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  3. METRONIDAZOLE 400MG TABLET

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METRONIDAZOLE 400MG TABLET, Pack of 10 TABLETS
METRONIDAZOLE 400MG TABLET, Pack of 10 TABLETS
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Composition :

METRONIDAZOLE-400MG

Manufacturer/Marketer :

RPL India Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About METRONIDAZOLE 400MG TABLET

METRONIDAZOLE 400MG TABLET belongs to a group of medicines called Antimicrobials,' used to treat bacterial infections of the blood, brain, lung, bone, pelvic area, stomach lining, intestines, gum, teeth, following childbirth, or wound infection following an operation. It is also used to treat infected leg ulcers, pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by the Trichomonas parasite, amoebiasis (parasitic infection of the colon), and to prevent infections after surgery.

METRONIDAZOLE 400MG TABLET contains metronidazole, which works by preventing the production of proteins required by the harmful microorganisms for their survival. Thereby, METRONIDAZOLE 400MG TABLET treats bacterial and parasitic infections.

Your doctor will decide the dose and duration depending on the type of infection. Some common side effects of METRONIDAZOLE 400MG TABLET are nausea, vomiting, upset stomach, loss of appetite, dry mouth, and a metallic taste. Most of these side effects do not require medical attention and typically resolve on their own over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take METRONIDAZOLE 400MG TABLET if you are allergic to any of its components. METRONIDAZOLE 400MG TABLET should not be used during pregnancy, especially during the first trimester and while breastfeeding. Do not drive or operate heavy machinery after taking METRONIDAZOLE 400MG TABLET, as it may cause dizziness and drowsiness. Avoid consumption of alcohol while on treatment with METRONIDAZOLE 400MG TABLET and for 48 hours after completing the course, as it may cause unpleasant side effects. Keep your doctor informed about your health condition and any medications you are taking to help rule out any potential side effects.

Uses of METRONIDAZOLE 400MG TABLET

METRONIDAZOLE 400MG TABLET is used to treat bacterial and protozoal infections. The detailed uses of METRONIDAZOLE 400MG TABLET are as follows:

  • Bacterial infections: METRONIDAZOLE 400MG TABLET is widely used to treat infections caused by anaerobic bacteria, including those affecting the lungs, throat, bone and joints, skin and soft tissues, blood, brain, pelvic area, stomach lining, and intestines.
  • Protozoal infections: METRONIDAZOLE 400MG TABLET is effective against protozoa such as Entamoeba histolytica (linked to amoebic dysentery); it inhibits protozoal reproduction. It is also used to treat urinary or genital infections caused by the Trichomonas parasite.
  • Dental infections: METRONIDAZOLE 400MG TABLET is often prescribed in dentistry to address gum and oral cavity infections, particularly those caused by anaerobic bacteria. It may be used in combination with other antibiotics for enhanced effectiveness.
  • Helicobacter Pylori Eradication: METRONIDAZOLE 400MG TABLET is used as part of a combination therapy to eradicate Helicobacter pylori, a bacterium associated with peptic ulcers. It is typically used alongside other antibiotics and proton pump inhibitors.
  • Further Applications: METRONIDAZOLE 400MG TABLET is also used to treat bacterial infections following childbirth or wound infections after surgery.

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Side effects of Metronidazole 400mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Inflammation of Vagina needs immediate attention and cannot be ignored.
  • Get a physical examination and prevent wearing clothes that can hold heat and moisture.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Follow your doctor's instructions, and rest well with proper medication.
  • Take a balanced diet and get regular screenings to reduce inflammation.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.

Directions for Use

  • METRONIDAZOLE 400MG TABLET can be taken with or without food. However, if it causes stomach discomfort, taking it with food may help.
  • Take it exactly as prescribed by your doctor, who will determine the appropriate dose and timing based on the severity of your infection.
  • Swallow it whole with a glass of water.
  • Do not crush, chew, or break it.

Key Benefits

METRONIDAZOLE 400MG TABLET contains metronidazole used to treat and prevent bacterial and parasitic infections, including blood, brain, bone, lung, stomach lining, pelvic area and genital infections, amoebiasis, gum and teeth infections, infected leg ulcers or pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by Trichomonas parasite. Furthermore, it can also be used to treat infections that occur after childbirth or wound infections that follow surgery. It works by preventing the production of proteins required by the harmful microorganisms for their survival. Thereby, METRONIDAZOLE 400MG TABLET helps treat bacterial and parasitic infections.

How METRONIDAZOLE 400MG TABLET Works

METRONIDAZOLE 400MG TABLET contains metronidazole, which works by preventing the production of proteins required by the harmful microorganisms for their survival. Thereby, METRONIDAZOLE 400MG TABLET treats bacterial and parasitic infections.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of METRONIDAZOLE 400MG TABLET

Do not take more than the prescribed dose of METRONIDAZOLE 400MG TABLET, as it may cause an overdose. The symptoms of an overdose include nausea, vomiting, seizures (fits), loss of muscle coordination, and numbness, burning, pain, or tingling in the hands or feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take METRONIDAZOLE 400MG TABLET if you are allergic to any of its components. METRONIDAZOLE 400MG TABLET should not be used during pregnancy, especially during the first trimester. Please inform your doctor if you are pregnant or planning to become pregnant. Avoid breastfeeding while taking METRONIDAZOLE 400MG TABLET and for 12-24 hours after completing the course. Do not drive or operate heavy machinery after taking METRONIDAZOLE 400MG TABLET, as it may cause dizziness and drowsiness. Inform your doctor before taking METRONIDAZOLE 400MG TABLET if you have any medical conditions, such as Clostridium difficile-associated diarrhoea, bone marrow depression/low blood count, CNS disorder, epilepsy, porphyria (blood disorder), peripheral neuropathy, or heart, liver, or kidney problems.

Drug-Drug Interactions

verifiedApollotooltip
MetronidazoleDisulfiram
Critical
MetronidazoleAmprenavir
Critical

Drug-Drug Interactions

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MetronidazoleDisulfiram
Critical
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Coadministration of Disulfiram with Metronidazole 400mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole 400mg Tablet and Disulfiram together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
MetronidazoleAmprenavir
Critical
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Co-administration of Amprenavir with Metronidazole 400mg Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Metronidazole 400mg Tablet with Amprenavir is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience throbbing in the head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetronidazoleEthanol
Critical
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Drinking alcohol while taking Metronidazole 400mg Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Taking Metronidazole 400mg Tablet with Ethanol is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetronidazoleBusulfan
Severe
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Coadministration of Busulfan and Metronidazole 400mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole 400mg Tablet and Busulfan together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
MetronidazoleMebendazole
Severe
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Coadministration of Metronidazole 400mg Tablet with mebendazole may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Metronidazole 400mg Tablet and mebendazole, they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms like fever, body ache, painful red rash, cough, peeling of the skin, or Drooling, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MetronidazoleWarfarin
Severe
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Coadministration of Metronidazole 400mg Tablet with warfarin can increase the risk of bleeding.

How to manage the interaction:
There is a possible interaction between Metronidazole 400mg Tablet and warfarin, but they can be taken together if a doctor has prescribed them. Consult a doctor if experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without talking to a doctor.
MetronidazoleFluconazole
Moderate
How does the drug interact with Metronidazole 400mg Tablet 400mg Tablet:
Co-administration of Fluconazole together with Metronidazole 400mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
-Taking Metronidazole 400mg Tablet with Fluconazole together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of METRONIDAZOLE 400MG TABLET to restore healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods, such as yoghurt, cheese, sauerkraut, and kimchi, can help restore the intestines' good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Whole grains, such as whole-grain bread and brown rice, should be included in the diet.
  • Avoid intake of alcoholic beverages with METRONIDAZOLE 400MG TABLET as it can make you dehydrated and affect your sleep. This can make it harder for your body to help METRONIDAZOLE 400MG TABLET fight off infections.
  • If you have diarrhoea, drink appropriate amounts of fluids to avoid dehydration.

Habit Forming

No

Therapeutic Class

ANTIMICROBIALS

METRONIDAZOLE 400MG TABLET Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol while on treatment with METRONIDAZOLE 400MG TABLET and for 48 hours after completing the course to avoid unpleasant side effects such as nausea, vomiting, stomach pain, palpitations, headache, and hot flushes.

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Pregnancy

Unsafe

METRONIDAZOLE 400MG TABLET should not be used during pregnancy, especially during the first trimester. Inform your doctor if you are pregnant or planning to become pregnant.

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Breast Feeding

Unsafe

METRONIDAZOLE 400MG TABLET may pass into breast milk. Avoid breastfeeding while taking METRONIDAZOLE 400MG TABLET and for 12-24 hours after completing the course.

bannner image

Driving

Caution

METRONIDAZOLE 400MG TABLET may cause dizziness and drowsiness; therefore, avoid driving or operating machinery unless you are alert.

bannner image

Liver

Caution

METRONIDAZOLE 400MG TABLET should be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your liver condition.

bannner image

Kidney

Caution

METRONIDAZOLE 400MG TABLET should be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your kidney condition.

bannner image

Children

Safe if prescribed

METRONIDAZOLE 400MG TABLET should be given to children only if prescribed by a doctor. Your doctor may adjust the dose as per the age of your child.

FAQs

METRONIDAZOLE 400MG TABLET is used to treat and prevent bacterial and parasitic infections, including blood, brain, bone, lung, stomach lining, pelvic area and genital infections, amoebiasis, gum and teeth infections, infected leg ulcers or pressure sores, stomach ulcers caused by Helicobacter pylori, urinary or genital infections caused by the Trichomonas parasite. Furthermore, it can also be used to treat infections that occur after childbirth or wound infections following surgery.

METRONIDAZOLE 400MG TABLET works by preventing the production of proteins required by harmful microorganisms for their survival. Thereby, METRONIDAZOLE 400MG TABLET helps treat and prevent bacterial and parasitic infections.

No. You should complete the full course of METRONIDAZOLE 400MG TABLET as prescribed by your doctor. Consult your doctor if you experience any difficulty while taking METRONIDAZOLE 400MG TABLET.

No. METRONIDAZOLE 400MG TABLET is an antimicrobial medicine that acts only against bacterial infections, not against viral infections such as the common cold and flu.

If you miss a dose of METRONIDAZOLE 400MG TABLET, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular schedule. Never take a double dose to make up for the missed one.

METRONIDAZOLE 400MG TABLET may cause jaundice in a rare case. Please consult your doctor immediately if you notice yellowing of the skin and eyes.

No. Do not stop taking METRONIDAZOLE 400MG TABLET until the course is completed, as prescribed by the doctor. If you stop taking it, your problem may reoccur. If you experience any difficulty or adverse events that persist while taking it, report them to your doctor and seek appropriate treatment.

METRONIDAZOLE 400MG TABLET may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori). Even so, it can only be used if advised by a doctor.

Do not take more than the prescribed dose of METRONIDAZOLE 400MG TABLET, as it may cause an overdose. The symptoms of an overdose include nausea, vomiting, seizures (fits), loss of muscle coordination, and numbness, burning, pain, or tingling in the hands or feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

If the symptoms do not improve within a few days after starting this medicine or if they worsen, consult your doctor. They will reassess the condition and provide guidance on appropriate treatment.

METRONIDAZOLE 400MG TABLET may interact with certain medications. So, do not use any other medications with METRONIDAZOLE 400MG TABLET unless recommended by the doctor. Your doctor will check for potential interactions and prescribe you if necessary.

Antibiotics like METRONIDAZOLE 400MG TABLET may reduce the vaccine's activity. To ensure an adequate vaccine response, vaccination should be administered at least 14 days after completing treatment with METRONIDAZOLE 400MG TABLET or 10 days before starting therapy with METRONIDAZOLE 400MG TABLET. Talk to your doctor if you have any questions or concerns.

Let your doctor know about your child’s medical history and ongoing medications before prescribing METRONIDAZOLE 400MG TABLET.

Yes, it is normal. METRONIDAZOLE 400MG TABLET can cause urine discolouration. This is harmless and should resolve on its own once your child stops taking the medication.

METRONIDAZOLE 400MG TABLET may interfere with some drugs. Always check with a doctor before giving any medication, especially if your child is feverish. The doctor will advise the best course of treatment for your child.

To ensure the medication's effectiveness and progress of the medical condition, the doctor may perform certain lab tests, such as a complete blood count (CBC), liver function test (LFT), and kidney function test (KFT) if necessary.

Common side effects of METRONIDAZOLE 400MG TABLET may include nausea, vomiting, upset stomach, loss of appetite, dry mouth, and a metallic taste. Most of these side effects do not require medical attention and will gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA
Other Info - MET0230

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 5, 2025 | 11:24 AM IST

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Reference

  1. https://www.drugs.com/metronidazole.html
  2. https://medlineplus.gov/druginfo/meds/a689011.html
  3. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=93e4f174-4fe0-4cfd-a0cf-d0963e082107
  4. https://labeling.pfizer.com/showlabeling.aspx?id=570
  5. https://www.medsafe.govt.nz/Consumers/cmi/m/Metrogyl.pdf
  6. https://webmedpharmacy.co.uk/media/pil/sti/PIL_metronidazole_400mg_tabs.pdf
  7. https://www.nhs.uk/medicines/metronidazole/about-metronidazole/
  8. https://www.medicines.org.uk/emc/files/pil.5882.pdf
  9. https://www.drugs.com/drug-interactions/metronidazole-index.html?filter=3

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