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  3. Pegihep 100 Injection 1's

Pegihep 100 Injection 1's, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pegihep 100 Injection is used to treat Chronic (long-term) hepatitis C infection. It contains Peginterferon alpha-2b, which works by decreasing the amount of hepatitis C virus (HCV) in the body. In some cases, Pegihep 100 Injection may cause side effects such as injection site reactions, breathing problems (including shortness of breath), feeling depressed, trouble sleeping, thinking, or concentrating, dizziness, severe stomach pain or cramps, fever or chills, and painful or inflamed muscles (sometimes severe).

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Composition :

PEGINTERFERON ALFA 2B-100MCG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Pegihep 100 Injection

Pegihep 100 Injection is in a class of medications called interferons. It can be used alone or in combination with other medications to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage and who have not been treated with interferon-alpha (a medication similar to peginterferon alfa-2b) in the past.

Pegihep 100 Injection contains Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body. 

In some cases, Pegihep 100 Injection may cause side effects such as injection site reactions, breathing problems (including shortness of breath), feeling depressed, trouble sleeping, thinking, or concentrating, dizziness, severe stomach pain or cramps, fever or chills and painful or inflamed muscles (sometimes severe). Pegihep 100 Injection can induce or worsen serious or fatal conditions like infections, mental illness, mood and behaviour issues, or thoughts of hurting or killing oneself or others. You are advised to talk to your doctor if any of the side effects persist or worsen.

Extreme caution should be exercised while using Pegihep 100 Injection in patients with leukopenia, thrombocytopenia, renal Insufficiency and depression. So, inform your doctor about all your medical conditions. Also, let your doctor know about all medications you are taking to rule out the potential interactions and adverse events. Pegihep 100 Injection should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. It is unknown whether the components of this medicinal product are excreted in human milk. Breast-feeding should be stopped before starting treatment. Dosage is determined by body surface area and body weight in children three years of age and older and adolescent patients.

Uses of Pegihep 100 Injection

Pegihep 100 Injection is used in the treatment of Chronic (long-term) hepatitis C infection. The detailed uses of Pegihep 100 Injection are as follows:<br/>• Chronic Hepatitis C: Pegihep 100 Injection is used to treat chronic hepatitis C infection. It also helps reduce viral load and slow liver damage.<br/>• Treats melanoma: Pegihep 100 Injection is used as adjuvant therapy to help prevent recurrence after surgical removal of melanoma.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Pegihep 100 Injection will be administered by a nurse or doctor.• Do not self-administer.

Medicinal Benefits

Pegihep 100 Injection contains Interferon beta-1A, which belongs to the class of medications called interferons. It can be used alone or in combination with other medications to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage and who have not been treated with interferon-alpha (a medication similar to peginterferon alfa-2b) in the past. It works by modulating the body's immune system.

How Pegihep 100 Injection Works

Pegihep 100 Injection contains Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body.

Storage

• Store in a cool and dry place away from sunlight.
• Keep out of sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Pegihep 100 Injection
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Mood swings can be managed but cannot be controlled. Therefore, spending time in nature can help you feel light and improve your mood.
  • Practice meditation, deep breathing and do regular exercise that can positively affect your mood. Also helps in processing the situation before responding to it.
  • Food has direct impact on mood. Therefore, eat foods that are less processed and reduce sugar intake.
  • Consult your doctor if the mood swings are uncontrollable or unmanageable.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Pegihep 100 Injection

Since Pegihep 100 Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Pegihep 100 Injection cause or worsen serious or fatal autoimmune, ischemic, neuropsychiatric, and infectious illnesses. Patients with these diseases should be examined on a regular basis by clinical and laboratory testing, and they should discontinue taking Pegihep 100 Injection. Many, but not all, of these issues are resolved once the PEG-Intron medicine is stopped. Only a physician with experience managing hepatitis C patients should initiate and monitor treatment. Pregnancy must be avoided at all costs in female patients or partners of male patients taking Pegihep 100 Injection in combination with ribavirin. Females of childbearing potential must use an effective contraceptive during treatment and four months after treatment. Male patients or their female partners must use an effective contraceptive during treatment and for seven months after treatment is completed. The use of Pegihep 100 Injection in children and adolescents with serious psychiatric problems is not advised. Patients having a history of depression and/or suicide attempts should be closely monitored. Use of Pegihep 100 Injection is contraindicated in populations with hypersensitivity to the active substance, to any interferon, or to any of the excipients present in Pegihep 100 Injection. Let your doctor know if you have a history of severe pre-existing cardiac disease, including unstable or uncontrolled cardiac disease in the previous six months, severe, debilitating medical conditions, autoimmune hepatitis or a history of autoimmune disease, severe hepatic dysfunction or decompensated cirrhosis of the liver, pre-existing thyroid disease unless it can be controlled with conventional treatment, epilepsy and/or compromised central nervous system (CNS) function and HCV/HIV patients with cirrhosis and a Child-Pugh score ≥ 6.

Drug-Drug Interactions

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Peginterferon alfa-2bCladribine
Severe
Peginterferon alfa-2bEltrombopag
Severe

Drug-Drug Interactions

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Peginterferon alfa-2bCladribine
Severe
How does the drug interact with Pegihep 100 Injection:
Taking Pegihep 100 Injection with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Pegihep 100 Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Peginterferon alfa-2bEltrombopag
Severe
How does the drug interact with Pegihep 100 Injection:
When Eltrombopag is combined with Pegihep 100 Injection the serum concentration of Eltrombopag can be increased.

How to manage the interaction:
Although taking Eltrombopag and Pegihep 100 Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms, it's important to call your doctor right away. These symptoms include chronic hepatitis C, advanced liver disease, cirrhosis, liver failure, and other liver-related problems. You should also seek medical attention if you experience confusion, fever, joint pain, swelling, or any other unusual symptoms. Don't hesitate to reach out to a doctor if you have concerns about your health. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid heavily processed foods and saturated fats.
  • Include fruits, vegetables, and whole grains in the diet.
  • Try to stay active. Choose moderate exercises.
  • Quit smoking.
  • Prevent stress by doing meditation or yoga.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS
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Alcohol

Caution

Avoid consumption of alcohol while taking Pegihep 100 Injection.

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Pregnancy

Unsafe

If you are pregnant or plan to become pregnant, do not use Pegihep 100 Injection. You should not begin taking Pegihep 100 Injection until a pregnancy test has revealed that you are not pregnant. You or your partner may use effective birth control measures and be tested for pregnancy every month during your treatment and for six months afterwards. If you become pregnant at this period, contact your doctor right away. Pegihep 100 Injection may harm your fetus.

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Breast Feeding

Unsafe

You should not breastfeed your baby while on treatment with Pegihep 100 Injection as it may harm your infant.

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Driving

Unsafe

Do not drive or operate any machinery as Pegihep 100 Injection may make you drowsy, dizzy, or confused.

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Liver

Unsafe

Pegihep 100 Injection is not recommended for use in patients with decompensated liver disease as it may worsen the condition. Inform your doctor if you have liver cirrhosis before receiving Pegihep 100 Injection.

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Kidney

Caution

Use Pegihep 100 Injection with caution if you have kidney disease, as this medicine may worsen your condition. Inform your doctor if you have kidney problems.

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Children

Consult your doctor

Safety and effectiveness of Pegihep 100 Injection in pediatric patients below the age of 18 years have not been established. Please consult your doctor for more information.

Have a query?

FAQs

Pegihep 100 Injection is used to treat Chronic (long-term) hepatitis C infection.

Pegihep 100 Injection contains Peginterferon alpha-2b works by decreasing the amount of hepatitis C virus (HCV) in the body.

No, it may not be effective in preventing the spread of hepatitis C to others.

Peginterferon alfa-2b is used alone or in combination with other medication to treat chronic (long-term) hepatitis C infection. It may not cure hepatitis C or keep you from developing complications like cirrhosis (liver scarring), liver failure, or liver cancer.

A combination of Pegihep 100 Injection with telbivudine is not recommended.

Pegihep 100 Injection cause or worsen serious or life-threatening autoimmune, ischemic, neuropsychiatric and infectious diseases. Patients with these conditions should be continuously evaluated through clinical and laboratory examinations on a regular basis and stop using Pegihep 100 Injection. Many, but not all, of these problems are resolved after PEG-Intron medication is discontinued.

Yes, you can take over-the-counter medication to reduce fever. However, if fever persists, consult your doctor.

Yes, Pegihep 100 Injection may impair fertility. If you have concerns regarding this, please discuss with your doctor.

No, Pegihep 100 Injection does not cause weight gain. Instead, it may cause weight loss as side effect. If you experience sudden changes in weight, consult a doctor.

Yes, Pegihep 100 Injection may cause side effects such as injection site reactions, feeling depressed, breathing problems (including shortness of breath), trouble sleeping, dizziness, painful or inflamed muscles, severe stomach pain or cramps, and fever or chills. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - PEG0101

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.hepatitisc.uw.edu/page/treatment/drugs/peginterferon-alfa-2b-drug
  2. https://www.ema.europa.eu/en/documents/product-information/pegintron-epar-product-information_en.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/pegsche080701lb.htm
  4. https://medlineplus.gov/druginfo/meds/a605030.html

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