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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Plavix Tablet is used for the prevention of heart attack or stroke in people at high risk of heart disease. It contains Clopidogrel, which helps in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easily through your veins, making it less likely to form a serious blood clot. So, it helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, or peripheral arterial disease (heart problem due to narrowed blood vessels). In some cases, you may experience side effects such as nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhoea, stomach pain, indigestion, or heartburn. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

CLOPIDOGREL-75MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Plavix Tablet

Plavix Tablet is used for the prevention of heart attack or stroke in people at high risk of heart disease. A heart attack generally refers to the blocked flow of blood to the heart because of the blockage of arteries. A heart blockage is most often a build-up of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

Plavix Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Plavix Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easily through your veins, making it less likely to form a serious blood clot. So, an intake of Plavix Tablet helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, or peripheral arterial disease (heart problem due to narrowed blood vessels).

The recommended daily dose of Plavix Tablet is 75 mg once daily orally, with or without food. It should be swallowed whole with a glass of water. Do not chew, bite or break it. Your doctor will advise you how often you take your tablets based on your medical condition. In some cases, you may experience nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhoea, stomach pain, indigestion, or heartburn. If the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Stopping a sudden intake of Plavix Tablet may worsen your condition and increase your risk of cardiovascular death, heart attack, and stroke. Let your doctor know if you have any liver, kidney, or heart problems. Plavix Tablet should be taken cautiously in pregnant or breastfeeding women. It should be not given to people with a bleeding disorder (haemophilia), active pathological bleeding, like a peptic ulcer, or bleeding in the brain (intracranial haemorrhage). Do not take Plavix Tablet with aspirin or ibuprofen for pain relief while you are using Plavix Tablet . It may increase the chance of having stomach ulcers or severe gastric bleeding.

Uses of Plavix Tablet

Prevention of heart attack, Prevention of stroke, Prevention of heart-related chest pain (angina).

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Plavix Tablet plays a vital role in preventing the formation of harmful blood clots in your blood vessels by making platelets (clotting agents) stick together. Thus, it helps to reduce the risk of heart attack, stroke, unstable angina (heart-related chest pain), and peripheral arterial disease (blocked or poor blood flow due to narrowed blood vessels) in heart disease patients and patients who have undergone recent heart surgery with a stent.

How Plavix Tablet Works

Plavix Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Plavix Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easily through your veins, making it less likely to form a serious blood clot. So, an intake of Plavix Tablet helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, or peripheral arterial disease (heart problem due to narrowed blood vessels).

Storage

Store in a cool and dry place away from sunlight
Side effects of Plavix Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

What if I have taken an overdose of Plavix Tablet

Do not take more than the prescribed dose of Plavix Tablet as it may cause overdose. The symptoms of overdose include unusual bleeding or bruising. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Indigestion medicines known as proton pump inhibitors like omeprazole should be used with caution while taking Plavix Tablet . Prolonged use of Plavix Tablet can cause bleeding problems (like nosebleeds, heavier periods, bleeding gums, and easy bruising). If you are going to have any surgery, discontinue taking Plavix Tablet 5 days before the surgery. Discontinuation of Plavix Tablet might increase the risk of heart attack, stroke, and other risks of cardiovascular events. So, do not stop taking Plavix Tablet suddenly. If you have had a recent stroke or heart attack, stop the intake of Plavix Tablet with painkillers like aspirin or ibuprofen, as it can increase your stomach or gastrointestinal bleeding. Purpura (blood leakage under the skin) has been observed with the use of Plavix Tablet , including in fatal cases.

Drug-Drug Interactions

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ClopidogrelMifepristone
Critical
ClopidogrelSelexipag
Critical

Drug-Drug Interactions

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ClopidogrelMifepristone
Critical
How does the drug interact with Plavix Tablet:
Taking Plavix Tablet together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Plavix Tablet with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
ClopidogrelSelexipag
Critical
How does the drug interact with Plavix Tablet:
When Selexipag and Plavix Tablet are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Plavix Tablet with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
ClopidogrelRepaglinide
Severe
How does the drug interact with Plavix Tablet:
Plavix Tablet increases the blood levels of Repaglinide, which results in increased effectiveness of Repaglinide. When these medicines are taken together, you may experience low blood sugar (hypoglycemia).

How to manage the interaction:
Although taking Plavix Tablet with Repaglinide may result in interaction, it can be taken if prescribed by a doctor. However, if you experience any signs of hypoglycemia (low blood sugar), consult your doctor immediately. Common symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, weakness, tremor, nausea, hunger, sweating, and palpitation. It is advised to monitor your blood sugar levels if you experience the above symptoms. Do not discontinue any medication without consulting a doctor.
ClopidogrelRamucirumab
Severe
How does the drug interact with Plavix Tablet:
The use of ramucirumab together with Plavix Tablet may raise the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Plavix Tablet and Ramucirumab, you can take these medicines together if prescribed by your doctor. If you notice these signs, contact your doctor immediately - feeling dizzy or lightheaded, dark or bloody stools, coughing, intense headaches, or weakness. Do not discontinue any medications without consulting your doctor.
ClopidogrelCabozantinib
Severe
How does the drug interact with Plavix Tablet:
Taking cabozantinib together with Plavix Tablet may increase the risk of bleeding.

How to manage the interaction:
Taking Plavix Tablet with Cabozantinib together can result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor immediately if you notice symptoms like bleeding, bruising, dizziness, or black stools. Do not stop using any medications without a doctor's advice.
ClopidogrelFluvoxamine
Severe
How does the drug interact with Plavix Tablet:
Taking fluvoxamine can lower the levels of Plavix Tablet in the blood, which can result in a decreased effectiveness of Plavix Tablet.

How to manage the interaction:
Taking Plavix Tablet and Fluvoxamine together possibly has an interaction, but you can take these medications together if your doctor has advised it. However, if you experience shortness of breath, dizziness, loss of balance, or trouble walking, consult your doctor immediately. Do not discontinue any medication without consulting your doctor.
ClopidogrelOmeprazole
Severe
How does the drug interact with Plavix Tablet:
When taken together omeprazole can lower the levels of Plavix Tablet in the blood, which can result in a decreased effectiveness of Plavix Tablet.

How to manage the interaction:
Taking omeprazole and Plavix Tablet together has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
ClopidogrelRosuvastatin
Severe
How does the drug interact with Plavix Tablet:
Taking rosuvastatin with Plavix Tablet can increase the blood levels of rosuvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although taking Plavix Tablet together with Rosuvastatin may result in an interaction, it can be taken if prescribed by your doctor. However, consult your doctor immediately if you experience chills, joint pain or swelling, skin rash, itching, nausea, vomiting, dark-colored urine, and/or yellowing of the skin or eyes. Do not discontinue any medication without consulting your doctor.
ClopidogrelRivaroxaban
Severe
How does the drug interact with Plavix Tablet:
Coadministration of Plavix Tablet with Rivaroxaban increases the risk of severe bleeding due to the additive effect.

How to manage the interaction:
Although taking Plavix Tablet with Rivaroxaban may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, coughing up or vomiting blood that looks like coffee grounds, or having a severe headache consult your doctor immediately. Do not discontinue any medication without consulting your doctor.
ClopidogrelTipranavir
Severe
How does the drug interact with Plavix Tablet:
Taking Tipranavir with Plavix Tablet can make the blood-thinning effects of Plavix Tablet stronger.

How to manage the interaction:
Although there is a possible interaction between Plavix Tablet and Tipranavir, you can take these medicines together if prescribed by your doctor. If you notice any bleeding, severe headaches, weakness, or black stools, contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A low cholesterol diet and a regular exercise regime complement treatment with Plavix Tablet effectively.
  • Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
  • Replacing most of your saturated fats with unsaturated fats can reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.
  • Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
  • Quit smoking and avoid excessive intake of alcohol.

Habit Forming

No

Therapeutic Class

ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS

Plavix Tablet Substitute

Substitutes safety advice
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    7.43per tablet
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  • Clopilet 75 mg Tablet 15's

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  • Clopitab Tablet 15's

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  • Deplatt 75 mg Tablet 15's

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    6.45per tablet
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Alcohol

Caution

You can drink alcohol with Plavix Tablet . But do not drink too much while taking this medicine. It can irritate your stomach.

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Pregnancy

Caution

Plavix Tablet should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Caution

Plavix Tablet should not be taken until prescribed. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Driving

Safe if prescribed

Plavix Tablet has no or negligible influence on the ability to drive or use machines.

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Liver

Safe if prescribed

No dosage adjustment is necessary in patients with liver disease.

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Kidney

Caution

Plavix Tablet should be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may have to adjust the dose.

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Children

Unsafe

Plavix Tablet is not recommended for children. The safety and effectiveness of Plavix Tablet have not been established in children due to limited testing of this drug on children by competent authorities across the world.

FAQs

Plavix Tablet is used to prevent heart attack or stroke in people at high risk of heart disease.

Plavix Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Plavix Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. It makes blood flow easily through your veins, making it less likely to form a serious blood clot. So, an intake of Plavix Tablet helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels).

Yes, Plavix Tablet causes blood to thin. It works by preventing platelets (a type of blood cell) from sticking together and forming clots.

Please consult your doctor if Plavix Tablet needs to be stopped before undergoing surgery. The doctor might ask you to stop taking Plavix Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure.

Do not take aspirin for pain relief or ibuprofen while you are taking Plavix Tablet unless your doctor says it's OK. They raise the risk of unusual bleeding.

When a blood clot is treated, guidelines recommend that patients take blood thinners for the rest of their lives. If they do not, the chance of developing a second clot is 30 to 40 per cent in the next 10 years.

There might be a problem if you are taking herbal therapies with Plavix Tablet , especially those that affect the blood, like Ginkgo Biloba and St John's wort plant extract used as an antidepressant. Together, taking can increase your risk of bleeding. Tell your doctor if you are using any type of herbal supplements before taking Plavix Tablet .

Yes, taking Plavix Tablet can increase the risk of bleeding as it contains aspirin, which is a blood thinner. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid any bleeding.

Plavix Tablet should be swallowed as a whole with water; do not crush or chew it. Plavix Tablet can be taken at any time of the day, but taking it at the same time daily would be better.

Yes, Plavix Tablet is a blood thinner. It contains clopidogrel, an antiplatelet medicine that prevents the formation of harmful blood clots.

No, Plavix Tablet is not a steroid. It is an antiplatelet medicine.

Plavix Tablet might lower the blood pressure. Not everyone experiences this as it is a rare side effect. Consult the doctor if you experience dizziness, blurred vision or light-headedness.

Do not take Plavix Tablet if you are allergic to any of its components, have severe liver disease or have a medical condition that causes bleeding such as a stomach ulcer or bleeding within the brain.

You can drink alcohol with Plavix Tablet . But do not drink too much alcohol as it can cause stomach irritation.

Avoid taking omeprazole along with Plavix Tablet as omeprazole can reduce the levels of clopidogrel and affect its working. Consult the doctor before taking omeprazole with Plavix Tablet .

Stopping Plavix Tablet may increase the risk of heart attack or stroke. Therefore, do not discontinue Plavix Tablet without consulting your doctor.

Plavix Tablet starts working within 2 hours of taking it.

Plavix Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of treatment based on your condition.

Yes, you can eat food while taking Plavix Tablet as it helps lower stomach irritation.

Be cautious while using sharp objects as you may bleed more easily or for a longer time than usual while you are taking Plavix Tablet . Let the doctor know that you are taking Plavix Tablet if you are due to undergo any surgery or dental procedure.

If you miss a dose of Plavix Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.

Consult the doctor before taking other medicines while on treatment with Plavix Tablet . Let the doctor know if you are using anticoagulants, painkillers, antidepressants or indigestion medicines.

Side effects of Plavix Tablet include diarrhoea, stomach pain, indigestion, heartburn, headache, nausea, vomiting, constipation, and dizziness. Consult the doctor if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.
Other Info - PLA0039

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