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compositionComposition:ACECLOFENAC-100MG+THIOCOLCHICOSIDE-4MG
prescriptionPrescription Medicine
Nise AT 4 Tablet 10's

Nise AT 4 Tablet is used to reduce and relieve pain due to muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions). It contains Thiocolchicoside and Aceclofenac, which relieve muscle stiffness and improve muscle movements, thereby relieving pain due to muscle spasms. It may cause side effects such as diarrhoea, dizziness, nausea, vomiting, stomach pain, or increased liver enzymes in the blood in some cases. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ACECLOFENAC-100MG+THIOCOLCHICOSIDE-4MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nise AT 4 Tablet

Nise AT 4 Tablet is used to reduce and relieve pain due to muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions).

Nise AT 4 Tablet is a combination of Thiocolchicoside and Aceclofenac. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improve muscle movements. Aceclofenac works by blocking the action of cyclo-oxygenase (COX) enzyme in the body involved in the production of certain chemical substances.

Common side effects include diarrhoea, dizziness, nausea, vomiting, stomach pain, or increased liver enzymes in the blood. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nise AT 4 Tablet or any other medicines, please tell your doctor. Nise AT 4 Tablet is not recommended for children below 18 years of age. Avoid taking Nise AT 4 Tablet if you are pregnant, as it may cause harm to the foetus. Nise AT 4 Tablet is excreted in breast milk. Therefore, Nise AT 4 Tablet is contraindicated in breastfeeding women as it may cause adverse effects on the baby.

Uses of Nise AT 4 Tablet

Nise AT 4 Tablet is used in the treatment of pain due to muscle spasms. The detailed uses of Nise AT 4 Tablet are as:

  • Pain relief: Nise AT 4 Tablet acts as a muscle relaxant that helps in providing relief from pain caused by muscle spasms associated with conditions such as degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions).
  • Inflammation reduction: Nise AT 4 Tablet helps to reduce inflammation in conditions like arthritis, improving mobility, reducing stiffness, and enhancing overall joint function.
  • Muscle stiffness: Nise AT 4 Tablet relieves muscle stiffness, improving mobility and facilitating smoother muscle movements.
  • Post-operative care: Nise AT 4 Tablet is often prescribed for post-operative pain management, helping patients recover more comfortably by reducing pain and inflammation after surgery.

Have a query?

Directions for Use

  • Take Nise AT 4 Tablet with food to avoid stomach upset or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Swallow the medicine as a whole with glass of water.
  • Do not crush, break, or chew it.

Key Benefits

  • Nise AT 4 Tablet is a combination of two drugs, namely, Thiocolchicoside and Aceclofenac, used to treat pain due to muscle spasms.
  • Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain.
  • This helps relieve muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms.
  • Aceclofenac is a non-steroidal anti-inflammatory drug (pain killer) that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances, such as prostaglandins, that cause pain and swelling.

How Nise AT 4 Tablet Works

Nise AT 4 Tablet is a combination of two drugs: Thiocolchicoside (muscle relaxant) and Aceclofenac (a non-steroidal anti-inflammatory drug). Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms. Aceclofenac is a non-steroidal anti-inflammatory drug (pain killer) that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body, which is involved in producing certain chemical substances, such as prostaglandins, that cause pain and swelling.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nise AT 4 Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Nise AT 4 Tablet

Do not take more than the prescribed dose of Nise AT 4 Tablet as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • If you are allergic to Nise AT 4 Tablet or any other medicines, please tell your doctor.
  • Nise AT 4 Tablet is not recommended for children below 18 years of age.
  • Avoid taking Nise AT 4 Tablet if you are pregnant as it may cause harm to the fetus.
  • Nise AT 4 Tablet is excreted in breast milk. Therefore, Nise AT 4 Tablet is contraindicated in breastfeeding women as it may cause adverse effects on the baby.
  • Do not consume alcohol with Nise AT 4 Tablet as it may increase the risk of severe adverse effects.
  • If you have asthma, diabetes, high blood pressure, stomach ulcer, high cholesterol, chickenpox, porphyria (rare inherited disorder), systemic lupus erythematosus, ulcerative colitis or Crohn’s disease, diarrhoea, bowel pain, vomiting, and weight loss), galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption, G-6-PD deficiency, fits, muscular hypotonia, flaccid paresis, bleeding or blood clotting disorders, kidney, liver or heart diseases, inform your doctor before taking Nise AT 4 Tablet .

Drug-Drug Interactions

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AceclofenacAtenolol
Severe

Drug-Drug Interactions

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AceclofenacAtenolol
Severe
How does the drug interact with Nise AT 4 Tablet:
Co-administration of Atenolol with Nise AT 4 Tablet could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Nise AT 4 Tablet, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regular exercise helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes, instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice pack or hot-pack on the muscle for 15-20minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

[MUSCLE RELAXANTS]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Nise AT 4 Tablet as it may increase the risk of severe adverse effects.

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Pregnancy

Unsafe

Nise AT 4 Tablet is not recommended for pregnant women, especially in the last 3 months of pregnancy, as it may cause harm to the foetus. However, please consult your doctor if you are pregnant.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Nise AT 4 Tablet as it may be excreted in breast milk and cause adverse effects in the baby. However, please consult a doctor if you are breastfeeding.

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Driving

Caution

Nise AT 4 Tablet may cause drowsiness, tiredness, dizziness or vision problems in some people. Therefore, avoid driving if you feel any of these symptoms after taking Nise AT 4 Tablet .

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Liver

Caution

Take Nise AT 4 Tablet with caution, especially if you have a history of liver disease. The dose may be adjusted by your doctor as required. Avoid taking Nise AT 4 Tablet if you have severe liver failure.

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Kidney

Caution

Take Nise AT 4 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Nise AT 4 Tablet if you have severe kidney disease.

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Children

Unsafe

Nise AT 4 Tablet is not recommended for children as the safety and effectiveness were not established.

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Heart

Unsafe

This medicine is contraindicated in cardiac patients due to its adverse effects.

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Geriatrics

Caution

Nise AT 4 Tablet can be given in elderly patients with caution due to the serious adverse effects.

FAQs

Nise AT 4 Tablet is used to reduce and relieve pain due to muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, and torticollis (neck muscle contractions).

Nise AT 4 Tablet contains Thiocolchicoside and Aceclofenac. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms. Aceclofenac is a non-steroidal anti-inflammatory drug (pain killer) that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body, which is involved in producing certain chemical substances, such as prostaglandins, that cause pain and swelling.

Nise AT 4 Tablet may affect sperm cells and thereby cause problems with male fertility. Therefore, please consult your doctor before taking Nise AT 4 Tablet if you are planning to become a father.

Nise AT 4 Tablet may cause diarrhoea as a side effect. It is not necessary for everyone taking Nise AT 4 Tablet to experience this side effect. However, if the condition persists or worsens, please consult a doctor.

You are not recommended to take Nise AT 4 Tablet with warfarin as co-administration of these two medicines may increase the bleeding risk more easily. However, if you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately for safe use.

Nise AT 4 Tablet may trigger fits, especially in patients at risk or those already suffering from them. Therefore, please inform your doctor if you have a history of fits before taking Nise AT 4 Tablet .

You are recommended to use Nise AT 4 Tablet for as long as your doctor has prescribed it. However, if the symptoms persist even after using Nise AT 4 Tablet for 7 days, stop taking Nise AT 4 Tablet and consult a doctor.

Avoid taking Nise AT 4 Tablet if you are allergic to it. Inform your doctor if you have a history of stomach ulcers, heart disease, high blood pressure, bleeding disorders, liver or kidney problems. Consult your doctor before using Nise AT 4 Tablet if you are pregnant or breastfeeding and it best to avoid alcohol while taking Nise AT 4 Tablet as it can increase the risk of stomach ulcers and bleeding.

No, Nise AT 4 Tablet is not addictive. However, it's important to use it only as prescribed by your doctor.

Nise AT 4 Tablet is generally used for short-term and can be stopped when the pain is relieved. However, it should be used for the duration as advised by your doctor.

Yes, some people may experience dizziness (feeling weak, faint, unsteady, or lightheaded) after taking Nise AT 4 Tablet . It is best to take a short break and restart once you feel better if you are experiencing light-headedness or dizziness. However, consult your doctor if your condition persists or worsens.

The use of Nise AT 4 Tablet may be harmful to patients with known allergies to painkillers or components of this medicine. It should also be avoided in individuals with a history of stomach ulcers, heart failure, high blood pressure, liver disease, and kidney problems. Therefore, if you have any medical conditions, inform your doctor before taking Nise AT 4 Tablet .

Yes, Nise AT 4 Tablet can be taken with Vitamin B-complex. Vitamin B-complex helps to treat vitamin deficiency, which may be the cause of your symptoms. However, please consult your doctor before taking Nise AT 4 Tablet with other medicines or supplements.

Long-term use of Nise AT 4 Tablet can cause kidney damage due to the reduction in prostaglandins, which normally protect the kidneys. It's important to monitor kidney function regularly and consult your doctor if you have any concerns or pre-existing kidney conditions.

No, taking more than the recommended dose will not improve its effectiveness but may lead to increased side effects. Consult your doctor if you think you have taken more doses of Nise AT 4 Tablet or experience worsening symptoms while taking Nise AT 4 Tablet .

Take Nise AT 4 Tablet in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nise AT 4 Tablet is to be taken with food.

You are recommended to consult your doctor before taking other medicines with Nise AT 4 Tablet to avoid potential drug interactions. Some medications that may interact with Nise AT 4 Tablet include anti-hypertensives, antidiabetic medications, and antidepressants. These interactions can affect the effectiveness of the medications or increase the risk of side effects. Therefore, it is important to inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment.

If you suspect an overdose of Nise AT 4 Tablet , it is crucial to seek immediate medical attention. Symptoms of an overdose may include nausea, seizures (fits) and drowsiness. If you experience any of these symptoms, consult your doctor.

The side effects of Nise AT 4 Tablet are diarrhoea, dizziness, nausea, vomiting, stomach pain and increased liver enzymes in the blood. If these persist or worsen, consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - NIS0087

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Dec 3, 2025 | 7:31 AM IST

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