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  3. Papaverine Hydrochloride Inj

Papaverine Hydrochloride Inj, Pack of 1 INJECTION
Papaverine Hydrochloride Inj, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Papaverine Hydrochloride Injection is used to treat circulatory problems, smooth muscle spasms, peripheral vascular disease, and erectile dysfunction (impotence). It contains Papaverine which works by relaxing the blood vessels and smooth muscles and improving blood flow. In some cases, this medicine may cause side effects such as nausea, stomach upset, constipation, diarrhoea, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

PAPAVERINE-60MG

Manufacturer/Marketer :

Retort Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Papaverine Hydrochloride Injection

Papaverine Hydrochloride Injection belongs to the group of medicines called vasodilators used to treat circulatory problems, visceral spasms (gastrointestinal colic, urinary tract and biliary spasms), peripheral vascular disease, vascular spasm associated with angina pectoris, myocardial infarction, pulmonary and peripheral embolism. Additionally, Papaverine Hydrochloride Injection is also used to treat erectile dysfunction (impotence). 

Papaverine Hydrochloride Injection contains ‘Papaverine’, which works by relaxing the blood vessels; this helps the blood to flow easily to the heart and through the body. Thereby, Papaverine Hydrochloride Injection helps improve the blood flow in patients with circulatory problems. Papaverine Hydrochloride Injection exerts a spasmolytic effect by relaxing the smooth muscles. Thereby, helps in treating smooth muscle spasms. Papaverine Hydrochloride Injection helps to treat erectile dysfunction by relaxing the smooth muscles and increasing the blood flow to the penis.

In some cases, you may experience common side effects such as nausea, stomach upset, constipation, diarrhoea, and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Consult your doctor if you are pregnant, planning for pregnancy, or breastfeeding. Papaverine Hydrochloride Injection may cause dizziness and drowsiness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Papaverine Hydrochloride Injection should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects/interactions.

Uses of Papaverine Hydrochloride Injection

Treatment of Circulation problems, smooth muscle spasms, peripheral vascular disease, erectile dysfunction (impotence).

Directions for Use

Papaverine Hydrochloride Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Papaverine Hydrochloride Injection belongs to the group of medicines called vasodilators. It is used to treat circulatory problems, visceral spasms (gastrointestinal colic, urinary tract and biliary spasms), peripheral vascular disease, vascular spasms associated with angina pectoris, myocardial infarction, and pulmonary and peripheral embolism. Additionally, Papaverine Hydrochloride Injection is also used to treat erectile dysfunction (impotence). Papaverine Hydrochloride Injection works by relaxing the blood vessels; this helps the blood to flow easily to the heart and through the body. Thereby, Papaverine Hydrochloride Injection helps improve the blood flow in patients with circulatory problems. Papaverine Hydrochloride Injection is a non-specific, direct-acting smooth muscle relaxant causing a vasodilating effect on the blood vessels and other smooth muscle systems. Papaverine Hydrochloride Injection exerts a spasmolytic effect by relaxing the smooth muscles. Papaverine Hydrochloride Injection helps to treat erectile dysfunction by relaxing the smooth muscles and increasing the blood flow to the penis. Papaverine Hydrochloride Injection may also be used to control high blood pressure.

How Papaverine Hydrochloride Injection Works

Papaverine Hydrochloride Injection contains ‘Papaverine’, which works by relaxing the blood vessels; this helps the blood to flow easily to the heart and through the body. Thereby, Papaverine Hydrochloride Injection helps improve the blood flow in patients with circulatory problems. Papaverine Hydrochloride Injection exerts a spasmolytic effect by relaxing the smooth muscles. Thereby, helps in treating smooth muscle spasms. Papaverine Hydrochloride Injection helps to treat erectile dysfunction by relaxing the smooth muscles and increasing the blood flow to the penis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Papaverine Hydrochloride Inj
  • Avoid holding and empty the bladder at regular intervals.
  • Apply cold or ice packs for few minutes.
  • Exercise regularly and maintain a healthy lifestyle.
  • Make sure to have an adequate sleep.
  • Maintain healthy diet containing fruits and vegetables.
  • Exercise regularly and maintain a healthy weight.
  • Manage cholesterol and blood pressure.
  • Limit intake of caffeine and alcohol.
  • Avoid vaping and tobacco smoke.
  • Get enough sleep.
  • Talk to your doctor about antiarrhythmic drugs or other medications to treat your condition.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.

What if I have taken an overdose of Papaverine Hydrochloride Injection

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience symptoms of overdose such as drowsiness, weakness, vomiting, dizziness, sweating, double vision, fast heartbeats, redness, and uncontrolled eye movement.

Drug Warnings

Do not take Papaverine Hydrochloride Injection if you are allergic to any of its contents; if you have severe heart failure, myocardial infarction, heart attack, heart rhythm disorders, and intracranial hypertension. Inform your doctor if you have heart disease, glaucoma, high blood pressure, liver or kidney disease. Consult your doctor if you are pregnant, planning for pregnancy, or breastfeeding. Papaverine Hydrochloride Injection may cause dizziness and drowsiness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Papaverine Hydrochloride Injection should not be given to children as safety and effectiveness have not been established.

Drug-Drug Interactions

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PapaverineEscitalopram
Severe
PapaverineHydroxyzine
Severe

Drug-Drug Interactions

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PapaverineEscitalopram
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Combining Papaverine Hydrochloride Inj with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Co-administration of Escitalopram with Papaverine Hydrochloride Inj can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor if you experience symptoms like a slow heart rate, dizziness, fainting, or shortness of breath. Do not discontinue any medications without consulting your doctor.
PapaverineHydroxyzine
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Taking Hydroxyzine with Papaverine Hydrochloride Inj increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Hydroxyzine with Papaverine Hydrochloride Inj together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
PapaverineDoxepin
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Co-administration of Papaverine Hydrochloride Inj with Doxepin can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Papaverine Hydrochloride Inj with Doxepin together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
PapaverineOfloxacin
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Coadministration of Ofloxacin with Papaverine Hydrochloride Inj can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Ofloxacin with Papaverine Hydrochloride Inj together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PapaverineSolifenacin
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Coadministration of Papaverine Hydrochloride Inj with Solifenacin can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Papaverine Hydrochloride Inj with Solifenacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PapaverineClofazimine
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Co-administration of Papaverine Hydrochloride Inj with clofazimine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Papaverine Hydrochloride Inj with clofazimine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
PapaverineClomipramine
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Co-administration of Papaverine Hydrochloride Inj with clomipramine can increase the risk of irregular heart rhythms.

How to manage the interaction:
Although taking clomipramine and Papaverine Hydrochloride Inj together can cause an interaction, it can be taken if your doctor has suggested it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
PapaverineGranisetron
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Taking granisetron with Papaverine Hydrochloride Inj increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Granisetron with Papaverine Hydrochloride Inj together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PapaverineLoperamide
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Combining Loperamide with Papaverine Hydrochloride Inj can raise the chance of an abnormal heart rhythm.

How to manage the interaction:
Although taking Loperamide and Papaverine Hydrochloride Inj together can cause an interaction, it can be taken if your doctor has suggested it. however, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations contact a doctor right away. Do not stop using any medications without consulting a doctor.
PapaverineNorfloxacin
Severe
How does the drug interact with Papaverine Hydrochloride Inj Hydrochloride Inj:
Coadministration of Norfloxacin with Papaverine Hydrochloride Inj can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Papaverine Hydrochloride Inj together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Muscle spasms: 

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid extremely cold and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • Hot or cold therapy can be helpful for treating muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20 minutes.
  • Stay hydrated, and drink plenty of water.

Circulatory problems: 

  • Include fruits, vegetables, and fibre-rich whole grains in the diet.
  • Avoid high-calorie foods, sauces and sugars.
  • Limit consumption of alcohol.
  • Avoid tobacco.

Erectile dysfunction:

  • Maintain a healthy weight, eat a balanced diet, and exercise regularly.
  • Avoid the consumption of alcohol, as consuming an excessive amount of alcohol might temporarily impair your ability to get an erection.
  • Avoid the usage of tobacco.
  • Share intimate time with your partner.
  • Stay sexually active to prevent problems with erectile dysfunction.

Habit Forming

Yes

Therapeutic Class

VASODILATORS
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Alcohol

Caution

You are advised not to consume alcohol while on treatment with Papaverine Hydrochloride Injection as it might cause increased dizziness and drowsiness.

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Pregnancy

Caution

Consult your doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide if Papaverine Hydrochloride Injection can be taken by breastfeeding mothers or not.

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Driving

Caution

Papaverine Hydrochloride Injection may cause dizziness and drowsiness. Therefore you are advised to drive and operate machinery only if you are alert.

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Liver

Caution

Papaverine Hydrochloride Injection should be used with caution in patients with liver impairment. Please consult your doctor if you have liver impairment/liver disease or any concerns regarding this.

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Kidney

Caution

Please consult your doctor if you have kidney impairment/kidney disease or any concerns regarding this.

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Children

Unsafe

Papaverine Hydrochloride Injection should not be given to children as safety and effectiveness have not been established.

Have a query?

FAQs

Papaverine Hydrochloride Injection works by relaxing the blood vessels; this helps the blood to flow easily to the heart and through the body. Thereby, Papaverine Hydrochloride Injection helps in improving the blood flow in patients with circulatory problems.

Papaverine Hydrochloride Injection helps treat erectile dysfunction by causing direct smooth muscle relaxation and increasing the blood flow to the penis with blood, resulting in an erection.

Papaverine Hydrochloride Injection might cause priapism (prolonged erection). Consult a doctor immediately if the erection lasts for more than 4 hours.

Papaverine Hydrochloride Injection is a non-specific, direct-acting smooth muscle relaxant causing a vasodilating effect on the blood vessels and other smooth muscle systems. Papaverine Hydrochloride Injection exerts a spasmolytic effect by relaxing the smooth muscles of the gastrointestinal, bronchial, urinary tract, and biliary smooth muscles. Thereby, helps in treating muscle spasms.

Postural hypotension could be a side-effect of Papaverine Hydrochloride Injection. Postural hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better. People on treatment with Papaverine Hydrochloride Injection are advised to regularly monitor their blood pressure levels to avoid such unpleasant events.

Country of origin

INDIA

Manufacturer/Marketer address

21, 2, Mc Nichols Rd, Chentarnipet, Chennai, Tamil Nadu 600031
Other Info - PAP0013

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a682707.html
  2. https://www.medsafe.govt.nz/profs/Datasheet/d/dblPapaverineHydrochlorideinj.pdf
  3. https://data.health.gov.il/drugs/alonim/Rishum_11_458479319.pdf
  4. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9e5e2ce4-7a57-4c61-a826-64c8d11d038e
  5. https://www.healthdirect.gov.au/medicines/brand/amt,35936011000036101/papaverine-hydrochloride-dbl#downloads
  6. https://www.drugs.com/mtm/papaverine.html
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