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  3. Nirmet Injection 100 ml

Nirmet Injection 100 ml, Pack of 1 Infusion
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Composition :

METRONIDAZOLE-500MG

Manufacturer/Marketer :

Nirlife Healthcare

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Nirmet Injection

Nirmet Injection belongs to a group of medicines known as antibacterial agents used to treat severe bacterial infections of the bone, skin and skin structure, blood, joint, abdomen, central nervous system, respiratory, and gynaecological systems, meningitis (infection of the membranes that surround the brain and spinal cord), and endocarditis (infection of the heart lining and valves). 

Nirmet Injection contains Metronidazole, which suppresses protein synthesis by interacting with DNA and causing helical DNA structure loss and strand breakage. As a result, it induces cell death in susceptible organisms. Thus, Nirmet Injection treats bacterial infections.

Nirmet Injection will be administered by a healthcare professional; do not self-administer. Some common side effects of Nirmet Injection are nausea, vomiting, diarrhoea, constipation, and injection site reaction. These side effects are temporary and may resolve after some time. However, if any of the side effects persist or worsen, contact the doctor.

Let your doctor know if you are allergic to metronidazole. Consult your doctor if you are pregnant, planning to get pregnant, or if you are breastfeeding. Do not operate heavy machinery or drive after taking Nirmet Injection as it may cause dizziness and drowsiness. Avoid consumption of alcohol while on treatment with Nirmet Injection as it may cause unpleasant side effects.

Uses of Nirmet Injection

Nirmet Injection used in the treatment of bacterial infections. The detailed uses of Nirmet Injection are as follows:
• Treatment of Infections: Nirmet Injection effectively treats various infections, including intra-abdominal, skin, gynecologic, septicemia, bone and joint, CNS, respiratory tract, and endocarditis, by eliminating anaerobic bacteria and parasites, stopping their growth, and alleviating symptoms.
• Surgical Prophylaxis: Nirmet Injection is used as a surgical prophylaxis to prevent postoperative infections, particularly for surgeries involving the gastrointestinal tract.
• Management of Clostridium Difficile Infection: Nirmet Injection is used to manage severe Clostridium difficile infections, especially when oral medication is not possible.
• Amoebic Dysentery Treatment: Nirmet Injection is used to treat amoebic dysentery, a severe intestinal infection caused by the Entamoeba histolytica parasite.
• Combination Therapy: Nirmet Injection is often used in combination with other antibiotics to treat serious infections, offering a broad spectrum of action and enhancing treatment effectiveness.

Directions for Use

Nirmet Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Nirmet Injection belongs to a group of medicines known as anti-bacterial agents used to treat severe bacterial infections of the bone, skin and skin structure, blood, joint, abdomen, central nervous system, gynecologic, respiratory infections, meningitis (infection of the membranes that surround the brain and spinal cord), and endocarditis (infection of the heart lining and valves). Nirmet Injection contains Metronidazole, which suppresses protein synthesis by interacting with DNA and causes helical DNA structure loss and strand breakage. As a result, it induces cell death in susceptible organisms. Thereby, Nirmet Injection treats bacterial infections.

How Nirmet Injection Works

Nirmet Injection contains Metronidazole, which suppresses protein synthesis by interacting with DNA and causing helical DNA structure loss and strand breakage. As a result, it induces cell death in susceptible organisms. Thus, Nirmet Injection treats bacterial infections.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nirmet Injection 100 ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Nirmet Injection

A health care professional administers Nirmet Injection in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include nausea, vomiting, loss of muscle coordination, numbness, pain, burning, or tingling in your hands or feet, and seizures. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

Do not take Nirmet Injection if you are allergic to any of the components. Consult your doctor if you are pregnant, plan to get pregnant or if you are breastfeeding. Do not operate heavy machinery or drive after taking Nirmet Injection as it may cause dizziness and drowsiness. Inform your doctor if you have bone marrow depression/low blood count, kidney impairment, CNS disorder, liver or heart problems, peripheral neuropathy, epilepsy, Crohn's disease (a condition in which the body attacks the lining of the digestive tract), yeast infection, oedema (swelling), or blood disorders.

Drug-Drug Interactions

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MetronidazoleAmprenavir
Critical
MetronidazoleDisulfiram
Critical

Drug-Drug Interactions

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MetronidazoleAmprenavir
Critical
How does the drug interact with Nirmet Injection 100 ml:
Co-administration of Amprenavir with Nirmet Injection 100 ml can increase the risk or severity of side effects.

How to manage the interaction:
Taking Nirmet Injection 100 ml with Amprenavir is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience throbbing in the head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetronidazoleDisulfiram
Critical
How does the drug interact with Nirmet Injection 100 ml:
Coadministration of Disulfiram with Nirmet Injection 100 ml can increase the risk of side effects.

How to manage the interaction:
Taking Nirmet Injection 100 ml and Disulfiram together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
MetronidazoleEthanol
Critical
How does the drug interact with Nirmet Injection 100 ml:
Drinking alcohol while taking Nirmet Injection 100 ml can increase the risk or severity of side effects.

How to manage the interaction:
Taking Nirmet Injection 100 ml with Ethanol is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MetronidazoleMebendazole
Severe
How does the drug interact with Nirmet Injection 100 ml:
Coadministration of Nirmet Injection 100 ml with mebendazole may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Nirmet Injection 100 ml and mebendazole, they can be taken together if your doctor has prescribed them. However, if you experience any unusual symptoms like fever, body ache, painful red rash, cough, peeling of the skin, or Drooling, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MetronidazoleWarfarin
Severe
How does the drug interact with Nirmet Injection 100 ml:
Coadministration of Nirmet Injection 100 ml with warfarin can increase the risk of bleeding.

How to manage the interaction:
There is a possible interaction between Nirmet Injection 100 ml and warfarin, but they can be taken together if a doctor has prescribed them. Consult a doctor if experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without talking to a doctor.
MetronidazoleBusulfan
Severe
How does the drug interact with Nirmet Injection 100 ml:
Coadministration of Busulfan and Nirmet Injection 100 ml may increase the risk of side effects.

How to manage the interaction:
Taking Nirmet Injection 100 ml and Busulfan together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
MetronidazoleFluconazole
Moderate
How does the drug interact with Nirmet Injection 100 ml:
Co-administration of Fluconazole together with Nirmet Injection 100 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
-Taking Nirmet Injection 100 ml with Fluconazole together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Nirmet Injection to restore healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet. This food can be easily digested by gut bacteria, which helps stimulate their growth. Whole grains like whole-grain bread and brown rice should also be included in the diet.
  • Avoid intake of alcoholic beverages with Nirmet Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid Nirmet Injection in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Nirmet Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Nirmet Injection to avoid unpleasant side effects such as stomach pain, nausea, vomiting, flushing, and headache.

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Pregnancy

Caution

Please consult your doctor. Nirmet Injection should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Nirmet Injection .

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Driving

Caution

Nirmet Injection may cause dizziness and drowsiness; thus, avoid operating machinery or driving vehicles unless you are alert.

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Liver

Caution

Nirmet Injection to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your liver condition.

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Kidney

Caution

Nirmet Injection to be taken with extreme caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending on your kidney condition.

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Children

Consult your doctor

Limited information about the use of Nirmet Injection in paediatric patients. Please seek medical advice. Your doctor will weigh the benefits and risks before prescribing this medicine to your child.

Have a query?

FAQs

Nirmet Injection belongs to a group of medicines known as antibacterial agents used to treat severe bacterial infections of the bone, skin and skin structure, blood, joint, abdomen, central nervous system, respiratory, and gynaecological systems, meningitis (infection of the membranes that surround the brain and spinal cord), and endocarditis (infection of the heart lining and valves).

Nirmet Injection suppresses protein synthesis by interacting with DNA, causing helical DNA structure loss and strand breakage. As a result, it induces cell death in susceptible organisms, treating bacterial infections.

Caution should be exercised. Nirmet Injection may enhance the anticoagulant activity of warfarin and other oral anticoagulants by extending prothrombin time. Inform your doctor if you are taking such medications.

No. Nirmet Injection is an antibacterial medicine that acts only against bacterial infections, not viral infections like the common cold and flu.

Nirmet Injection should only be used to treat or prevent infections that have been proven or are strongly suspected to be caused by susceptible anaerobic bacteria.

Extreme caution should be exercised while using Nirmet Injection in patients with severe liver damage, blood formation disorder, brain, spinal cord or nervous disease. So, let your doctor know if you have any of these conditions.

Country of origin

INDIA

Manufacturer/Marketer address

5th Floor, Commerce House 5, Near Vodafone office, Behind YMCA club, Prahaladnagar Road, Ahmedabad-380051
Other Info - NIR0003

Disclaimer

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

May 2, 2025 | 12:51 PM IST

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Reference

  1. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=d46870f5-e2b1-46bd-8413-4a0a8bcf3175&type=display
  2. https://www.medicines.org.uk/emc/files/pil.13293.pdf
  3. https://www.medicines.org.uk/emc/product/1842/smpc#gref
  4. https://www.nhs.uk/medicines/metronidazole/about-metronidazole/
  5. https://www.drugs.com/drug-interactions/metronidazole-index.html?filter=3

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