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Mesbro Solution 3 ml

Mesbro Solution 3 ml

Prescription drug
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Composition

MESNA-600MG/3ML

Manufacturer/Marketer

Sparsh Remedies Pvt Ltd

Consume Type

INHALATION

Return Policy

Not Returnable

Expires on or after

Jan-25

About Mesbro Solution 3 ml

Mesbro Solution 3 ml belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our body breaks down the anticancer agent (Ifosfamide) to form a chemical (acrolein) that can harm and irritate the bladder. Mesbro Solution 3 ml reduces the risk of inflammation and bleeding in the bladder due to other anti-cancer medications. 

Mesbro Solution 3 ml contains 'Mesna', a chemo-protectant medicine. It works by altering the breakdown of anti-cancer agents (Ifosfamide) found in urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Mesbro Solution 3 ml should be used as advised by your physician. Avoid using more than the recommended dose. The dose of medicine will be advised by your doctor based on your health condition. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms and fever. Most of these side effects of Mesbro Solution 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Mesbro Solution 3 ml is not recommended if you are allergic to it or any of its ingredients. Women of childbearing age should use an effective birth control method to prevent getting pregnant. While utilising Mesbro Solution 3 ml to track your CBC, your doctor could advise routine urine and blood tests (blood cell count). Because of various underlying clinical disorders, including thrombocytopenia, Mesbro Solution 3 ml is contraindicated for usage in hematuria. While using Mesbro Solution 3 ml, it is advisable to consume at least 1-2 litres of liquids every day. Due to significant adverse effects, this medication should not be used in pregnant or nursing women; thus, consult your doctor before beginning treatment with Mesbro Solution 3 ml.

Uses of Mesbro Solution 3 ml

Treatment of Ifosfamide-induced hemorrhagic cystitis

Medicinal Benefits

Mesbro Solution 3 ml is a member of the 'chemoprotectant' class of drugs, which are principally used to stop urine bleeding caused by the anticancer drug ifosfamide (ifosfamide-induced hemorrhagic cystitis). Additionally, it lessens the chance that anti-cancer medications would induce bladder irritation and bleeding. It includes Mesna, which detoxifies the urotoxic ifosfamide (anti-cancer medication) metabolites by chemically interacting with them. Additionally, it binds to other urotoxic metabolites and prevents their bladder-damaging effects.

Directions for Use

Respirator solution: Mesbro Solution 3 ml is meant for inhalation/instillation (tracheopulmonary use) only and not to be injected. Read the instruction leaflet carefully before using it. Use as prescribed by the doctor.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mesbro Solution 3 ml

  • Nausea
  • Headache
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Lethargy
  • Rash
  • Diarrhea
  • Lightheadedness
  • Abdominal pain
  • Flu-like symptoms
  • Fever

Drug Warnings

Do not use Mesbro Solution 3 ml if you are allergic to it or any of its ingredients. Mesbro Solution 3 ml should be used under the supervision of a doctor only. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a 6-month gap between your last dose of name and your next pregnancy. Regular urine and blood test should be done while using this medicine to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is important to drink at least 1 litre of fluid daily while using Mesbro Solution 3 ml. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery.

Drug Interactions

Drug-Disease Interactions: Mesbro Solution 3 ml is known to interact in patients with an autoimmune disorder like rheumatoid arthritis (pain and inflammation in the joints), systemic lupus erythematosus (a severe form of lupus in which pain and fatigue occur in joints), or nephritis (a type of kidney problem).

Drug-Food Interactions: Inform your doctor about all vitamins, and minerals you are taking.

Drug-Drug Interactions: Mesbro Solution 3 ml is known to interact with anticoagulants (anisindione, dicumarol, warfarin).

Drug-Drug Interactions Checker List

  • ANISINDIONE
  • DICUMAROL
  • WARFARIN

Habit Forming

No

Diet & Lifestyle Advise

  • Empty your bladder frequently in the first 24 hours of chemotherapy (cancer treatment). If any pain occurs during urination, let your doctor know it.
  • Nausea can occur as a side effect of chemotherapy. Eat small and frequent meals to avoid it, or you can take any anti-nausea medicine.
  • Sleep at least 8 hours a day and take plenty of rest.
  • Maintain good nutrition. Eat home-cooked and freshly prepared food. Avoid junk, oily and spicy food.

Special Advise

  • Regular blood and urine test are required while using Mesbro Solution 3 ml.
  • Mesbro Solution 3 ml may interfere with enzymatic creatinine phosphokinase (CPK) activity tests that use a thiol compound (N-acetylcysteine) for CPK reactivation. This may result in a falsely low CPK level. Inform your doctor about the use of Mesbro Solution 3 ml.
  • Mesbro Solution 3 ml may interfere with a certain laboratory test (for urinary ketones), possibly causing false test results. Hence inform your doctor or laboratory personnel about the use of this medicine.

Disease/Condition Glossary

Ifosfamide-induced Hemorrhagic cystitis: It is a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It occurs when an individual undergoes planned chemotherapy (for cancer treatment). During chemotherapy, an anticancer medication called 'ifosfamide' causes inflammation and bleeding of the bladder, which is passed into the urine. The colour of urine may vary from pink to red in colour.  

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Alcohol

Caution

Consumption of alcohol while using Mesbro Solution 3 ml may increase the risk of drowsiness. Hence, avoid alcohol intake.

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Pregnancy

Unsafe

Mesbro Solution 3 ml is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before using Mesbro Solution 3 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Unsafe

If you are nursing, you should not use Mesbro Solution 3 ml since it is known to pass through the breast milk and damage the infant. Keep a week gap between ceasing Mesbro Solution 3 ml and nursing.

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Driving

Unsafe

Mesbro Solution 3 ml is known to cause blurred vision and drowsiness. So, do not drive or operate machinery which requires your concentration.

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Liver

Caution

Let your doctor know if you have a history of liver disease before using Mesbro Solution 3 ml. If necessary, your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Let your doctor know if you have a history of kidney diseases before using Mesbro Solution 3 ml. If necessary, your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Use is not recommended as the safety and efficacy of Mesbro Solution 3 ml have not been established in children. Moreover, Mesbro Solution 3 ml contains benzyl alcohol, which is known to cause a gasping syndrome in children.

Country of origin

INDIA

Manufacturer/Marketer address

C-504, NIRMAN PALACE, PUMP HOUSE, ANDHERI EAST MH 400093
Other Info -

FAQs

Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Mesbro Solution 3 ml works by making this natural chemical less harmful or toxic. However, Mesbro Solution 3 ml does not change ifosfamide's anti-cancer effects.
An autoimmune disease is a condition where the immune system targets the body's healthy tissues, leading to discomfort, edema, and damage. Nephritis, systemic lupus erythematosus, and rheumatoid arthritis are a few examples of autoimmune diseases.
No, Mesbro Solution 3 ml should not be taken along with anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.
In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.

Disclaimer

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