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  3. Mesna Injection 1's

Mesna Injection 1's, Pack of 1 Injection
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Mesna Injection is used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It contains Mesna, a chemo-protectant medicine. It works by altering the breakdown of anticancer agents (Ifosfamide) found in urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.
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Composition :

MESNA-100MG

Manufacturer/Marketer :

United Laboratories

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Mesna Injection

Mesna Injection belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our bodies degrade the anticancer drug (ifosfamide) to generate a compound (acrolein) that can injure and irritate the bladder. Mesna Injection decreases the risk of bladder irritation and bleeding caused by other anti-cancer drugs.

Mesna Injection contains 'Mesna', a chemo-protectant medicine that alters the breakdown of anti-cancer agents (Ifosfamide) found in the urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Mesna Injection will be administered to your vein by a trained healthcare professional; hence, do not self-administer. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms, fever, and injection site reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Mesna Injection is not recommended if you are allergic to it or any of its ingredients. An effective birth control measure should be taken to avoid pregnancy in women of a mother-bearing you’re your doctor may suggest regular urine and blood test while receiving Mesna Injection to monitor your CBC (blood cell count). Mesna Injection is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is advised to drink at least 1-2 litres of fluid daily while receiving Mesna Injection. This medicine should be avoided in pregnant and breastfeeding populations due to serious side effects; hence inform your doctor before administration.

Uses of Mesna Injection

Treatment of Ifosfamide-induced hemorrhagic cystitis

Directions for Use

Mesna Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Mesna Injection belongs to a class of medication known as 'chemoprotectant' primarily used to prevent bleeding into the urine by a particular anticancer medicine known as ifosfamide (ifosfamide-induced hemorrhagic cystitis). It also reduces the risk of inflammation and bleeding in the bladder by receiving anti-cancer medication. It contains Mesna, which works by reacting chemically with the urotoxic ifosfamide (anti-cancer medicines) metabolites, resulting in their detoxification. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

How Mesna Injection Works

Mesna Injection contains 'Mesna', a chemo-protectant medicine that alters the breakdown of anti-cancer agents (Ifosfamide) found in the urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Storage

Store in a cool and dry place away from sunlight
Side effects of Mesna Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

What if I have taken an overdose of Mesna Injection

As Mesna Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not take this injection if you are allergic to Mesna Injection or any of its ingredients. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a three-month gap between your last dose of Mesna Injection and your next pregnancy. Regular urine and blood test should be done while receiving Mesna Injection to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery. 

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Empty your bladder frequently in the first 24 hours of chemotherapy (cancer treatment). If any pain occurs during urination, let your doctor know it.
  • Nausea can occur as a side effect of chemotherapy. Eat small and frequent meals to avoid it, or you can take any anti-nausea medicine.
  • Sleep at least 8 hours a day and take plenty of rest.
  • Maintain good nutrition. Eat home-cooked and freshly prepared food. Avoid junk, oily and spicy food.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS
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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Mesna Injection as it may lead to serious side effects.

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Pregnancy

Unsafe

Mesna Injection is not recommended to be used in pregnancy as it may cause serious side effects. Use effective birth control measures before starting the treatment with Ifosamide and for 3 months after completing the treatment. If you get pregnant while you are receiving Mesna Injection, inform your doctor.

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Breast Feeding

Unsafe

Mesna Injection should not be used if you are breastfeeding as it is known to pass through the breast milk and harm your infant. Do not breastfeed for at least one week following your last dosage of mesna or ifosfamide.

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Driving

Unsafe

Mesna Injection is known to cause blurred vision and drowsiness. So, do not drive or operate machinery, which requires mental alertness.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before receiving Mesna Injection.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before receiving Mesna Injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

The safety and efficacy of Mesna Injection in children have not been established. Moreover, Mesna Injection contains benzyl alcohol, which is known to cause a gasping syndrome in children. Hence, use is not recommended.

FAQs

Mesna Injection is used to treat Ifosfamide-induced hemorrhagic cystitis.

Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Mesna Injection works by making this natural chemical less harmful or toxic. However, Mesna Injection does not change ifosfamide's anti-cancer effects.

No, Mesna Injection should not be taken with an anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.

An autoimmune disorder is a condition in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage. Some autoimmune disorders are rheumatoid arthritis, systemic lupus erythematosus or nephritis.

Please inform your doctor if you observe any change in the urine colour (like if you have red/pink-coloured urine).

In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.

Mesna Injection is given with ifosfamide or cyclophosphamide to prevent haemorrhagic cystitis which is a serious side effect caused by the toxic metabolite acrolein produced when these drugs are metabolized.

Yes, Mesna Injection is compatible with potassium chloride and doxorubicin. Though no interactions were found, it is advised to consult the doctor before taking Mesna Injection with potassium chloride and doxorubicin.

No, Mesna Injection is not a chemotherapy drug by itself. However, it is used along with chemotherapy drugs like Ifosfamide to prevent haemorrhagic cystitis, a side effect caused by the toxic metabolites of Ifosfamide, such as acrolein.

No, Mesna Injection is not cytotoxic. It is used as a chemo protectant, mainly to prevent haemorrhagic cystitis caused by chemotherapy drugs. It protects the bladder from damage by detoxifying toxic metabolites such as acrolein. Mesna Injection itself does not have cytotoxic effects, it is administered with cytotoxic drugs.

No, Mesna Injection is not a vesicant. Instead, Mesna Injection serves as a chemo protectant to safeguard the bladder from toxic metabolites produced by chemotherapy drugs, particularly preventing haemorrhagic cystitis.

The side effects of Mesna Injection include headache, nausea, vomiting, fever, diarrhoea, lethargy, flushing (sense of warmth in the face, ears, neck, and trunk), rash, light-headedness, abdominal pain, flu-like symptoms, and injection site reactions. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

8/3, Asaf Ali Road, New Delhi-110002
Other Info - MES0005

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Author Details

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Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:45 PM IST

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Reference

  1. https://www.drugs.com/mtm/mesna-oral-injection.htmlhttp://chemocare.com/chemotherapy/drug-info/Mesnex.aspx
  2. https://medlineplus.gov/druginfo/meds/a695034.html
  3. https://my.clevelandclinic.org/health/drugs/20286-mesna-injection
  4. https://www.rxlist.com/mesnex-drug.htm
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