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compositionComposition:GLIPIZIDE-5MG+METFORMIN-500MG
prescription
Prescription Medicine
info
Marknase MF 5mg/500mg Tablet
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLIPIZIDE-5MG+METFORMIN-500MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Marknase MF 5mg/500mg Tablet

Marknase MF 5mg/500mg Tablet is a prescription medicine used to manage high blood sugar in adults with type 2 diabetes. It is prescribed alongside diet and exercise to help improve blood sugar control and prevent long-term complications.

To get the best results, you must take Marknase MF 5mg/500mg Tablet consistently every day, exactly as prescribed by your healthcare provider. It is typically taken with meals, usually with breakfast or your first main meal of the day, to reduce the chance of an upset stomach. Incorporating a balanced diet and regular physical activity into your daily routine is essential to support the effects of this medicine.

While taking Marknase MF 5mg/500mg Tablet, you may experience mild side effects like a temporary upset stomach or a metallic taste in your mouth. However, you must contact your doctor immediately if you experience severe symptoms, such as unusual muscle pain, trouble breathing, or extreme fatigue, which could indicate a rare but serious build-up of acid in your blood.

Talk to your doctor before starting this medicine if you have a history of kidney issues, liver damage, or heart failure. Do not take this if you have severe kidney disease, severe liver damage, or metabolic acidosis.

This medicine can interact with other substances, such as alcohol, which can significantly increase your risk of low blood sugar or serious blood acid complications. If you are pregnant, breastfeeding, or over the age of 65, consult your doctor or pharmacist to ensure this medicine is safe for your specific situation.

Uses of Marknase MF 5mg/500mg Tablet

Marknase MF 5mg/500mg Tablet is used to help control blood sugar levels in adults with type 2 diabetes mellitus when lifestyle measures alone are not sufficient.

  • Type 2 Diabetes Mellitus: Marknase MF 5mg/500mg Tablet helps improve blood sugar control by increasing insulin release from the pancreas and reducing the amount of glucose produced by the liver. It is used alongside a healthy diet and regular exercise to maintain stable blood sugar levels.
     

Key Benefits

Marknase MF 5mg/500mg Tablet combines two complementary diabetes medicines to provide effective blood sugar management and long-term health benefits.

  • Provides effective blood sugar control: It helps keep blood glucose levels within the target range throughout the day, reducing fluctuations in blood sugar.
  • Targets multiple causes of high blood sugar: The combination works through different mechanisms to improve overall glucose control more effectively than either medicine alone in many patients.
  • Reduces the risk of diabetes complications: Maintaining healthy blood sugar levels helps lower the risk of complications affecting the nerves, kidneys, eyes, and cardiovascular system.
  • Supports long-term diabetes management: Consistent blood sugar control can help improve overall health and reduce the likelihood of diabetes-related hospitalisations.
  • Offers the convenience of combination therapy: By combining two medications into a single tablet, it may simplify treatment and improve adherence to therapy.
  • Promotes an active and healthy lifestyle: Better glucose control can help improve energy levels and support participation in daily activities and regular physical exercise.
     

Directions for Use

To achieve the best blood sugar control, take Marknase MF 5mg/500mg Tablet exactly as prescribed by your doctor and follow your treatment plan consistently.

  • Swallow the tablet whole with a full glass of water.
  • Take the medication with food to help reduce the risk of stomach upset and improve tolerability.
  • Try to take your dose at the same time each day to maintain consistent blood sugar control and establish a regular routine.
  • Follow your doctor's instructions regarding the timing and dosage of your medication.
  • Monitor your blood sugar levels as recommended by your healthcare provider.
  • Continue following a healthy diet and regular exercise programme while taking this medication.
  • Do not change your dose or stop taking the medicine without consulting your doctor, even if you feel well.
     

How Marknase MF 5mg/500mg Tablet Works

This combination medicine contains two active ingredients that work in different ways to help your body manage blood sugar levels. The first active ingredient works by encouraging your pancreas to release more insulin. Insulin is the hormone responsible for moving sugar out of your bloodstream and into your cells where it can be used for energy. By increasing insulin release, this component helps lower sudden spikes in blood sugar, especially after meals. The second active ingredient works in two ways: it decreases the amount of sugar that your liver naturally produces and releases into your blood, and it helps your muscles use the insulin your body already makes more efficiently. Together, these two mechanisms provide a highly effective, coordinated approach to maintaining healthy blood glucose levels throughout the day.
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Alcohol

Caution

You are recommended to avoid consumption of alcohol with Marknase MF 5mg/500mg Tablet as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).

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Pregnancy

Caution

Marknase MF 5mg/500mg Tablet may affect the fetus during pregnancy. Please consult your doctor before starting Marknase MF 5mg/500mg Tablet.

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Breast Feeding

Caution

There is no sufficient data on how Marknase MF 5mg/500mg Tablet affects breastfeeding. It is safe to seek medical advice before you start Marknase MF 5mg/500mg Tablet if you are lactating.

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Driving

Caution

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you may experience dizziness or drowsiness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Marknase MF 5mg/500mg Tablet.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases when you are prescribed Marknase MF 5mg/500mg Tablet.

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Children

Caution

Please seek advice from a doctor before giving Marknase MF 5mg/500mg Tablet to a child.

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Heart

Consult your doctor

Marknase MF 5mg/500mg Tablet should be used with caution if you have any cardiac problems. This medicine is contraindicated in patients with severe heart failure.

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Geriatrics

Caution

Caution should be exercised in geriatric patients while taking Marknase MF 5mg/500mg Tablet.

What if I have taken an overdose of Marknase MF 5mg/500mg Tablet

An overdose of Marknase MF 5mg/500mg Tablet may result in lactic acidosis or severe low blood sugar. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Consistent carbohydrate intake: Spread your carbohydrate intake evenly across your meals throughout the day to avoid sudden spikes or drops in blood sugar.
  • Regular physical activity: Aim for moderate exercise, such as brisk walking, for at least 30 minutes on most days of the week, as this helps your body use insulin more effectively.
  • Stay hydrated: Drink plenty of water throughout the day to support your kidney function and help your body process the medication safely.
  • Monitor blood sugar: Keep a regular log of your blood sugar readings as recommended by your healthcare provider to track how well your treatment plan is working.
     

Have a query?

How Soon It Starts Working

The time required for Marknase MF 5mg/500mg Tablet to start to work: The time required for Marknase MF 5mg/500mg Tablet to show its action is not clinically established.

The time for which the effects of Marknase MF 5mg/500mg Tablet last: The duration of action for Marknase MF 5mg/500mg Tablet is not clinically established.

What if you forget to take Marknase MF 5mg/500mg Tablet

If you miss a dose of Marknase MF 5mg/500mg Tablet, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Marknase MF 5mg/500mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F and 77°F). •Keep the medication in its original container with the lid tightly closed.

Drug Warnings

  • Carry a Source of Fast-Acting Sugar: Always carry a fast-acting source of sugar, such as glucose tablets, fruit juice, or hard candy, in case you experience sudden symptoms of low blood sugar.
  • Monitor Blood Sugar More Frequently During Special Situations: Check your blood sugar levels more frequently when you are sick, under unusual stress, or travelling across different time zones.
  • Inform Healthcare Providers Before Procedures: Inform your doctor or dentist that you are taking Marknase MF 5mg/500mg Tablet before undergoing any surgery or medical procedures.
  • Follow Precautions for Contrast Dye Procedures: If you need to have a scan or X-ray that involves contrast dye, you must temporarily stop taking Marknase MF 5mg/500mg Tablet before the procedure and wait at least 48 hours afterward to restart. Talk to your doctor for specific instructions.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Marknase MF 5mg/500mg Tablet may interact with medications that affect blood sugar levels or alter the body's response to treatment.

  • Beta-blockers and certain blood pressure medications: These medicines may mask some warning signs of low blood sugar, such as a rapid heartbeat, making hypoglycaemia more difficult to recognise.
  • Diuretics (water tablets): Certain diuretics can raise blood sugar levels and may reduce the effectiveness of Marknase MF 5mg/500mg Tablet.
  • Corticosteroids: Steroid medications may increase blood glucose levels, making diabetes more difficult to control.
  • Other diabetes medications, including insulin: Using Marknase MF 5mg/500mg Tablet together with other blood sugar-lowering medicines can increase the risk of hypoglycaemia (low blood sugar).

Drug-Food Interactions

Certain foods and beverages may affect the safety and effectiveness of Marknase MF 5mg/500mg Tablet.

  • Alcohol: Excessive alcohol consumption can increase the risk of low blood sugar and may also raise the risk of lactic acidosis, a rare but serious complication associated with metformin.

Drug-Disease Interactions

Certain medical conditions may require special precautions or make this medication unsuitable.

  • Kidney disease: Reduced kidney function can increase the accumulation of metformin in the body and raise the risk of serious side effects. Severe kidney impairment is generally a contraindication to treatment.
  • Liver disease: Significant liver impairment may increase the risk of lactic acidosis and affect blood sugar regulation.
  • Diabetic ketoacidosis (DKA): Marknase MF 5mg/500mg Tablet should not be used to treat diabetic ketoacidosis, which requires immediate medical attention and specialised treatment.
  • Conditions associated with poor oxygen supply: Severe heart failure, shock, or serious respiratory illness may increase the risk of lactic acidosis and require careful medical evaluation before using this medication.
     
Glipizide + MetforminGatifloxacin
Critical
Glipizide + MetforminIopamidol
Critical

Drug-Drug Interactions

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Glipizide + MetforminGatifloxacin
Critical
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Glipizide with Gatifloxacin may affect both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Glipizide can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Do not discontinue the medications without consulting a doctor.
Glipizide + MetforminIopamidol
Critical
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using your medications without talking to a doctor.
Glipizide + MetforminIopromide
Critical
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
Glipizide + MetforminMetrizamide
Critical
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Glipizide + MetforminIomeprol
Critical
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Glipizide + MetforminIodixanol
Critical
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
Glipizide + MetforminMoxifloxacin
Severe
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Taking Moxifloxacin with Glipizide may cause both high blood sugar levels or and, less frequently, low blood glucose.

How to manage the interaction:
Although there is a possible interaction Glipizide can be taken with Moxifloxacin if prescribed by the doctor. Consult the doctor if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Do not discontinue the medications without consulting a doctor.
Glipizide + MetforminEnoxacin
Severe
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Taking Enoxacin with Glipizide may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glipizide can be taken with Enoxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Do not discontinue the medications without consulting a doctor.
Glipizide + MetforminCinoxacin
Severe
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Taking Cinoxacin with Glipizide may affect blood glucose levels (both hyperglycemia - high blood glucose and, less frequently, hypoglycemia - low blood glucose).

How to manage the interaction:
Although there is a possible interaction Glipizide can be taken with Cinoxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Do not discontinue the medications without consulting a doctor.
Glipizide + MetforminEthanol
Severe
How does the drug interact with Marknase MF 5mg/500mg Tablet:
Co-administration of Marknase MF 5mg/500mg Tablet with Ethanol may increase the risk of Lactic acidosis (excessive lactic acid production in blood).

How to manage the interaction:
Although there is a possible interaction between Marknase MF 5mg/500mg Tablet and Ethanol, you can take these medicines together if prescribed by a doctor. However, if you have symptoms such as weakness, muscle pain, increased drowsiness, dizziness, stomach pain or discomfort, slow or irregular heartbeat difficulty in breathing, or loss of appetite, contact a doctor immediately. Do not stop using any medications without a doctor’s advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Marknase MF 5mg/500mg Tablet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Marknase MF 5mg/500mg Tablet promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It works by reducing the sugar production by cells in the liver and delaying sugar absorption from the intestines.

You are not recommended to stop taking Marknase MF 5mg/500mg Tablet on your own, as discontinuing Marknase MF 5mg/500mg Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Marknase MF 5mg/500mg Tablet, please consult your doctor so that alternative medicine may be prescribed.

In type 1 diabetes, the body does not produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completely. In type 2 diabetes, though islet cells are working, the body does not respond to insulin as the body becomes resistant to insulin.

Marknase MF 5mg/500mg Tablet should preferably be taken with meals. Taking it with food helps reduce gastrointestinal side effects such as nausea, stomach discomfort, and diarrhoea while helping maintain blood sugar control.

Marknase MF 5mg/500mg Tablet contains two anti-diabetic drugs, namely Glipizide and Metformin, as its active ingredients.

Marknase MF 5mg/500mg Tablet may cause side effects such as low blood sugar, nausea, indigestion, headache, diarrhoea, stomach pain, or blurred vision. If these side effects persist or worsen, please consult your doctor.

Yes, Marknase MF 5mg/500mg Tablet can cause hypoglycemia (low blood sugar). Symptoms may include hunger, dizziness, sweating, headache, nausea, irritability, shakiness, anxiety, or a fast heartbeat. The risk increases if you miss or delay meals, exercise more than usual, consume alcohol, or take other antidiabetic medicines. If you experience symptoms of low blood sugar, consume a fast-acting source of sugar such as fruit juice, glucose tablets, or candy. Regular blood sugar monitoring is recommended.

Yes, the use of Marknase MF 5mg/500mg Tablet can cause lactic acidosis. It is a medical emergency which occurs due to increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the metformin and thus, it is contraindicated in patients with underlying kidney disease, elderly patients or who consume large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, feeling of cold in arms and legs, dizziness, tiredness, difficulty in breathing, stomach pain, nausea, vomiting or slow heart rate. If you experience these symptoms, stop taking Marknase MF 5mg/500mg Tablet and consult your doctor immediately.

Yes, long term use of Marknase MF 5mg/500mg Tablet can cause Vitamin B12 deficiency. It interferes with absorption of Vitamin B12 in the stomach. If untreated, it may cause nerve problems and anemia and the patient may feel numbness and tingling sensation in the hands and feet, urinary problems, weakness, change in mental status and difficulty in maintaining balance (ataxia). To prevent such problems, some researchers recommend an intake of Vitamin B12 from external sources at least once a year.

Marknase MF 5mg/500mg Tablet is contraindicated in patients with known allergy to any of its components or excipients. Also, it should be avoided in patients with moderate to severe kidney disease and in patients with underlying metabolic acidosis including diabetic ketoacidosis.

No. Alcohol should be avoided or strictly limited while taking Marknase MF 5mg/500mg Tablet because it can increase the risk of hypoglycaemia (low blood sugar) and lactic acidosis, a rare but serious medical condition associated with metformin.

Store Marknase MF 5mg/500mg Tablet at room temperature protected from moisture. Keep it out of reach of children.

Marknase MF 5mg/500mg Tablet overdose can result in serious complications such as hypoglycaemia (low blood sugar) or lactic acidosis. Hence, if you suspect an overdose, seek medical attention immediately.

Take Marknase MF 5mg/500mg Tablet exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water. Do not break, crush, or chew it, as this may affect how the medicine works.

If you experience signs of low blood sugar, such as sweating, shakiness, or dizziness, immediately consume 15 grams of fast-acting sugar (like fruit juice, soda, or hard candy). Wait 15 minutes, check your blood sugar again, and repeat if necessary. Talk to your doctor if this happens frequently.

While some of the active ingredients in this medicine are considered weight-neutral or may support mild weight reduction when paired with diet and exercise, Marknase MF 5mg/500mg Tablet is not a weight-loss medication. Talk to your doctor for personalized weight management advice.

The medicine begins working shortly after your first few doses to help manage blood sugar spikes after meals. However, it may take several weeks of consistent use, alongside diet and lifestyle changes, to see the full benefit in your routine lab tests. Talk to your doctor to monitor your progress.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking Marknase MF 5mg/500mg Tablet. This medicine is generally not preferred during pregnancy or breastfeeding, and your doctor may recommend alternative treatments that are considered safer.

Yes. Your doctor will regularly order blood tests to monitor your long-term blood sugar control (HbA1c) and check your kidney and liver function to ensure the medicine remains safe for you to use. Talk to your doctor about how often you need these tests.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Glipizide Metformin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. National Center for Biotechnology Information (NCBI). Nbk459177 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026] Check here
  3. National Center for Biotechnology Information (NCBI). Pmc4214027 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Glipizide+metformin HCl. [Accessed on 29 Jan. 2019] Check here
  5. Glipizide and Metformin Hydrochloride. 2016. [Accessed on 08 Apr. 2019] Check here
  6. American Diabetes Association 14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S200-S210 Check here
  7. Glipizide and metformin [Drug Label]. 2013. [Accessed on 16 Jan. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

3/3, Subhash Nagar, Manimajra, Chandigarh- 160 101
Other Info - MA17077
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