Mrka P 500mg/325mg Tablet

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Composition:MEFENAMIC ACID-500MG+PARACETAMOL-325MG

Prescription Medicine

Mrka P 500mg/325mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. The medicine provides effective pain relief and helps improve comfort in conditions involving inflammation and fever.

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

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More about the Product

Composition :

MEFENAMIC ACID-500MG+PARACETAMOL-325MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Mrka P 500mg/325mg Tablet

Mrka P 500mg/325mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, osteoarthritis, and rheumatoid arthritis. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Mrka P 500mg/325mg Tablet contains Mefenamic acid and Paracetamol, which block the action of a chemical messenger known as cyclo-oxygenase (COX), which produces other chemical prostaglandins.

Mrka P 500mg/325mg Tablet may cause common side effects such as nausea, vomiting, indigestion, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Mrka P 500mg/325mg Tablet may cause dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Mrka P 500mg/325mg Tablet

Mrka P 500mg/325mg Tablet is used to treat pain, inflammation, osteoarthritis, and rheumatoid arthritis. The detailed uses of Mrka P 500mg/325mg Tablet are as follows:

Pain Relief: Mrka P 500mg/325mg Tablet is commonly used to alleviate moderate to severe pain, including headaches, dental pain, and muscle aches.
Menstrual Pain Management: Mrka P 500mg/325mg Tablet is frequently prescribed to relieve dysmenorrhea, which refers to painful menstrual cramps, providing comfort during menstruation.
Fever Reduction: Mrka P 500mg/325mg Tablet can be effective in lowering fever, making it suitable for treating febrile conditions associated with various infections.
Post-Surgical Pain Relief: Mrka P 500mg/325mg Tablet may be used to manage pain following surgical procedures, helping patients recover more comfortably.
Treatment of Inflammatory Conditions: Mrka P 500mg/325mg Tablet can be utilised to reduce inflammation and pain associated with conditions such as arthritis and other inflammatory disorders.

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Directions for Use

Recommended to take Mrka P 500mg/325mg Tablet with food to reduce stomach upset or as advised by your doctor.
Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
Swallow the medicine as a whole with glass of water.
Do not crush, break, or chew it.

Key Benefits

Relieves pain: Helps reduce mild to moderate pain such as headache, toothache, and muscle pain.
Reduces fever: Helps lower high body temperature during infections.
Eases menstrual pain: Effective in relieving cramps and discomfort during periods.
Reduces inflammation: Helps decrease swelling and inflammation associated with pain.
Provides quick comfort: Helps improve overall comfort in conditions causing pain and fever.

How Mrka P 500mg/325mg Tablet Works

Mrka P 500mg/325mg Tablet contains two drugs, Mefenamic acid and Paracetamol. Mrka P 500mg/325mg Tablet blocks the action of a chemical messenger known as the cyclo-oxygenase (COX) enzyme, which produces other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

Storage

Store in a cool and dry place away from sunlight

Side effects of Mrka P 500mg/325mg Tablet

Stomach Ulcer

Do not consume spicy foods, caffeine, and alcohol.
Choose low-acid fruits and vegetables like apples, melons, and carrots.
Include whole grains like whole-wheat bread, oatmeal, and brown rice.
Limit processed meats like hotdogs and sausages.
Avoid fatty, spicy, or acidic salad dressings.
Limit tomatoes and tomato-based products.
Quit smoking to promote ulcer healing.
Adopt a balanced diet and lifestyle to reduce the risk of peptic ulcers.

Bleeding Stomach

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Gas Or Fart

Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:

Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Mrka P 500mg/325mg Tablet

Do not take more than the prescribed dose of Mrka P 500mg/325mg Tablet as it may cause an overdose. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

Do not take Mrka P 500mg/325mg Tablet if you are allergic to any of its contents; if you have severe heart, kidney or liver failure; or if you have suffered bleeding problems such as bleeding from the stomach or bowels while taking painkillers or if you have peptic ulcers or inflammatory bowel disease.
Inform your doctor if you have high blood pressure, heart problems, high cholesterol, dehydration, asthma, gastrointestinal bleeding, ulceration, perforation of the stomach and intestine, or liver and kidney problems.
Consult your doctor if you are pregnant or breastfeeding.
Mrka P 500mg/325mg Tablet may cause dizziness, so drive only if you are alert.
Stop taking Mrka P 500mg/325mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the stomach or intestines, such as blood in the stool.
Do not take any other NSAIDs for pain relief along with Mrka P 500mg/325mg Tablet unless prescribed by the doctor.

Drug-Drug Interactions

Mefenamic acidKetorolac

Critical

Mefenamic acidMeloxicam

Critical

Drug-Drug Interactions

Mefenamic acidKetorolac

Critical

How does the drug interact with Mrka P 500mg/325mg Tablet:
Coadministration of Mrka P 500mg/325mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Mefenamic acidMeloxicam

Critical

How does the drug interact with Mrka P 500mg/325mg Tablet:
Co-administration of Mrka P 500mg/325mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.

Mefenamic acidRivaroxaban

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
Coadministration of Mrka P 500mg/325mg Tablet with Rivaroxaban can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Rivaroxaban together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Mefenamic acidIndometacin

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
The combined use of Indometacin and Mrka P 500mg/325mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Indometacin with Mrka P 500mg/325mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

Mefenamic acidDasatinib

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
Co-administration of Mrka P 500mg/325mg Tablet with Dasatinib can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Dasatinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Mefenamic acidTacrolimus

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
Coadministration of Mrka P 500mg/325mg Tablet with Tacrolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Tacrolimus together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Mefenamic acidFlurbiprofen

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
Co-administration of Mrka P 500mg/325mg Tablet with Flurbiprofen can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Flurbiprofen together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of dizziness, lightheadedness, unusual bleeding or bruising, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Mefenamic acidDanaparoid

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
Using danaparoid together with Mrka P 500mg/325mg Tablet can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possibility of interaction between Mrka P 500mg/325mg Tablet and Danaparoid, but it can be taken if prescribed by a doctor. If you notice any of these signs - bruising, swelling, vomiting, headache, dizziness, weakness, bleeding, or blood in your urine or stools, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Mefenamic acidTenofovir alafenamide

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
The combined use of Mrka P 500mg/325mg Tablet and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Mefenamic acidLithium

Severe

How does the drug interact with Mrka P 500mg/325mg Tablet:
Co-administration of Mrka P 500mg/325mg Tablet with Lithium can increase Lithium levels in the body.

How to manage the interaction:
Taking Mrka P 500mg/325mg Tablet with Lithium together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, contact a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

Diet

Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
Drink plenty of water to stay hydrated and support overall health.
Eat a balanced diet that includes fruits, vegetables, and whole grains to support better recovery.

Physical activity

Do light activities such as walking or stretching once pain starts improving.
Avoid heavy exercise or strenuous work if you have severe pain or fever.
Performing yoga may also help improve joint flexibility and manage pain.

Sleep

Get adequate sleep, as rest can help reduce inflammation and swelling.

Lifestyle changes

De-stress yourself by meditating, reading, taking a warm bubble bath, or listening to soothing music.
Acupuncture, massage and physical therapy may also be helpful.
Avoid smoking and alcohol consumption.

Habit Forming

Therapeutic Class

[ANALGESICS]

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Mrka P 500mg/325mg Tablet as it may cause increased dizziness. It can also increase the risk of stomach bleeding.

Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant or have any concerns about this; your doctor will prescribe only if the benefits outweigh the risks.

Breast Feeding

Consult your doctor

Please consult your doctor before taking Mrka P 500mg/325mg Tablet; your doctor will decide whether Mrka P 500mg/325mg Tablet can be taken by breastfeeding mothers or not.

Driving

Caution

Mrka P 500mg/325mg Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

Children

Consult your doctor

Please consult your doctor. Your doctor will prescribe the dose and duration based on your child's condition.

Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed, extreme caution should be exercised.

Geriatrics

Caution

Mrka P 500mg/325mg Tablet should be used with caution in geriatric patients. Please consult your physician.

FAQs

What is the use of Mrka P 500mg/325mg Tablet?

Mrka P 500mg/325mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis.

How does Mrka P 500mg/325mg Tablet work?

Mrka P 500mg/325mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandins. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

Is Mrka P 500mg/325mg Tablet used to treat arthritis?

Mrka P 500mg/325mg Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Arthritis is joint tenderness and swelling.

I have stomach ulcers. Can I take Mrka P 500mg/325mg Tablet?

Avoid taking Mrka P 500mg/325mg Tablet if you have stomach ulcers, bleeding problems, or heart problems. Talk to your doctor regarding your concerns; he/she may prescribe alternative medicine.

Does Mrka P 500mg/325mg Tablet cause diarrhoea?

Diarrhoea might be a side-effect of Mrka P 500mg/325mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Is Mrka P 500mg/325mg Tablet used to relieve period pain?

Mrka P 500mg/325mg Tablet is used to relieve menstrual (period) pain and manage excessively heavy periods. Take Mrka P 500mg/325mg Tablet only as prescribed by the doctor.

Is it safe to take Mrka P 500mg/325mg Tablet for longer durations?

Mrka P 500mg/325mg Tablet is generally prescribed for short-term use. Do not take Mrka P 500mg/325mg Tablet for longer durations, as it might increase the risk of kidney problems and stomach bleeding.

Country of origin

India

Other Info - MR51954

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Mar 12, 2026 | 8:26 AM IST

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