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PRAZOQOL DSR TABLET is composed of two medicines, namely: Domperidone and Pantoprazole. Domperidone is a prokinetic and anti-nausea agent that helps to treat indigestion and stomach pain. On the other hand, Pantoprazole is a proton pump inhibitor that reduces the excess stomach acid formation by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). PRAZOQOL DSR TABLET is a widely used medicine to treat peptic ulcers and gastroesophageal reflux disease (GERD). PRAZOQOL DSR TABLET prevents the release of stomach acid and relieves symptoms of food pipe lining inflammation (esophagitis), and gastroesophageal reflux disease (GERD), or heartburn.

Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, that is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall responsible for the release of gastric acid secretion damaging tissues in the food pipe, stomach, and duodenum.

PRAZOQOL DSR TABLET can be prescribed to the adults and children aged 12 years and over. It is better to take PRAZOQOL DSR TABLET an hour before a meal. PRAZOQOL DSR TABLET should be swallowed whole with a glass of water. Do not chew, crush, or break it. Avoid intake of PRAZOQOL DSR TABLET for more than four weeks of duration without consulting the doctor. You can increase the efficacy of PRAZOQOL DSR TABLET by taking a small meal or snacks frequently. Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep fried/processed foods, carbonated drinks, acidic foods like citrus fruits/vegetables (tomatoes).

Like all medicines, PRAZOQOL DSR TABLET may cause side effects, although not everybody gets them. The most common side effects of PRAZOQOL DSR TABLET are diarrhoea, stomach pain, flatulence (gas), dryness in the mouth, dizziness, and headache. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor. Prolonged intake of Pantoprazole is associated with a low level of Vitamin B12 and low magnesium. Hence yearly test of Vitamin B12 and magnesium is required if you are taking PRAZOQOL DSR TABLET for the long term. Use of PRAZOQOL DSR TABLET is contraindicated in people with lupus (autoimmune inflammatory disease).


Gastroesophageal reflux disease (GERD), Heartburn due to hyperacidity, Inflammation of food pipe (esophagitis), Peptic ulcer

Medicinal Benefits

PRAZOQOL DSR TABLET plays a vital role in preventing nausea, vomiting, stomach upset, stomach pain, peptic ulcer, and other conditions due to hyperacidity or acid reflux. Pantoprazole prevents proton pumps gate from producing an excessive amount of stomach acid. While Domperidone stops nausea (feeling sick) and vomiting (being sick) blocking messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting center.

Directions for Use

It is better to take PRAZOQOL DSR TABLET an hour before a meal. PRAZOQOL DSR TABLET should be swallowed whole with a glass of water. Do not chew, crush, or break it. Do not take PRAZOQOL DSR TABLET for more than 4 weeks of duration without consulting the doctor.


Most of the side effects of PRAZOQOL DSR TABLET do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Some common side effects of PRAZOQOL DSR TABLET headache, diarrhoea, nausea, abdominal pain, vomiting, flatulence, dizziness, and arthralgia (joint pain). Very rarely, it may cause swelling of the tongue and/or throat, difficulty in swallowing, difficulties in breathing, allergic facial swelling, severe dizziness with a very fast heartbeat, and heavy sweating. blistering of the skin, acute kidney injury, yellowing of the skin, fever, rash, and enlarged kidneys sometimes with painful urination, and lower back pain (serious inflammation of the kidneys), possibly leading to kidney failure. This requires immediate medical attention.

In-Depth Precautions and Warning

Drug Warnings

You should avoid taking PRAZOQOL DSR TABLET if you are allergic to PRAZOQOL DSR TABLET or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy, and breastfeeding mothers. PRAZOQOL DSR TABLET may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of PRAZOQOL DSR TABLET may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), Vitamin B12, and magnesium deficiency. Intake of PRAZOQOL DSR TABLET may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool) immediately consult the doctor. 

Safety Advice

  • Safety Warning


    It is best to avoid alcohol while taking medication.

  • Safety Warning


    Consult Your Doctor

    If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. You should use this medicine only if your doctor considers the benefit for you greater than the potential risk for your unborn child or baby.

  • Safety Warning

    Breast Feeding

    Consult Your Doctor

    The name is not recommended during breast-feeding. However, your doctor may prescribe it for you during breast-feeding if he/she feels that the benefit to you outweighs the risk. You should not take $ name without doctor's advice.

  • Safety Warning


    Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking PRAZOQOL DSR TABLET you should not drive or operate any machinery or vehicles.

  • Safety Warning


    In patients with severe liver impairment, the liver enzymes should be monitored regularly during treatment with pantoprazole, particularly on long-term use

  • Safety Warning


    If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking the PRAZOQOL DSR TABLET.

Habit Forming


Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
  • Before going to sleep try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows, instead, one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
  • Avoid taking alcohol and smoking cigarette. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter) which prevents backflow of the stomach acid back into the food pipe.
  • Include high fibre containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidant, calcium and vitamin B 12 that can help cope with the long term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help in the prevention of excess stomach acid production. Cranberry juice can be beneficial in the peptic ulcer and H Pyroli infection.
  • Avoid regular sitting continuously, as it can increase stomach acid production. Try to take a break of 5 minutes in 1 hour by brisk walking or stretching.

Other Information (PRA0235)

This item is Not Returnable.

Expires on or after - Mar-22

Patients Concern

Disease/Condition Glossary

Normally a thick layer of mucous protects the stomach against its own acid secretion. But, in long run, it gets eroded by excessive stomach acid production leading to complications like GERD, peptic ulcer, and Zollinger Ellison syndrome. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe that causes heartburn. On the other hand, a peptic ulcer is a painful condition followed by the development of sores or ulcers in the stomach lining or duodenum (first part of the small intestine). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.


No, PRAZOQOL DSR TABLET is a prescribed drug with minimal side-effects. Only take it if your doctor has recommended it to you for acidity.

PRAZOQOL DSR TABLET can be safely taken as long as your doctor has prescribed it to you.

Yes, taking PRAZOQOL DSR TABLET for a very long time can cause calcium depletion from the body leading to weakening of bones. Hence a calcium and vitamin D supplement is recommended along with PRAZOQOL DSR TABLET to replenish calcium depletion in the body.

Yes. PRAZOQOL DSR TABLET can alter certain medical tests like neuroendocrine tumours (secretin stimulation test), and urine screening tests for tetrahydrocannabinol (THC). So before undergoing such diagnostics test contact your doctor.

Prolonged intake of PRAZOQOL DSR TABLET may weaken your bone and lower haemoglobin level. Your doctor may prescribe you Vitamin B12 for enhancing haemoglobin and calcium/vitamin D/magnesium supplements for bone health.

Combination of pantoprazole and domperidone is effective & safe.



Manufacturer/Marketer address

Proqol Healthcare Pvt. Ltd., No 6 , Shop No 5, 2nd Floor, Sneham Commercial complex, MTH Road, Padi, Chennai- 600050



MRP: 121.00


10 Tablet in 1 Strip