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  3. Methergin Injection 1's

Methergin Injection 1's, Pack of 1 Injection
Methergin Injection 1's, Pack of 1 Injection
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Synonym :

METHYLERGOMETRINE MALEATE

Composition :

METHYLERGOMETRINE-0.2MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Methergin Injection

Methergin Injection belongs to the class of medication called 'ergot alkaloids' or 'uterotonic' primarily used to prevent and stop heavy bleeding (postpartum-third stage of labour bleeding) after childbirth or after a miscarriage in cesarean section. Besides this, it is also used to improve uterine contraction (antepartum) and produce uterine contraction during the third stage of labor (postpartum). Postpartum haemorrhage is heavy bleeding (more than normal) after the birth of the baby.

Methergin Injection contains a semi-synthetic ergot alkaloid 'Methylergometrine', that stimulates uterine muscles and increases the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increasing contractions and producing labour. As a result, these increased uterine contractions help in the child's delivery and substantially reduce excessive uterine bleeding. 

Methergin Injection will be administered by a healthcare professional. Do not self-administer. The most common side effects of Methergin Injection are nausea, vomiting, stomach pain, and mild headache in some cases. Most of these side effects of Methergin Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you ever had surgery on the uterus, cesarean, or premature labour, please inform your doctor to avoid any complications. If you have been given prostaglandins, then do not take Methergin Injection; if both medicines are taken together, it can increase the contractions. Methergin Injection should not be used for a prolonged time if the contractions do not increase or have severe pre-eclamptic toxemia (high blood pressure, protein in the urine, and swelling), blood or heart circulation problem. 

Uses of Methergin Injection

Treatment of Postpartum haemorrhage.

Directions for Use

Methergin Injection will be administered by a healthcare professional under strict medical supervision. Do not self-administer.

Medicinal Benefits

Methergin Injection contains a semi-synthetic ergot alkaloid 'Methylergometrine' primarily used to stop heavy bleeding postpartum, i.e. third stage of labour bleeding after childbirth or after a miscarriage in cesarean section. Additionally, it plays a significant role in birth by increasing uterus contractions and inducing labour in pregnant women. Methergin Injection works by stimulating uterine muscles and expanding the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increases the contraction,s and hence induces labour. As a result, these increased uterine contractions help deliver the child and substantially reduce excessive uterine bleeding.

How Methergin Injection Works

Methergin Injection contains a semi-synthetic ergot alkaloid 'Methylergometrine', that stimulates uterine muscles and increases the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), increasing contractions and producing labour. As a result, these increased uterine contractions help in the child's delivery and substantially reduce excessive uterine bleeding.

Storage

Store in a cool and dry place away from sunlight
Side effects of Methergin Injection
  • Stress levels should be managed by practicing yoga and meditation regularly.
  • Maintain a proper sleeping schedule.
  • Maintain a balanced diet containing low glycemic index like fruits, vegetables, proteins and grains.
  • Do not consume alcohol.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Methergin Injection

The overdose of Methergin Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms after receiving Methergin Injection, please inform your doctor immediately.

Drug Warnings

Do not take Methergin Injection if you are allergic to Methergin Injection or any of its ingredients. Increasing the dose of Methergin Injection can be harmful if your womb already has too strong contractions, any obstructions in the pathway that might prevent the delivery or if the baby is not receiving a sufficient oxygen supply. Also, the use of Methergin Injection is not advisable if the baby is wrongly positioned in the birth canal, the baby’s head is too large to fit through the pelvis, the placenta lies near the neck of the womb, the placenta separates from the womb before birth, the womb is over-extended and likely to tear (in case you are carrying more than one baby). If you have been given prostaglandins, do not use Methergin Injection within 6 hours as both medications, if taken together, can increase the contractions. Methergin Injection should not be used for a prolonged time if the contractions do not increase or if you have severe pre-eclamptic toxaemia (high blood pressure, protein in the urine, and swelling) or blood or heart circulation problems.

Drug-Drug Interactions

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MethylergometrineSumatriptan
Critical
MethylergometrineKetoconazole
Critical

Drug-Drug Interactions

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MethylergometrineSumatriptan
Critical
How does the drug interact with Methergin Injection:
Coadministration of Sumatriptan with Methergin Injection can reduce the blood flow and increase the risk of high blood pressure or heart-related problems.

How to manage the interaction:
Taking Sumatriptan with Methergin Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MethylergometrineKetoconazole
Critical
How does the drug interact with Methergin Injection:
Using Ketoconazole with Methergin Injection can increase the concentration of Methergin Injection, which may lead to side effects.

How to manage the interaction:
Taking Ketoconazole with Methergin Injection is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineRitonavir
Critical
How does the drug interact with Methergin Injection:
Taking Methergin Injection with Ritonavir can significantly increase the blood levels and effects of Methergin Injection.

How to manage the interaction:
Taking Methergin Injection with Ritonavir is not recommended, but can be taken together if prescribed by a doctor. In case you experience any side effects like severe abdominal discomfort, nausea, vomiting, tingling or numbness, weakness or pain in the muscles, pale skin, blue or purple discoloration on fingers or toes, tightness or pain in the chest, irregular heartbeat, intense headache, breathing difficulties, confusion, or slurred speech, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethylergometrineVoriconazole
Critical
How does the drug interact with Methergin Injection:
Coadministration of Methergin Injection with Voriconazole may increase the blood level of Methergin Injection.

How to manage the interaction:
Although Methergin Injection with Voriconazole can cause an interaction, they can be taken if prescribed by a doctor. Do not discontinue any medication without consulting a doctor.
MethylergometrineClarithromycin
Critical
How does the drug interact with Methergin Injection:
When Methergin Injection is taken with Clarithromycin, the amount of Methergin Injection in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Clarithromycin with Methergin Injection is generally avoided as it can lead to an interaction, it can be taken only when advised by a doctor. Do not stop using any medications without a doctor's advice.
MethylergometrineGlyceryl trinitrate
Critical
How does the drug interact with Methergin Injection:
Coadministration of Methergin Injection with Glyceryl trinitrate can increase the levels and side effects of Methergin Injection.

How to manage the interaction:
Taking Methergin Injection with Glyceryl trinitrate is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, headache, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor. Do not discontinue any medications without first consulting your doctor.
MethylergometrineItraconazole
Critical
How does the drug interact with Methergin Injection:
Co-administration of Methergin Injection and Itraconazole may increase the blood levels of Methergin Injection.

How to manage the interaction:
Methergin Injection and itraconazole may interact, but if prescribed by a doctor, they can be used together. Do not discontinue any medications without first consulting your doctor.
MethylergometrineEphedrine
Severe
How does the drug interact with Methergin Injection:
Taking Ephedrine with Methergin Injection may lead to an increase in the risk of high blood pressure.

How to manage the interaction:
Although taking Ephedrine with Methergin Injection may lead to an interaction, it can be taken if prescribed by the doctor. It is advised to maintain your blood pressure. Do not discontinue any medications without a doctor's advice.
MethylergometrinePhenylephrine
Severe
How does the drug interact with Methergin Injection:
Taking Phenylephrine with Methergin Injection can led to side effects like increased blood pressure.

How to manage the interaction:
Taking Phenylephrine with Methergin Injection can lead to an interaction but can be taken if prescribed by the doctor. It is advised to monitor your blood pressure regularly. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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METHYLERGOMETRINE-0.2MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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METHYLERGOMETRINE-0.2MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of Methergin Injection with Grapefruit and Grapefruit may lead to an increase in the effectiveness of Methergin Injection. Avoid or limit grapefruit and grapefruit juice consumption with Methergin Injection. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

  • Long walks can help to relieve stress, keep your body strong, and help in easy delivery.
  • Please take a little bit of Castrol oil as it is known to stimulate prostaglandin, which ripens the cervix and get labor started.
  • Some food like dates, raspberry tea leaves are known to ripen the cervix and get labor started.
  • Acupressure also stimulates labor and helps in delivery.

Habit Forming

No

Therapeutic Class

OXYTOCIC, UTEROTONIC, ECBOLIC

Methergin Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

It is not known if alcohol affects Methergin Injection. Consult your doctor.

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Pregnancy

Unsafe

Methergin Injection is not recommended for use during pregnancy.

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Breast Feeding

Unsafe

It is advised to avoid breastfeeding for at least 12 hours after taking Methergin Injection as this medicine may pass into breast milk and can harm a nursing baby.

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Driving

Unsafe

Avoid driving and operating machinery.

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Liver

Safe if prescribed

Methergin Injection is not known to show any interaction in liver disease.

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Kidney

Caution

Methergin Injection to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose will be adjusted by your doctor.

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Children

Unsafe

Methergin Injection is not recommended for children below the age of 18 years. The safety and effectiveness of Methergin Injection have not been established in children.

Have a query?

FAQs

Methergin Injection is used to prevent and stop heavy bleeding (postpartum-third stage of labour bleeding) after childbirth or after a miscarriage in cesarean section. Besides this, it is also used to improve uterine contraction (antepartum) and produce uterine contraction during the third stage of labor (postpartum).

Methergin Injection works by stimulating uterine muscles and increasing the uterus' contractions, thus reducing blood loss. It also increases the effects of a natural substance called prostaglandins (PGs), and increases the contraction, thereby inducing labour pain in pregnant women. As a result, these increased uterine contractions help in the child's delivery and substantially reduce excessive uterine bleeding.

If you have a previous premature delivery or a cesarian section, or cervical surgery, please inform your doctor before starting Methergin Injection. Also, mention a detailed medical history to your doctor to avoid any complications.

The most common side effects of Methergin Injection include nausea, vomiting, stomach pain, mild headache. You might also feel increased uterine contractions for some time, but these are manageable under medical supervision.

It is suggested to avoid grapefruit and grapefruit juice while taking Methergin Injection as it can worsen the side effects of Methergin Injection.

It is advised to tell your doctor if you are using antifungal medicine (Fluconazole) or other medicine, including prescription and over-the-counter medicines, vitamins, and herbal products, as taking Methergin Injection with some medications may cause serious side effects.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - MET0066

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://www.drugs.com/sfx/methergine-side-effects.html
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/006035s078lbl.pdf

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