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N S 0.45% Infusion

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

N S 0.45% Infusion is used for fluid replacement. It contains Sodium chloride, which helps maintain the balance of fluid in and around the body’s cells and tissues. It aids in restoring the normal salt balance. It serves as a source of electrolytes and water, providing hydration. Sometimes, N S 0.45% Infusion may cause injection site reactions such as irritation, swelling, tenderness, and redness.

Composition :

SODIUM CHLORIDE-0.45%W/V

Manufacturer/Marketer :

Baxter India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About N S 0.45% Infusion

N S 0.45% Infusion is indicated for the replacement of extracellular fluid, parenteral replenishment of fluid and sodium chloride as required by the patient’s clinical condition, and treatment of metabolic acidosis in the presence of fluid loss.

N S 0.45% Infusion contains Sodium chloride, which helps maintain the balance of fluid in and around the body’s cells and tissues. It aids in restoring the normal salt balance.

In some cases, N S 0.45% Infusion may cause injection site reactions, including irritation, swelling, tenderness, and redness. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if the side effects persist or worsen.

Tell your doctor if you are allergic to any components in N S 0.45% Infusion. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and any medications you are taking. Please consult your doctor if you have any concerns about using N S 0.45% Infusion in children.

Uses of N S 0.45% Infusion

N S 0.45% Infusion is used in the treatment of Fluid replacement. The detailed uses of N S 0.45% Infusion are as follows:

Fluid Replacement: N S 0.45% Infusion helps to rehydrate patients by replenishing fluids lost due to illness, surgery, or other medical conditions.
Electrolyte Balance: N S 0.45% Infusion maintains electrolyte balance by replenishing sodium and chloride levels, which are crucial for various bodily functions.
Dilution of Medications: N S 0.45% Infusion serves as a diluent for medications, allowing safe and effective intravenous administration.
Wound Irrigation: N S 0.45% Infusion cleanses wounds, promoting a clean environment and helping prevent infection.
Maintenance of Catheter Patency: N S 0.45% Infusion is used to flush catheters and IV lines, preventing clot formation and maintaining patency.

Have a query?

Directions for Use

N S 0.45% Infusion is administered by a qualified healthcare professional, typically in a hospital or clinic setting.
Your doctor will determine the appropriate dosage and frequency based on your condition and other factors.
Follow your healthcare provider's instructions regarding the medication, including any steps to track your progress and precautions to take during treatment.

Medicinal Benefits

N S 0.45% Infusion helps prevent and treat salt and fluid imbalances in the body.
N S 0.45% Infusion helps maintain the balance of fluid in and around the body’s cells and tissues.
It aids in restoring the normal salt balance.
N S 0.45% Infusion acts as a source of electrolytes and water for hydration.
Sodium chloride may be used to dilute or prepare some drugs for use and irrigation (wash out wounds).

How N S 0.45% Infusion Works

N S 0.45% Infusion contains Sodium chloride, which helps maintain the balance of fluid in and around the body's cells and tissues. It aids in the restoration of the normal salt balance. N S 0.45% Infusion also acts as a source of electrolytes and water for hydration.

Storage

• Store in a cool and dry place away from sunlight.• Keep N S 0.45% Infusion out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Side effects of N S 0.45% Infusion

Heart Failure

Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
Take care of change in your weight as there can be sudden changes.
Rest and refrain from physical activity, and restart after a few days.
Reduce your salt intake and control your diet with the help of a dietician.
Track your symptoms and keep your follow-up appointments to manage severe side effects.

Excess Water In The Body

Blood Clotting Disorder

Inform your doctor about your blood clotting disorder for proper diagnosis and treatment.
Avoid unusual clotting by following your physician's prescription for medications.
Do not stand or sit for extended periods of time.
Regular workouts help one to enhance circulation and lower blood clot danger.
Give up smoking to better your health.
Maintain a healthy weight to reduce pressure on veins and lower blood clot risk.

Inflammation Of A Vein

Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:

If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.

Injection Site Reaction

Injection site reaction can include numbness or redness.
Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
Apply cold compress for pain relief.
Practice good hygiene and keep the injection site away from heat and pressure.

Excess Fluid In The Body

Your doctor may stop or adjust the dose of your medication that might be causing fluid buildup and may prescribe diuretics to help remove extra fluid.
Limit your intake of salt and monitor how much fluid you drink regularly.
Regularly check your weight and blood pressure, and keep track of your urine output to see how your condition is improving.
Stay at a healthy weight, drink alcohol in moderation, limit caffeine intake, and quit smoking to help prevent your symptoms from getting worse.
Exercise regularly, get enough sleep, and manage stress to improve your overall health.

What if I have taken an overdose of N S 0.45% Infusion

N S 0.45% Infusion is administered in a hospital setting under the supervision of your doctor or medical personnel. Thus, an overdose is quite improbable. While in the hospital, you will be constantly monitored to ensure that any unpleasant side effects are handled. If you are concerned about the volume of solution given, or are worried about any effects you notice, talk to your healthcare professional.

Drug Warnings

Tell your doctor if you are allergic to any components in N S 0.45% Infusion.
Inform your doctor if you have heart failure, hypernatraemia (high serum levels of sodium), cardio-pulmonary disease, high blood pressure, pre-eclampsia of pregnancy, liver or kidney problems; if you are receiving drugs that may increase sodium retention; or if you are elderly or very young.
Consult your doctor if you are pregnant or breastfeeding.

Drug-Drug Interactions

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

Regularly drink fluids to prevent dehydration.
If you are unable to drink large volumes of fluids, try drinking small sips frequently.
Consume foods rich in water, such as watermelon, cucumber, tomatoes, broccoli, spinach, oranges, Brussels sprouts, and apples.

Habit Forming

Therapeutic Class

ELECTROLYTES

N S 0.45% Infusion Substitute

Otsuka Hafnor 0.45% Infusion

by Others

₹0.11per tablet

Nirlife Sodium Chloride 0.45% Infusion 500 ml

by AYUR

₹0.35per tablet

Alcohol

Consult your doctor

It is unknown if alcohol interacts with N S 0.45% Infusion. Please consult your doctor if you have any concerns.

Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before receiving N S 0.45% Infusion.

Breast Feeding

Consult your doctor

If you are breastfeeding, inform your doctor before receiving N S 0.45% Infusion.

Driving

Safe if prescribed

N S 0.45% Infusion is unlikely to affect your ability to drive.

Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving N S 0.45% Infusion.

Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving N S 0.45% Infusion. N S 0.45% Infusion should be used with caution in patients with renal insufficiency.

Children

Consult your doctor

Please consult your doctor. Your doctor may prescribe N S 0.45% Infusion as required based on the condition of your child.

FAQs

What is the use of N S 0.45% Infusion?

N S 0.45% Infusion is indicated for the extracellular fluid replacement, parenteral replenishment of fluid and sodium chloride as required by the patientâ€™s clinical condition, and treatment of metabolic acidosis in the presence of fluid loss. It helps prevent and treat salt and fluid imbalances in the body.

How does N S 0.45% Infusion help?

N S 0.45% Infusion helps maintain the balance of fluid in and around the body's cells and tissues. It aids in the restoration of the normal salt balance. N S 0.45% Infusion acts as a source of electrolytes and water for hydration.

Is it safe to take corticosteroids while on treatment with N S 0.45% Infusion?

Caution is advised if you are taking corticosteroids or corticotropin. Please consult your doctor.

Does N S 0.45% Infusion cause hyponatremia?

N S 0.45% Infusion may cause hyponatremia (low level of sodium). The risk for hyponatremia is increased in elderly, paediatric patients, postoperative patients, and patients taking drugs which may increase the risk of hyponatremia. Close clinical monitoring in such patients is advised.

Country of origin

India

Other Info - NSIN156

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 23, 2025 | 1:01 PM IST

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Drug-Drug Interactions

Drug-Food Interactions

N S 0.45% Infusion Substitute

Otsuka Hafnor 0.45% Infusion

Nirlife Sodium Chloride 0.45% Infusion 500 ml

FAQs

What is the use of N S 0.45% Infusion?

How does N S 0.45% Infusion help?

Is it safe to take corticosteroids while on treatment with N S 0.45% Infusion?

Does N S 0.45% Infusion cause hyponatremia?

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