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Madratol 25mg Tablet ER belongs to a group of medicines called “Antihypertensive” used alone or together with other drugs to treat high blood pressure (hypertension), symptoms caused by an overactive thyroid gland, heart-related chest pain (angina), heart rhythm disorder (arrhythmia). Besides this, it also helps in relieving symptoms of migraine-related headaches. High blood pressure adds to the workload of the heart and arteries. Hypertension or high blood pressure is a long-term force of the blood against the arteries that may lead to various heart diseases. It can damage the blood vessels (arteries) of the brain, heart, and kidneys if it continues for a long time, resulting in a stroke, heart failure or kidney failure. Lowering blood pressure reduces the risk of stroke, heart attack and heart-related chest pain (angina).
Madratol 25mg Tablet ER plays a vital role in relaxing blood vessels by blocking the action of certain natural substances in your body. It helps slow down the heart rate, making it easier for pumping more blood around the body. This lowers your blood pressure and reduces the risk of having a stroke, a heart attack, other heart problems or kidney problems in the future. Madratol 25mg Tablet ER needs to be taken regularly to be effective.
You are advised to take this medicine for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects, such as tiredness, dizziness, stomach pain, nightmares, irregular heart rate and skin rash. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. However, you are advised to talk to your doctor if you experience these side effects persistently.
Don't stop taking this medicine without talking to your doctor first. Stopping abruptly may cause changes in your heart rhythm and blood pressure, cause chest pain or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Madratol 25mg Tablet ER should not be used to avoid heart attacks. You should not use Madratol 25mg Tablet ER if you have heart rhythm problems, diabetes, kidney disease or failure, COPD (Chronic Obstructive Pulmonary Disease). Avoid driving and operating heavy machinery as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur so patients using Madratol 25mg Tablet ER should get up with caution. Before taking Madratol 25mg Tablet ER, inform your doctor if you are going to have surgery or an anaesthetic.
Madratol 25mg Tablet ER contains Metoprolol tartrate that works by blocking beta receptors, namely beta 1 and beta 2. Madratol 25mg Tablet ER blocks beta 1 receptor located in the heart cells that lower heart rate and decreases the heart's blood pumping frequency decreasing raised blood pressure. On the other hand, Madratol 25mg Tablet ER also blocks beta 2 receptors located in the lungs (bronchioles) and blood vessels of skeletal muscle narrowing it. This, in turn, lowers your overall body's blood pressure and helps in reducing the risk of having a stroke, heart problems, or kidney problems in the future. A Madratol 25mg Tablet ER also improves heart-related chest pain (angina) and may increase a person's stamina to exercise with angina. It also blocks the effects of epinephrine, which causes the heart to beat slower. Additionally, Madratol 25mg Tablet ER reduces symptoms of essential tremor (fits), and prevent migraine. Madratol 25mg Tablet ER can reduce symptoms of too much thyroid hormone (thyrotoxicosis) and can be taken together with thyroid-related medicines to treat an overactive thyroid.
Do not take Madratol 25mg Tablet ER if you are allergic (hypersensitive) to Madratol 25mg Tablet ER or any ingredients present in it. Please consult your doctor before taking Madratol 25mg Tablet ER if you are pregnant or planning to conceive, and breastfeeding. It should not be given to children. Don't stop taking Madratol 25mg Tablet ER without talking to your doctor first. Stopping Madratol 25mg Tablet ER gradually may cause changes in your heart rhythm and blood pressure, cause chest pain or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Before taking Madratol 25mg Tablet ER, inform your doctor if you have diabetes mellitus, liver cirrhosis, myasthenia gravis, psoriasis, or if you have a slow heart rate or blood vessel disorder. Do not take Madratol 25mg Tablet ER with medicines like monoamine oxidase inhibitors (MAOIs) for depression, other blood pressure-lowering medicines such as nifedipine, verapamil, diltiazem disopyramide or quinidine (to treat irregular heartbeat). Inform your doctor about all your current ongoing medications before taking Madratol 25mg Tablet ER. Do not consume alcohol while on this medication.
Drug-Drug Interactions: Madratol 25mg Tablet ER may interact with other blood pressure medications (acebutolol, atenolol, bisoprolol, carteolol, esmolol, metoprolol, nadolol, nebivolol or sotalol), medicines for treating depression (isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine), an ergot medicine (dihydroergotamine, ergonovine, ergotamine, methylergonovine), high blood pressure medications such as hydralazine, clonidine or prazosin; stomach ulcers medication such as cimetidine; epilepsy medication such as barbiturates; malaria medication such as mefloquine.
Drug-Food Interactions: Madratol 25mg Tablet ER may interact with alcohol, grapefruit and protein-enriched foods. Using Madratol 25mg Tablet ER together with ayurvedic, homoeopathy, Unani, herbal supplements or any other OTC items may decrease the effects of Madratol 25mg Tablet ER. Hence, it is better to maintain at least 2 hours gap between the administration of Madratol 25mg Tablet ER and these products.
Drug-Disease Interactions: Madratol 25mg Tablet ER is not recommended for people with heart rhythm problems, diabetes, liver or kidney disease or failure, or COPD (Chronic Obstructive Pulmonary Disease).
Hypertension: High blood pressure is a chronic condition when the blood pressure and the heart's workload is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg and, diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.
Alcohol
Unsafe
Drinking alcohol may increase tiredness, lower blood pressure causing dizziness or drowsiness. So avoid its intake with Madratol 25mg Tablet ER.
Pregnancy
Caution
Madratol 25mg Tablet ER is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Breast Feeding
Caution
Madratol 25mg Tablet ER is not recommended if you are breast-feeding women unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Driving
Unsafe
You may experience dizziness, tiredness, or blurred vision while taking Madratol 25mg Tablet ER. So, it is not recommended to drive, use machinery, or perform other tasks.
Liver
Caution
Madratol 25mg Tablet ER is not recommended in patients with liver disease or failure. Your doctor may prescribe Madratol 25mg Tablet ER depending on your condition.
Kidney
Caution
Madratol 25mg Tablet ER is not recommended in patients with kidney disease or failure. Your doctor may prescribe Madratol 25mg Tablet ER depending on your condition.
Children
Unsafe
The safety and efficacy of Madratol 25mg Tablet ER in children have not been established.
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