking Macirol Tablet with Ritonavir may increase the blood levels of Macirol Tablet.

How to manage the interaction:
There may be a possibility of interaction between Macirol Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes, contact your doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
  • Try to include heart-healthy omega-3-fatty acids containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
  • Be mindful of salt; consume no more than 2,300 mg each day.
  • Limit or avoid alcohol consumption.
  • Quitting smoking is the best strategy to lower the risk of heart disease.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Macirol Tablet Substitute

Substitutes safety advice

Product Substitutes

bannner image

Alcohol

Caution

It is advised to limit alcohol intake since alcohol consumption with Macirol Tablet may increase the risk of low blood pressure and cause adverse effects, such as dizziness, fainting, light-headedness or headache.

bannner image

Pregnancy

Unsafe

Macirol Tablet is not recommended in pregnancy. It can affect and harm the developing baby. You are advised to get a pregnancy test done before starting Macirol Tablet . You should get a negative pregnancy test for sure before using Macirol Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Macirol Tablet to avoid pregnancy.

bannner image

Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Macirol Tablet in breastfeeding/nursing mothers.

bannner image

Driving

Unsafe

Macirol Tablet can cause side effects such as headaches and hypotension, and the symptoms of your condition can also make you less fit to drive.

bannner image

Liver

Caution

Let your doctor know before taking Macirol Tablet if you have any history of liver diseases or very high levels of liver enzymes in your blood. Your doctor will weigh the benefits and any potential risks before prescribing Macirol Tablet .

bannner image

Kidney

Caution

If you have kidney problems, talk to your doctor before using Macirol Tablet . Macitentan may lead to more blood pressure reduction and a decrease in haemoglobin in patients with kidney problems. Please consult the doctor, and your doctor will weigh the benefits and any potential risks before prescribing Macirol Tablet .

bannner image

Children

Unsafe

Safety and effectiveness of Macirol Tablet have not been established in patients below 18 years of age.

Have a query?

FAQs

Macirol Tablet belongs to the class of 'anti-hypertensive drugs', primarily used to treat high blood pressure in the lungs' arteries (pulmonary arterial hypertension).

Macirol Tablet consists of Macitentan. It is an anti-hypertensive medicine that lowers blood pressure by widening the pulmonary arteries and making the heart pump blood efficiently.

No, it is a prescribed drug given by a physician for treating specific medical conditions. Taking it on your own can cause unwanted side effects.

Even if you feel good, do not stop using the Macirol Tablet . It should be used as prescribed by your doctor to prevent the recurrence of symptoms and worsening of the disease.

Macirol Tablet should be used with caution in cases of any allergic reactions, heart failure, liver, kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention), and hypotension (low blood pressure).

Shortness of breath, weariness (tiredness), feeling faint or dizzy, chest discomfort (angina), a rapid heartbeat (palpitations), and swelling (oedema) in the legs, ankles, feet, or tummy are all common symptoms of pulmonary hypertension (abdomen).

Although pulmonary hypertension cannot be cured, there are treatments that can help you control your symptoms and manage your condition. It may be possible to prevent irreversible damage to your pulmonary arteries (which are the blood vessels that supply your lungs) if the cause is detected and treated early.

Female patients of reproductive potential must use acceptable methods of contraception during treatment with Macirol Tablet and for a month after treatment with this medicine. One highly effective form of contraception (intrauterine devices, contraceptive implants or tubal sterilization) or a combination of methods (hormone method with a barrier method or two barrier methods) is advised. Please consult the doctor if you have any concerns.

Macirol Tablet can be taken with or without food. Macirol Tablet should be swallowed as a whole with water; do not crush or chew it.

Macirol Tablet might impair fertility in men of reproductive potential by decreasing the sperm count. Talk to the doctor if you have any concerns regarding this.

The doctor may recommend liver enzyme tests, and blood tests before and during treatment with Macirol Tablet . Females of reproductive potential should get a pregnancy test before initiation of treatment with Macirol Tablet .

Macirol Tablet is not recommended during pregnancy as it may cause foetal harm, females of reproductive potential should use effective contraception during treatment and for a month after the treatment. Macirol Tablet may cause liver problems, low blood count, fluid retention and low sperm count. Consult the doctor immediately if you notice signs of liver problems (nausea, vomiting, yellowing of eyes and skin, upper stomach pain, tiredness, loss of appetite, fever, dark urine, and itching) or fluid retention (unusual weight gain or swelling of your ankles or legs).

Yes, Macirol Tablet lowers blood pressure. It is used to treat high blood pressure in the lungs.

Macirol Tablet may cause anaemia (low blood count), usually during the first weeks after starting therapy. Consult the doctor if you notice signs of anaemia like rapid breathing, tiredness, and pale skin.

Macirol Tablet may cause side effects like headaches, inflammation of the airways, and oedema. Most of these side effects of Macirol Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Consern Pharma Private Limited, Kuljive Mahajan(Mg. Director), Rural Focal Point, V.P.O. Tibba, Ludhiana - 141120, Punjab, India.
Other Info - MAC0380

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 18, 2025 | 6:54 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/5223/smpc#gref
  2. https://www.medicines.org.uk/emc/files/pil.5223.pdf
  3. https://opsumithcp.com/support-and-resources/video-library/support-for-opsumit/

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