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  3. Pirfenex 200 mg Table 15's

Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
Pirfenex 200 mg Table 15's, Pack of 15 TABLETS
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axis icici
bhim UPI
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Pirfenex 200 mg Table is used to treat idiopathic pulmonary fibrosis (lung disease). It contains Pirfenidone, which helps reduce the scarring and swelling in the lungs. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, and headache. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

PIRFENIDONE-200MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pirfenex 200 mg Table

Pirfenex 200 mg Table is used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease that is marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, which makes it difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.
 
Pirfenex 200 mg Table contains ‘Pirfenidone’, which helps reduce scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better. Pirfenex 200 mg Table helps in slowing down the progress of idiopathic pulmonary fibrosis. 

In some cases, you may experience certain common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Pirfenex 200 mg Table if you are pregnant or breastfeeding. Pirfenex 200 mg Table may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Pirfenex 200 mg Table as it could lead to increased dizziness. Pirfenex 200 mg Table is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Pirfenex 200 mg Table

Treatment of Idiopathic pulmonary fibrosis.

Directions for Use

Take Pirfenex 200 mg Table with food. Swallow Pirfenex 200 mg Table as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Pirfenex 200 mg Table is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Pirfenex 200 mg Table can help effectively slow the rate of lung function decline by 50%. Pirfenex 200 mg Table helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better. Pirfenex 200 mg Table helps in slowing down the progress of idiopathic pulmonary fibrosis.

How Pirfenex 200 mg Table Works

Pirfenex 200 mg Table contains ‘Pirfenidone’, which helps reduce scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better. Pirfenex 200 mg Table helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Pirfenex 200 mg Table
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Pirfenex 200 mg Table

Take Pirfenex 200 mg Table only as prescribed by the doctor. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Pirfenex 200 mg Table if you are allergic to any of its components; if you have a severe or end-stage liver impairment or kidney disease requiring dialysis; if you are taking fluvoxamine (anti-depressant). Inform your doctor if you are taking any medicines that might make you photosensitive, if you smoke or have kidney or liver problems. Consult your doctor before taking Pirfenex 200 mg Table if you are pregnant or breastfeeding. Pirfenex 200 mg Table may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Pirfenex 200 mg Table as it could lead to increased dizziness. Pirfenex 200 mg Table is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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PirfenidonePhenobarbital
Critical
PirfenidonePrimidone
Critical

Drug-Drug Interactions

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PirfenidonePhenobarbital
Critical
How does the drug interact with Pirfenex 200 mg Table:
When Pirfenex 200 mg Table is taken with Phenobarbital, it can decrease the effects of Pirfenex 200 mg Table.

How to manage the interaction:
Taking Pirfenex 200 mg Table with Phenobarbital is not recommended but can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
PirfenidonePrimidone
Critical
How does the drug interact with Pirfenex 200 mg Table:
Coadministration of Pirfenex 200 mg Table with primidone can reduce levels and the effects of Pirfenex 200 mg Table.

How to manage the interaction:
Although there is an interaction between Pirfenex 200 mg Table and primidone, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneCarbamazepine
Critical
How does the drug interact with Pirfenex 200 mg Table:
Taking Pirfenex 200 mg Table with Carbamazepine it reduces the levels and effects of Pirfenex 200 mg Table.

How to manage the interaction:
Taking Pirfenex 200 mg Table with Carbamazepine is not recommended but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidoneRifampicin
Critical
How does the drug interact with Pirfenex 200 mg Table:
Taking Pirfenex 200 mg Table with rifampicin can reduce the levels and effects of Pirfenex 200 mg Table

How to manage the interaction:
Although there is an interaction between Pirfenex 200 mg Table and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneEnoxacin
Severe
How does the drug interact with Pirfenex 200 mg Table:
When Enoxacin is taken with Pirfenex 200 mg Table, it can increase the levels of Pirfenex 200 mg Table, which may lead to side effects.

How to manage the interaction:
Although taking Pirfenex 200 mg Table and Enoxacin together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneLeflunomide
Severe
How does the drug interact with Pirfenex 200 mg Table:
Taking Leflunomide with Pirfenex 200 mg Table may increase the risk of liver damage.

How to manage the interaction:
Co-administration of Pirfenex 200 mg Table with Leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidoneAminolevulinic acid
Severe
How does the drug interact with Pirfenex 200 mg Table:
Co-administration of Aminolevulinic acid and Pirfenex 200 mg Table may increase the risk of skin burn.

How to manage the interaction:
There may be a possibility of interaction between Pirfenex 200 mg Table and Aminolevulinic acid, but it can be taken if prescribed by a doctor. Avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours after treatment. Do not discontinue any medications without consulting a doctor.
PirfenidoneKetoconazole
Severe
How does the drug interact with Pirfenex 200 mg Table:
Coadministration of Ketoconazole and Pirfenex 200 mg Table may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Pirfenex 200 mg Table together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
PirfenidoneCiprofloxacin
Severe
How does the drug interact with Pirfenex 200 mg Table:
When ciprofloxacin is taken Pirfenex 200 mg Table, the blood levels of Pirfenex 200 mg Table may increase, which may lead to side effects.

How to manage the interaction:
Although taking ciprofloxacin and Pirfenex 200 mg Table together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you have any of the following symptoms, fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medications without a doctor's advice.
PirfenidoneLomitapide
Severe
How does the drug interact with Pirfenex 200 mg Table:
Taking Lomitapide with Pirfenex 200 mg Table may increase the risk of liver damage

How to manage the interaction:
There may be a possibility of interaction between Pirfenex 200 mg Table and Lomitapide, but it can be taken if prescribed by a doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit and its products while using Pirfenex 200 mg Table can increase the risk of side effects. Avoid grape fruit and its products during treatment with Pirfenex 200 mg Table.

Diet & Lifestyle Advise

  • Watch out for triggers that make the cough worse, such as smoke, foods, air-conditioning, high altitude, etc.

  • Exercise moderately. Eat healthily.

  • Follow the pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.

  • Quit smoking.

  • Get ample rest.

  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.

  • Lean proteins such as fish, meat, and poultry are the best.

  • Hydration is important. Drink plenty of water, herbal tea, and fruit juices.

  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Pirfenex 200 mg Table Substitute

Substitutes safety advice

  • Fibrodone Tablet 10's

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  • Fiboresp Tablet 10's

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Product Substitutes

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Alcohol

Caution

It is not known if alcohol interacts with Pirfenex 200 mg Table . However, avoid consumption of alcohol while taking Pirfenex 200 mg Table as it may cause increased dizziness.

bannner image

Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Pirfenex 200 mg Table can be taken by breastfeeding mothers or not.

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Driving

Caution

Pirfenex 200 mg Table might cause dizziness and tiredness. Drive or operate machinery only if you are alert.

bannner image

Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this. Pirfenex 200 mg Table is not recommended for patients with severe hepatic impairment.

bannner image

Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns. Pirfenex 200 mg Table is not recommended for patients with an end-stage renal disease requiring dialysis.

bannner image

Children

Unsafe

Pirfenex 200 mg Table is not recommended for children below 18years as the safety and effectiveness has not been established.

Have a query?

FAQs

Pirfenex 200 mg Table is used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease that is marked by a progressive decline in lung function.

Pirfenex 200 mg Table helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Pirfenex 200 mg Table might make you photosensitive (sensitivity to sunlight). Avoid exposure to sunlight and sunlamps. Wear SPF 50+ sunscreen and protective clothing to reduce exposure to sunlight. Talk to your doctor if you are taking any medicines known to cause photosensitivity. If you notice any symptoms of photosensitivity, consult a doctor.

Do not discontinue Pirfenex 200 mg Table without consulting your doctor. To treat your condition effectually, continue taking Pirfenex 200 mg Table for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Pirfenex 200 mg Table .

Diarrhoea might be a side-effect of Pirfenex 200 mg Table . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

No, avoid smoking prior to the start of the treatment and while taking Pirfenex 200 mg Table as smoking might alter the effectiveness of Pirfenex 200 mg Table .

Weight loss could occur due to loss of appetite. Maintain proper weight by eating healthy food. Your doctor might monitor your weight whilst taking Pirfenex 200 mg Table . Consult your doctor if you notice severe weight loss.

Pirfenex 200 mg Table is not recommended for children below 18 years as the safety and effectiveness have yet to be established.

Taking Pirfenex 200 mg Table on an empty stomach may cause stomach discomfort. So, take Pirfenex 200 mg Table with food. Swallow Pirfenex 200 mg Table as a whole with a glass of water; do not chew or crush it.

While taking Pirfenex 200 mg Table , your doctor will monitor you regularly for potential side effects. This includes checking your liver and kidney function, blood cell count, weight, and skin for any reactions. They will also perform eye exams and monitor your lung function. Regular check-ups are crucial to ensure safe treatment. Be sure to follow your doctor's instructions and attend all scheduled appointments.

Continuing treatment with Pirfenex 200 mg Table is crucial because it helps slow down the progression of idiopathic pulmonary fibrosis (IPF), reduces the risk of lung function decline, and manages symptoms like cough and shortness of breath. This helps improve your quality of life and keeps you active. Stopping treatment may lead to disease progression, so it's essential to stick with your treatment plan and consult your doctor for personalized advice.

Common side effects of Pirfenex 200 mg Table may include nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

No, Pirfenex 200 mg Table is not a steroid. It is an antifibrotic medication, which means it helps to reduce scarring (fibrosis) in the lungs. It reduces inflammation and slows the progression of idiopathic pulmonary fibrosis (IPF), a chronic lung disease. While steroids can be used to reduce inflammation, Pirfenidone is a specific medication designed to target fibrosis in the lungs and has a different mechanism of action.

Pirfenex 200 mg Table is right for you if you have idiopathic pulmonary fibrosis (IPF) and your doctor has prescribed it to slow down lung scarring and progression.

Do not discontinue Pirfenex 200 mg Table without consulting your doctor, even if your condition appears to be under control. Stopping the medication abruptly may lead to a resurgence of symptoms and a loss of progress made. Continue taking the medication as prescribed and only discontinue use under the guidance of your healthcare provider. Regular monitoring and adjustments to your treatment plan will help ensure the best possible management of your condition.

While taking Pirfenex 200 mg Table , be sure to avoid excessive sun exposure and use sunscreen to protect your skin. Quit smoking to ensure the medication works effectively and to improve your overall health. Also, refrain from taking other medications without consulting your doctor, as they may interact with Pirfenex 200 mg Table . Additionally, limit your consumption of grapefruit and grapefruit juice to minimize potential side effects. By following these guidelines, you can safely manage your treatment and optimize your health outcomes.

The survival rate of pulmonary fibrosis varies depending on several factors, including the patient's age, health, lifestyle, and the severity of the disease at diagnosis. According to the European Respiratory Society, the median overall survival time of patients with idiopathic pulmonary fibrosis (IPF) is 4.5 years. However, survival rates can vary significantly, with some patients living up to 10 years or more after diagnosis.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - PIR0134

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.3705.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208780s000lbl.pdf
  3. https://www.drugs.com/mtm/pirfenidone.html
  4. https://www.esbriethcp.com/
  5. https://www.uhb.nhs.uk/Downloads/pdf/PiPirfenidone.pdf
  6. https://www.uhs.nhs.uk/Media/UHS-website-2019/Patientinformation/Respiratory/Pirfenidone-patient-information.PDF
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