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  3. Premarin Vaginal Cream 14 gm

Premarin Vaginal Cream 14 gm, Pack of 1 CREAM
Premarin Vaginal Cream 14 gm, Pack of 1 CREAM
Premarin Vaginal Cream 14 gm, Pack of 1 CREAM
Premarin Vaginal Cream 14 gm, Pack of 1 CREAM
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Composition :

CONJUGATED ESTROGENS-0.625MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

VAGINAL

Return Policy :

Not Returnable

Expires on or after :

About Premarin Vaginal Cream

Premarin Vaginal Cream is used as hormone replacement therapy (HRT) to treat symptoms associated with menopause. During menopause, the estrogen levels decrease, which leads to hot flushes. It is also used to relieve moderate to severe pain during sexual intercourse due to menopause.

Premarin Vaginal Cream contains conjugated estrogens used as hormone replacement therapy (HRT). It works by replacing the estrogen hormone in menopausal women. It also regulates the secretions of hormones such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help improve the symptoms of menopause.

Premarin Vaginal Cream is applied directly to the vagina. It should be used as recommended by your doctor. Do not use it for a longer duration than advised. After applying, if you get any allergic reactions such as vaginal burning, irritation or itching, stop using it and inform your doctor on priority. Because it is a topical cream, avoid using it on wounds, cuts, or burns. It may cause certain common side effects such as vaginal discharge, pain and swelling in the breasts, discharge from the nipples, changes in breast tissue, feeling or being sick, bloating, abdominal pain, headache etc. 

Premarin Vaginal Cream should be avoided if you are allergic to it or if any ingredients are present in it. Inform your doctor about your current medical history, as this medicine should not be used in patients with breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), thrombosis (have a blood clot in the veins), deep vein thrombosis (clotting of blood in the legs) or pulmonary embolism (clotting of blood in the lungs), heart attack or angina (chest pain), inherited porphyria (a blood disorder) or liver disease. Premarin Vaginal Cream is not recommended for use in pregnant and breastfeeding women. If you develop jaundice (yellowing of the skin and eyes), high blood pressure and migraine-like headache, become pregnant or notice signs of a blood clot such as redness, swelling and pain in the legs, sudden chest pain or difficulty in breathing, stop treatment and inform your doctor immediately. Inform your doctor if you have any intolerance to sugar.

Uses of Premarin Vaginal Cream

Treatment of moderate to severe hot flashes, changes in and around the vagina, and other symptoms of menopause or low estrogen levels (hypoestrogenism)

Directions for Use

• Follow your doctor's instructions regarding the dosage and duration.• Check the label for directions and use it as advised by the doctor. Fill the applicator with the medicine as directed. Insert the applicator high into the vagina and squeeze the plunger to release the medication.• Wash the applicator with warm, soapy water and throughly rinse it.

Medicinal Benefits

Premarin Vaginal Cream contains ‘conjugated estrogens’, a hormone replacement therapy (HRT). In menopause, estrogen levels become too low, so Premarin Vaginal Cream works by replacing this hormone. It also regulates the secretions of other hormones from the pituitary gland, such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help to reduce the symptoms of menopause.

How Premarin Vaginal Cream Works

Premarin Vaginal Cream contains conjugated estrogens used as hormone replacement therapy (HRT). It works by replacing the estrogen hormone in menopausal women. It also regulates the secretions of hormones such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help improve the symptoms of menopause.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Premarin Vaginal Cream

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.

Drug Warnings

Before using Premarin Vaginal Cream, inform your doctor if you are allergic to it. Also, inform if you have fibroids inside the womb, growth of womb lining outside the womb (endometriosis), excessive thickening of the womb lining (endometrial hyperplasia), increased risk of developing blood clots, increased risk of getting estrogen-sensitive cancer (in people with a family history of breast cancer), high blood pressure, diseases associated with liver, kidney, or heart, fluid retention (oedema), diabetes, gallbladder stones, migraine or severe headache, systemic lupus erythematosus, epilepsy (fits), asthma, osteosclerosis (a condition affecting eardrum and hearing), hypocalcemia (low calcium levels in the blood), and high levels of fat in the blood. Premarin Vaginal Cream increases the risk of endometrial hyperplasia and endometrial cancer, so your doctor may prescribe you the hormonal medicine ‘progesterone’ to minimize this risk. Inform your doctor if you are pregnant or breastfeeding, as Premarin Vaginal Cream is not recommended for use in such a population.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Wear loose, layered clothing during the night time, especially in warm weather. This prevents hot flushes.

  • Manage your weight. Shed excess weight by exercising regularly if you are obese or overweight. 

  • Apply moisturizers to prevent skin dryness.

  • Limit alcohol intake and quit smoking.

  • Maintain hygiene.

Habit Forming

No

Therapeutic Class

HORMONES
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Alcohol

Caution

Avoid consumption of alcohol as it may worsen your condition by increasing the risk of side effects.

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Pregnancy

Unsafe

Premarin Vaginal Cream is a category X drug. This medicine is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before using Premarin Vaginal Cream. Your doctor may prescribe an alternative based on the medical condition.

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Breast Feeding

Unsafe

Premarin Vaginal Cream may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before using Premarin Vaginal Cream. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe if prescribed

It is not known whether Premarin Vaginal Cream will affect your ability to drive. Hence consult your doctor.

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Liver

Unsafe

Premarin Vaginal Cream should not be used in patients with liver diseases. Hence inform your doctor if you have liver problems before using this medicine.

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Kidney

Caution

Premarin Vaginal Cream should be used with caution in patients with severe kidney diseases. Hence, If you have a pre-existing or a history of kidney disease, inform your doctor before using Premarin Vaginal Cream. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Premarin Vaginal Cream is not recommended for use in children.

Have a query?

FAQs

Premarin Vaginal Cream is used as hormone replacement therapy (HRT) to treat symptoms associated with menopause. It is also used to relieve moderate to severe pain during sexual intercourse due to menopause.

Premarin Vaginal Cream works by replacing the deficient estrogen hormone in menopausal women. It effectively reduces the symptoms and improves health conditions.

Premarin Vaginal Cream does not act as a contraceptive. You may need an additional contraceptive agent to prevent pregnancy if you have not had a menstrual period in less than 12 months or under 50 years. So, consult your doctor for advice.

Your doctor will decide the dose of Premarin Vaginal Cream based on your health condition. Do not use more than the recommended dose of Premarin Vaginal Cream.

Premarin Vaginal Cream increases the risk of breast cancer. However, the risk increases when given only HRT (hormone replacement therapy) and longer durations.

Country of origin

Canada

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ?G? Block , Bandra Kurla Complex, Bandra East , Mumbai ? 400051.
Other Info - PRE0033

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:23 AM IST

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Reference

  1. https://www.webmd.com/drugs/2/drug-78022/conjugated-estrogens-vaginal/details
  2. https://www.premarinvaginalcream.com/about
  3. https://www.mayoclinic.org/drugs-supplements/conjugated-estrogens-vaginal-route/side-effects/drg-20075461?p=1#:~:text=Conjugated%20estrogens%20vaginal%20cream%20is,only%20with%20your%20doctor's%20prescription.
  4. https://www.premarinvaginalcream.comites/default/files/2022-04/PP-PVC-USA-0783_PVC_How_to_Apply_Guide_1.pdf

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