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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Pentanerv-SR 450 Tablet is used to manage or prevent neuropathic pain and epilepsy. Besides this, occasionally it is used to treat migraine headaches. It contains Gabapentin, which decreases the abnormal excitability of neurons (nerve cells) in the brain and helps in relieving nerve pain and lowers the risk of seizures. It may cause some side effects such as sleepiness, tiredness and dizziness. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

GABAPENTIN-450MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pentanerv-SR 450 Tablet

Pentanerv-SR 450 Tablet belongs to a group of medications called anticonvulsants used to manage or prevent neuropathic pain and epilepsy. Besides this, occasionally used to treat migraine headaches. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain. On the other hand, epilepsy is a nervous system disorder that occurs due to disturbed nerve cell activity in the brain.

Pentanerv-SR 450 Tablet contains Gabapentin' which works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain and lowers the risk of seizures. Besides this, it also decreases the number of pain signals sent out by damaged nerves in the body.

Pentanerv-SR 450 Tablet is available on prescription. It comes as capsules, tablets, and a liquid that you drink. Pentanerv-SR 450 Tablet can be taken by adults and children aged six years and over. Take Pentanerv-SR 450 Tablet exactly as directed. Please do not take more or less of it or take it more often than prescribed by your doctor. Sometimes, you may experience some side effects, including feeling sleepy, tired and dizzy. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Pentanerv-SR 450 Tablet for as long as your doctor has prescribed. Please do not stop taking Pentanerv-SR 450 Tablet without consulting your doctor as it could cause withdrawal symptoms. Do not take Pentanerv-SR 450 Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Pentanerv-SR 450 Tablet may cause drowsiness and dizziness, so drive if you are alert. Pentanerv-SR 450 Tablet should not be given to children unless prescribed. Avoid consuming alcohol along with Pentanerv-SR 450 Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed of your health condition and medicines to rule out any side effects.

Uses of Pentanerv-SR 450 Tablet

Pentanerv-SR 450 Tablet is used in the treatment of Neuropathic pain and Epilepsy. The detailed uses of Pentanerv-SR 450 Tablet are as follows:
•Neuropathic Pain Relief: Pentanerv-SR 450 Tablet is widely used to manage nerve pain caused by conditions such as diabetic neuropathy and postherpetic neuralgia, offering significant relief from discomfort.
•Seizure Management: Pentanerv-SR 450 Tablet serves as an adjunct therapy for partial seizures in both adults and children, enhancing control over seizure episodes.
•Restless Legs Syndrome: Pentanerv-SR 450 Tablet may be prescribed to alleviate symptoms of restless legs syndrome, providing relief from discomfort and improving sleep quality.
•Anxiety Disorders: In some cases, Pentanerv-SR 450 Tablet is used off-label for anxiety treatment, helping to lower anxiety levels and promote a sense of calm.
•Fibromyalgia Treatment: Pentanerv-SR 450 Tablet is effective in managing fibromyalgia symptoms, including widespread pain and sleep disturbances, thereby improving the overall quality of life for affected individuals.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it. Oral Solution/Suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup provided by the pack.

Medicinal Benefits

Pentanerv-SR 450 Tablet belongs to a class of medications called 'anticonvulsants' used to prevent neuropathic pain (pain due to damaged nerves), fibromyalgia (musculoskeletal pain), and epilepsy (fits). It works by binding to the specific site on voltage-gated calcium channels and blocking the action of overexcited channels; this helps in relieving nerve pain and lowers the risk of seizures. Overall it reduces nerve pain by interfering with pain signals travelling through the damaged nerves and the brain.

How Pentanerv-SR 450 Tablet Works

Pentanerv-SR 450 Tablet contains Gabapentin' which works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain and lowers the risk of seizures. Besides this, it also decreases the number of pain signals sent out by damaged nerves in the body.

Storage

Store in a cool and dry place away from sunlight
Side effects of Pentanerv-SR 450 Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Practice eating a balanced diet containing leafy greens, berries, fish, nuts, whole grains, lean protein, dark chocolate, sweet potatoes.
  • Exercising regularly and maintain a healthy lifestyle.
  • Practice different relaxation techniques
  • Cognitive behavioural therapy (CBT) is helpful.
  • Practice Yoga and meditation regularly.
  • Avoid intake of alcohol and caffeine.
  • Avoid foods containing Sodium, foods high in sugar, unhealthy fats, hot foods and drinks.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

What if I have taken an overdose of Pentanerv-SR 450 Tablet

Do not take more than the prescribed dose of Pentanerv-SR 450 Tablet as it may cause overdose. The symptoms of overdose include slurred speech, drowsiness, diarrhoea, or double vision. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Pentanerv-SR 450 Tablet if you are allergic to any of its contents. Inform your doctor before taking Pentanerv-SR 450 Tablet if you have symptoms of suicidal ideation or behaviour, drug addiction, chronic pulmonary insufficiency, muscle weakness, heart problems, liver/kidney impairment. Please do not stop taking Pentanerv-SR 450 Tablet without consulting your doctor as it could cause withdrawal symptoms. Do not take Pentanerv-SR 450 Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Avoid driving and consuming alcohol along with Pentanerv-SR 450 Tablet it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Avoid taking St John's Wort herbal supplement (antidepressant) while taking Pentanerv-SR 450 Tablet as it might cause increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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GabapentinTramadol
Severe
GabapentinEsketamine
Severe

Drug-Drug Interactions

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GabapentinTramadol
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Co-administration of Tramadol with Pentanerv-SR 450 Tablet may cause central nervous system depression and lead to serious side effects such as respiratory distress (build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Pentanerv-SR 450 Tablet and Tramadol, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, please consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
GabapentinEsketamine
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Combining Pentanerv-SR 450 Tablet with Esketamine can increase the risk of side effects.

How to manage the interaction:
Although taking Pentanerv-SR 450 Tablet and Esketamine together can evidently cause an interaction, it can be taken if a doctor has suggested it. Consult a doctor if you experience any symptoms such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not stop using any medications without a doctor's advice.
GabapentinBuprenorphine
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Co-administration of Buprenorphine and Pentanerv-SR 450 Tablet may cause central nervous system depression and lead to serious side effects (respiratory distress -build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Pentanerv-SR 450 Tablet and Buprenorphine, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
GabapentinMethadone
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Co-administration of Methadone and Pentanerv-SR 450 Tablet may cause central nervous system depression and lead to serious side effects such as respiratory distress (build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Pentanerv-SR 450 Tablet and Methadone, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, please consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
GabapentinOxycodone
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Combining Oxycodone with Pentanerv-SR 450 Tablet can increase the risk of CNS depression.

How to manage the interaction:
Taking Pentanerv-SR 450 Tablet with Oxycodone together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any symptoms like trouble breathing, dizziness, or trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
GabapentinSodium oxybate
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Taking Pentanerv-SR 450 Tablet with Sodium oxybate can increase the side effects on the central nervous system.

How to manage the interaction:
Although taking Pentanerv-SR 450 Tablet and Sodium oxybate together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs - feeling tired, dizzy, lightheaded, confused, sad, having low blood pressure, or difficulty breathing - make sure to contact your doctor right away. Do not stop using any medications without talking to a doctor.
GabapentinButorphanol
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Co-administration of Butorphanol and Pentanerv-SR 450 Tablet may cause central nervous system depression and lead to serious side effects such as respiratory distress (build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Pentanerv-SR 450 Tablet and Butorphanol, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, please consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GabapentinSufentanil
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Combining Sufentanil with Pentanerv-SR 450 Tablet can increase the risk of CNS depression.

How to manage the interaction:
There may be a possibility of interaction between Pentanerv-SR 450 Tablet and Sufentanil, but it can be taken if prescribed by a doctor. It's important to keep an eye on your health and talk to a doctor about any concerns. They can recommend different options that won't cause any problems. If you notice any symptoms like trouble breathing, feeling dizzy or tired, or having trouble focusing, make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.
GabapentinPentazocine
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Taking Pentazocine with Pentanerv-SR 450 Tablet can increase the risk of serious side effects.

How to manage the interaction:
Although taking Pentazocine and Pentanerv-SR 450 Tablet together can evidently cause an interaction, but it can be taken if a doctor has suggested it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GabapentinRemifentanil
Severe
How does the drug interact with Pentanerv-SR 450 Tablet:
Combining Remifentanil with Pentanerv-SR 450 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pentanerv-SR 450 Tablet with Remifentanil together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any symptoms like trouble breathing, dizziness, or trouble focusing, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain.
  • Rest well, get plenty of sleep.
  • Try to take a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.
  • Acupuncture can be helpful by stimulating pressure points.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Pentanerv-SR 450 Tablet Substitute

Substitutes safety advice
  • Gabapin SR 450 Tablet 10's

    by Others

    32.67per tablet
  • Gabapax SR-450 Tablet 15's

    by Others

    34.90per tablet
  • Gabax SR 450 mg Tablet 10's

    by Others

    15.75per tablet
  • Pentanerv Grds 450 Tablet 10's

    by Others

    39.90per tablet
  • Rygab 450mg Tablet ER

    by Others

    17.10per tablet
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Alcohol

Unsafe

It is unsafe to consume alcohol since it may worsen the side effects like dizziness and sleepiness.

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Pregnancy

Caution

Pentanerv-SR 450 Tablet is a category B1 pregnancy drug. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing Pentanerv-SR 450 Tablet .

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Breast Feeding

Caution

Usually, you can breastfeed while taking Pentanerv-SR 450 Tablet . Please consult your doctor before starting Pentanerv-SR 450 Tablet . Your doctor will weigh the benefits and potential risks before prescribing Pentanerv-SR 450 Tablet .

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Pentanerv-SR 450 Tablet . Pentanerv-SR 450 Tablet can also sometimes cause blurry/double vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Take Pentanerv-SR 450 Tablet with caution, especially if you have or had a history of liver disease/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Pentanerv-SR 450 Tablet with caution, especially if you have or had a history of kidney disease/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Pentanerv-SR 450 Tablet is not recommended for children below the age of 6 years. The safety and efficacy of Pentanerv-SR 450 Tablet have not established.

FAQs

Pentanerv-SR 450 Tablet is used to treat epilepsy and neuropathic pain.

Pentanerv-SR 450 Tablet is an anticonvulsant drug. In epilepsy, it works by stopping seizures by reducing the abnormal electrical activity in the brain. In nerve pain, it interferes with pain messages travelling through the brain and down the spine to block pain.

Do not drive or operate machinery if you experience dizziness or drowsiness while using Pentanerv-SR 450 Tablet . Pentanerv-SR 450 Tablet can also sometimes cause blurry/double vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

Dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of hands and feet, and dry mouth are some of the common side effects which might occur in people taking Pentanerv-SR 450 Tablet for a longer time.

Yes, Pentanerv-SR 450 Tablet may cause weight gain because as it, increases your hunger. However, regular physical exercise a balance diet with low-calorie food may help you keep your weight stable. Please consult your doctor if you have any further concerns to keep your weight stable.

Some persons, after taking it for a long time, have become addicted to Pentanerv-SR 450 Tablet . If this happens, once you stop taking the drug, you'll have withdrawal symptoms. If you are worried about being physically dependent on gabapentin, talk to your doctor.

Pentanerv-SR 450 Tablet is intended to use to manage or prevent neuropathic pain and epilepsy. It can help improve sleep in some cases. While it's not specifically approved for insomnia. it's crucial to consult with a healthcare professional to discuss your specific needs and potential risks.

Yes, Pentanerv-SR 450 Tablet can cause weight gain in some individuals. While this isn't a common side effect, it's a potential consequence. If you're worried about weight gain while taking gabapentin, it's important to discuss your concerns with your doctor. They can help you evaluate the benefits and risks of the medication and explore alternative treatment options if needed.

The onset of pain relief from Pentanerv-SR 450 Tablet can vary from person to person. While some people feel better after a few days, others may take many weeks to observe a significant change. If you don't see any relief after a few weeks or if your pain worsens, you should see your doctor.

Pentanerv-SR 450 Tablet may cause weight gain in some people. While this does not happen for everyone, it's a possibility. If you're worried about weight gain while taking gabapentin, it's important to discuss your concerns with your doctor. They can help you evaluate the benefits and risks of the medication and explore alternative treatment options if needed.

The duration of Pentanerv-SR 450 Tablet treatment varies based on individual factors. Your condition, how your body responds, the severity of your symptoms, and your doctor's recommendations will determine how long you'll need to take it. Always follow your doctor's instructions and avoid stopping the medication abruptly.

Very few people taking Pentanerv-SR 450 Tablet have serious problems. These include Suicidal thoughts, inflamed pancreas, hallucinations and allergic reactions. If you experience any of these serious side effects while taking gabapentin, it's important to seek medical attention immediately.

Pentanerv-SR 450 Tablet is not typically considered habit-forming. It does not have the same addictive potential as opioids.

No, you should not take Pentanerv-SR 450 Tablet off and on. Stopping and starting the medication can lead to unpredictable side effects and may not effectively manage your nerve pain.

Taking more than the recommended dose of Pentanerv-SR 450 Tablet can lead to serious side effects. If you or someone you know has taken too much gabapentin, it is important to seek medical attention immediately. Call you’re your doctor or go to the nearest hospital.

Before taking the Pentanerv-SR 450 Tablet , let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

While taking Pentanerv-SR 450 Tablet , it is essential to avoid alcohol and other sedating medications to prevent excessive drowsiness and impaired judgment. Avoid driving or operating machinery until you know how Gabapentin affects your coordination. To prevent seizures, don't stop taking Gabapentin abruptly without consulting your doctor. If you need to take antacids, wait at least 2 hours before taking Gabapentin to avoid interference with its absorption. If you're pregnant or breastfeeding, discuss the risks and benefits of Gabapentin with your healthcare provider.

Pentanerv-SR 450 Tablet does not affect any type of contraception.

Pentanerv-SR 450 Tablet may cause dizziness or drowsiness. It can also sometimes cause blurry/double vision, so avoid driving in such situations. Seek medical attention if the symptoms persist.

Take Pentanerv-SR 450 Tablet with caution, especially if you have or had a history of kidney disease/conditions. The dose may be adjusted by your doctor as required. So, inform your doctor about your condition before prescribing Pentanerv-SR 450 Tablet .

It's generally not recommended to take Pentanerv-SR 450 Tablet during pregnancy or breastfeeding without careful consideration and discussion with your doctor. They can provide the most accurate and appropriate information for your specific circumstances.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - PEN0404

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