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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Polyxx 500000IU Injection is used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms. It contains Polymyxin B, which destroys bacterial cell membranes and kills infection-causing bacteria. Thereby, it helps treat bacterial infections. In some cases, Polyxx 500000IU Injection may cause side effects such as pain at the injection site, flushing, dizziness, and diarrhoea.

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Whats That

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Synonym :

POLYMYXIN B SULPHATE

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Polyxx 500000IU Injection

Polyxx 500000IU Injection belongs to the group of medicines called antibiotics used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms.

Polyxx 500000IU Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

In some cases, Polyxx 500000IU Injection may cause side effects such as pain at the injection site, flushing, dizziness, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. However, consult a doctor if the side effects persist or worsen.

Let the doctor know if you are allergic to any of the components in Polyxx 500000IU Injection. Consult the doctor if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Polyxx 500000IU Injection

Polyxx 500000IU Injection is used in the treatment of Bacterial infections. The detailed uses of Polyxx 500000IU Injection are as follows:<br/>• Treat bloodstream infections: Polyxx 500000IU Injection is effective against septicemia caused by resistant gram-negative bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli.<br/>• Manage meningitis: Polyxx 500000IU Injection is administered intrathecally to treat bacterial meningitis, especially when caused by Pseudomonas aeruginosa or Haemophilus influenzae.<br/>• Treat urinary tract infections: Polyxx 500000IU Injection helps eliminate gram-negative pathogens in complicated or hospital-acquired UTIs.<br/>• Address pulmonary infections: Polyxx 500000IU Injection is used in cases of pneumonia and pulmonary embolism caused by multidrug-resistant gram-negative bacteria.<br/>

Directions for Use

• Polyxx 500000IU Injection will be administered by a healthcare professional.• Do not self-administer it.

Medicinal Benefits

Polyxx 500000IU Injection belongs to the group of medicines called antibiotics used to treat bacterial infections such as urinary tract infections, meningitis, bloodstream infections, and corneal and subconjunctival eye infections caused by susceptible organisms. Polyxx 500000IU Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

How Polyxx 500000IU Injection Works

Polyxx 500000IU Injection contains Polymyxin B, which works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Polyxx 500000IU Injection out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Polyxx 500000IU Injection

As Polyxx 500000IU Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not receive Polyxx 500000IU Injection if you are allergic to any of its components. Consult the doctor if you are pregnant or breastfeeding. Seek medical attention if you experience symptoms of kidney problems (unable to pass urine, change in how much urine you pass), nerve problems (weakness, irritation, feeling sleepy, blurred eyesight, change in balance, numbness or tingling around the mouth or in the arms or legs, or trouble breathing), or Clostridium difficile associated diarrhoea/CDAD (stomach pain, cramps, very loose, watery, or bloody stool). Let the doctor know if you are taking any prescription/non-prescription medicines, including supplements or herbal products.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Polyxx 500000IU Injection:
Co-administration of Polyxx 500000IU Injection and Vecuronium together may cause serious breathing problems.

How to manage the interaction:
Taking Polyxx 500000IU Injection with Vecuronium together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any breathing difficulty, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Polyxx 500000IU Injection:
Co-administration of Deferasirox and Polyxx 500000IU Injection may increase the risk of kidney problems.

How to manage the interaction:
Although taking Polyxx 500000IU Injection and Deferasirox together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, swelling, breathing difficulty, bone pain, muscle pain, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyxx 500000IU Injection:
Taking Adefovir dipivoxil with Polyxx 500000IU Injection may increase the risk of side effects.

How to manage the interaction:
Although taking Polyxx 500000IU Injection and Adefovir dipivoxil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, decreased hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyxx 500000IU Injection:
Taking Human immunoglobulin with Polymyxin- b, may raise the risk of kidney problems.

How to manage the interaction:
Although taking Human immunoglobulin and Polyxx 500000IU Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Polymyxin bCholera, live attenuated
Severe
How does the drug interact with Polyxx 500000IU Injection:
Taking Polyxx 500000IU Injection and Cholera together may lead to a decrease in the effectiveness of the vaccine.

How to manage the interaction:
There may be a possibility of interaction between Polyxx 500000IU Injection and Cholera, live attenuated, but it can be taken if prescribed by a doctor. It is advised not to receive the cholera vaccination until at least 14 days after finishing your Polyxx 500000IU Injection therapy in order to ensure an appropriate immune response. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyxx 500000IU Injection:
Co-administration of Sirolimus and Polyxx 500000IU Injection together may increase the risk or severity of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Sirolimus and Polyxx 500000IU Injection, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
Polymyxin bIodamide
Severe
How does the drug interact with Polyxx 500000IU Injection:
Co-administration of Iodamide with Polyxx 500000IU Injection may increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Polyxx 500000IU Injection and Iodamide, you can take these medicines together if prescribed by a doctor. However, contact a doctor immediately if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pain, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Polyxx 500000IU Injection:
Taking Kanamycin with Polyxx 500000IU Injection can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Polyxx 500000IU Injection and Kanamycin, but it can be taken if prescribed by a doctor. However, if you experience hearing loss, ringing in the ears, vertigo, difficulty breathing, nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyxx 500000IU Injection:
When Neomycin and Polyxx 500000IU Injection are taken together, there is an increased possibility of severe side effects.

How to manage the interaction:
Taking Polyxx 500000IU Injection with Neomycin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, hearing loss, ringing in the ears, vertigo, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Polyxx 500000IU Injection:
Co-administration of Polyxx 500000IU Injection may increase the effects of Suxamethonium when taken in combination.

How to manage the interaction:
Co-administration of Suxamethonium with Polyxx 500000IU Injection can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include whole grains, fruits, and vegetables in your diet. 
  • Taking probiotics after antibiotic treatment and eating high-fibre and prebiotic foods may help reduce side effects and support digestion.
  • Exercising regularly helps in improving overall health. 
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress.
  • Avoid processed and fried food.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS
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Alcohol

Consult your doctor

It is not known if alcohol interacts with Polyxx 500000IU Injection. Please consult the doctor.

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Pregnancy

Caution

The safety of polymyxin B in pregnancy has not been established. If you are pregnant or planning pregnancy, inform the doctor before receiving Polyxx 500000IU Injection.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Polyxx 500000IU Injection. Caution is advised while administering Polyxx 500000IU Injection to lactating women.

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Driving

Consult your doctor

It is unknown if Polyxx 500000IU Injection affects your ability to drive. Drive only if you are alert.

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Liver

Consult your doctor

If you have a history of liver problems, inform the doctor before receiving Polyxx 500000IU Injection.

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Kidney

Caution

If you have a history of kidney problems, inform the doctor before receiving Polyxx 500000IU Injection.

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Children

Safe if prescribed

Polyxx 500000IU Injection may be safe for use in children if prescribed by the doctor.

Have a query?

FAQs

Polyxx 500000IU Injection is used to treat Bacterial infections.

Polyxx 500000IU Injection works by destroying bacterial cell membranes and killing infection-causing bacteria. Thereby, it helps treat bacterial infections.

Diarrhoea might be a side effect of Polyxx 500000IU Injection. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult the doctor if the condition persists or worsens.

Polyxx 500000IU Injection may cause nerve problems. Consult the doctor if you experience weakness, irritation, change in balance, feeling sleepy, blurred eyesight, trouble breathing, numbness or tingling sensation in the arms and legs.

Polyxx 500000IU Injection will be administered by a healthcare professional. Do not self-administer.

Yes, Polyxx 500000IU Injection is safe when used only under the doctor’s supervision. However, it may cause pain at the injection site, flushing, dizziness, and diarrhoea while using it.

The common side effects of Polyxx 500000IU Injection may include pain at the injection site, flushing, dizziness, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. However, consult a doctor if the side effects persist or worsen.

Country of origin

India
Other Info - PO20488

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