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  1. Home
  2. Medicine

  3. P-Coff DX Syrup

Prescription drug
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P-Coff DX Syrup, Pack of 1 Syrup
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Extra 15% Off with Bank Offers

Composition :

CHLORPHENIRAMINE MALEATE-4MG/5ML + DEXTROMETHORPHAN HYDROBROMIDE-10MG/5ML

Manufacturer/Marketer :

Pacific Meditech Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About P-Coff DX Syrup

P-Coff DX Syrup is used to treat coughs associated with a runny nose, sneezing, and throat irritation. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection.

P-Coff DX Syrup is a combination of two drugs: Chlorphenamine maleate and Dextromethorphan hydrobromide. Chlorphenamine maleate blocks the effects of histamine, reducing allergy symptoms. Dextromethorphan hydrobromide prevents cough by blocking signals from the brain’s cough centre.

In some cases, P-Coff DX Syrup may cause certain common side effects such as dry mouth/throat/nose, drowsiness, blurred vision, constipation, dizziness, and restlessness. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

If you are pregnant or breastfeeding, it is advised to inform your doctor before starting P-Coff DX Syrup. P-Coff DX Syrup is not recommended for children below 2 years of age. Keep your doctor informed about your health condition and any medications you are taking to rule out any potential side effects/interactions.

Uses of P-Coff DX Syrup

P-Coff DX Syrup is used to treat Cough. The detailed uses of P-Coff DX Syrup are as follows:

  • Cough Relief: P-Coff DX Syrup provides cough relief by acting on the brain's cough centre, reducing the frequency and intensity of coughing and preventing throat irritation.
  • Allergic Symptoms: P-Coff DX Syrup can be used to treat allergy-related symptoms, including throat discomfort, sneezing, and a runny nose.
  • Sleep Aid: P-Coff DX Syrup supports individuals who are having trouble sleeping because of a cough or respiratory pain by adding sedative properties.

Have a query?

Directions for Use

  • P-Coff DX Syrup can be taken with or without food. However, taking it with food or milk may help reduce stomach upset.
  • It is usually taken every 4-6 hours or as prescribed by your doctor.
  • Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided with the pack.
  • Avoid using regular household spoons, as they may not accurately measure the dose.

Medicinal Benefits

  • P-Coff DX Syrup is a combination of two drugs: Chlorphenamine maleate (antihistamine) and Dextromethorphan hydrobromide (cough suppressant).
  • Chlorphenamine maleate belongs to the class of antihistamines, also known as anti-allergic agents, that work by blocking the action of histamine, a substance responsible for causing allergic reactions.
  • Dextromethorphan hydrobromide belongs to the class of cough suppressants that block the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough.
  • Eases sneezing, runny nose, and watery eyes from allergies.
  • Reduces itching and irritation in the nose and throat.
  • Relief from dry and irritating cough.

How P-Coff DX Syrup Works

P-Coff DX Syrup is a combination of two drugs: Chlorphenamine maleate and Dextromethorphan hydrobromide. Chlorphenamine maleate works by blocking the action of histamine, a substance responsible for causing allergic reactions. Dextromethorphan hydrobromide blocks the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Together, P-Coff DX Syrup helps to relieve cough, cold and allergic symptoms.

Storage

• Store in a cool and dry place away from sunlight.• Keep P-Coff DX Syrup out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of P-Coff DX Syrup
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.

What if I have taken an overdose of P-Coff DX Syrup

Avoid exceeding the recommended dose as it might cause serious side effects. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take P-Coff DX Syrup if you are allergic to any of the contents.
  • Avoid using P-Coff DX Syrup if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine, and methylene blue injection in the past 14 days.
  • P-Coff DX Syrup should not be used in elderly patients with confusion.
  • It is advised to seek medical help if the cough does not go away or if it is followed by a high fever, skin rash, or persistent headache.
  • P-Coff DX Syrup may cause drowsiness, dizziness, and blurred vision in some patients; therefore, drive only if you are alert.
  • Avoid alcohol consumption along with P-Coff DX Syrup as it might cause increased dizziness.

Drug-Drug Interactions

verifiedApollotooltip
DextromethorphanPhenelzine
Critical
DextromethorphanSelegiline
Critical

Drug-Drug Interactions

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DextromethorphanPhenelzine
Critical
How does the drug interact with P-Coff DX Syrup:
Co-administration of Phenelzine and P-Coff DX Syrup can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Phenelzine and P-Coff DX Syrup can lead to an interaction. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DextromethorphanSelegiline
Critical
How does the drug interact with P-Coff DX Syrup:
Co-administration of P-Coff DX Syrup and Selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Selegiline with P-Coff DX Syrup can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering, shaking, blurred vision, muscle spasm, stiffness, incoordination, stomach cramps, nausea, vomiting, or diarrhea - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
DextromethorphanRasagiline
Critical
How does the drug interact with P-Coff DX Syrup:
Taking Rasagiline with P-Coff DX Syrup can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking P-Coff DX Syrup with Rasagiline is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor. Do not discontinue any medications without consulting a doctor.
DextromethorphanTranylcypromine
Critical
How does the drug interact with P-Coff DX Syrup:
Taking Tranylcypromine with P-Coff DX Syrup can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking P-Coff DX Syrup with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fit blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
DextromethorphanPargyline
Critical
How does the drug interact with P-Coff DX Syrup:
Co-administration of Pargyline and P-Coff DX Syrup can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of P-Coff DX Syrup and Pargyline can lead to an interaction. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DextromethorphanIsocarboxazid
Critical
How does the drug interact with P-Coff DX Syrup:
Co-administration of Isocarboxazid with P-Coff DX Syrup can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking P-Coff DX Syrup and Isocarboxazid can lead to an interaction. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DextromethorphanProcarbazine
Critical
How does the drug interact with P-Coff DX Syrup:
Co-administration of P-Coff DX Syrup and Procarbazine may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of Procarbazine with P-Coff DX Syrup can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering, shaking, blurred vision, muscle spasm, stiffness, incoordination, stomach cramps, nausea, vomiting, or diarrhea - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
ChlorpheniraminePotassium chloride
Critical
How does the drug interact with P-Coff DX Syrup:
Taking P-Coff DX Syrup and Potassium chloride (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking P-Coff DX Syrup with Potassium chloride it not recommended as it can lead to an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor. Do not discontinue any medications without a doctor's advice.
ChlorpheniraminePotassium citrate
Critical
How does the drug interact with P-Coff DX Syrup:
Taking P-Coff DX Syrup and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking P-Coff DX Syrup with Potassium citrate is not recommended as it can lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DextromethorphanOndansetron
Severe
How does the drug interact with P-Coff DX Syrup:
Co-administration of Ondansetron and P-Coff DX Syrup may increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Ondansetron and P-Coff DX Syrup, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as seizures (fits), extreme changes in blood pressure, confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, tremors, incoordination, blurred vision, muscle spasms or stiffness, nausea, vomiting, stomach cramp, and diarrhea, contact a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as they may increase mucus production. Also, avoid processed or refined foods. Instead, replace baked foods, fried foods, white bread, white pasta, french fries, sugary desserts, and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid a dry throat. It also helps loosen mucus.
  • Avoid citrus fruits as they may worsen the cough.
  • Eat fruits rich in water content, such as pears, watermelon, peaches, and pineapples.

Habit Forming

No

Therapeutic Class

EXPECTORANT AND COUGH PRODUCTS

P-Coff DX Syrup Substitute

Substitutes safety advice
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Alcohol

Unsafe

P-Coff DX Syrup may increase the effects of alcohol, so it is advised to avoid alcohol consumption.

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Pregnancy

Consult your doctor

Consult a doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Please consult a doctor if you have any concerns. Your doctor will decide if P-Coff DX Syrup can be taken by breastfeeding mothers or not.

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Driving

Caution

P-Coff DX Syrup may cause dizziness and drowsiness. Therefore, drive only if you are alert after taking P-Coff DX Syrup.

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Liver

Caution

Take P-Coff DX Syrup with caution, especially if you have a history of liver diseases. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take P-Coff DX Syrup with caution, especially if you have a history of kidney diseases. The dose may be adjusted by your doctor as required in severe kidney disease.

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Children

Caution

P-Coff DX Syrup is not recommended for children below 2 years of age. However, it can be used by children older than 2 years of age if prescribed by a child specialist.

FAQs

P-Coff DX Syrup is used to treat cough due to runny nose, sneezing, and throat irritation.

P-Coff DX Syrup contains Chlorphenamine maleate and Dextromethorphan hydrobromide. Chlorphenamine maleate blocks the action of histamine, a substance responsible for causing allergic reactions. Dextromethorphan hydrobromide works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Thus, decreasing the urge to cough.

P-Coff DX Syrup may be used to relieve allergic symptoms such as sneezing, runny nose, throat irritation, or watery eyes. P-Coff DX Syrup contains Chlorphenamine maleate, an anti-allergic drug that works by blocking the action of histamine, a substance responsible for causing allergic reactions.

P-Coff DX Syrup may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking P-Coff DX Syrup to experience this side effect. However, to avoid such side effects, drink plenty of water, rinse your mouth regularly, practice good oral hygiene, and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.

You are recommended to take P-Coff DX Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen even after one week of using P-Coff DX Syrup, please consult your doctor.

It is advised not to stop taking P-Coff DX Syrup without consulting your doctor, as it may worsen the cough or cause recurring symptoms. Therefore, take P-Coff DX Syrup for as long as your doctor has prescribed it, and if you experience any difficulty while taking P-Coff DX Syrup, please consult your doctor.

Caution should be advised while using P-Coff DX Syrup in people with Prostate problems. So, it should be taken only under the supervision of the doctor.

P-Coff DX Syrup should not be taken along with medicines called monoamine oxidase inhibitors (MAOIs), which are used in the treatment of psychiatric illness.

P-Coff DX Syrup is not recommended for children below 2 years of age. However, it can be used by children older than 2 years of age if prescribed by a child specialist.

Caution is advised when using P-Coff DX Syrup in individuals with eye problems. It should be taken only under the supervision of a doctor.

Yes, P-Coff DX Syrup is a good option to treat dry cough.

Symptoms, such as cough and congestion, are usually relieved within 30 minutes to an hour of taking the P-Coff DX Syrup, depending on the individual's response and the intensity of the symptoms.

P-Coff DX Syrup is a combination of two drugs: Chlorphenamine maleate and Dextromethorphan hydrobromide.

No, taking more than the prescribed dose may not be more effective; it may raise the possibility of experiencing severe adverse reactions.

There is no substantial research yet on using P-Coff DX Syrup in breastfeeding mothers. If you are a nursing mother, let your doctor know before taking P-Coff DX Syrup; your doctor will decide whether breastfeeding mothers can take it or not.

Yes, P-Coff DX Syrup may make you feel sleepier or drowsier.

P-Coff DX Syrup is safe to use if the doctor prescribes it, but it has specific limitations.

No, P-Coff DX Syrup is not an antibiotic medication. It is a combination of an antihistamine and an antitussive.

No, it is not recommended to treat fever. It is intended to treat cough.

P-Coff DX Syrup should be taken for the duration prescribed by the doctor based on your condition. Usually, it is taken every 8-12 hours.

The timing of taking P-Coff DX Syrup can vary depending on the specific instructions your healthcare professional provides.

Common side effects of P-Coff DX Syrup may include dry mouth/throat/nose, drowsiness, blurred vision, constipation, dizziness, and restlessness. Most of these side effects of P-Coff DX Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - PC13695

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Oct 6, 2025 | 7:58 AM IST

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Reference

  1. https://india-pharma.gsk.com/media/701324/piriton-cs.pdf
  2. https://www.drugs.com/mtm/chlorpheniramine-and-dextromethorphan.html
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