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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Polyfic Plus 750000 Units Injection is used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms. It contains Polymyxin B, which destroys bacterial cell membranes and kills infection-causing bacteria. Thereby, it helps treat bacterial infections. In some cases, Polyfic Plus 750000 Units Injection may cause side effects such as pain at the injection site, flushing, dizziness, and diarrhoea.

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Whats That

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Synonym :

POLYMYXIN B SULPHATE

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Polyfic Plus 750000 Units Injection

Polyfic Plus 750000 Units Injection belongs to the group of medicines called antibiotics used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms.

Polyfic Plus 750000 Units Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

In some cases, Polyfic Plus 750000 Units Injection may cause side effects such as pain at the injection site, flushing, dizziness, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. However, consult a doctor if the side effects persist or worsen.

Let the doctor know if you are allergic to any of the components in Polyfic Plus 750000 Units Injection. Consult the doctor if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Polyfic Plus 750000 Units Injection

Polyfic Plus 750000 Units Injection is used in the treatment of Bacterial infections. The detailed uses of Polyfic Plus 750000 Units Injection are as follows:<br/>• Treat bloodstream infections: Polyfic Plus 750000 Units Injection is effective against septicemia caused by resistant gram-negative bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli.<br/>• Manage meningitis: Polyfic Plus 750000 Units Injection is administered intrathecally to treat bacterial meningitis, especially when caused by Pseudomonas aeruginosa or Haemophilus influenzae.<br/>• Treat urinary tract infections: Polyfic Plus 750000 Units Injection helps eliminate gram-negative pathogens in complicated or hospital-acquired UTIs.<br/>• Address pulmonary infections: Polyfic Plus 750000 Units Injection is used in cases of pneumonia and pulmonary embolism caused by multidrug-resistant gram-negative bacteria.<br/>

Directions for Use

• Polyfic Plus 750000 Units Injection will be administered by a healthcare professional.• Do not self-administer it.

Medicinal Benefits

Polyfic Plus 750000 Units Injection belongs to the group of medicines called antibiotics used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms. Polyfic Plus 750000 Units Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

How Polyfic Plus 750000 Units Injection Works

Polyfic Plus 750000 Units Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Polyfic Plus 750000 Units Injection out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Polyfic Plus 750000 Units Injection

As Polyfic Plus 750000 Units Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not receive Polyfic Plus 750000 Units Injection if you are allergic to any of its components. Consult the doctor if you are pregnant or breastfeeding. Seek medical attention if you experience symptoms of kidney problems (unable to pass urine, change in how much urine you pass), nerve problems (weakness, irritation, feeling sleepy, blurred eyesight, change in balance, numbness or tingling around the mouth or in the arms or legs, or trouble breathing), or Clostridium difficile associated diarrhoea/CDAD (stomach pain, cramps, very loose, watery, or bloody stool). Let the doctor know if you are taking any prescription/non-prescription medicines, including supplements or herbal products.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Polyfic Plus 750000 Units Injection:
Coadministration of Amikacin with Polyfic Plus 750000 Units Injection may increase the risk of severe side effects.

How to manage the interaction:
Although taking Amikacin and Polymyxin- b together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience ringing in the ears, difficulty breathing, vomiting, irregular urination, swelling, muscle pain, dizziness, or palpitation. Do not stop using any medications without talking to a doctor.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Taking Tenofovir alafenamide with Polyfic Plus 750000 Units Injection can increase the chance of side effects.

How to manage the interaction:
Taking Tenofovir alafenamide with Polyfic Plus 750000 Units Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Co-administration of Netilmicin with Polyfic Plus 750000 Units Injection can increase the risk of side effects.

How to manage the interaction:
Co-administration of Netilmicin with Polyfic Plus 750000 Units Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, hearing loss, ringing in the ears, vertigo, consult a doctor. Do not discontinue any medications without a doctor's advice.
Polymyxin bCholera, live attenuated
Severe
How does the drug interact with Polyfic Plus 750000 Units Injection:
Taking Polyfic Plus 750000 Units Injection and Cholera together may lead to a decrease in the effectiveness of the vaccine.

How to manage the interaction:
There may be a possibility of interaction between Polyfic Plus 750000 Units Injection and Cholera, live attenuated, but it can be taken if prescribed by a doctor. It is advised not to receive the cholera vaccination until at least 14 days after finishing your Polyfic Plus 750000 Units Injection therapy in order to ensure an appropriate immune response. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Co-administration of Polyfic Plus 750000 Units Injection and Vecuronium together may cause serious breathing problems.

How to manage the interaction:
Taking Polyfic Plus 750000 Units Injection with Vecuronium together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any breathing difficulty, consult the doctor. Do not stop using any medications without a doctor's advice.
Polymyxin bBCG vaccine
Severe
How does the drug interact with Polyfic Plus 750000 Units Injection:
When the BCG vaccine is used with Polyfic Plus 750000 Units Injection, its effectiveness may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Polyfic Plus 750000 Units Injection and BCG vaccine, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Taking Everolimus and Polyfic Plus 750000 Units Injection together may increase the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Everolimus and Polyfic Plus 750000 Units Injection, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Taking Kanamycin with Polyfic Plus 750000 Units Injection can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Polyfic Plus 750000 Units Injection and Kanamycin, but it can be taken if prescribed by a doctor. However, if you experience hearing loss, ringing in the ears, vertigo, difficulty breathing, nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Co-administration of Polyfic Plus 750000 Units Injection with Atracurium may cause serious breathing problems

How to manage the interaction:
There may be a possibility of interaction between Polyfic Plus 750000 Units Injection and Atracurium, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Polyfic Plus 750000 Units Injection:
Coadministration of Tenofovir disoproxil with Polyfic Plus 750000 Units Injection can increase the risk of side effects.

How to manage the interaction:
Taking Tenofovir disoproxil with Polyfic Plus 750000 Units Injection together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include whole grains, fruits, and vegetables in your diet. 
  • Taking probiotics after antibiotic treatment and eating high-fibre and prebiotic foods may help reduce side effects and support digestion.
  • Exercising regularly helps in improving overall health. 
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress.
  • Avoid processed and fried food.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Polyfic Plus 750000 Units Injection. Please consult the doctor.

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Pregnancy

Caution

The safety of polymyxin B in pregnancy has not been established. If you are pregnant or planning pregnancy, inform the doctor before receiving Polyfic Plus 750000 Units Injection.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Polyfic Plus 750000 Units Injection. Caution is advised while administering Polyfic Plus 750000 Units Injection to lactating women.

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Driving

Consult your doctor

It is unknown if Polyfic Plus 750000 Units Injection affects your ability to drive. Drive only if you are alert.

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Liver

Consult your doctor

If you have a history of liver problems, inform the doctor before receiving Polyfic Plus 750000 Units Injection.

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Kidney

Caution

If you have a history of kidney problems, inform the doctor before receiving Polyfic Plus 750000 Units Injection.

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Children

Safe if prescribed

Polyfic Plus 750000 Units Injection may be safe for use in children if prescribed by the doctor.

Have a query?

FAQs

Polyfic Plus 750000 Units Injection is used to treat Bacterial infections.

Polyfic Plus 750000 Units Injection works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

Diarrhoea might be a side effect of Polyfic Plus 750000 Units Injection. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult the doctor if the condition persists or worsens.

Polyfic Plus 750000 Units Injection may cause nerve problems. Consult the doctor if you experience weakness, irritation, change in balance, feeling sleepy, blurred eyesight, trouble breathing, numbness or tingling sensation in the arms and legs.

Polyfic Plus 750000 Units Injection will be administered by a healthcare professional. Do not self-administer.

Yes, Polyfic Plus 750000 Units Injection is safe when used only under the doctor’s supervision. However, it may cause pain at the injection site, flushing, dizziness, and diarrhoea while using it.

The common side effects of Polyfic Plus 750000 Units Injection may include pain at the injection site, flushing, dizziness, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. However, consult a doctor if the side effects persist or worsen.

Country of origin

INDIA

Manufacturer/Marketer address

Shantisadan, Mirzapur Road, Ahmedabad -380001
Other Info - POL0493

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