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compositionComposition:ENOXAPARIN-10MG
prescription
Prescription Medicine
info
Manox-40 PFS Injection 0.4 ml

Manox-40 PFS Injection 0.4 ml is used to prevent or treat blood clots caused by medical conditions, such as unstable angina, after an operation or long periods of bed rest due to illness, after a heart attack, and the formation of blood clots in the dialysis machine tubes. It contains Enoxaparin, which prevents existing blood clots from growing larger, allowing your body to break them down and prevent them from harming you. Also, it inhibits the formation of new blood clots in your blood. It may cause side effects such as increased liver enzymes, skin rash (hives,urticaria), itchy red skin, bruising or pain at the injection site, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ENOXAPARIN-10MG

Manufacturer/Marketer :

Maan Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Manox-40 PFS Injection 0.4 ml

Manox-40 PFS Injection 0.4 ml is an injectable prescription medicine used to prevent and treat harmful blood clots in the body. It helps keep your blood flowing smoothly, lowering the risk of life-threatening events like a stroke, heart attack, or blood clots in the lungs. Doctors frequently prescribe it for people recovering from surgery or those with medical conditions that limit their mobility.

This medicine is typically injected once or twice daily, and it is crucial to use it consistently at the same times every day to maintain a steady level in your body. Because this is a parenteral injection, it can be used with or without food. Staying well-hydrated and performing gentle leg exercises, as advised by your doctor, can also help improve your circulation and support your recovery.

While taking Manox-40 PFS Injection 0.4 ml, you may experience mild bruising, pain, or redness at the injection site. However, you must contact your doctor immediately if you notice serious side effects, such as unusual bleeding that will not stop, severe bruising, or blood in your urine or stool.

Before starting this medication, tell your doctor if you have a history of bleeding disorders, kidney problems, high blood pressure, or stomach ulcers. Do not take this medicine if you currently have active major bleeding or if you have ever had a severe reaction that lowered your blood platelet count after using heparin.

Using this medicine alongside other blood thinners or common pain relievers like ibuprofen can greatly increase your risk of bleeding. It is also important to limit alcohol use and speak with your healthcare provider if you are pregnant, breastfeeding, or managing health conditions as an elderly individual, as your dose may need close monitoring.

Uses of Manox-40 PFS Injection 0.4 ml

Manox-40 PFS Injection 0.4 ml is used to prevent and treat blood clots, helping reduce the risk of serious complications caused by blocked blood vessels. 

  • Deep vein thrombosis (DVT): Manox-40 PFS Injection 0.4 ml helps prevent and treat blood clots that form in the deep veins of your legs, reducing pain and swelling.
  • Pulmonary embolism (PE): This medicine treats blood clots that have travelled to the lungs, helping to restore normal breathing and blood flow.
  • Unstable angina and heart attacks: It prevents new blood clots from forming in the blood vessels of the heart, protecting patients who are experiencing severe chest pain or recovering from a heart attack.
  • Clot prevention during surgery: It is used to protect patients undergoing orthopaedic surgeries (like hip or knee replacements) or general abdominal surgeries from developing clots due to temporary immobility.
     

Key Benefits

Manox-40 PFS Injection 0.4 ml helps prevent and treat blood clots, reducing the risk of serious complications caused by clot formation. It provides effective anticoagulant protection in a variety of medical conditions and recovery situations.

  • Prevents Blood Clot Formation: Helps stop harmful blood clots from forming in the veins, particularly after surgery or during periods of reduced mobility.
  • Prevents Clot Growth: Helps prevent existing blood clots from becoming larger, allowing the body's natural processes to break them down over time.
  • Reduces Clot-Related Complications: Lowers the risk of serious conditions such as pulmonary embolism, stroke, and other clot-related emergencies.
  • Relieves Symptoms of Blood Clots: May help reduce pain, swelling, and discomfort associated with blood clots as treatment progresses.
  • Supports Convenient Home Treatment: Pre-filled syringes allow many patients to continue treatment safely at home without frequent hospital visits.
     

Directions for Use

This medicine is given as an injection just under the skin (subcutaneously), typically in the stomach area. Follow these steps for a safe injection:

  • Wash your hands thoroughly and clean the injection area on your abdomen with an alcohol wipe. Let the skin dry completely.
  • Remove the protective cap from the needle. Do not push the air bubble out of the syringe unless your healthcare provider specifically tells you to do so.
  • Gently pinch a fold of skin on your abdomen between your thumb and index finger.
  • Insert the needle straight down at a 90-degree angle all the way into the skin fold. Press the plunger down steadily to inject the medication.
  • Pull the needle straight out and release the skin fold. Do not rub the injection site after the injection, as this can cause bruising or pain.

Always follow your doctor's exact instructions regarding how and when to use this medication.
 

How Manox-40 PFS Injection 0.4 ml Works

Enoxaparin, the active ingredient in Manox-40 PFS Injection 0.4 ml, belongs to a class of medications known as anticoagulants, commonly called blood thinners. It works by targeting and blocking specific natural proteins in your blood that are responsible for the clotting process. By neutralising these proteins, the medicine prevents blood clots from forming and stops any current clots from getting larger. Because the medicine keeps the clot from growing, it gives your body the opportunity to naturally break down and dissolve the clot on its own. This action keeps your blood flowing freely through your veins and arteries, protecting vital organs from damage caused by blocked blood flow.
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Alcohol

Unsafe

Limit intake of alcohol as it may increase the risk of bleeding.

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Pregnancy

Caution

Manox-40 PFS Injection 0.4 ml is not recommended for use in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Manox-40 PFS Injection 0.4 ml.

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Breast Feeding

Caution

Manox-40 PFS Injection 0.4 ml is not recommended for use in breastfeeding unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Manox-40 PFS Injection 0.4 ml.

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Driving

Safe if prescribed

It does not affect your ability to drive.

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Liver

Caution

If you have a history of liver diseases or pre-existing liver conditions, please inform your doctor before taking this Manox-40 PFS Injection 0.4 ml.

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Kidney

Caution

If you have a history of kidney diseases or pre-existing kidney conditions, please inform your doctor before taking this Manox-40 PFS Injection 0.4 ml.

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Children

Unsafe

It is not recommended for treatment in children under 18 years of age as safety and efficacy have not been established.

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Heart

Caution

Manox-40 PFS Injection 0.4 ml can be used in heart patients for the prevention of blood clots. However, caution should be exercised while receiving Manox-40 PFS Injection 0.4 ml.

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Geriatrics

Caution

Geriatric patients can receive Manox-40 PFS Injection 0.4 ml if prescribed by the physician. It's important to use it under close medical supervision with tailored dosing and regular monitoring.

What if I have taken an overdose of Manox-40 PFS Injection 0.4 ml

The overdose of Manox-40 PFS Injection 0.4 ml is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Manox-40 PFS Injection 0.4 ml, please inform your doctor immediately.

Diet & Lifestyle Advise

  • Use a soft-bristled toothbrush: This simple change reduces the risk of causing your gums to bleed while brushing your teeth.
  • Switch to an electric razor: Using an electric shaver instead of a manual razor blade helps prevent accidental cuts and nicks that can bleed excessively.
  • Protect yourself from falls: Avoid high-impact contact sports, strenuous activities, or situations where you might slip, fall, or injure your head, as internal bleeding can be very dangerous.
  • Stay consistently hydrated: Drinking plenty of water helps maintain healthy blood volume and supports smooth circulation.
  • Move gently and regularly: If you are recovering from surgery, perform light ankle circles or short walks as recommended by your doctor to keep your blood moving and prevent new clots.
     

Have a query?

How Soon It Starts Working

The time required for Manox-40 PFS Injection 0.4 ml to start to work: Manox-40 PFS Injection 0.4 ml ideally shows its action within 20 to 60 minutes after administration. The time for which the effects of Manox-40 PFS Injection 0.4 ml last: The effect of Manox-40 PFS Injection 0.4 ml lasts for 12 hours.

What if you forget to take Manox-40 PFS Injection 0.4 ml

As this medication will be administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

•Store Manox-40 PFS Injection 0.4 ml syringes at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Do not freeze the syringes, and do not store them in the refrigerator, as cold temperatures can affect the medication.

Drug Warnings

  • Inspect the syringe: Before injecting, always check the liquid inside the syringe. Do not use it if you see particles, cloudiness, or any discolouration.
  • Rotate injection sites: Switch the side of your abdomen where you inject each day (alternating between left and right) to help prevent hard lumps, pain, or skin damage from developing.
  • Do not clear the air bubble: Unless specifically told to do so by your healthcare provider, do not press the plunger to push the air bubble out before injecting. This bubble helps ensure you receive the full dose and keeps the medicine from leaking.
  • Never reuse needles: Use a brand-new, sterile pre-filled syringe for every injection, and discard it immediately after a single use.
  • Spinal procedure warning: If you need to have a spinal tap, spinal anaesthesia, or an epidural while using this medicine, notify your doctor immediately. There is a risk of developing a spinal blood clot, which can lead to long-term paralysis. Watch for warning signs like back pain, numbness, tingling, or muscle weakness in your legs.
     

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Drug-Drug Interactions

The following medicines may interact with Manox-40 PFS Injection 0.4 ml and increase the risk of bleeding or other complications: 

  • Other blood thinners: Taking this medicine with other anticoagulants can dramatically increase your risk of severe bleeding.
  • Pain relievers (NSAIDs): Using nonsteroidal anti-inflammatory drugs like ibuprofen, naproxen, or high-dose aspirin can irritate your stomach lining and significantly increase your risk of bleeding.
  • Platelet inhibitors: Medicines used to prevent blood clots in the arteries, such as clopidogrel, can increase bleeding risks when combined with this injection.

Drug-Disease Interactions
Inform your doctor if you have any of the following conditions before using Manox-40 PFS Injection 0.4 ml, as special precautions may be required: 

  • Kidney disease: Your body clears this medication through the kidneys. If you have kidney problems, the medicine can build up in your body, increasing your risk of bleeding; your doctor may need to adjust your dose.
  • History of stomach ulcers: If you have active or past stomach ulcers, using this blood thinner increases the risk of developing a severe stomach bleed.
  • Uncontrolled high blood pressure: Very high, uncontrolled blood pressure increases your risk of bleeding in the brain while taking blood thinners.
  • Bleeding disorders: If you have haemophilia or other conditions that prevent your blood from clotting normally, this medicine can lead to severe haemorrhage.
     

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Manox-40 PFS Injection 0.4 ml is used to prevent or treat blood clots caused by medical conditions, such as unstable angina, after an operation or long periods of bed rest due to illness, after a heart attack, and the formation of blood clots in the dialysis machine tubes.
Manox-40 PFS Injection 0.4 ml contains Enoxaparin, which is low molecular weight heparin or LMWH. Manox-40 PFS Injection 0.4 ml works by stopping existing blood clots from getting any bigger. This helps your body to break them down and prevents them from causing you harm. On the other hand, it stops new blood clots from forming in your blood.
Yes, this Manox-40 PFS Injection 0.4 ml is given based on your age and body weight. If you have low body weight, the chances of increased risk of bleeding are high, so mostly low doses are prescribed by your doctor. You may be monitored closely for signs of clot formation.
No, do not take this Manox-40 PFS Injection 0.4 ml if you have a stomach ulcer. Please inform your doctor about this condition before receiving it.
Increases in liver enzymes are the most common side effect with Manox-40 PFS Injection 0.4 ml. Regular lipid profile tests are recommended to avoid any additional complications.
No, Manox-40 PFS Injection 0.4 ml dosage should be given exactly as prescribed by the doctor.
Manox-40 PFS Injection 0.4 ml contains Enoxaparin as it active ingredient.
Manox-40 PFS Injection 0.4 ml is mostly prescribed for angina (chest pain), deep vein thrombosis (blood clot in veins) and as a post-surgery precautionary step.
Yes, there are many substitutes available in the market. However, please note that all these substitutes have the same composition and thus should be administered with the same set of precautions.
Yes. Bleeding is one of the most important side effects of Manox-40 PFS Injection 0.4 ml. Contact your doctor immediately if you notice unusual bruising, purple spots on the skin, blood in the urine, black tarry stools, bleeding gums, frequent nosebleeds, or any other unusual bleeding.
The side effects of Manox-40 PFS Injection 0.4 ml include bleeding, increases in liver enzymes, bruise more easily than usual, pink patches on your skin, skin rash (hives, urticaria), itchy red skin, pain or bruising at the injection site and headache. If these side effects persist or worsen, please inform your doctor.
The dose and duration of Manox-40 PFS Injection 0.4 ml is prescribed by a doctor based on the underlying condition and the patient’s response to the treatment.
Manox-40 PFS Injection 0.4 ml is usually injected under the skin (subcutaneous injection). It may be administered by a healthcare professional or self-administered if you have been properly trained by your doctor or nurse. Follow the injection technique and dosing instructions provided by your healthcare provider.
Tell your doctor if you have a heart valve fitted or have high blood pressure, gastric ulcer, kidney problems or diabetes. Also, let your doctor know if you ever had a reaction to heparin or had a recent stroke, spinal or brain surgery. The chances of complications and side effects increase in these conditions.
Store Manox-40 PFS Injection 0.4 ml below 25°C. Do not freeze. Keep it out of reach and sight of children.
Yes, Manox-40 PFS Injection 0.4 ml is used in the treatment of heart attack and chest pain once the patient has received the standard treatment. It is administered along with another blood thinner like aspirin. As it is a blood thinner, it prevents the blood from clotting and prevents any further episodes and complications.
It is usually recommended to inject this medicine into the fatty tissue of your abdomen (stomach area). Injecting it into other areas, like your thigh or arm, may affect how quickly your body absorbs the medicine. Talk to your doctor if you need advice on alternative injection sites.
No. The small air bubble is intentionally included to help deliver the full dose and reduce leakage of medication from the injection site. Do not remove the air bubble unless specifically instructed by your healthcare provider.
For minor bleeding, like a small cut, apply firm pressure. If you experience major or continuous bleeding, such as a nosebleed that will not stop, blood in your urine, or black stools, seek medical help immediately. Talk to your doctor if you notice any unusual bruising.
You should avoid pain relievers called NSAIDs, which include ibuprofen and naproxen, because they can increase your risk of bleeding. If you need pain relief, talk to your doctor or pharmacist to find a safer alternative.
Manox-40 PFS Injection 0.4 ml usually begins working within 1–2 hours after injection. The effects of a dose generally last about 12–24 hours, although this may vary depending on kidney function and other individual factors.
The effects of a single injection typically wear off within 12 to 24 hours, though this can take longer if you have kidney issues. Always follow your doctor's exact schedule. Talk to your doctor if you have questions about your dosing times.
Unlike some other blood thinners, this medicine usually does not require frequent routine blood tests to monitor clotting times. However, your doctor may occasionally check your platelet levels or kidney function. Talk to your doctor for personalised advice.
It is best to limit or avoid alcohol while using this medicine, as alcohol can increase the risk of stomach bleeding and affect how your blood clots. Talk to your doctor or pharmacist about safe alcohol consumption during your treatment.

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Country of origin

India

Manufacturer/Marketer address

Plot No 1, Gidc, Phase 2, Modhera Road, Modhera, Mehsana - 384212
Other Info - MAN0667
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