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compositionComposition:NIVOLUMAB-240MG
prescriptionPrescription Medicine
Opdyta 240 mg Injection 24 ml

Opdyta 240 mg Injection 24 ml used to treat various cancers, including Metastatic Melanoma, metastatic non-small cell lung cancer, Renal Cell Carcinoma, Hepatocellular carcinoma, Colorectal Cancer, Malignant pleural mesothelioma, Stomach Cancer, Squamous cell carcinoma of head and neck, and Urothelia carcinoma. It contains Nivolumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death receptor-1 (PD-1), thereby stopping the abnormal growth of cancer cells.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NIVOLUMAB-240MG

Manufacturer/Marketer :

Bristol-Myers Squibb India Pvt Ltd

Consume Type :

Parenteral

Return Policy :

Not Returnable

About Opdyta 240 mg Injection 24 ml

Opdyta 240 mg Injection 24 ml is an anti-cancer medicine used in the treatment of Melanoma in combination with ipilimumab and other cancers in adults. Melanoma is a severe form of skin cancer that spreads primary melanoma cells to distant organs such as lymph nodes, lungs, liver, brain, and bones. This medicine is used in treating advanced renal cell carcinoma, hepatocellular carcinoma, colorectal cancer, metastatic non-small cell lung cancer, metastatic melanoma, gastric cancer, classical Hodgkin’s disease, urothelial carcinoma, malignant pleural mesothelioma and head and neck cancer.

Opdyta 240 mg Injection 24 ml contains Nivolumab, which belongs to the class of monoclonal antibody. It works by inhibiting the action of a programmed death receptor-1 (PD-1), thereby stopping the abnormal growth of cancer cells.

Opdyta 240 mg Injection 24 ml may cause certain side effects such as diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, loss of appetite and injection site reactions. Inform your doctor if any of these side effects persist for longer. Opdyta 240 mg Injection 24 ml will be administered by an oncologist trained in administering anti-cancer agents. 

Avoid receiving Opdyta 240 mg Injection 24 ml and inform your doctor if you are allergic to it or any other components of it. Before taking Opdyta 240 mg Injection 24 ml, tell your doctor if you have/had liver or kidney disease, autoimmune disorders such as ulcerative colitis or Crohn's disease, a history of organ transplants, received an allogeneic stem cell transplant, or had radiation treatment to the chest. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Avoid breastfeeding while taking this Opdyta 240 mg Injection 24 ml.

Uses of Opdyta 240 mg Injection 24 ml

Opdyta 240 mg Injection 24 ml is used in the treatment of cancer. The detailed use of Opdyta 240 mg Injection 24 ml is as follows:

  • Treatment of cancer: Opdyta 240 mg Injection 24 ml is used in the treatment of various cancers like non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), melanoma, renal cell carcinoma (kidney cancer), hodgkin lymphoma, head and neck squamous cell carcinoma, urothelial carcinoma (bladder cancer), esophageal and gastric cancers, liver cancer.

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Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Opdyta 240 mg Injection 24 ml will be administered by a nurse or doctor.
  • Do not self-administer.

Key Benefits

Opdyta 240 mg Injection 24 ml contains Nivolumab, which is used in the treatment of different types of cancers. It works by inhibiting the action of a programmed death receptor-1 (PD-1) that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other body parts.

How Opdyta 240 mg Injection 24 ml Works

Opdyta 240 mg Injection 24 ml contains Nivolumab, which belongs to the class of monoclonal antibody. It works by inhibiting the action of a programmed death receptor-1 (PD-1), thereby stopping the abnormal growth of cancer cells.
Side effects of Opdyta 240 mg Injection 24 ml
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

What if I have taken an overdose of Opdyta 240 mg Injection 24 ml

As Opdyta 240 mg Injection 24 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

To treat your condition effectually, continue receiving Opdyta 240 mg Injection 24 ml for the period that your doctor has prescribed. Opdyta 240 mg Injection 24 ml may cause severe immune-mediated adverse reactions (IMAR) such as immune-mediated colitis, hepatitis, hepatotoxicity, nephritis, endocrinopathies, pneumonitis, complications of allogeneic Hematopoietic Stem Cell Transplantation (allo HSCT) and dermatologic reactions. It may also cause infusion-related reactions in some patients. Therefore, caution should be exercised if you have/had liver or kidney disease, any history of organ transplant, gastrointestinal disorders, myasthenia gravis, received a stem cell transplant that uses donor stem cells (allogeneic), undergone radiation treatment to the chest and autoimmune disorders such as ulcerative colitis, or Crohn’s disease while receiving Opdyta 240 mg Injection 24 ml. Discontinue the treatment if any severe infusion reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

verifiedApollotooltip
NivolumabLenalidomide
Severe
NivolumabThalidomide
Severe

Drug-Drug Interactions

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NivolumabLenalidomide
Severe
How does the drug interact with Opdyta 240 mg Injection 24 ml:
These drugs together may raise the likelihood of adverse effects.

How to manage the interaction:
There may be a possibility of interaction between Lenalidomide and Opdyta 240 mg Injection 24 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
NivolumabThalidomide
Severe
How does the drug interact with Opdyta 240 mg Injection 24 ml:
Taking Thalidomide with Opdyta 240 mg Injection 24 ml may increase the risk of serious side effects.

How to manage the interaction:
Although taking thalidomide and Opdyta 240 mg Injection 24 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

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Alcohol

Consult your doctor

It is unknown whether Opdyta 240 mg Injection 24 ml interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Opdyta 240 mg Injection 24 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Opdyta 240 mg Injection 24 ml. You should not become pregnant while you are receiving Opdyta 240 mg Injection 24 ml for at least five months from the last dose of Opdyta 240 mg Injection 24 ml. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Opdyta 240 mg Injection 24 ml should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least five months from the last dose of medicine.

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Driving

Not applicable

Opdyta 240 mg Injection 24 ml will be administered to hospitalized patients.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Inform your doctor if you experience severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, or jaundice (yellowing of the skin or eyes). Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Opdyta 240 mg Injection 24 ml. Tell your doctor if you have little or no urination, swelling in your feet or ankles, or blood in your urine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

Opdyta 240 mg Injection 24 ml is not recommended for children below 12 years. It is safe for use in children above 12 years for the treatment of microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer. It will be administered only if the benefits outweigh the risks.

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Heart

Consult your doctor

Please consult your doctor before receiving Opdyta 240 mg Injection 24 ml if you have pre-existing heart problems. Your doctor will prescribe Opdyta 240 mg Injection 24 ml if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Opdyta 240 mg Injection 24 ml to geriatric patients. Your doctor will prescribe Opdyta 240 mg Injection 24 ml if the benefits outweigh the risks.

FAQs

Opdyta 240 mg Injection 24 ml is used to treat various cancers, including Metastatic Melanoma, metastatic non-small cell lung cancer, Renal Cell Carcinoma, Hepatocellular carcinoma, Colorectal Cancer, Malignant pleural mesothelioma, Stomach Cancer, Squamous cell carcinoma of head and neck, and Urothelia carcinoma.

Opdyta 240 mg Injection 24 ml contains Nivolumab, which works by inhibiting the action of a programmed death receptor-1 (PD-1) that causes the multiplication of cancerous cells.

Country of origin

India

Manufacturer/Marketer address

1St Floor,`A` Block,Shiv Sagar Estate,Dr.A.B.Road,Worli, Mumbai,Maharashtra. 400018,India
Other Info - OPD0008

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

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