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compositionComposition:NALOXONE-400MCG
prescriptionPrescription Medicine
Nex 400mcg/1ml Injection
Nex 400mcg/1ml Injection
Nex 400mcg/1ml Injection

Nex 400mcg/1ml Injection contains Naloxone, used to treat opioid dependence. It works by blocking the effect of opioid receptors and thereby blocks the effects of opioids. It is used along with counselling and social support to help patients dependent on opioid drugs. This medicine is also used after surgery to reverse the effects of opiates given during surgery.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

NALOXONE-400MCG

Manufacturer/Marketer :

Neon Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

Nex 400mcg/1ml Injection is an opioid antagonist used to treat opioid overdose. This medicine is given as an emergency treatment where the use of high-potency opioids as a chemical weapon is suspected and as temporary prophylaxis of respiratory and/or central nervous system depression in military personnel and chemical incident responders.

Nex 400mcg/1ml Injection contains Naloxone, which belongs to the class of opioid receptor antagonists. It works by blocking the effect of opioid receptors and blocks the effects. Thereby it helps treat opioid overdose.

Nex 400mcg/1ml Injection may cause certain side effects such as nausea, vomiting, injection site reactions, dizziness, and headache.  If Nex 400mcg/1ml Injection causes any serious discomfort, speak with a doctor. Nex 400mcg/1ml Injection will be administered by the physician in an emergency.

Nex 400mcg/1ml Injection is generally given on an emergency basis. The patient's caregiver should inform the doctor about his/her previous medical and medication history beforehand. Also, inform the doctor if the patient is pregnant, planning to become pregnant, or breastfeeding.

Uses of Nex 400mcg/1ml Injection

Nex 400mcg/1ml Injection is used in the treatment of Opioid overdose. The detailed uses of Nex 400mcg/1ml Injection are as follows:

  • Opioid overdose reversal: Nex 400mcg/1ml Injection is used as an emergency treatment to rapidly reverse the life-threatening effects of opioid overdose. It restores normal breathing and consciousness by blocking opioid receptors in the brain.
  • Neonatal abstinence syndrome (NAS): Nex 400mcg/1ml Injection may be used in new borns who experience withdrawal symptoms due to opioid exposure during pregnancy. It helps stabilize breathing and neurological function.
  • Postoperative opioid-induced respiratory depression: Nex 400mcg/1ml Injection is administered to counteract slowed breathing caused by opioid medications given during or after surgery.
  • Adjunct in opioid maintenance therapy: Nex 400mcg/1ml Injection is sometimes included in treatment programs for opioid use disorder to prevent misuse and manage withdrawal symptoms.

Key Benefits

Nex 400mcg/1ml Injection contains Naloxone, which belongs to the class of medications called 'opioid-antagonist' used to treat opioid dependence. It works by blocking the effect of opioid receptors and thereby blocks the effects of opioids. It is used along with counselling and social support to help patients dependent on opioid drugs. This medicine is also used after surgery to reverse the effects of opiates given during surgery.

Side effects of Nex 400mcg/1ml Injection
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Nex 400mcg/1ml Injection will be administered by a healthcare professional.
  • Do not self-administer it.
Nex 400mcg/1ml Injection contains Naloxone, which belongs to the class of opioid receptor antagonists. It works by blocking the effect of opioid receptors and blocks the effects. Thereby it helps treat opioid overdose.
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Alcohol

Unsafe

Consumption of alcohol is not recommended during treatment with this medicine as it can worsen the condition of the patient.

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Pregnancy

Caution

Nex 400mcg/1ml Injection should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. If administered during pregnancy, the doctor may need to monitor your unborn baby carefully after you receive the medication.

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Breast Feeding

Caution

Consult the doctor if you are breastfeeding. Caution should be exercised while using Nex 400mcg/1ml Injection in nursing mother.

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Driving

Caution

Nex 400mcg/1ml Injection will be administered in the hospital setting.

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Liver

Caution

Nex 400mcg/1ml Injection should be used with caution in patients with liver disease. So, inform your doctor if you have liver impairment. Regular monitoring of liver function tests is advisable while on treatment with this medicine.

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Kidney

Caution

Caution is recommended while administering Nex 400mcg/1ml Injection to patients with renal impairment. So, inform your doctor if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Nex 400mcg/1ml Injection.

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Children

Caution

Nex 400mcg/1ml Injection should be used in children only if advised by the doctor.

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Heart

Caution

Nex 400mcg/1ml Injection can be used in individuals with heart problems, but with caution. It may trigger side effects like arrhythmias, hypertension, or pulmonary edema, especially during rapid opioid reversal. Always consult your doctor before use to ensure it's safe for your condition.

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Geriatrics

Safe if prescribed

Nex 400mcg/1ml Injection can be given to geriatric patients in emergency opioid overdose situations. However, older adults may be more sensitive to side effects like agitation or changes in blood pressure, so close monitoring is essential.

As Nex 400mcg/1ml Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Diet & Lifestyle Advise

  • Eat foods high in carbohydrates, especially the complex carbohydrates present in starchy food items like legumes (e.g., beans, lentils and peas), root vegetables (e.g., potatoes and carrots), pasta and bread, along with protein in meals.
  • A patient should consume supplements and vitamins as per their doctor's recommendation.
  • The patient should change his drinking priorities and prefer drinks like apple cider, vanilla shake, juice or lemonade with sparkling water, etc.
  • Get physical activity and enough rest.
  • Reduce caffeine and stop smoking, if possible.

Have a query?

Drug Warnings

Nex 400mcg/1ml Injection is generally given on an emergency basis. The patient's caregiver should inform the doctor about his/her previous medical and medication history beforehand. Also, let the doctor know if the patient is pregnant, planning to become pregnant, or breastfeeding.  Inform your doctor if you have increased blood pressure, liver/kidney disease, or are taking any medications before receiving Nex 400mcg/1ml Injection. Do not use other medications without the doctor's notice, especially opioid-containing ones. It may cause precipitation of severe opioid withdrawal and risk of recurrent respiratory and central nervous system depression. Hence, the patient should be monitored carefully after administration of Nex 400mcg/1ml Injection.

Drug-Drug Interactions

verifiedApollotooltip
NaloxoneNaloxegol
Severe
NaloxoneDroperidol
Severe

Drug-Drug Interactions

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NaloxoneNaloxegol
Severe
How does the drug interact with Nex 400mcg/1ml Injection:
Coadministration of Nex 400mcg/1ml Injection and Naloxegol can enhance the risk of opioid withdrawal (a response to a sudden lack of opioids in the body).

How to manage the interaction:
Although taking Nex 400mcg/1ml Injection and Naloxegol together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like sweating, tearing, runny nose, chills, diarrhea, stomach pain, nausea, vomiting, anxiety, insomnia, irritability, or restlessness, it's important to call your doctor right away. Do not stop using any medications without talking to a doctor.
NaloxoneDroperidol
Severe
How does the drug interact with Nex 400mcg/1ml Injection:
Coadministration of Nex 400mcg/1ml Injection and Droperidol can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Nex 400mcg/1ml Injection and Droperidol together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience weakness, tiredness, drowsiness, chest pain or discomfort, confusion, muscle pain, cramps, dizziness, nausea, or vomiting consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

No
[OPIOID ANTAGONISTS]

FAQs

Nex 400mcg/1ml Injection is used to treat Opioid overdose.

Nex 400mcg/1ml Injection contains Naloxone, which works by inhibiting the effect of opioid receptors and thereby blocks the effects of opioids.

No, Nex 400mcg/1ml Injection should not be used with an opioid analgesic, as it may cause serious adverse effects of the drug. If you have any concerns, please discuss them with your doctor.

Inform your doctor about your medical conditions, allergic reactions, and medications you are already taking (especially opioid analgesics). Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding.

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Santoshini Reddy GDoctor badge

Reviewed By

  • Santoshini Reddy G

    M Pharmacy

Last Updated

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INDIA
140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.
Other Info - NEX0046

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