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  3. Pletoz 50 Tablet 10's

Prescription drug
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Pletoz 50 Tablet 10's, Pack of 10 TABLETS
Pletoz 50 Tablet 10's, Pack of 10 TABLETS
Pletoz 50 Tablet 10's, Pack of 10 TABLETS
Pletoz 50 Tablet 10's, Pack of 10 TABLETS
Pletoz 50 Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Pletoz 50 Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness or weakness in the legs on walking in such patients. It contains Cilostazole, which works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise. In some cases, you may experience headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea.
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Composition :

CILOSTAZOLE-50MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pletoz 50 Tablet

Pletoz 50 Tablet contains vasodilator (blood vessel widening) medication, Cilostazole, which is primarily used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness or weakness in the legs on walking in such patients. Intermittent claudication is a peripheral vascular disease in which you have cramp-like pain in your legs when you walk and is caused by an insufficient blood supply in your legs.

Pletoz 50 Tablet works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise.

Pletoz 50 Tablet should be taken regularly in dose and duration as advised by the doctor. It would be best to take it on an empty stomach and at a fixed time every day. Your doctor will advise you on the exact dosage and how often you must take Pletoz 50 Tablet based on your medical condition. In some cases, you may experience headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea. Most of these side effects of Pletoz 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Pletoz 50 Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Also, it is not suitable for some people. Inform your doctor before starting Pletoz 50 Tablet if you have any kidney or liver disease, plan to become pregnant, or are breastfeeding. Also, lifestyle changes should be continued with Pletoz 50 Tablet for best results. Do not take the Pletoz 50 Tablet if you ever had heart failure, chest pain, heart disease, and blood pressure. Before taking the Pletoz 50 Tablet , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Pletoz 50 Tablet

Treatment of Intermittent claudication

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Directions for Use

• Take Pletoz 50 Tablet on an empty stomach 1 hour before or 2 hours after a meal, or as advised by your doctor.• It is advised to take Pletoz 50 Tablet once daily; however, follow your doctor’s recommendation regarding the dosage and duration. • Swallow Pletoz 50 Tablet as a whole with a glass of water. • Do not crush, chew or break it.

Medicinal Benefits

Pletoz 50 Tablet contains, Cilostazole, which is a vasodilator that works by widening the blood vessel and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your legs' blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise.

How Pletoz 50 Tablet Works

Pletoz 50 Tablet works by widening the blood vessels and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation.

Storage

Keep out of sight and reach of children.
Side effects of Pletoz 50 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Your doctor may adjust the dose of your medication, discontinue, or switch to alternative medicines to manage your symptoms.
  • Drink plenty of water and caffeine-free drinks.
  • Eat more fibre by consuming fruits, vegetables, and whole grains.
  • Avoid processed, spicy, or fatty foods.
  • Try not to skip meals, delay eating, or eat too quickly.
  • Regular exercise can help improve digestion and promote better stool movement.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Pletoz 50 Tablet

Do not take more than the prescribed dose of Pletoz 50 Tablet as it may cause overdose. The symptoms of overdose include diarrhoea, dizziness, fainting, severe headache, fast or irregular heartbeat. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Pletoz 50 Tablet should not be given to the people allergic to Pletoz 50 Tablet , have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. Do not take Pletoz 50 Tablet with grapefruit juice or St John wort plant as it might affect the absorption of Pletoz 50 Tablet .  Tell your doctor that you are using Pletoz 50 Tablet before undergoing any dental or other surgery. Your doctor might stop this medicine before the surgery. It is best to take Pletoz 50 Tablet on an empty stomach and at a fixed time every day. Pletoz 50 Tablet should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side effects. Also, lifestyle changes should be continued with Pletoz 50 Tablet for best results and a speedy recovery.

Drug-Drug Interactions

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CilostazolMesoridazine
Critical
CilostazolThioridazine
Critical

Drug-Drug Interactions

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CilostazolMesoridazine
Critical
How does the drug interact with Pletoz 50 Tablet:
When Mesoridazine is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Mesoridazine with Pletoz 50 Tablet, is not recommended but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolThioridazine
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Thioridazine, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Thioridazine with Pletoz 50 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolCisapride
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Cisapride and Pletoz 50 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolPimozide
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Pimozide with Pletoz 50 Tablet is not generally advised, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolSparfloxacin
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Sparfloxacin and Pletoz 50 Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolZiprasidone
Critical
How does the drug interact with Pletoz 50 Tablet:
When Pletoz 50 Tablet is taken with Ziprasidone, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Using Ziprasidone and Pletoz 50 Tablet is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
CilostazolVandetanib
Severe
How does the drug interact with Pletoz 50 Tablet:
Co-administration of vandetanib with Pletoz 50 Tablet can increase the risk of irregular heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking vandetanib with Pletoz 50 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CilostazolNelfinavir
Severe
How does the drug interact with Pletoz 50 Tablet:
Co-administration of nelfinavir with Pletoz 50 Tablet may increase the risk of side effects.

How to manage the interaction:
Taking nelfinavir with Pletoz 50 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CilostazolIsavuconazole
Severe
How does the drug interact with Pletoz 50 Tablet:
Taking Isavuconazole with Pletoz 50 Tablet may increase the blood levels of Pletoz 50 Tablet, which may result in side effects.

How to manage the interaction:
Taking Isavuconazole with Pletoz 50 Tablet together can possibly result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as nausea, dizziness, lightheadedness, fainting, bleeding, irregular heartbeat or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CilostazolPosaconazole
Severe
How does the drug interact with Pletoz 50 Tablet:
Taking Pletoz 50 Tablet with posaconazole can increase the blood levels of Pletoz 50 Tablet. This may increase the risk and severity of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole and Pletoz 50 Tablet, they can be taken together if advised by your doctor. However, contact your doctor if you experience dizziness, lightheadedness, fainting, nausea, diarrhea, bleeding, heart palpitations, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in improving overall health. Take a break between exercises if you feel uneasy. Finding the right exercise is the key.

  • Rest well, and get plenty of sleep.

  • Take proper care of your legs and feet.

  • Wear shoes that fit you well.

  • Check your feet daily for any cracks or sores.

  • Try to stay warm. Avoid cold temperatures.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Pletoz 50 Tablet Substitute

Substitutes safety advice
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Alcohol

Safe if prescribed

No interaction found; in case of any discomfort, consult your doctor.

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Pregnancy

Caution

Pletoz 50 Tablet is not recommended during pregnancy unless your doctor considers it essential. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Breast Feeding

Unsafe

Pletoz 50 Tablet is not recommended for breastfeeding mothers as it may harm the baby.

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Driving

Caution

Drive with caution, Pletoz 50 Tablet may cause blurry vision and dizziness or weariness may occur.

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Liver

Caution

Pletoz 50 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Pletoz 50 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

Pletoz 50 Tablet is not recommended for children. The safety and effectiveness of Pletoz 50 Tablet have not been established in children due to limited testing of this drug on children. If necessary, your doctor will decide whether to give Pletoz 50 Tablet or not.

FAQs

Pletoz 50 Tablet is used to treat intermittent claudication (pain in the legs due to insufficient blood flow). It also reduces cramping, numbness, or weakness in the legs when walking in such patients.

Pletoz 50 Tablet works by widening the blood vessel and reducing the blood clotting time, thereby decreasing stickiness in blood vessels. Hence, increasing the blood supply to the limbs. It can also increase the distance you can walk without pain since it improves your leg's blood circulation.

No, you should not stop taking Pletoz 50 Tablet even if you feel better as the pain might come back and become even worse.

Yes, taking Pletoz 50 Tablet can increase bleeding risk as it contains cilostazole, which increases bleeding time. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid bleeding. Let your doctor know before going any surgical procedure that you are taking Pletoz 50 Tablet .

No, it is a prescribed drug given by a physician for preventing specific medical conditions. Taking it on your own can cause unwanted side-effects.

If you forget to take Pletoz 50 Tablet at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.

Yes, Pletoz 50 Tablet contains cilostazole which increases the blood clotting time. It works by preventing platelets (a type of blood cell) from sticking together and forming clots, preventing heart attack and stroke.

Pletoz 50 Tablet may cause side effects like headaches, ankle swelling, diarrhoea, abnormal stools, vomiting, and nausea. Most of these side effects of Pletoz 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Pletoz 50 Tablet might lower the blood pressure; taking Pletoz 50 Tablet with blood pressure-lowering medicines might further decrease the blood pressure. Therefore, please consult the doctor before taking Pletoz 50 Tablet with other blood pressure-lowering medicines.

You may notice an improvement in 2-4 weeks. However, it might take 12 weeks to notice the full benefits of Pletoz 50 Tablet . Keep taking Pletoz 50 Tablet for the prescribed duration to treat your condition effectively.

No, do not smoke if you are taking Pletoz 50 Tablet as smoking might affect the working of Pletoz 50 Tablet .

You are advised to take Pletoz 50 Tablet for the duration prescribed by the doctor. The duration of treatment will depend upon your condition and response to the treatment.

Yes, you may need to stop taking Pletoz 50 Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure. Let the doctor know if you are due to undergo surgery.

Pletoz 50 Tablet might lower the blood pressure as it widens the blood vessels. Therefore, if you have low blood pressure/high blood pressure or if you are taking blood pressure-lowering medicines, please consult the doctor.

Pletoz 50 Tablet is not advised for patients with heart failure due to its potential to increase platelet aggregation, which could lead to higher mortality rates in these individuals.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - PLE0008

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:35 AM IST

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Reference

  1. https://patient.info/medicine/cilostazol-tablets
  2. https://www.drugs.com/mtm/cilostazol.html

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